ORCID Profile
0000-0002-3354-4317
Current Organisation
RMIT University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Functional Materials | Nanobiotechnology | Materials Engineering | Nanotechnology | Electrochemistry | Synthesis of Materials | Sensor Technology (Chemical aspects) | Nanomaterials | Nanotechnology | Natural Products Chemistry | Biochemistry and Cell Biology | Condensed Matter Physics | Chemical Characterisation of Materials | Instruments And Techniques | Biological Physics | Organometallic Chemistry | Environmental Biotechnology | Analytical biochemistry | Biosensor Technologies | Metals and Alloy Materials | Environmental Biotechnology Diagnostics (incl. Biosensors) | Analytical Chemistry | Sensor technology (incl. chemical aspects) | Catalysis and Mechanisms of Reactions | Bioinorganic Chemistry | Macromolecular and Materials Chemistry | Inorganic Chemistry | Bioinorganic Chemistry | Physical Chemistry (Incl. Structural) | Biotechnology Not Elsewhere Classified | Nanoscale Characterisation | Industrial biotechnology | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Analytical Chemistry not elsewhere classified | Environmental Chemistry (Incl. Atmospheric Chemistry) | Quantum Optics | Electronic and Magnetic Properties of Condensed Matter; Superconductivity | Cell Metabolism | Nanobiotechnology
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in Technology | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Chemical sciences | Expanding Knowledge in Engineering | Energy Conservation and Efficiency not elsewhere classified | Management of Solid Waste from Energy Activities | Emerging Defence Technologies | Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) | Human Diagnostics | National Security | Physical sciences | Environmentally Sustainable Mineral Resource Activities not elsewhere classified | Fuel Cells (excl. Solid Oxide) | Integrated Circuits and Devices | Management of Gaseous Waste from Manufacturing Activities (excl. Greenhouse Gases) | Urban and Industrial Air Quality | Management of Greenhouse Gas Emissions from Information and Communication Services | Integrated circuits and devices | Solar-Photovoltaic Energy | Human Pharmaceutical Treatments (e.g. Antibiotics) | Plastic Products (incl. Construction Materials) | Diagnostic Methods | Environmental health | Expanding Knowledge in the Physical Sciences | Medical Instruments |
Related Links
Publications
Moving forward in plant food safety and security through NanoBioSensors: Adopt or adapt biomedical technologies?
Publisher: Wiley
Date: 17-04-2015
Abstract: Plant-based foods are integral part of our day-to-day diet. Increasing world population has put forth an ever increasing demand for plant-based foods, and food security remains a major concern. Similarly, biological, chemical, and physical threats to our food and increasing regulatory demands to control the presence of foreign species in food products have made food safety a growing issue. Nanotechnology has already established its roots in erse disciplines. However, the food industry is yet to harness the full potential of the unique capabilities offered by this next-generation technology. While there might be safety concerns in regards to integration of nanoproducts with our food products, an aspect of nanotechnology that can make remarkable contribution to different elements of the food chain is the use of nanobiosensors and diagnostic platforms for monitoring food traceability, quality, safety, and nutritional value. This brings us to an important question that whether existing diagnostic platforms that have already been well developed for biomedical and clinical application are suitable for food industry or whether the demands of the food industry are altogether different that may not allow adoption/adaptation of the existing technology. This review is an effort to raise this important "uncomfortable" yet "timely" question.
Donor-Induced Performance Tuning of Amorphous SrTiO 3 Memristive Nanodevices: Multistate Resistive Switching and Mechanical Tunability
Publisher: Wiley
Date: 14-04-2015
Complexation of plasmid DNA and poly(ethylene oxide)/poly(propylene oxide) polymers for safe gene delivery
Publisher: Springer Science and Business Media LLC
Date: 25-05-2018
Controlling the morphological and redox properties of the CuTCNQ catalyst through solvent engineering
Publisher: Springer Science and Business Media LLC
Date: 03-2019
Alkali-activated electrospun carbon nanofibers as an efficient bifunctional adsorbent for cationic and anionic dyes
Publisher: Elsevier BV
Date: 12-2019
Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC
Publisher: Springer Science and Business Media LLC
Date: 05-2017
Importance of Phase Purity in Two-Dimensional β-Co(OH)2 for Driving Oxygen Evolution
Publisher: American Chemical Society (ACS)
Date: 18-08-2022
Decoupling the effects of the size, wall thickness, and porosity of curcumin-loaded chitosan nanocapsules on their anticancer efficacy: Size is the winner
Publisher: American Chemical Society (ACS)
Date: 29-10-2013
DOI: 10.1021/LA3033836
Abstract: Polymer nanocapsules have gained an important place as drug delivery vehicles for a myriad of biomedical applications. However, the influence of nanocapsule size, wall thickness, and porosity toward controlling the drug delivery efficiency of nanocapsular systems is not well understood. We report a facile template-mediated approach for the development of near monodispersed chitosan nanocapsules of different sizes, wall thicknesses, and porosities in a controllable manner. The ability of this approach to finely tune the structural characteristics of chitosan nanocapsules enabled us to systematically investigate the influence of capsule size, wall thickness, and porosity on their efficiency as drug delivery vehicles against mouse mastocytoma cells after loading them with curcumin, a natural lipophilic anticancer drug. This study establishes an important finding in the field of nanocapsule-based drug delivery systems that although several structural characteristics of a nanocapsule might be responsible in influencing their efficiency as a chemotherapeutic carrier, the size of the nanocapsules is likely to play the most important role in dictating the chemotherapeutic efficiency of such systems.
