ORCID Profile
0000-0002-6145-2129
Current Organisations
University of Queensland
,
East China Normal University
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Publisher: Springer Science and Business Media LLC
Date: 10-11-2016
Publisher: Wiley
Date: 30-08-2018
Abstract: Innovations in nanofabrication have expedited advances in hollow-structured nanomaterials with increasing complexity, which, at the same time, set challenges for the precise determination of their intriguing and complicated 3D configurations. Conventional transmission electron microscopy (TEM) analysis typically yields 2D projections of 3D objects, which in some cases is insufficient to reflect the genuine architectures of these 3D nano-objects, providing misleading information. Advanced analytical approaches such as focused ion beam (FIB) and ultramicrotomy enable the real slicing of nanomaterials, realizing the direct observation of inner structures but with limited spatial discrimination. Electron tomography (ET) is a technique that retrieves spatial information from a series of 2D electron projections at different tilt angles. As a unique and powerful tool kit, this technique has experienced great advances in its application in materials science, resolving the intricate 3D nanostructures. Here, the exceptional capability of the ET technique in the structural, chemical, and quantitative analysis of hollow-structured nanomaterials is discussed in detail. The distinct information derived from ET analysis is highlighted and compared with conventional analysis methods. Along with the advances in microscopy technologies, the state-of-the-art ET technique offers great opportunities and promise in the development of hollow nanomaterials.
Publisher: American Chemical Society (ACS)
Date: 12-2017
DOI: 10.1021/JACS.7B08974
Abstract: Plasmid DNA molecules with unique loop structures have widespread bioapplications, in many cases relying heavily on delivery vehicles to introduce them into cells and achieve their functions. Herein, we demonstrate that control over delicate nanotopography of silica nanoparticles as plasmid DNA vectors has significant impact on the transfection efficacy. For silica nanoparticles with rambutan-, raspberry-, and flower-like morphologies composed of spike-, hemisphere-, and bowl-type subunit nanotopographies, respectively, the rambutan-like nanoparticles with spiky surfaces demonstrate the highest plasmid DNA binding capability and transfection efficacy of 88%, higher than those reported for silica-based nanovectors. Moreover, it is shown that the surface spikes of rambutan nanoparticles provide a continuous open space to bind DNA chains via multivalent interactions and protect the gene molecules sheltered in the spiky layer against nuclease degradation, exhibiting no significant transfection decay. This unique protection feature is in great contrast to a commercial transfection agent with similar transfection performance but poor protection capability against enzymatic cleavage. Our study provides new understandings in the rational design of nonviral vectors for efficient gene delivery.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7TB02836A
Abstract: This work reports the significance of the carbonisation temperature of mesoporous carbon hollow spheres (MCHS) in therapeutic protein delivery.
Publisher: American Chemical Society (ACS)
Date: 15-12-2016
Publisher: MDPI AG
Date: 25-09-2021
DOI: 10.3390/JMSE9101057
Abstract: Following a brief review of their biology, this contribution is an attempt to provide a global overview of the catches of mesopelagic fishes (of which 2.68 million tonnes were officially reported to the FAO) throughout the world ocean from 1950 to 2018, to serve as a baseline to a future development of these fisheries. The overview is based on a thorough scanning of the literature dealing with commercial or experimental fisheries for mesopelagics and their catches, and/or the mesopelagic bycatch of other fisheries. All commercial (industrial and artisanal) fisheries for mesopelagic fishes were included, as well as experimental fisheries of which we were aware, while catches performed only to obtain scientific s les were omitted. The processes of generating bycatch and causing discards are discussed, with emphasis on Russian fisheries. From peer-reviewed and gray literature, we lifted information on mesopelagic fisheries and assembled it into one document, which we then summarized into two text tables with catch data, one by country/region, the other by species or species groups.
