ORCID Profile
0000-0002-4577-2915
Current Organisation
UNSW Sydney
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Civil Engineering | Structural Engineering | Structural Engineering | Construction Materials | Construction Engineering | Building Science And Techniques | Infrastructure Engineering and Asset Management | Structural engineering | Powder and Particle Technology | Process Control and Simulation | Composite Materials | Mineral Processing/Beneficiation | Civil Engineering not elsewhere classified | Metals and Alloy Materials | Materials Engineering | Composite and Hybrid Materials | Civil Geotechnical Engineering | Civil Engineering Not Elsewhere Classified | Earthquake Engineering | Chemical Engineering | Civil engineering | Construction Engineering | Geotechnical Engineering | Ship and Platform Structures | Risk Engineering (excl. Earthquake Engineering) | Fluidisation and Fluid Mechanics |
Civil Construction Design | Cement and Concrete Materials | Civil | Metals (e.g. Composites, Coatings, Bonding) | Commercial Construction Design | Civil | Cement and concrete materials | Civil Construction Processes | Commercial Construction Processes | Industrial Construction Design | Structural Metal Products | Road Infrastructure and Networks | Rail Infrastructure and Networks | Metals (composites, coatings, bonding, etc.) | Expanding Knowledge in Engineering | Residential Construction Design | Industrial Construction Processes | Environmentally Sustainable Construction not elsewhere classified | Emerging Defence Technologies | Inorganic Industrial Chemicals | Personnel | Management of Solid Waste from Construction Activities | Management of Greenhouse Gas Emissions from Construction Activities | Environmentally Sustainable Energy Activities not elsewhere classified | Construction Materials Performance and Processes not elsewhere classified | Ground transport not elsewhere classified | Polymeric Materials (e.g. Paints) | Construction not elsewhere classified | Civil | Expanding Knowledge in Built Environment and Design | Basic Iron and Steel Products | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Physical Sciences | Beneficiation or Dressing of Iron Ores | Beneficiation or Dressing of Non-Metallic Minerals (incl. Diamonds)
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2002
Publisher: Universitat Politècnica València
Date: 27-06-2018
DOI: 10.4995/ASCCS2018.2018.7200
Abstract: Spiral welded stainless tubes are produced by helical welding of a continuous strip of stainless steel. Recently, concrete-filled spiral welded stainless steel tubes have found increasing application in the construction industry due to their ease of fabrication and aesthetic appeal. However, an in-depth understanding of the behaviour of this type of structure is still needed due to the lack of proper design guidance and insufficient experimental verification. In this paper, the mechanical performance of concrete-filled spiral welded stainless steel tubes will be numerically investigated with a commercial finite element software package, through which an experimental program can be designed properly. Specifically, the proposed finite element models take into account the effects of material and geometric nonlinearities. Moreover, the initial imperfections of stainless steel tubes and the form of helical welding will be appropriately included. Enhancement of the understanding of the analysis results can be achieved by extending results through a series of parametric studies based on the developed finite element model. Thus, the effects of various design parameters will be further evaluated by using the developed finite element model. Furthermore, for the purposes of wide application of such types of structure, the accuracy of the behaviour prediction in terms of ultimate strength based on current design codes will be studied. The authors herein compared the load capacity between the finite element analysis results and the existing codes of practice.
Publisher: Elsevier BV
Date: 04-2015
Publisher: Elsevier BV
Date: 10-2015
Publisher: Elsevier BV
Date: 2023
Publisher: Elsevier BV
Date: 03-2007
Publisher: SAGE Publications
Date: 09-2012
DOI: 10.1260/1369-4332.15.9.1559
Abstract: The behaviour of composite steel-concrete beams subjected to pure flexure and the presence of flexure and shear is fairly well understood and provisions do exist in international codes of practice for their design, however in most instances the influence of the concrete slab is not included in the strength design of the composite beam in shear. Combined internal actions including the presence of torsion and flexure have also been considered of late. These actions combine to occur in edge beams and curved composite beams and thus are of significant practical interest. Of increasing interest has become the presence of axial force and flexure in composite beams. These internal actions need to be considered in the design of raking beams of stadia, elevated approach spans for bridges and interchanges and in the design of integral abutment bridges and cable stayed bridges. Furthermore, composite beams in floor systems for braced multi-storey buildings are often required to resist axial force, flexure and shear force. This paper considers the effects of the presence of axial force in conventional composite beams. The effects of different forms of axial force and flexure combinations are considered in this paper. An analytical treatment, experiments and design approaches are given in this paper which is useful for structural engineers. Furthermore research in this area is also discussed. This paper will also present the results of an extensive experimental series to study the behaviour of high performance steel sections subjected to transverse impact loads which are able to simulate either a collision or blast. The experimental program has considered both mild structural steel and stainless steel hollow sections both filled and unfilled being tested. The purpose of the tests was to identify the potential advantages of using concrete infill to increase the energy absorption capability of steel hollow sections.
