ORCID Profile
0000-0002-8554-1660
Current Organisations
UNIVERSITY OF LISBON (UL), School of Agriculture (ISA)
,
Universidade Federal da Bahia
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Publisher: Frontiers Media SA
Date: 12-10-2017
Publisher: Oxford University Press (OUP)
Date: 03-01-2013
DOI: 10.1039/C2IB20206A
Abstract: Although attempts have been made to unveil protein-protein and host-pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to develop common conserved intra-species protein-protein interaction (PPI) networks first time for four Cp strains (Cp FRC41, Cp 316, Cp 3/99-5, and Cp P54B96) followed by development of a common conserved inter-species bacterial PPI using conserved proteins in multiple pathogens (Y. pestis, M. tuberculosis, C. diphtheriae, C. ulcerans, E. coli, and all four Cp strains) and E. Coli based experimentally validated PPI data. Furthermore, the interacting proteins in the common conserved inter-species bacterial PPI were used to generate a conserved host-pathogen interaction (HP-PPI) network considering human, goat, sheep, bovine, and horse as hosts. The HP-PPI network was validated, and acetate kinase (Ack) was identified as a novel broad spectrum target. Ceftiofur, penicillin, and two natural compounds derived from Piper betel were predicted to inhibit Ack activity. One of these Piper betel compounds found to inhibit E. coli O157:H7 growth similar to penicillin. The target specificity of these betel compounds, their effects on other studied pathogens, and other in silico results are currently being validated and the results are promising.
Publisher: Informa UK Limited
Date: 15-03-2021
DOI: 10.1080/07391102.2021.1898473
Abstract: The genus
Publisher: Cold Spring Harbor Laboratory
Date: 08-02-2023
DOI: 10.1101/2023.02.07.527551
Abstract: Human activity has fundamentally altered wildfire on Earth, creating serious consequences for human health, global bio ersity, and climate change. However, it remains difficult to predict fire interactions with land use, management, and climate change, representing a serious knowledge gap and vulnerability. We used expert assessment to combine opinions about past and future fire regimes from 98 wildfire researchers. We asked for quantitative and qualitative assessments of the frequency, type, and implications of fire regime change from the beginning of the Holocene through the year 2300. Respondents indicated that direct human activity was already influencing wildfires locally since at least ~ 12,000 years BP, though natural climate variability remained the dominant driver of fire regime until around 5000 years BP. Responses showed a ten-fold increase in the rate of wildfire regime change during the last 250 years compared with the rest of the Holocene, corresponding first with the intensification and extensification of land use and later with anthropogenic climate change. Looking to the future, fire regimes were predicted to intensify, with increases in fire frequency, severity, and/or size in all biomes except grassland ecosystems. Fire regime showed quite different climate sensitivities across biomes, but the likelihood of fire regime change increased with higher greenhouse gas emission scenarios for all biomes. Bio ersity, carbon storage, and other ecosystem services were predicted to decrease for most biomes under higher emission scenarios. We present recommendations for adaptation and mitigation under emerging fire regimes, concluding that management options are seriously constrained under higher emission scenarios.
Publisher: Informa UK Limited
Date: 22-06-2021
Publisher: Springer Science and Business Media LLC
Date: 08-04-2016
Location: Portugal
Location: Portugal
Location: Portugal
Location: India
Location: Brazil
No related grants have been discovered for Sandeep Tiwari.