Aki Laakso

How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 03-2010

DOI: 10.1227/01.NEU.0000365518.47684.98

Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 12-2014

DOI: 10.1161/STROKEAHA.114.006096

Abstract: Common variants have been identified using genome-wide association studies which contribute to intracranial aneurysms (IA) susceptibility. However, it is clear that the variants identified to date do not account for the estimated genetic contribution to disease risk. Initial analysis was performed in a discovery s le of 2617 IA cases and 2548 controls of white ancestry. Novel chromosomal regions meeting genome-wide significance were further tested for association in 2 independent replication s les: Dutch (717 cases 3004 controls) and Finnish (799 cases 2317 controls). A meta-analysis was performed to combine the results from the 3 studies for key chromosomal regions of interest. Genome-wide evidence of association was detected in the discovery s le on chromosome 9 ( CDKN2BAS rs10733376: P .0×10 −11 ), in a gene previously associated with IA. A novel region on chromosome 7, near HDAC9 , was associated with IA (rs10230207 P =4.14×10 −8 ). This association replicated in the Dutch s le ( P =0.01) but failed to show association in the Finnish s le ( P =0.25). Meta-analysis results of the 3 cohorts reached statistical significant ( P =9.91×10 −10 ). We detected a novel region associated with IA susceptibility that was replicated in an independent Dutch s le. This region on chromosome 7 has been previously associated with ischemic stroke and the large vessel stroke occlusive subtype (including HDAC9 ), suggesting a possible genetic link between this stroke subtype and IA.

Duke University

Location: United States of America

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University Of Oulu

Location: Finland

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University Of Turku

Location: Finland

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Oulu University Hospital

Location: Finland

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Helsinki University Central Hospital

Location: Finland

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University Of Helsinki

Location: Finland

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Helsinki University Hospital

Location: Finland

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