Publisher: Springer Nature Switzerland
Date: 2023
Publisher: Elsevier BV
Date: 12-2004
Publisher: Wiley
Date: 21-09-2004
DOI: 10.1002/NME.1091
Publisher: Elsevier BV
Date: 04-2006
Publisher: Elsevier BV
Date: 02-2015
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 04-2006
Publisher: Elsevier BV
Date: 03-2017
Publisher: Elsevier BV
Date: 09-2017
Publisher: CRC Press
Date: 29-08-2002
Publisher: Elsevier BV
Date: 07-2009
Publisher: Elsevier BV
Date: 09-2017
Publisher: Hindawi Limited
Date: 2013
DOI: 10.1155/2013/159508
Abstract: Cystic fibrosis (CF) is a disease which predisposes in iduals to recurrent infective exacerbations of suppurative lung disease however, empyema is a rare complication in these patients. Empyemas secondary to Staphylococcus aureus and Burkholderia cepacia have been described in patients with CF. We report the case of pleural empyema with mixed S. aureus and Pseudomonas aeruginosa infection in a 34-year-old woman with CF, which was managed with ultrasound-guided pigtail catheter insertion, fibrinolysis, and antibiotic therapy. Physicians should be aware of this unusual complication in CF patients, especially those receiving an immunosuppressive therapy.
Publisher: Elsevier BV
Date: 03-2019
Publisher: Elsevier BV
Date: 09-2015
Publisher: Elsevier BV
Date: 09-2013
Publisher: Elsevier BV
Date: 12-2012
Publisher: Elsevier BV
Date: 07-2020
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 11-2014
Publisher: Research Publishing Services
Date: 2013
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 10-2022
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 09-2015
Publisher: Thomas Telford Ltd.
Date: 02-1998
Publisher: American Society of Civil Engineers
Date: 18-05-2010
Publisher: Elsevier BV
Date: 10-2016
Publisher: Elsevier BV
Date: 2011
Publisher: Elsevier BV
Date: 06-1996
Publisher: Elsevier BV
Date: 1995
Publisher: Elsevier BV
Date: 04-2020
Publisher: Elsevier BV
Date: 1995
Publisher: Elsevier BV
Date: 08-2015
Publisher: SAGE Publications
Date: 24-07-2021
DOI: 10.1177/20414196211033310
Abstract: With the increase of terrorist attacks over the past decades, many engineering societies have started issuing design guides to calculate blast loads on structures. While such guides can be successfully used to assess blast loads due to single detonations, the effects of multiple detonations are often overlooked. In this research, the enhancement in blast parameters resulting from simultaneously detonating multiple charges is investigated, emphasising the interaction of blast waves with narrow targets. A parametric CFD study using the finite volume code Viper::Blast was performed where the number of charges, their arrangement, and the scaled stand-off distances were changed. It is found that, when detonated simultaneously, multiple charges return much higher pressure and impulse values compared to an equivalent single charge. Moreover, an arced arrangement of multiple charges is more efficient than a flat arrangement in enhancing blast wave parameters. Such enhancement is beneficial in scenarios involving demolition. Approximate methods to compute blast wave parameters from multiple simultaneously detonated spherical charges are presented in this study, where pressure and impulse from multiple charges can be computed by only knowing the parameters resulting from an equivalent single charge.
Publisher: Wiley
Date: 09-2017
DOI: 10.1002/CEPA.52
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 09-2023
Publisher: American Society of Civil Engineers
Date: 22-05-2002
DOI: 10.1061/40616(281)49
Publisher: Wiley
Date: 06-1998
DOI: 10.1002/(SICI)1099-1794(199806)7:2<113::AID-TAL94>3.0.CO;2-I
Publisher: American Society of Civil Engineers
Date: 22-05-2002
DOI: 10.1061/40616(281)52
Publisher: American Society of Civil Engineers
Date: 25-02-2011
DOI: 10.1061/41142(396)46
Publisher: Elsevier BV
Date: 10-2023
Publisher: Elsevier BV
Date: 11-2015
Publisher: Wiley
Date: 30-06-2021
DOI: 10.1002/TAL.1883
Abstract: This paper investigates the behavior of high‐rise composite buildings with composite shear walls and concrete‐filled steel tubular (CFST) columns using a numerical model in OpenSees. In the model, the geometric and material nonlinearity of structural elements are captured by utilizing a fiber force‐based beam‐column elements with rigorously modified material stress–strain relationships. Besides, the confining effect of the concrete core, the semi‐rigid connections, and the coupling effect of composite shear walls is carefully taken into consideration. Finally, the case study of a 42‐storey composite building is conducted using the proposed model to provide a thorough understanding about the behavior of this kind of building. It shows that this innovative building has high loading capacity and significantly reduces the dimension of structural members (up to 50%) compared with the conventional RC building at the same loading capacity. Through the validation with test data, the suggested constitutive laws have shown the simplicity and high accuracy since the value of model error is only around 7%. In addition, the simulation results also indicate that the model can capture well the nonlinear behavior of tested specimens, especially, the failure and the formation of plastic hinges of coupling composite shear walls implicitly.
