ORCID Profile
0000-0002-2557-7768
Current Organisation
Institute of Geology and Geophysics Chinese Academy of Sciences
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Publisher: Oxford University Press (OUP)
Date: 03-01-2013
DOI: 10.1039/C2IB20206A
Abstract: Although attempts have been made to unveil protein-protein and host-pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to develop common conserved intra-species protein-protein interaction (PPI) networks first time for four Cp strains (Cp FRC41, Cp 316, Cp 3/99-5, and Cp P54B96) followed by development of a common conserved inter-species bacterial PPI using conserved proteins in multiple pathogens (Y. pestis, M. tuberculosis, C. diphtheriae, C. ulcerans, E. coli, and all four Cp strains) and E. Coli based experimentally validated PPI data. Furthermore, the interacting proteins in the common conserved inter-species bacterial PPI were used to generate a conserved host-pathogen interaction (HP-PPI) network considering human, goat, sheep, bovine, and horse as hosts. The HP-PPI network was validated, and acetate kinase (Ack) was identified as a novel broad spectrum target. Ceftiofur, penicillin, and two natural compounds derived from Piper betel were predicted to inhibit Ack activity. One of these Piper betel compounds found to inhibit E. coli O157:H7 growth similar to penicillin. The target specificity of these betel compounds, their effects on other studied pathogens, and other in silico results are currently being validated and the results are promising.
Publisher: Bentham Science Publishers Ltd.
Date: 12-2023
DOI: 10.2174/0929867330666230330092725
Abstract: The COVID-19 pandemic, caused by the coronavirus, SARS-CoV-2, has claimed millions of lives worldwide in the past two years. Fatalities among the elderly with underlying cardiovascular disease, lung disease, and diabetes have particularly been high. A biometrics analysis on author’s keywords was carried out, and searched for possible links between various coronavirus studies over the past 50 years, and integrated them. We found keywords like immune system, immunity, nutrition, malnutrition, micronutrients, exercise, inflammation, and hyperinflammation were highly related to each other. Based on these findings, we hypothesized that the human immune system is a multilevel super complex system, which employs multiple strategies to contain microorganism infections and restore homeostasis. It was also found that the behavior of the immune system is not able to be described by a single immunological theory. However, one main strategy is “self-destroy and rebuild”, which consists of a series of inflammatory responses: 1) active self-destruction of damaged/dysfunctional somatic cells 2) removal of debris and cells 3) rebuilding tissues. Thus, invading microorganisms’ clearance could be only a passive bystander response to this destroy–rebuild process. Microbial infections could be self-limiting and promoted as an indispensable essential nutrition for the vast number of genes existing in the microorganisms. The transient nutrition surge resulting from the degradation of the self-destroyed cell debris coupled with the existing nutrition state in the patient may play an important role in the pathogenesis of COVID-19. Finally, a possible coping strategies to mitigate COVID-19, including vaccination is also discussed.
Publisher: MDPI AG
Date: 30-08-2022
DOI: 10.3390/ANTIBIOTICS11091170
Abstract: Salmonella Typhimurium is associated with foodborne diseases worldwide, including in Peru, and its emerging antibiotic resistance (AMR) is now a global public health problem. Therefore, country-specific monitoring of the AMR emergence is vital to control this pathogen, and in these aspects, whole genome sequence (WGS)—based approaches are better than gene-based analyses. Here, we performed the antimicrobial susceptibility test for ten widely used antibiotics and WGS-based various analyses of 90 S. Typhimurium isolates (human, animal, and environment) from 14 cities of Peru isolated from 2000 to 2017 to understand the lineage and antimicrobial resistance pattern of this pathogen in Peru. Our results suggest that the Peruvian isolates are of Typhimurium serovar and predominantly belong to sequence type ST19. Genomic ersity analyses indicate an open pan-genome, and at least ten lineages are circulating in Peru. A total of 48.8% and 31.0% of isolates are phenotypically and genotypically resistant to at least one antibiotic, while 12.0% are multi-drug resistant (MDR). Genotype–phenotype correlations for ten tested drugs show % accuracy, and % specificity. Sensitivity above 90% was only achieved for ciprofloxacin and ceftazidime. Two lineages exhibit the majority of the MDR isolates. A total of 63 different AMR genes are detected, of which 30 are found in 17 different plasmids. Transmissible plasmids such as lncI-gamma/k, IncI1-I(Alpha), Col(pHAD28), IncFIB, IncHI2, and lncI2 that carry AMR genes associated with third-generation antibiotics are also identified. Finally, three new non-synonymous single nucleotide variations (SNVs) for nalidixic acid and eight new SNVs for nitrofurantoin resistance are predicted using genome-wide association studies, comparative genomics, and functional annotation. Our analysis provides for the first time the WGS-based details of the circulating S. Typhimurium lineages and their antimicrobial resistance pattern in Peru.
