ORCID Profile
0000-0001-7821-9406
Current Organisations
Australian Bureau of Meteorology
,
National Cheng Kung University
,
Ditmanson Medical Foundation Chia-Yi Christian Hospital
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Publisher: American Meteorological Society
Date: 2012
Publisher: Copernicus GmbH
Date: 03-2023
DOI: 10.5194/GMD-2023-7
Abstract: Abstract. The Australian Bureau of Meteorology has developed a national hydrological projections (NHP) service for Australia. With the focus on hydrological change assessment, the NHP service aims at being complementary to climate projections work carried out by many federal and state governments, universities, and other organisations across Australia. The projections comprise an ensemble of application-ready bias-corrected climate model data and derived hydrological projections at daily temporal and 0.05° × 0.05° spatial resolution for the period 1960–2099 and two emission scenarios (RCP 4.5 and RCP 8.5). The spatial resolution of the projections matches that of gridded historical reference data used to perform the bias correction and the Bureau's operational gridded hydrological model. Three bias correction techniques were applied to four CMIP5 global climate models (GCMs) and one to output from a regional climate model forced by the same four GCMs, resulting in a 16-member ensemble of bias-corrected GCM data for each emission scenario. The bias correction was applied to fields of precipitation, minimum and maximum temperature, downwelling shortwave radiation and surface winds. These variables are required inputs to the Bureau's landscape water balance hydrological model (AWRA-L) which was forced using the bias-corrected GCM and RCM data to produce a 16-member ensemble of hydrological output. The hydrological output variables include root-zone soil moisture (moisture in the top 1 m soil layer), potential evapotranspiration and runoff. Here we present an overview of the production of the hydrological projections, including GCM selection, bias correction methods and their evaluation, technical aspects of their implementation and ex les of analysis performed to construct the NHP service. The data are publicly available on the National Computing Infrastructure (0.25914/6130680dc5a51) and a user interface is accessible at awo.bom.gov.au roducts rojection/.
Publisher: SAGE Publications
Date: 03-2011
Abstract: Pro-opiomelanocortin (POMC) is a precursor of various neuropeptides. POMC-derived neuropeptides are potent inflammation inhibitors and immunosuppressants. Evidence that osteoarthritis (OA) is an inflammatory disease is accumulating. We assessed whether intra-articular gene delivery of POMC ameliorates experimentally induced OA in a rat model. OA was induced in Wistar rats by anterior cruciate ligament-transection (ACLT) in the knee of one hind limb. Adenoviral vector encoding human POMC (AdPOMC) was injected intra-articularly into the knee joints after ACLT. The transgene expression and the inflammatory responses were evaluated using immunoblotting, immunohistochemistry and enzyme-linked immunosorbent assay. The treated joints were assessed histologically for manifestations of the disease. Human POMC was expressed in the chondrocytes and synovial membrane after the intra-articular injection. POMC gene transfer reduced nuclear factor- κB activity and the levels of interleukin-1 β in HTB-94 chondrosarcoma cells and Raw 264.7 macrophages it also reduced microvessel density in the synovium. Histological examination showed that symptoms of OA in AdPOMC-treated rats were less severe than in rats treated with either empty adenoviral vector (AdNull) or normal saline. Intra-articular injection of adenoviral vectors expressing POMC significantly suppressed the progression and severity of OA, and reduced inflammatory responses and angiogenesis. POMC gene delivery may offer novel therapeutic approach for treating OA.
Publisher: American Meteorological Society
Date: 10-2015
Abstract: The aim of this study is to examine the statistics of convective storms and their concomitant changes with thermodynamic variability. The thermodynamic variability is analyzed by performing a cluster analysis on variables derived from radiosonde releases at Brisbane Airport in Australia. Three objectively defined regimes are found: a dry, stable regime with mainly westerly surface winds, a moist northerly regime, and a moist trade wind regime. S-band radar data are analyzed and storms are identified using objective tracking software [Thunderstorm Identification, Tracking, Analysis, and Nowcasting (TITAN)]. Storm statistics are then investigated, stratified by the regime subperiods. Convective storms are found to form and maintain along elevated topography. Probability distributions of convective storm size and rain rate are found to follow lognormal distributions with differing mean and variance among the regimes. There was some evidence of trimodal storm-top heights, located at the trade inversion (1.5–2 km), freezing level (3.6–4 km), and near 6 km, but it was dependent on the presence of the trade inversion. On average, storm volume and height are smallest in the trade regime and rain rate is largest in the westerly regime. However, westerly regime storms occur less frequently and have shorter lifetimes, which were attributed to the enhanced stability and decreased humidity profiles. Furthermore, time series of diurnal rain rate exhibited early morning and midafternoon maxima for the northerly and trade regimes but were absent for the westerly regime. The observations indicate that westerly regime storms are primarily driven by large-scale forcing, whereas northerly and trade wind regime storms are more responsive to surface characteristics.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
Location: Australia
Location: Taiwan, Province of China
Location: Taiwan, Province of China
Location: United Kingdom of Great Britain and Northern Ireland
Location: Taiwan, Province of China
Location: No location found
No related grants have been discovered for Chao-Liang Wu.