Publisher: Elsevier BV
Date: 08-2009
Publisher: IOP Publishing
Date: 19-07-2201
Publisher: Elsevier BV
Date: 08-2021
Publisher: Research Publishing Services
Date: 2012
Publisher: Elsevier BV
Date: 2010
Publisher: Wiley
Date: 2007
DOI: 10.1002/NME.1873
Publisher: Elsevier BV
Date: 03-2013
Publisher: Elsevier BV
Date: 04-2018
Publisher: Elsevier BV
Date: 11-2011
Publisher: CRC Press
Date: 21-08-2019
Publisher: American Society of Civil Engineers
Date: 25-02-2011
DOI: 10.1061/41142(396)13
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2001
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-2014
Publisher: American Society of Civil Engineers
Date: 25-02-2011
DOI: 10.1061/41142(396)14
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-1995
Publisher: International Association for Bridge and Structural Engineering (IABSE)
Date: 2012
DOI: 10.2749/222137912805111096
Abstract: Post-tensioned composite steel-concrete slabs represent an economical form of construction for flooring systems. These consist of thin-walled profiled steel sheeting, post-tensioning strands, concrete and non-prestressed reinforcement. The particularity of this structural solution relies on the ability of the profiled steel sheeting to act as permanent formwork and, once the concrete has hardened, as external reinforcement. Unlike the case of steel reinforcing bars, which are cast in the concrete, the sheeting does not benefit from being totally embedded in the concrete. For this reason, the structural response significantly depends upon the interaction between the profiled steel sheeting and the concrete. In this context, this paper presents the experimental results of two series of tests carried out on six simply-supported post-tensioned composite s les at both service and ultimate conditions. The s les considered in this study have been cast using Stramit Condeck HP® and Stramit PrimeForm® steel decks. Standard material property tests are carried out on the concrete, steel decking and steel prestressing strands to determine their respective properties. Two analytical models were derived as part of this project to predict the response of the slabs at ultimate and service conditions, respectively. The former one is based on a rigid-plastic analysis and accounts for the partial shear connection behaviour of the composite slab system. The particularity of the long-term model relies on its ability to capture the non-uniform shrinkage profile produced by the lack of moisture egress from the underside of the slab due to the presence of the steel decking. Comparisons between the numerical and experimental results are carried out and briefly discussed. Further comparisons with experimental results are required to properly validate the adequacy of the proposed analytical models.
Publisher: Elsevier BV
Date: 10-2015
Publisher: Thomas Telford Ltd.
Date: 05-1997
Publisher: Elsevier BV
Date: 08-2019
Publisher: Elsevier BV
Date: 05-2014
Publisher: Elsevier BV
Date: 04-2010
Publisher: Elsevier BV
Date: 04-1998
Publisher: Elsevier BV
Date: 03-2017
Publisher: Elsevier BV
Date: 2022
Publisher: Elsevier BV
Date: 11-2020
Publisher: Elsevier BV
Date: 04-2022
Publisher: Wiley
Date: 1998
Publisher: Informa UK Limited
Date: 2015
Publisher: Elsevier BV
Date: 07-2023
Publisher: Elsevier BV
Date: 04-2016
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 05-2011
Publisher: Elsevier BV
Date: 04-2019
Publisher: Elsevier BV
Date: 04-2009
Publisher: Elsevier BV
Date: 07-2019
Publisher: Wiley
Date: 2005
DOI: 10.1002/NME.1337
Publisher: International Association for Bridge and Structural Engineering (IABSE)
Date: 2004
Publisher: Elsevier BV
Date: 06-2004
Publisher: Elsevier BV
Date: 02-2002
Publisher: The Hong Kong Institute of Steel Construction
Date: 05-12-2020
Publisher: Elsevier BV
Date: 08-2019
Publisher: Elsevier BV
Date: 11-2016
Publisher: Elsevier BV
Date: 03-2017
Publisher: Elsevier BV
Date: 04-2009
Publisher: Elsevier BV
Date: 02-2001
Publisher: Elsevier BV
Date: 05-2016
Publisher: Elsevier BV
Date: 09-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 08-2019
Publisher: Elsevier BV
Date: 09-2021
Publisher: Elsevier BV
Date: 08-2023
Publisher: Research Publishing Services
Date: 2012
Publisher: SAGE Publications
Date: 11-2014
DOI: 10.1260/1369-4332.17.11.1657
Abstract: Cables are important components of a cable-stayed bridge, and the cable tension is a crucial factor in determining the overall condition assessment of a cable-stayed bridge structure. Based on the vibration frequency method, a wireless monitoring system for bridge cable tension force monitoring has been investigated and experimentally validated through laboratory and field tests in this paper. The vibration frequency-based method for cable tension measurement, the design method of the wireless measurement system with embedded identification algorithm, the test procedures, and relevant results are discussed, respectively. The developed wireless monitoring system is verified by a bridge model test in the laboratory and full-scale bridge tests in the field. Field experimental results show that the relative error between this wireless monitoring system and the reference wired system values is within 0.5%. Therefore, the developed wireless measurement system can provide an estimation of cable tension with sufficient accuracy. Moreover, the developed system is highly integrated and convenient in terms of installation and dismantling, and it has potential applicability prospects in emergency for the quick detection of cable tension.