CHAPTER 23. Nanozyme-Based Environmental Monitoring
Publisher: Royal Society of Chemistry
Date: 2017
Defect Compensation in Nitrogen-Doped β-Ga2O3 Nanowires: Implications for Bipolar Nanoscale Devices
Publisher: American Chemical Society (ACS)
Date: 28-04-2022
Cobalt nanoparticles incorporated into hollow doped porous carbon capsules as a highly efficient oxygen reduction electrocatalyst
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CY01371C
Abstract: MOF nanocrystals are employed for the design and synthesis of cobalt nanoparticles embedded into hollow doped porous carbon electrocatalyst.
Transferrin-conjugated quasi-cubic SPIONs for cellular receptor profiling and detection of brain cancer
Publisher: Elsevier BV
Date: 10-2019
Biological shape-controlled synthesis of silver nanoplates
Publisher: IEEE
Date: 02-2010
Galvanic replacement mediated synthesis of hollow Pt nanocatalysts: Significance of residual Ag for the H2 evolution reaction
Publisher: Elsevier BV
Date: 08-2009
Acoustic-Excitonic Coupling for Dynamic Photoluminescence Manipulation of Quasi - 2D MoS 2 Nanoflakes
Publisher: Wiley
Date: 12-03-2015
Electrochemical formation of platinum nanostructures for fuel cell applications
Publisher: IEEE
Date: 02-2010
Mercury vapor sensor enhancement by nanostructured gold deposited on nickel surfaces using galvanic replacement reactions
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM33480A
Gold nanospikes formed through a simple electrochemical route with high electrocatalytic and surface enhanced Raman scattering activity
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B910830K
Abstract: We demonstrate a simple electrochemical route to produce uniformly sized gold nanospikes without the need for a capping agent or prior modification of the electrode surface, which are predominantly oriented in the {111} crystal plane and exhibit promising electrocatalytic and SERS properties.
Fast and Highly Sensitive Detection of Pathogens Wreathed with Magnetic Nanoparticles Using Dark-Field Microscopy
Publisher: American Chemical Society (ACS)
Date: 23-09-2018
DOI: 10.1021/ACSSENSORS.8B00785
Abstract: Cryptosporidium parvum ( C. parvum) is a highly potent zoonotic pathogen, which can do significant harm to both human beings and livestock. However, existing technologies or methods are deficient for rapid on-site detection of water contaminated with C. parvum. Better detection approaches are needed to allow water management agencies to stop major breakouts of the pathogen. Herein, we present a novel detection method for cryptosporidium in a tiny drop of s le using a magnetic nanoparticle (MNP) probe combined with dark-field microscopy in 30 min. The designed MNP probes bind with high affinity to C. parvum, resulting in the formation of a golden garland-like structure under dark-field microscopy. This MNP-based dark-field counting strategy yields an amazing PCR-like sensitivity of 8 attomolar (aM) (5 pathogens in 1 μL). Importantly, the assay is very rapid (∼30 min) and is very simple to perform as it involves only one step of mixing and magnetic separation, followed by dropping on a slide for counting under dark-field microscope. By combining the advantages of the specific light-scattering characteristic of MNP probe under dark field and the selective magnetic separation ability of functionalized MNP, the proposed MNP-based dark-field enumeration method offers low cost and significant translational potential.
Mono- to few-layer non-van der Waals 2D lanthanide-doped NaYF4nanosheets with upconversion luminescence
Publisher: IOP Publishing
Date: 12-10-2020
Abstract: NaYF 4 is an efficient host material for lanthanide-based upconversion luminescence and has attracted immense interest for potential applications in photovoltaics, lasers and bioimaging. However, being a non-van der Waals (non-vdW) material, there have been thus far no reports on exfoliation of bulk NaYF 4 to nanosheets and their upconversion luminescence properties. Here, we demonstrate for the first time the fabrication of lanthanide-containing NaYF 4 2D nanosheets using a soft liquid-phase exfoliation method and report on their optical, electronic and chemical characteristics. The nanosheets exfoliated from NaYF 4 :Yb,Er microcrystals consisting mainly of β -NaYF 4 become enriched in α -NaYF 4 post exfoliation and have a large micron-sized planar area with a preferential (100) surface orientation. X-ray absorption spectroscopy confirms that both Yb and Er doping ions are retained in the exfoliated nanosheets. Through centrifugation, NaYF 4 2D nanosheets are successfully obtained with thicknesses ranging from a monolayer to tens of layers. Optical analysis of in idual nanosheets shows that they exhibit both optical down-conversion and upconversion properties, albeit with reduced emission intensities compared with the parent microparticles. Further exploration of their electronic structure by density functional theory (DFT) calculations and photoelectron spectroscopy reveals the formation of surface F atom defects and a shrinkage of the electronic bandgap in ultrathin nanosheets. Our findings will trigger further interest in non-vdW 2D upconversion nanomaterials.
