ORCID Profile
0000-0003-1063-4990
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Organic chemical synthesis | Synthesis of Materials | Organic chemistry | Nanomaterials | Catalysis and Mechanisms of Reactions | Macromolecular and Materials Chemistry | Interdisciplinary Engineering not elsewhere classified | Nanotechnology | Organic Chemical Synthesis | Analytical Spectrometry | Physical Chemistry (Incl. Structural) | Nanotechnology not elsewhere classified | Sociology and Social Studies of Science and Technology |
Industrial Chemicals and Related Products not elsewhere classified | Human Pharmaceutical Treatments (e.g. Antibiotics) | Workforce Transition and Employment | Expanding Knowledge in the Chemical Sciences | Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) | Manufacturing not elsewhere classified | Expanding Knowledge in Technology
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1SM05428G
Publisher: American Chemical Society (ACS)
Date: 21-02-2022
Publisher: American Chemical Society (ACS)
Date: 09-12-2012
DOI: 10.1021/LA2032994
Abstract: A strategy for tethering lipid liquid crystalline submicrometer particles (cubosomes) to a gold surface for the detection of proteins is reported. Time-resolved quartz crystal microbalance (QCM-D) was used to monitor the cubosome-protein interaction in real time. To achieve specific binding, cubosomes were prepared from the nonionic surfactant phytantriol, block-copolymer, Pluronic F-127, and a secondary biotinylated lipid, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethyleneglycol)-2000], which enabled attachment of the particles to a neutravidin (NAv)-alkanethiol monolayer at the gold surface of the QCM sensor chip. A second set of cubosomes was further functionalized with addition of the glycolipid (G(M1)) to facilitate a specific binding uptake of the protein, cholera toxin B subunit (CT(B)), from solution. QCM-D confirmed the specificity of the cubosome-NAv binding. The analysis of titration experiments, also performed with QCM, suggests that an optimal concentration of cubosomes is required for the efficient packing of the particles at the surface: high cubosome concentrations lead to chaotic cubosome binding onto the surface, sterically inhibiting surface attachment, or require significant reorganization to permit uniform cubosome coverage. The methodology enabled the straightforward preparation of a complex nanostructured edifice, which was then used to specifically capture analyte proteins (cholera toxin B subunit or free NAv) from solution, supporting the potential for development of this approach as a biosensing platform.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0RE00442A
Abstract: An efficient and scalable enone-promoted method for the decarboxylation of trans -4-hydroxy-proline has been developed in flow to provide access to ( R )-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone.
Publisher: Springer Science and Business Media LLC
Date: 16-06-2009
DOI: 10.1007/S00249-009-0493-2
Abstract: The reversed cubic phases (Q(II)) are a class of self-assembled hiphile-water structures that are rich in ersity and structural complexity. These nanostructured liquid crystalline materials are generating much interest owing to their unique surface morphology, biological relevance and potential technological and medical applications. The structure of Q(II) phases in binary hiphile-water systems is affected by the molecular structure of surfactant, water content, temperature and pressure. The presence of additives also plays an important role. The structure and phase behaviour of ternary Q(II) phases, which are comprised of two miscible hiphiles and water, significantly differ from the binary system alone. The modulation of the phase behaviour through the addition of a second hiphile offers an opportunity to control the size and shape of the nanostructures using a 'bottom-up' approach. In this mini-review, we discuss the structure of reversed cubic phases of hiphile-water systems and highlight the modulation of cubic-phase structure in ternary-phase systems. We also extend this review to bulk cubic phases and the corresponding nanoscale dispersions, cubic-phase nanoparticles.
Publisher: Wiley
Date: 18-08-2020
Publisher: Wiley
Date: 06-06-2023
Abstract: Dual nucleophilic phosphine photoredox catalysis is yet to be developed due to facile oxidation of the phosphine organocatalyst to the phosphoranyl radical cation. Herein, we report a reaction design that avoids this event and exploits traditional nucleophilic phosphine organocatalysis with photoredox catalysis to allow the Giese coupling with ynoates. The approach has good generality, while its mechanism is supported by cyclic voltametric, Stern–Volmer quenching, and interception studies.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC05722F
Abstract: Visible light irradiation of 8-aminoquinoline Pd( ii ) complexes initiates photoinduced electron transfer with alkyl halides, affording C–H halogenation over C–C bond adducts. A method for inert C(sp 3 )–H bond halogenation (Br, Cl and I) is reported.