Publisher: American Society of Civil Engineers (ASCE)
Date: 12-2006
Publisher: Research Publishing Services
Date: 2012
Publisher: Elsevier BV
Date: 03-2019
Publisher: Elsevier BV
Date: 07-2016
Publisher: Elsevier BV
Date: 02-2018
Publisher: Elsevier BV
Date: 2017
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2013
Publisher: Elsevier BV
Date: 05-2017
Publisher: Elsevier BV
Date: 03-2009
Publisher: Elsevier BV
Date: 06-2021
Publisher: Elsevier BV
Date: 10-2013
Publisher: Elsevier BV
Date: 12-2022
Publisher: Elsevier BV
Date: 09-2021
Publisher: SAGE Publications
Date: 02-2006
DOI: 10.1260/136943306776232855
Abstract: This paper addresses the issue of the deformations that occur in composite steel-concrete beams caused by the quasi-viscoelastic effects of creep and shrinkage of the concrete slab, and in which the effects of partial shear interaction (PI) at the interface between the slab and the steel joist are included in the analysis. By making recourse to an algebraic representation of the viscoelastic response of the concrete, the formulation in this paper leads to a unique and useful solution of the problem in closed form, which follows from the establishment of a second order linear differential equation. The solution therefore does not require a discretisation along the beam as is usually required for numerical techniques, but only one discretisation in the time domain, and furthermore the resulting solution is generic in the sense that it may be applied for a variety of loading and restraint conditions. Specific solutions, which are validated against a numerical technique reported elsewhere, are presented for the cases of a simply supported beam, an encastré beam and for a propped cantilever.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Institution of Engineering and Technology (IET)
Date: 2012
DOI: 10.1049/EL.2011.2573
Publisher: Elsevier BV
Date: 06-2004
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 07-2015
Publisher: Elsevier BV
Date: 05-2012
Publisher: Elsevier BV
Date: 02-2023
Publisher: American Society of Civil Engineers (ASCE)
Date: 03-2004
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2002
Publisher: Research Publishing Services
Date: 2010
Publisher: Elsevier
Date: 2022
Publisher: Elsevier BV
Date: 03-2016
Publisher: American Society of Civil Engineers
Date: 03-02-2006
DOI: 10.1061/40826(186)32
Publisher: Research Publishing Services
Date: 2012
Publisher: Elsevier BV
Date: 06-2005
Publisher: SAGE Publications
Date: 05-2012
DOI: 10.1260/1369-4332.15.5.771
Abstract: Shear connectors are widely used in composite bridges that provide composite action. Their damage will reduce the load-carrying capacity of the structure. In this study, a novel method based on Kullback-Leibler distance (KLD) was developed to assess the integrity of the shear connectors. A bridge model was constructed in the laboratory and some removable anchors were specially designed and fabricated to link the beams and slab that were cast separately. Each anchor consists of a threaded bar that penetrates through the soffit of the beam and ties up into an embedded nut cap to simulate a shear connector in the real bridges. Different damage scenarios were introduced by pulling out some connectors. Vibration tests were carried out in each damage scenario. Various damage detection methods have been applied and results show that the method was able to detect all the assumed damage scenarios successfully and consistently.
Publisher: Informa UK Limited
Date: 03-05-2016
Publisher: Elsevier BV
Date: 12-2011
Publisher: Elsevier BV
Date: 11-2023
Publisher: Elsevier BV
Date: 2002
Publisher: Elsevier BV
Date: 06-2006
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2011
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-1995
Publisher: Elsevier BV
Date: 05-2000
Publisher: Elsevier BV
Date: 10-2014
Publisher: Elsevier BV
Date: 11-2019
Publisher: Elsevier BV
Date: 06-2002
Publisher: Elsevier BV
Date: 07-2022
Publisher: IEEE
Date: 09-2010
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2003
Publisher: Elsevier BV
Date: 06-2016
Publisher: Elsevier BV
Date: 02-2017
Publisher: OMICS Publishing Group
Date: 2016
Publisher: Research Publishing Services
Date: 2010
Publisher: Elsevier BV
Date: 11-2015
Publisher: The Hong Kong Institute of Steel Construction
Date: 05-09-2018
Publisher: MDPI AG
Date: 06-08-2022
DOI: 10.3390/SU14159696
Abstract: Monitoring the corrosion of steel rebars is paramount to ensuring the safety and serviceability of reinforced concrete (RC) structures. Conventional electro-chemical techniques can provide an overall estimate of the extent of corrosion. However, a detailed account of the extent of corrosion would help in understanding the residual strength of corroding RC structures. A passive wave-based technique such as acoustic emissions can identify the location of corrosion but always requires the presence of transducers on the structure. In active wave-based techniques, the structure is excited through a pulse excitation and their subsequent response to this excitation is measured. Thus, for active techniques, the transducers need not always be present in the structure. In guided wave ultrasonics, the excitation pulse is imparted through a waveguide to determine the state of corrosion. This technique relies on parameters such as time of flight or attenuation of the incident signal to predict the state of corrosion. These parameters can be susceptible to uncertainties in the transducer of ultrasonic coupling. In the present study, concrete specimens with embedded steel bars have been subjected to accelerated corrosion. They have been monitored with a combination of active and passive techniques. The received signals are analyzed through a modified S-Transform-based time-frequency approach to obtain a range of modes that propagate through the specimen. The changes in the modal composition of the guided wave signals due to corrosion are parameterized and correlated to various stages of corrosion. A holistic understanding of the stages of corrosion is developed by the inclusion of acoustic emission hits to guided wave parameters. Based on the Guided Wave Ultrasonics and acoustic emission parameters, corrosion has been classified into Initiation, Intermediate, and Advanced. Subsequently, destructive tests have been performed to measure the residual strength of the corroded bars. Thus, this paper presents a novel proof of concept study for monitoring corrosion with Guided Wave Ultrasonics and acoustic emissions.
