ORCID Profile
0000-0002-4565-7618
Current Organisations
Boston University
,
Boston University School of Medicine
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Publisher: Elsevier BV
Date: 02-2016
Publisher: Springer Science and Business Media LLC
Date: 26-09-2017
Publisher: Springer Science and Business Media LLC
Date: 12-2016
Publisher: Public Library of Science (PLoS)
Date: 30-06-2017
Publisher: Springer Science and Business Media LLC
Date: 09-03-2016
DOI: 10.1038/NCOMMS10933
Abstract: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES , P =2.55 × 10 −11 ), 6p25.2 (rs73718779, SERPINB6 , P =1.97 × 10 −8 ) and 3q28 (rs9815073, LPP , P =3.62 × 10 −8 ), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11 , P =1.00 × 10 −11 ) in the combined analysis. We find suggestive evidence ( P × 10 −7 ) for two additional new loci at 4q24 (rs10028805, BANK1 , P =7.19 × 10 −8 ) and 3p22.2 (rs1274963, CSRNP1 , P =2.12 × 10 −7 ). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
Publisher: Springer Science and Business Media LLC
Date: 08-01-2015
DOI: 10.1038/NCOMMS6751
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P =3.95 × 10 −15 ) and HLA-B (rs2922994, P =2.43 × 10 −9 ) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Publisher: BMJ
Date: 10-2017
Publisher: Oxford University Press (OUP)
Date: 09-02-2016
DOI: 10.1093/HMG/DDW027
Publisher: Oxford University Press (OUP)
Date: 08-04-2023
DOI: 10.1093/IJE/DYAD046
Abstract: Adult obesity is a strong risk factor for endometrial cancer (EC) however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47–3.29) and young adulthood (OR = 1.26, 95% CI = 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre erimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.
Publisher: Elsevier BV
Date: 10-2014
Publisher: Elsevier BV
Date: 02-2019
Publisher: Springer Science and Business Media LLC
Date: 16-06-2013
DOI: 10.1038/NG.2652
Publisher: Springer Science and Business Media LLC
Date: 28-09-2014
DOI: 10.1038/NG.3105
Publisher: Springer Science and Business Media LLC
Date: 28-06-2016
Location: United States of America
Location: United States of America
No related grants have been discovered for Kimberly Bertrand.