ORCID Profile
0000-0003-3418-2204
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Publisher: Elsevier BV
Date: 12-2020
Publisher: Wiley
Date: 26-08-2022
DOI: 10.1002/LARY.30362
Abstract: This study evaluates and compares the prognostic significance of 18 F‐fluoro‐deoxyglucose‐positron emission tomography ( 18 F‐FDG PET) volumetric parameters in human papillomavirus‐related oropharyngeal squamous cell carcinoma (OPSCC). A retrospective review of all patients treated for OPSCC with curative intent between 2012 and 2018 was performed. Volumetric parameters analyzed included the maximum standardized uptake value (SUV max ), SUV peak , metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in both the primary tumor and nodal metastases. Prognostic significance was determined using Cox proportional hazards models for disease‐free survival (DFS) and overall survival (OS). Primary tumor MTV and TLG significantly correlated with both DFS and OS however the commonly reported SUV max was not found to be predictive. Nodal measures of SUV max , MTV, and TLG were not significant predictors of survival outcomes. A higher burden of metabolically active primary tumor as measured on volumetric 18 F‐FDG PET parameters is associated with poorer DFS and OS. This improved prognostication may be used to counsel patients and select those appropriate for treatment de‐escalation in the future. 3 Laryngoscope , 133:1667–1672, 2023
Publisher: Elsevier BV
Date: 04-2016
DOI: 10.1016/J.JPEDS.2015.10.093
Abstract: To examine the utility of continuous metabolic syndrome (cMetS) scores vs a dichotomous metabolic syndrome (MetS) definition in youth to predict adult type 2 diabetes mellitus (T2DM) and carotid intima-media thickness (IMT). Participants (n = 1453) from the population-based, prospective, observational Cardiovascular Risk in Young Finns Study who were examined in youth (when aged 9-18 years) and re-examined 15-25 years later. Four cMetS scores were constructed according to procedures most often used in the literature that comprised the youth risk factor inputs of body mass index, blood pressure, glucose, insulin, high-density lipoprotein-cholesterol, and triglycerides. Adult outcomes included T2DM and high carotid IMT (≥ 90 th percentile). For a 1 SD increase in cMetS scores in youth, participants had a 30%-78% increased risk of T2DM and 12%-61% increased risk of high carotid IMT. Prediction of adult T2DM and high carotid IMT using cMetS scores in youth was essentially no different to a dichotomous MetS definition with area under the receiver-operating characteristic curve ranging from 0.54-0.60 (continuous definitions) and 0.55-0.59 (dichotomous) with 95% CIs often including 0.5, and integrated discrimination improvement from -0.2% to -0.6%. cMetS scores in youth are predictive of cardiometabolic outcomes in adulthood. However, they do not have increased predictive utility over a dichotomous definition of MetS.
Publisher: Elsevier BV
Date: 06-2023
Publisher: AME Publishing Company
Date: 04-2023
DOI: 10.21037/AJO-22-37
Publisher: Australian Society of Plastic Surgeons
Date: 30-03-2021
Abstract: The practice of delivering cosmetic injectables in the outpatient setting continues to grow in Australia.1 The increase in demand has seen a dramatic rise in the number of new cosmetic injectable clinics using telehealth prescribing services. Lipodissolve treatment is an ex le of a non-surgical procedure that aims to improve the appearance of a ‘double chin’ by injection of phosphatidylcholine (PC) and deoxycholic acid (DCA) into submental adipose tissue. We describe a case of an airway complication and hospitalisation secondary to the injection of Lipodissolve in the neck of a 23-year-old female.
No related grants have been discovered for Sanith Cheriyan.