Publisher: Research Publishing Services
Date: 2012
Publisher: Research Publishing Services
Date: 2013
Publisher: Elsevier BV
Date: 2017
Publisher: Informa UK Limited
Date: 2015
Publisher: ISEC Press
Date: 07-2017
DOI: 10.14455/ISEC.RES.2017.135
Abstract: Increasing the sustainability of construction materials is a key goal in the construction industry. As the demand for high-rise residential structures grows, new more efficient methods of achieving sustainability are required. Rendering larger structures demountable to enable the re-use of steel structural members is one solution. The aim of this study was to investigate and assess the behavior of blind bolted column-column connections between concrete filled steel tubes in axial tension. The investigation aimed to address the need for accurate design guidelines for tensile members in the composite design standards such as Eurocode 4 and encourage the use of column-column connections in large-scale demountable structures. A numerical investigation of the blind bolted column-column connection has been performed using ABAQUS. The model consisted of two concrete filled square hollow steel sections connected using sleeve plates welded to the top tube only, as well as 16 M20 Lindapter Hollo-bolts connecting the tubes. The numerical investigation revealed that the sections tested conformed with AS1170.1 regarding columns in tension. Results of the numerical investigation have been compared against experimental results for a continuous CFST and it was found that the connections performed better in tension. The parametric analysis revealed no dependence of the shape of force-displacement relationships on diameter to thickness ratio, concrete compressive strength or yield stress.
Publisher: Elsevier BV
Date: 09-2022
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2007
Publisher: American Association for Cancer Research (AACR)
Date: 2018
DOI: 10.1158/1535-7163.TARG-17-A082
Abstract: Background: Activation of the p53 pathway by inhibiting MDM2 has been proposed as a novel strategy for cancer therapy. We previously reported the phase 1 results in solid tumor patients (pts) of RO6839921, a small-molecule pegylated IV prodrug of the MDM2 antagonist idasanutlin (active principle = AP), which was developed with the goal of reducing exposure variability to improve the therapeutic index. We report here on the safety, PK, PD, and activity in AML pts. Methods: This was an open-label phase I monotherapy study evaluating RO6839921 in R/R AML pts on a 5-day dosing schedule. Primary objectives were to identify dose-limiting toxicities (DLTs) and the maximum tolerated dose (MTD, DLT rate ≤ 33%). Secondary objectives were to assess PK, PD, and preliminary activity. Maximum escalation increments followed a Modified Fibonacci sequence. TP53 mutational status was assessed by next-generation sequencing from bone marrow s les. Serum MIC-1 (macrophage inhibitory cytokine-1), a p53 transcriptional target, was analyzed by Elecsys® ECL as a PD marker of p53 activation. Results: 26 DLT-evaluable pts were treated at doses between 120-300 mg AP. The MTD was 250 mg with DLTs reported at 250 mg (2/8 pts, 25%) and 300 mg (2/5 pts, 40%) (table). Related AEs ≥ G3 in & % of pts included febrile neutropenia (3/26, 11.5%), epistaxis and platelet count decreased (both 2/26, 7.7%). Related AEs of all grades observed in & 20% pts were diarrhea, nausea, vomiting, decreased appetite, and fatigue. PK analyses showed rapid and near-complete conversion of prodrug to AP and dose-proportional exposure across the doses tested (table). Variability ranged from 30-47% (22-54% for idasanutlin). 11/26 pts had evidence of antileukemic activity (CR, CRi/MLFS, PR, HI/SD) for a disease control rate of 42%, with a composite CR rate of 7.7% (1 CR, 1 CRi/MLFS 2/26) TP53 was evaluable in 24 pts 21 (87.5%) were wild type and 3 mutant (12.5%). 10/11 pts with activity were wild type and 1 did not have a s le. p53 activation was demonstrated by MIC-1 induction in serum and was associated with AP exposure. Conclusions: RO6839921 shows a PK profile similar to idasanutlin. The MTD of 250 mg AP qd x 5 days has a manageable safety profile in R/R AML at ~25% of the idasanutlin dose identified for development in this population. Single-agent antileukemic activity is observed in 42% pts overall, including 4 of 8 pts (50%) at the MTD. NCT02098967. Arm B Cohort(n)Dose(mg AP)Prior AML induction regimens (median and range)ELN risk at initial diagnosis (Favorable, Int-1, Int-2, Adverse)TP53 status (Wild Type, Mutant, or Not Evaluable)PK (AP on D5)DLT eventsAnti-leukemicactivity*FI-1I-2AdvCmax (µg/ml)AUC0-24 (hr*µg/ml)Cohort 1 (n = 6)1202 (0-4)00155 WT, 1 NE18 ± 690 ± 30none2 HI/SDCohort 2 (n = 7)2001 (1-4)13215 WT / 1 MT / 1 NE32 ± 3164 ± 41none1 PR, 2 HI/SDCohort 3 (n = 5)3002 (0-3)01133 WT / 2 MT42 ± 8335 ± 93G4 QTcF prolongation, G3 colitis1 CRi/MLFS, 1 HI/SDCohort 4MTD(n = 8)2501 (0-2)13138 WT43 ± 9 (n=3)278 ± 72 (n=3)G3 stomatitis, G3 diarrhea1 CR, 1 PR, 2 HI/SDTotal(n = 26)11 (42%) Citation Format: Karen Yee, Geoffrey Uy, Sarit Assouline, Carolyn D. Britten, Jianguo Zhi, Steven Blotner, William Pierceall, Brian Higgins, Lin-Chi Chen. A phase I study of the MDM2 antagonist RO6839921, a pegylated intravenous prodrug of idasanutlin, in patients with AML [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics 2017 Oct 26-30 Philadelphia, PA. Philadelphia (PA): AACR Mol Cancer Ther 2018 (1 Suppl):Abstract nr A082.