Publisher: American Chemical Society (ACS)
Date: 16-01-2019
DOI: 10.1021/ACS.MOLPHARMACEUT.8B00890
Abstract: Development of an effective and potent RNA delivery system remains a challenge for the clinical application of RNA therapeutics. Herein, we describe the development of an RNA delivery platform derived from self-assembled bicontinuous cubic lyotropic liquid crystalline phases, functionalized with zinc coordinated lipids. These metallo-cubosomes were prepared from a series of novel lipidic zinc(II)-bis(dipicolylamine) (Zn
Publisher: American Chemical Society (ACS)
Date: 23-09-2019
DOI: 10.1021/JACS.9B07370
Abstract: We report the discovery of a tandem catalytic process to reduce energy demanding substrates, using the [Ir(ppy)
Publisher: Elsevier BV
Date: 10-2017
DOI: 10.1016/J.IJPHARM.2017.08.116
Abstract: Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for Duchenne muscular dystrophy and spinal muscular atrophy. SSOs are administered without any delivery vector and require large doses to achieve the therapeutic benefit, primarily due to their poor cellular uptake. Although cell-penetrating peptides (CPP) have shown great potential in delivering SSOs into cells, their capacity as delivery vector is limited. Here we have studied the effect of lipid conjugation on the cell permeability of a known CPP (ApoE). Myristic acid was coupled at the N-terminus of ApoE to a C-terminal cysteine residue. The myristoylated ApoE (Myr-ApoE) was conjugated to a maleimide functionalised phosphorodiamidate morpholino oligonucleotide (PMO). The Myr-ApoE-PMO conjugate showed no cytoxicity and had significantly higher efficiency in cell permeability with 30% higher splice-switching activity compared to ApoE-PMO. The self-assembly properties of this hiphilic lipopeptide-PMO conjugate was assessed. Transmission electron microscopy showed formation of nanoparticles with hiphile behaviour and spherical structure. The self-assembly of Myr-ApoE-PMO into nanoparticles enabled it to better bind to cell membranes and to be more efficiently taken up by fibroblast cells. These results showed that modification of physico-chemical properties of peptides to produce peptide hiphiles enhances cellular uptake and can be used as an efficient delivery vector for therapeutic SSOs.
Publisher: Wiley
Date: 18-08-2020
Publisher: American Chemical Society (ACS)
Date: 28-05-2014
DOI: 10.1021/CS5004917
Publisher: Wiley
Date: 11-09-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2SC00203E
Abstract: Visible light induced singlet nucleophilic carbenes undergo rapid [2 + 1]-cycloaddition with tethered olefins to afford unique bicyclo[3.1.0]hexane and bicyclo[4.1.0]heptane scaffolds.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8OB00238J
Abstract: A method for the light-driven synthesis of aryl and vinyl alkyl thioethers from a range of C(sp 2 )–I bonds is reported.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Informa UK Limited
Date: 11-2010
Publisher: American Chemical Society (ACS)
Date: 25-10-2023
Publisher: American Chemical Society (ACS)
Date: 30-04-2020
DOI: 10.26434/CHEMRXIV.12220109.V1
Abstract: We report a new visible light-mediated carbonylative amidation of aryl, heteroaryl and alkyl halides. A tandem catalytic cycle of [Ir(ppy) 2 (dtb-bpy)] + generates a potent iridium photoreductant via a second catalytic cycle in the presence of DIPEA which productively engages aryl bromides, iodides and even chlorides as well as primary, secondary and tertiary alkyl iodides. The versatility of the in-situ generated catalyst is illustrated by compatibility with aliphatic and aromatic amines, high functional group tolerance and the late-stage amidation of complex natural products.
Publisher: American Chemical Society (ACS)
Date: 10-07-2018
Publisher: American Chemical Society (ACS)
Date: 18-03-2021
Publisher: American Chemical Society (ACS)
Date: 02-08-2022
Publisher: Wiley
Date: 22-06-2017
Abstract: Modification of the local density of optical states using metallic nanostructures leads to enhancement in the number of emitted quanta and photocatalytic turnover of luminescent materials. In this work, the fabrication of a metamaterial is presented that consists of a nanowire separated from a metallic mirror by a polymer thin film doped with a luminescent organometallic iridium(III) complex. The large spin-orbit coupling of the heavy metal atom results in an excited state with significant magnetic-dipole character. The nanostructured architecture supports two distinct optical modes and their assignment achieved with the assistance of numerical simulations. The simulations show that one mode is characterized by strong confinement of the electric field and the other by strong confinement of the magnetic field. These modes elicit drastic changes in the emitter's photophysical properties, including dominant nanocavity-derived modes observable in the emission spectra along with significant increases in emission intensity and the total decay rate. A combination of simulations and momentum-resolved spectroscopy helps explain the mechanism of the different interactions of each optical mode supported by the metamaterial with the excited state of the emitter.