Publisher: American Chemical Society (ACS)
Date: 28-10-2019
DOI: 10.1021/ACS.NANOLETT.9B02691
Abstract: Inhibiting the formation of new tumor blood vessels (so-called antiangiogenesis) and obstructing the established ones are two primary strategies in tumor vasculature targeted therapy. However, the therapeutic outcome of conventional methodologies relying on only one mechanism is rather limited. Herein, the first ex le of ultrasmall responsively aggregatable nanochelators that can intrinsically fulfill both antivasculature functions as well as high renal clearable efficiency is introduced. The nanochelators with sub-6 nm sizes exhibit not only systemic copper depletion activity for tumor antiangiogenesis but also, more surprisingly, the capability to transform from a "dispersed" state to an "aggregated" state to form large secondary particles in response to tumor microenvironment with elevated copper and phosphate levels for blood vessel obstruction. Compared to a benchmark antiangiogenic agent that can only inhibit the formation of tumor blood vessels, the nanochelators with unprecedented synergistic functions demonstrate significantly enhanced tumor inhibition activity in both breast cancer and colon cancer tumor models. Moreover, these ultrasmall nanochelators are noncytotoxic and renal clearable, ensuring superior biocompatibility. It is envisaged that the design of nanomaterials with ground-breaking properties and the synergistic antivasculature functions would offer a substantial conceptual advance for tumor vasculature targeted therapy and may provide vast opportunities for developing advanced nanomedicines.
Publisher: Cold Spring Harbor Laboratory
Date: 22-03-2022
DOI: 10.1101/2022.03.21.484660
Abstract: Migrating marine taxa encounter erse habitats that differ environmentally and in foraging conditions over a range of spatial scales. We examined body (RNA/DNA, length-weight residuals) and nutritional (fatty acid composition) condition of juvenile sockeye salmon ( Oncorhynchus nerka ) in British Columbia, while migrating through varied oceanographically waters. Fish were s led in the stratified northern Strait of Georgia (NSoG) the highly mixed Johnstone Strait (JS) and the transitional zone of Queen Charlotte Strait (QCS). In 2015, body and nutritional condition were high in the NSoG and responded rapidly to reach lowest levels in JS with its low prey availability, and showing signs of compensatory growth in QCS. In 2016, juvenile salmon had significantly lower condition in the NSoG than in 2015, although zooplankton biomass was similar, condition remained low in JS, and no compensatory growth was observed in QCS. We provide evidence that differences in juvenile salmon condition between the two years being due to changes in the food quality available to juvenile fish. Further, we propose that the TGH needs to be extended to incorporate food quality as a parameter to understand changes in fish condition and survival between years.
Publisher: American Chemical Society (ACS)
Date: 22-07-2021
Publisher: Springer Science and Business Media LLC
Date: 18-11-2021
Publisher: FSBSI TINRO Center
Date: 28-06-2022
DOI: 10.26428/1606-9919-2022-202-305-315
Abstract: The shift in strontium (Sr) concentrations in fish otoliths is a commonly used proxy for identification of marine environment entry during diadromous migrations. However, there is still controversy about the appearance of the Sr-based sea entry mark relative to the true point of entry. In this study, the Sr signal lag was assessed in otoliths of juvenile sockeye salmon ( Oncorhynchus nerka ) under experimental conditions replicating the transition to seawater during juveniles’ seaward migration. A Sr signal delay was observed to average at 8.2 (SD = 5.1) days for fish with a body length of 140–170 mm (and a weight of 30–70 g). This lag may be species-specific and should be taken into consideration when estimating marine entry timing and marine residence duration of juvenile salmon.
Publisher: Springer Science and Business Media LLC
Date: 06-10-2020
DOI: 10.1038/S41597-020-00676-Y
Abstract: The North Pacific Marine Salmon Diet Database is an open-access relational database built to centralize and make accessible salmon diet data through a standardized database structure. The initial data contribution contains 21,862 observations of salmon diet, and associated salmon biological parameters, prey biological parameters, and environmental data from the North Pacific Ocean. The data come from 907 unique spatial areas and mostly fall within two time periods, 1959–1969 and 1987–1997, during which there are more data available compared to other time periods. Data were extracted from 62 sources identified through a systematic literature review, targeting peer-reviewed and gray literature. The purpose of this database is to consolidate data into a common format to address gaps in our ecological understanding of the North Pacific Ocean, particularly with respect to salmon. This database can be used to address a variety of questions regarding salmon foraging, productivity, and marine survival. The North Pacific Marine Salmon Diet Database will continue to grow in the future as more data are digitized and become available.
Location: China
No related grants have been discovered for Evgeny Pakhomov.