Publisher: Elsevier BV
Date: 12-2009
Publisher: Elsevier BV
Date: 02-2011
Publisher: American Society of Civil Engineers (ASCE)
Date: 03-2000
Publisher: Elsevier BV
Date: 03-2009
Publisher: Elsevier BV
Date: 12-2020
Publisher: Trans Tech Publications, Ltd.
Date: 02-2014
DOI: 10.4028/WWW.SCIENTIFIC.NET/MSF.777.249
Abstract: Engineers are increasingly encouraged to consider sustainability in the design and construction of new civil engineering infrastructure. Sustainability can be achieved through the use of high strength materials thereby reducing quantity of materials required in construction where possible. Knowledge of residual stresses in fabricated columns is important in identifying whether the fabricated columns can be classified as heavily welded (HW) or lightly welded (LW). The determination of residual stresses can be used to determine the local buckling of stub columns. Residual stress magnitudes are also essential in the numerical modelling of buckling behaviour of columns. This paper outlines the challenges in measurement of residual stresses using neutron diffraction in fabricated high strength steel square tubes. The residual stress line scans and maps were measured using the Kowari Strain Scanner located at the Australian Nuclear and Science Organisation (ANSTO) in Australia.
Publisher: Elsevier BV
Date: 02-2020
Publisher: Elsevier BV
Date: 02-2002
Publisher: Elsevier BV
Date: 08-2018
Publisher: Elsevier BV
Date: 11-2020
Publisher: Universitat Politècnica València
Date: 27-06-2018
DOI: 10.4995/ASCCS2018.2018.8375
Abstract: This paper addresses the applications, behaviour and construction of high performance steels in steel-concrete composite structures. For the purposes of this paper, high performance steels will include high strength, stainless and weathering steels. Akin to many innovations in the construction industry, high performance steels have generally been adopted for the use in iconic projects well before design procedures have been developed in standards. This paper will provide a summary of many of the applications particularly as they pertain to iconic projects in Australasia and internationally. Recent research in these areas will also be summarised and important design parameters as they deviate from traditional mild structural steel will be highlighted. Australasian advances in the standardisation of both bridges and buildings incorporating high performance steels will also be summarised, with particular reference to the Australasian Design Codes in Bridge Structures, ASNZS 5100 Part 6 and Building Structures ASNZS 2327 which have both been published in 2017. The paper will conclude with suggestions for further research and will identify areas of significant gaps in Australasian and international standards which will also guide future research in this area.
Publisher: Elsevier BV
Date: 2017
Publisher: Elsevier BV
Date: 2016
Publisher: SAGE Publications
Date: 05-03-2013
Abstract: This article presents analytical solutions for buckling analysis of functionally graded plate based on a refined plate theory. Based on the refined shear deformation theory, the position of neutral surface is determined and the governing stability equations based on neutral surface are derived. There is no stretching–bending coupling effect in the neutral surface-based formulation, and consequently, the governing equations and boundary conditions of functionally graded plates based on neutral surface have the simple forms as those of isotropic plates. The closed-form solutions of buckling load are obtained for rectangular plates with various boundary conditions. The accuracy of neutral surface-based model is verified by comparing the obtained results with those reported in the literature. Finally, parameter studies are carried out to study the effects of power law index, thickness ratio, and aspect ratio on the critical buckling load of functionally graded plates.
Publisher: Elsevier BV
Date: 03-1996
Publisher: American Society of Civil Engineers
Date: 22-05-2002
DOI: 10.1061/40616(281)20
Publisher: American Society of Civil Engineers (ASCE)
Date: 06-2021
Publisher: Elsevier BV
Date: 12-2015
Publisher: Elsevier BV
Date: 11-2013
Publisher: International Association for Bridge and Structural Engineering (IABSE)
Date: 2015
DOI: 10.2749/222137815818357827
Abstract: In 2010 the structural Eurocodes replaced the equivalent national standards in all EU member states. As a result of this, many other countries around the world that have historical connections with the UK are now adopting the Eurocodes as their national standards. For steel construction, adoption is proving challenging in these countries. This paper describes the different approaches that are being used in the Asia-Pacific region.
Publisher: The Hong Kong Institute of Steel Construction
Date: 12-12-2018
Publisher: Elsevier BV
Date: 02-2021
Publisher: SAGE Publications
Date: 13-03-2020
Abstract: While the current state of blast-resistant design methods is based largely on empirical observations of actual explosive testing or numerical simulations, experimental testing remains the ultimate method for validating blast protection technologies. Field trials for performing systematic experimental studies are exceedingly expensive and inefficient. Conventional blast simulators (shock tubes) enable blast testing to be performed in a safe and controlled laboratory environment but are significantly deficient. The Australian National Facility of Physical Blast Simulation based on the ‘Advanced Blast Simulator’ concept was established to address the shortcomings of conventional blast simulators (shock tubes). The blast simulator at the National Facility of Physical Blast Simulation is a state-of-the-art design having a test section of 1.5 × 2.0 m with dual-mode driver able of operating with either compressed gas or gaseous detonation modes. The simulator is capable of a range of blast-test configurations such as full-reflection wall targets and diffraction model targets. This article aims to demonstrate the ability of the Advanced Blast Simulator in accurately generating a far-field blast environment suitable for high-precision and repeatable explosion testing of various building components. Blast pressure-time histories generated with the Advanced Blast Simulator are validated against equivalent TNT free-field curves reproduced with Conventional Weapons Effects Program. Numerical models based on Computational Fluid Dynamics were developed in ANSYS FLUENT to accurately characterise and visualise the internal flow environment of the National Facility of Physical Blast Simulation Advanced Blast Simulator. The Computational Fluid Dynamics model was also used to explain experimental observations and to determine density and dynamic pressure information for comparisons with free-field explosion conditions.