Publisher: Frontiers Media SA
Date: 25-10-2021
DOI: 10.3389/FEART.2021.765497
Abstract: The Qinshui Basin is in the Central Orogenic Belt of the North China Craton (NCC), and the production of coalbed methane accounts for 70% of China’s total coalbed methane output. Aiming at the unclear dynamic causes of large-scale coalbed methane accumulation in the basin and the unclear response relationship with the destruction of the NCC, we present joint illite crystallinity and vitrinite reflectance study across the Zijin Mountain and Qincan 1 wells of the Qinshui Basin, respectively. Inverse modeling suggested that tectono-thermal events occurred during the Early Cretaceous, associated with the maximum burial depth and heat flow. The maximum paleo-geothermal temperature and gradient reconstruction results recorded at the Carboniferous strata are 180–190°C and 6.5°C/100 m. The denudation thicknesses recorded by illite crystallinity of Zijinshan and the vitrinite reflectance of the Qincan 1 Well are 3,180.63 m and 3,269.32 m, respectively. We propose that the Qinshui Basin was affected by the extensional environment of the NCC, which caused deep lithospheric thinning and magma upwelling, and a tectono-thermal event occurred during the Early Cretaceous in Qinshui Basin. In addition, the accumulation of coalbed methane, triggered by a tectono-thermal event during the Early Cretaceous, is consistent with the early Cretaceous accumulation and mineralization events in the NCC. Overall, our results reflect the subduction event influence of the western Pacific plate into the East Asian continental plate on the tectono-thermal history of the Central Orogenic Belt of the NCC, which is theoretically significant for clarifying the thermal lithospheric thickness and rheological structure of the basin, as well as the evolutionary history of coalbed methane, and the basin response relationship to the destruction of the NCC.
Publisher: Elsevier BV
Date: 11-2014
Publisher: Geological Society of America
Date: 29-08-2019
DOI: 10.1130/B35338.1
Abstract: The most striking structural features in the interior of the Shan Plateau, southeast of the eastern Himalayan syntaxis, are a series of NE-trending faults that exhibit sinistral movement and an arcuate geometry. Their origin and tectonic evolution remain poorly understood. Furthermore, a switch in slip sense is recorded along many of these faults, but the timing of kinematic reversal is still unclear, hindering an understanding of the causal geodynamic mechanisms. We conducted an integrative study of apatite and zircon (U-Th)/He thermochronology, 40Ar/39Ar geochronology, and structural and geomorphic analysis to decipher the evolution of two major NE-trending faults: the Nantinghe and Dayingjiang faults. At least three deformation stages are identified within the Nantinghe fault zone, including top-to-the-SE/ESE thrusting, dextral ductile strike-slip shearing, and sinistral movement. Zircon and apatite (U-Th)/He data, collected from the northeastern terminus of the Nantinghe fault, reveal rapid cooling in the early Miocene. Combined with the 40Ar/39Ar data from sinistrally sheared mylonite, left-lateral movement on the Nantinghe fault is inferred to have initiated as early as ca. 20 Ma. The Dayingjiang fault reactivated as a sinistral brittle fault along the dextral Yingjiang shear zone. A two-stage thermal history is identified along the shear zone, with prominent cooling during dextral ductile shearing in the early- to mid-Miocene followed by a lower-magnitude cooling episode at ca. 11 Ma caused by sinistral transtension along the Dayingjiang fault. The evolution of the Nantinghe and Dayingjiang faults suggests that the NE-trending fault system in the Shan Plateau may have developed along preexisting structures and underwent diachronous slip-sense inversion in the late Cenozoic. The northward advance of the eastern Himalayan syntaxis caused a major change in both the regional stress field and fault geometries in the eastern India-Eurasia oblique convergence zone, contributing to the inversion of fault kinematics.
Publisher: Wiley
Date: 08-08-2020
DOI: 10.1111/GGR.12331
Publisher: Springer Science and Business Media LLC
Date: 08-04-2016
Location: China
Location: Brazil
No related grants have been discovered for Debmalya Barh.