Publisher: CSIRO Publishing
Date: 2011
DOI: 10.1071/CH10361
Abstract: The parallel between the lipidic microenvironments of the inverse bicontinuous cubic phase and the biological membrane distinguishes cubic phases as an attractive option for development of cell-free biosensors containing protein or glycolipid receptors. Herein we describe a novel strategy toward the creation of a biosensing platform derived from the surface attachment of a colloidally stable inverse cubic structure (cubosomes). We report the preparation of cubosomes composed of the hiphile phytantriol, the membrane glycolipid receptor monosialoganglioside-GM1 and the biotin-functionalized hiphile 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethyleneglycol)-2000] (bDSPE). The tethering of cubosomes to the various surfaces was mediated through bDSPE binding to streptavidin- and avidin-modified surfaces. Allylamine plasma polymer surface modification enhanced the surface immobilization of avidin, which increased the density of bound cubosomes. The resultant polymer–protein–cubosome complex was imaged by cryo-transmission electron microscopy analysis and the cubosome structure was impressively preserved within the complex. Cholera toxin binding to cubosomes containing GM1 was used to assess the performance of the cubosomes, subsequent to surface attachment, via a modified enzyme-linked immunosorbent assay. Specific immobilization of complex protein–receptor–cubosome systems paves the way for development of a structurally complex, heterogeneous platform for sensing applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2RA20135F
Publisher: CSIRO Publishing
Date: 2013
DOI: 10.1071/CH12463
Abstract: Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.
Publisher: Elsevier BV
Date: 10-2013
DOI: 10.1016/J.JCIS.2013.07.002
Abstract: The preparation and phase behavior of dispersed liquid crystalline particles comprised of phytantriol and various functionalised lipids are reported. These inverse bicontinuous cubic phase colloidal dispersions have been sterically stabilized with a triblock copolymer, Pluronic F127. The influence of added negatively charged hiphiles oleic acid and sodium dodecylsulfate, the positively charged hexadecyltrimethylammonium bromide, and monoolein a neutral hiphile, on phase behavior and cubic phase structure was examined by synchrotron small angle X-ray scattering (SAXS). Functionality was also introduced through ligand specific lipids monosialoganglioside-GM1 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000]. SAXS measurements showed that all of the additives affected the long-range order of the inverse cubic phase observed through either phase behavior changes or alteration in lattice parameter.
Publisher: American Chemical Society (ACS)
Date: 20-07-2018
DOI: 10.1021/ACS.ORGLETT.8B01971
Abstract: The annulative carbonylation of alkenyl-tethered arenediazonium salts using visible-light photocatalysis in continuous flow is described. The method furnishes a erse series of novel acetate-functionalized 2,3-dihydrobenzofurans at room temperature and moderate CO pressure (25 atm), delivering these products in a short time with straightforward scale-up. This continuous flow and free-radical approach overcomes the limitation of traditional Pd-catalyzed annulative carbonylation, giving valuable 2,3-dihydrobenzofurans in a predictable and regioselective manner.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3PY01015E
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1OB06317K
Abstract: We report the synthesis of a series of bivalent 1,2,3-triazole linked galactopyranosides as potential inhibitors of cholera toxin (CT). The inhibitory activity of the bivalent series was examined (ELISA) and the series showed low inhibitory activity (millimolar IC(50)s). Conversely, the monomeric galactotriazole analogues were strong inhibitors of cholera toxin (IC(50) = 71-75 μM).
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8OB02209G
Abstract: Regioselectivity of attack by the N -methyl-pyridinium-4-yl radical cation onto RNCX (X = O and S) depends on R and X.
Publisher: Wiley
Date: 06-06-2023
Abstract: Dual nucleophilic phosphine photoredox catalysis is yet to be developed due to facile oxidation of the phosphine organocatalyst to the phosphoranyl radical cation. Herein, we report a reaction design that avoids this event and exploits traditional nucleophilic phosphine organocatalysis with photoredox catalysis to allow the Giese coupling with ynoates. The approach has good generality, while its mechanism is supported by cyclic voltametric, Stern–Volmer quenching, and interception studies.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3RA47500J
Abstract: We report a new strategy to develop low molecular weight (18–28 kDa) poly( N -acryloylmorpholine) (PNAM) polymers as bivalent inhibitors of cholera toxin (CT) using Reversible Addition–Fragmentation chain Transfer (RAFT) technology.
Publisher: Wiley
Date: 21-09-2017
Abstract: Herein we describe the auxiliary-directed arylation of unactivated C(sp
Publisher: Beilstein Institut
Date: 08-12-2011
DOI: 10.3762/BJOC.7.194
Abstract: Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.