Publisher: Elsevier BV
Date: 2012
Publisher: The Hong Kong Institute of Steel Construction
Date: 12-12-2018
Publisher: The Hong Kong Institute of Steel Construction
Date: 12-12-2018
Publisher: Wiley
Date: 09-2017
DOI: 10.1002/CEPA.116
Publisher: Elsevier BV
Date: 04-2017
Publisher: SAGE Publications
Date: 2004
DOI: 10.1260/136943304322985729
Abstract: Composite steel-concrete beams are used widely in bridge and building construction as the main structural elements in flexure. Bridges, throughout the world have a design life and this may be reduced if traffic flows are increased or environmental degradation occurs. Similarly, building beams may become compromised for serviceability or strength when loads on floor systems are increased. These changes may reduce the design life and strength of such members and thus replacement or retrofitting may need to be considered. One method of retrofitting (stiffening and strengthening) a composite steel-concrete beam is to externally post-tension the beam. The application of external post-tensioning also has the effect of increasing the fatigue life of such members. This paper provides a set of detailed experiments on both a conventional and prestressed composite steel-concrete beam. A numerical model is then developed for the load-deflection response and this is calibrated with the test data. An extensive parametric study is then conducted to consider the influence of various parameters on the behaviour of these beams. Finally a rigid plastic analysis procedure is presented and calibrated with the test results with good effect. This procedure is considered to be amenable for design in assessing the flexural strength.
Publisher: Wiley
Date: 05-07-2022
Abstract: This study aimed to develop a novel technique to retain and stabilize compounds contributing to truffle aroma by encapsulation using β‐cyclodextrin. Two experiments were conducted. In the first experiment, the key volatile profile and microbial population of products resulting from three different encapsulation methods, namely direct mixing method (M1), direct mixing followed by ethanol addition method (M2), and paste method (M3), were compared with untreated truffles (positive control) over a 90‐day period. The M2‐derived product was the least optimal for retaining key volatile compounds despite showing the lowest microbial population. There was no significant difference in the volatile profile of products derived from M1 and M3 on day 0. However, it was observed that the M3‐derived product could retain its volatile profile better than the M1‐derived product by day 90. M3 was compared with freeze‐drying in the second experiment. Freeze‐dried truffles showed an overall higher relative percentage of volatiles than the M3‐derived product on day 0. However, by day 90, some volatile changes occurred in the freeze‐dried truffles but not in the M3‐derived product. The findings indicate that while freeze‐drying could adequately conserve truffle volatiles, the encapsulation of volatile compounds in β‐cyclodextrin could improve the volatile stability of truffle products and allow for longer storage times. Microbes were found in all encapsulated truffle products and freeze‐dried truffles on days 0 and 90, suggesting the need to explore the possibility of incorporating a decontamination step in the process prior to either encapsulation or freeze‐drying. A technique to capture and stabilize compounds responsible for truffle aroma by encapsulation using β‐cyclodextrin was developed and compared with freeze‐drying in this study. The overall finding suggests that while freeze‐drying of truffle could sufficiently preserve volatiles, encapsulating truffle volatiles with β‐cyclodextrin may improve its stability, extending its shelf life, which can be applied in the development of a natural truffle ingredient that can be applied in food product development.
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2006
Publisher: International Association for Bridge and Structural Engineering (IABSE)
Date: 2009
DOI: 10.2749/222137809796205674
Abstract: This paper investigates the finite element (FE) modelling of concrete-filled stainless steel tubular (CFSST) columns under ISO 834 standard fire, where heat properties, nonlinear material behaviour at elevated temperatures, enhanced strength corner properties of steel, and initial geometric imperfections were all included. Using the FE method, the behaviour of concrete-filled stainless steel tubular columns at elevated temperatures is compared with that of carbon steel composite columns.
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2005
Publisher: Elsevier BV
Date: 11-2017
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-2017
Publisher: Elsevier BV
Date: 10-2019
Publisher: Elsevier BV
Date: 08-2009
Publisher: Elsevier BV
Date: 03-2011
Publisher: Elsevier BV
Date: 07-2008
Publisher: Elsevier BV
Date: 06-2019
Publisher: Elsevier
Date: 2006
Publisher: Elsevier BV
Date: 2018
Publisher: Elsevier BV
Date: 09-2010
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2006
Publisher: Thomas Telford Ltd.
Date: 11-1995
Publisher: Elsevier BV
Date: 11-2015
Publisher: Research Publishing Services
Date: 2013
Publisher: Elsevier BV
Date: 04-2013
Publisher: Elsevier BV
Date: 07-2001
Publisher: Elsevier BV
Date: 10-2016
Publisher: SAGE Publications
Date: 07-2013
DOI: 10.1260/1369-4332.16.7.1163
Abstract: In conventional steel-concrete-steel (SCS) construction, the external steel plates are connected to the concrete infill by welded shear connectors. This paper describes an experimental programme in which the response of axially restrained non-composite (without shear connectors) SCS protective panels subject to impulsive loading was studied. A comprehensive parametric study was carried out to investigate the effects of different types of infill materials, amount of impact energy, and the bond between the concrete core and steel faceplates, on the performance of the protective panels. The experimental results showed that the panels developed high load-carrying capacity through the tensile membrane resistance of the steel faceplates at large deformation. The panels demonstrated a highly ductile response and were able to sustain large deformation up to 18 degrees end rotation without collapse. The high strength and high ductility characteristics of these SCS panels make them an economical alternative to the existing protective barrier structures.
