ORCID Profile
0000-0002-1713-7797
Current Organisations
The University of Edinburgh
,
University College Cork
,
University of Birmingham
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Publisher: Environmental Health Perspectives
Date: 08-2013
DOI: 10.1289/EHP.1206085
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2016
DOI: 10.1038/AJG.2016.106
Abstract: Clostridium difficile (C. difficile) may worsen the prognosis of ulcerative colitis (UC). The objectives of this study were to: (i) validate the International Classification of Diseases-10 (ICD-10) code for C. difficile (ii) determine the risk of C. difficile infection after diagnosis of UC (iii) evaluate the effect of C. difficile infection on the risk of colectomy and (iv) assess the association between C. difficile and postoperative complications. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated by comparing ICD-10 codes for C. difficile with stool toxin tests. A population-based surveillance cohort of newly diagnosed UC patients living in Alberta, Canada were identified from 2003 to 2009 (n=1,754). The effect of a C. difficile infection on colectomy was modeled using competing risk survival regression after adjusting for covariates. The effect of a C. difficile infection on postoperative complications was assessed using a mixed effects logistic regression model. The sensitivity, specificity, PPV, and NPV of the ICD-10 code for C. difficile were 82.1%, 99.4%, 88.4%, and 99.1%, respectively. The risk of C. difficile infection within 5 years of diagnosis with UC was 3.4% (95% confidence interval (CI): 2.5-4.6%). The risk of colectomy was higher among UC patients diagnosed with C. difficile (sub-hazard ratio (sHR)=2.36 95% CI: 1.47-3.80). C. difficile increased the risk of postoperative complications (odds ratio=4.84 95% CI: 1.28-18.35). C. difficile was associated with mortality (sHR=2.56 times 95% CI: 1.28-5.10). C. difficile diagnosis worsens the prognosis of newly diagnosed patients with UC by increasing the risk of colectomy, postoperative complications, and death.
Publisher: Oxford University Press (OUP)
Date: 30-12-2016
Publisher: Elsevier BV
Date: 07-2018
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Subrata Ghosh.