Publisher: Springer Science and Business Media LLC
Date: 03-05-2021
DOI: 10.1038/S41598-021-88932-Y
Abstract: Adolescence is a period of significant anatomical and functional brain changes, and complex interactions occur between mental health risk factors. The Longitudinal Adolescent Brain Study commenced in 2018, to monitor environmental and psychosocial factors influencing mental health in 500 adolescents, for 5 years. Participants are recruited at age 12 from the community in Australia’s Sunshine Coast region. In this baseline, cross-sectional study of N = 64 participants, we draw on the network perspective, conceptualising mental disorders as causal systems of interacting entities, to propose a Bayesian network (BN) model of lifestyle and psychosocial variables influencing chances of in iduals being psychologically well or experiencing psychological distress. Sensitivity analysis of network priors revealed that psychological distress (Kessler-10) was most affected by eating behaviour. Unhealthy eating increased the chance of moderate psychological distress by 600%. Low social connectedness increased the chance of severe psychological disorder by 200%. Certainty for psychological wellness required 33% decrease in unhealthy eating behaviours, 11% decrease in low social connectedness, and 9% reduction in less physical activity. BN can augment clinician judgement in mental disorders as probabilistic decision support systems. The full potential of BN methodology in a complex systems approach to psychopathology has yet to be realised.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC05181A
Abstract: The facile synthesis of the cage molecule (C 110 H 56 Br 2 ) via a remarkable three-fold homo-coupling macrocyclization reaction using continuous flow methodology is reported.
Publisher: Wiley
Date: 03-04-2017
Abstract: Biophysical studies were undertaken to investigate the binding and release of short interfering ribonucleic acid (siRNA) from lyotropic liquid crystalline lipid nanoparticles (LNPs) by using a quartz crystal microbalance (QCM). These carriers are based on phytantriol (Phy) and the cationic lipid DOTAP (1,2-dioleoyloxy-3-(trimethylammonium)propane). The nonlamellar phase LNPs were tethered to the surface of the QCM chip for analysis based on biotin-neutravidin binding, which enabled the controlled deposition of siRNA-LNP complexes with different lipid/siRNA charge ratios on a QCM-D crystal sensor. The binding and release of biomolecules such as siRNA from LNPs was demonstrated to be reliably characterised by this technique. Essential physicochemical parameters of the cationic LNP/siRNA lipoplexes-such as particle size, lyotropic phase behaviour, cytotoxicity, gene silencing and uptake efficiency-were also assessed. The SAXS data show that when the pH was lowered to 5.5 the structure of the lipoplexes did not change, thus indicating that the acidic conditions of the endosome were not a significant factor in the release of siRNA from the cationic lipidic carriers.
Publisher: American Chemical Society (ACS)
Date: 24-08-2007
DOI: 10.1021/BC0700640
Abstract: The cubic lyotropic mesophase composed of the ganglioside G(M1) and the synthetic surfactant phytantriol has been employed as a scaffold to prepare a polyvalent inhibitor of cholera toxin (CT). Surfactant mixtures containing up to 20% (w/w) G(M1) hytantriol afforded a hydrated insoluble gel-like material, which retained an inverse cubic phase (Q) structure in excess water and at 22 degrees C, as confirmed using small-angle X-ray scattering. The G(M1)-functionalized mesophases bind up to 98.8% of CT from solution containing 100 ng/mL of CT with a dissociation constant (K(d)) of 67-73 nM. The estimated IC50 values for the mesophase systems were 0.1-0.27 microM. The inhibitory effect of the mesophases may be enhanced through the high internal surface area of the inverse cubic phase in addition to the optimal self-orientation of G(M1) ligand to match the distribution of binding sites on the toxin surface. As a result, polyvalent inhibitor materials manufactured using these mesophase structures do not require precise control of ligand distribution, which offers advantages with respect to complexity of synthesis and formulation when compared to more rigid and conformationally restricted materials. This approach provides a route to a unique class of polyvalent inhibitors, which should be broadly applicable to a range of bacterial and plant toxins.
No related organisations have been discovered for Anastasios Polyzos.
Start Date: 06-2023
End Date: 06-2027
Amount: $927,301.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2023
End Date: 12-2025
Amount: $579,499.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2018
End Date: 12-2024
Amount: $3,279,502.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2021
End Date: 12-2023
Amount: $975,934.00
Funder: Australian Research Council
View Funded ActivityStart Date: 09-2022
End Date: 09-2027
Amount: $4,379,165.00
Funder: Australian Research Council
View Funded Activity