Publisher: Elsevier BV
Date: 08-2004
Publisher: Elsevier BV
Date: 04-2014
Publisher: Research Publishing Services
Date: 2013
Publisher: Elsevier BV
Date: 07-2021
Publisher: Wiley
Date: 06-1996
DOI: 10.1002/(SICI)1099-1794(199606)5:2<75::AID-TAL69>3.0.CO;2-R
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 05-2008
Publisher: Trans Tech Publications, Ltd.
Date: 06-2014
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.567.440
Abstract: Non-composite steel-concrete-steel panels develop high load-carrying capacity through the tensile membrane resistance of the steel faceplates at large displacement. The response of a full-scale barrier structure composed of the non-composite SCS panels and steel posts under various blast loading scenarios was investigated using non-linear finite element software LS-Dyna. The simulation results showed that the barrier was able to withstand very large blast energy. It can be concluded that non-composite SCS panels can provide an attractive solution to expedite construction of high-performance protective barriers to resist extreme blast loadings.
Publisher: Elsevier BV
Date: 03-2011
Publisher: SAGE Publications
Date: 12-2015
DOI: 10.1260/2041-4196.6.4.629
Abstract: Breaching activities are required for military operations in urban environment and for firefighters in emergency situations for saving lives. Explosive wall breaching is a key capability in military operations in urban terrain environments where the close proximity of urban structures significantly restricts the use of large demolition charges. Explosive breaching is also used by special operations groups as a means to gain entry into a structure where conventional breaching methods are not sufficient or the emergency situation requires immediate entry to save lives. This paper develops an analytical model for the explosive breaching of protective targets such as concrete and masonry walls. It provides simple analytical models based on the principles of blast physics and the conservation laws for the characteristics of contact charges required to produce a wall breach of the required shape and size. The model is validated using the experimental data. An illustrative ex le is included to demonstrate the model's ability to predict the size of a breach hole in a thick masonry wall.
Publisher: Elsevier BV
Date: 07-2017
Publisher: Elsevier BV
Date: 11-2021
Publisher: The American Association of Immunologists
Date: 15-04-2010
Abstract: Proteasomes are multisubunit proteases that initiate degradation of many Ags presented by MHC class I molecules. Vertebrates express alternate forms of each of the three catalytic proteasome subunits: standard subunits, and immunosubunits, which are constitutively expressed by APCs and are induced in other cell types by exposure to cytokines. The assembly of mixed proteasomes containing standard subunits and immunosubunits is regulated in a tissue specific manner. In this study, we report that the presence of mixed proteasomes in immune cells in LMP2−/− mice compromises multiple components that contribute to the generation of antiviral Ab responses, including splenic B cell numbers, survival and function of adoptively transferred B cells, Th cell function, and dendritic cell secretion of IL-6, TNF-α, IL-1β, and type I IFNs. These defects did not result from compromised overall protein degradation, rather they were associated with altered NF-κB activity. These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing.
Start Date: 2011
End Date: 03-2015
Amount: $255,000.00
Funder: Australian Research Council
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End Date: 12-2007
Amount: $210,000.00
Funder: Australian Research Council
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End Date: 04-2018
Amount: $255,000.00
Funder: Australian Research Council
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End Date: 03-2020
Amount: $159,698.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2016
End Date: 12-2019
Amount: $235,000.00
Funder: Australian Research Council
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End Date: 04-2016
Amount: $380,000.00
Funder: Australian Research Council
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End Date: 02-2007
Amount: $799,000.00
Funder: Australian Research Council
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End Date: 12-2013
Amount: $256,188.00
Funder: Australian Research Council
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End Date: 12-2012
Amount: $300,413.00
Funder: Australian Research Council
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End Date: 10-2012
Amount: $371,000.00
Funder: Australian Research Council
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End Date: 12-2015
Amount: $400,000.00
Funder: Australian Research Council
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End Date: 12-2012
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End Date: 12-2014
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Funder: Australian Research Council
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Funder: Australian Research Council
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End Date: 12-2016
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Funder: Australian Research Council
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End Date: 06-2005
Amount: $10,000.00
Funder: Australian Research Council
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End Date: 02-2020
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Funder: Australian Research Council
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End Date: 12-2021
Amount: $744,697.00
Funder: Australian Research Council
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End Date: 12-2013
Amount: $350,000.00
Funder: Australian Research Council
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End Date: 2015
Amount: $870,000.00
Funder: Australian Research Council
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End Date: 11-2015
Amount: $500,000.00
Funder: Australian Research Council
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End Date: 03-2021
Amount: $463,488.00
Funder: Australian Research Council
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End Date: 12-2023
Amount: $1,213,351.00
Funder: Australian Research Council
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End Date: 12-2019
Amount: $458,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2023
End Date: 02-2026
Amount: $520,020.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2020
End Date: 02-2023
Amount: $530,000.00
Funder: Australian Research Council
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