ORCID Profile
0000-0002-6017-6564
Current Organisation
University of Oslo
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Publisher: American Association for the Advancement of Science (AAAS)
Date: 08-01-2016
Abstract: Large earthquakes can trigger dangerous landslides across a wide geographic region. The 2015 M w 7.8 Gorhka earthquake near Kathmandu, Nepal, was no exception. Kargal et al. used remote observations to compile a massive catalog of triggered debris flows. The satellite-based observations came from a rapid response team assisting the disaster relief effort. Schwanghart et al. show that Kathmandu escaped the historically catastrophic landslides associated with earthquakes in 1100, 1255, and 1344 C.E. near Nepal's second largest city, Pokhara. These two studies underscore the importance of determining slope stability in mountainous, earthquake-prone regions. Science , this issue p. 10.1126/science.aac8353 see also p. 147
Publisher: Wiley
Date: 21-11-2014
Publisher: American Geophysical Union (AGU)
Date: 13-06-2000
DOI: 10.1029/00EO00187
Publisher: Elsevier BV
Date: 06-2019
Publisher: Copernicus GmbH
Date: 07-02-2020
Abstract: Abstract. Permafrost is present within almost all of the Antarctic's ice-free areas, but little is known about spatial variations in permafrost temperatures except for a few areas with established ground temperature measurements. We modelled a temperature at the top of the permafrost (TTOP) for all the ice-free areas of the Antarctic mainland and Antarctic islands at 1 km2 resolution during 2000–2017. The model was driven by remotely sensed land surface temperatures and downscaled ERA-Interim climate reanalysis data, and subgrid permafrost variability was simulated by variable snow cover. The results were validated against in situ-measured ground temperatures from 40 permafrost boreholes, and the resulting root-mean-square error was 1.9 ∘C. The lowest near-surface permafrost temperature of −36 ∘C was modelled at Mount Markham in the Queen Elizabeth Range in the Transantarctic Mountains. This is the lowest permafrost temperature on Earth, according to global-scale modelling results. The temperatures were most commonly modelled between −23 and −18 ∘C for mountainous areas rising above the Antarctic Ice Sheet and between −14 and −8 ∘C for coastal areas. The model performance was good where snow conditions were modelled realistically, but errors of up to 4 ∘C occurred at sites with strong wind-driven redistribution of snow.
Publisher: Wiley
Date: 10-2013
DOI: 10.1002/PPP.1792
Publisher: American Association for the Advancement of Science (AAAS)
Date: 16-09-2022
DOI: 10.1126/SCIIMMUNOL.ABI4611
Abstract: Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet established. Here, we report three families with immune-associated defects, poor growth, pancytopenia, and skin pigmentation abnormalities that segregate with biallelic DPP9 rare variants. Using patient-derived primary cells and biochemical assays, these variants were shown to behave as hypomorphic or knockout alleles that failed to repress NLRP1. The removal of a single copy of Nlrp1a/b/c , Asc , Gsdmd , or Il-1r , but not Il-18 , was sufficient to rescue the lethality of Dpp9 mutant neonates in mice. Similarly, dpp9 deficiency was partially rescued by the inactivation of asc , an obligate downstream adapter of the NLRP1 inflammasome, in zebrafish. These experiments suggest that the deleterious consequences of DPP9 deficiency were mostly driven by the aberrant activation of the canonical NLRP1 inflammasome and IL-1β signaling. Collectively, our results delineate a Mendelian disorder of DPP9 deficiency driven by increased NLRP1 activity as demonstrated in patient cells and in two animal models of the disease.
Publisher: Elsevier BV
Date: 04-2020
No related grants have been discovered for Andreas Kääb.