Synergistic influence of polyoxometalate surface corona towards enhancing the antibacterial performance of tyrosine-capped Ag nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3NR03806H
Abstract: We illustrate a new strategy to improve the antibacterial potential of silver nanoparticles (AgNPs) by their surface modification with the surface corona of biologically active polyoxometalates (POMs). The stable POM surface corona was achieved by utilising zwitterionic tyrosine amino acid as a pH-switchable reducing and capping agent of AgNPs. The general applicability of this approach was demonstrated by developing surface coronas of phosphotungstic acid (PTA) and phosphomolybdic acid (PMA) around AgNPs. Our investigations on Gram negative bacterium Escherichia coli demonstrate that in conjugation with AgNPs, the surface corona of POMs enhances the physical damage to the bacterial cells due to synergistic antibacterial action of AgNPs and POMs, and the ability of tyrosine-reduced AgNPs (AgNPs(Y)) to act as an excellent carrier and stabiliser for the POMs. The further extension of this study towards Gram positive bacterium Staphylococcus albus showed a similar toxicity pattern, whereas these nanomaterials were found to be biocompatible for PC3 epithelial mammalian cells, suggesting the potential of these materials towards specific antimicrobial targeting for topical wound healing applications. The outcomes of this work show that facile tailorability of nanostructured surfaces may play a considerable role in controlling the biological activities of different nanomaterials.
Emerging applications of metal-TCNQ based organic semiconductor charge transfer complexes for catalysis
Publisher: Elsevier BV
Date: 12-2016
Cobalt Sulfide Nanosheets as Peroxidase Mimics for Colorimetric Detection of l-Cysteine
Publisher: American Chemical Society (ACS)
Date: 12-2021
Aptamer-mediated “turn-off/turn-on” nanozyme activity of gold nanoparticles for kanamycin detection
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4CC07275H
Abstract: A new ultrafast and highly sensitive ‘turn-off/turn-on’ biosensing approach that combines the intrinsic peroxidase-like activity of gold nanoparticles (GNPs) with the high affinity and specificity of a ssDNA aptamer is presented.
Soft Exfoliation of 2D SnO with size-dependent optical properties
Publisher: IOP Publishing
Date: 08-06-2017
Ionic liquid mediated synthesis of nitrogen, carbon and fluorine-codoped rutile TiO2nanorods for improved UV and visible light photocatalysis
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4RA14510K
Abstract: The application of [BMIM][BF 4 ] ionic liquid as a designer solvent for the synthesis of multiple nonmetals-codoped rutile titania nanorods is presented. These nanorods show remarkable photoactivity under UV and visble light conditions.
Creating gold nanoprisms directly on quartz crystal microbalance electrodes for mercury vapor sensing
Publisher: IOP Publishing
Date: 07-2011
DOI: 10.1088/0957-4484/22/30/305501
Abstract: A novel electrochemical route is used to form highly {111}-oriented and size-controlled Au nanoprisms directly onto the electrodes of quartz crystal microbalances (QCMs) which are subsequently used as mercury vapor sensors. The Au nanoprism loaded QCM sensors exhibited excellent response-concentration linearity with a response enhancement of up to ∼ 800% over a non-modified sensor at an operating temperature of 28 °C. The increased surface area and atomic-scale features (step/defect sites) introduced during the growth of nanoprisms are thought to play a significant role in enhancing the sensing properties of the Au nanoprisms toward Hg vapor. The sensors are shown to have excellent Hg sensing capabilities in the concentration range of 0.123-1.27 ppm(v) (1.02-10.55 mg m(-3)), with a detection limit of 2.4 ppb(v) (0.02 mg m(-3)) toward Hg vapor when operating at 28 °C, and 17 ppb(v) (0.15 mg m(-3)) at 89 °C, making them potentially useful for air monitoring applications or for monitoring the efficiency of Hg emission control systems in industries such as mining and waste incineration. The developed sensors exhibited excellent reversible behavior (sensor recovery) within 1 h periods, and crucially were also observed to have high selectivity toward Hg vapor in the presence of ethanol, ammonia and humidity, and excellent long-term stability over a 33 day operating period.
Galvanic replacement of anions in metal-organic semiconductors: a spontaneous redox reaction between TCNQ1− and TCNQF40 (TCNQ = 7,7,8,8-tetracyanoquinodimethane)
Publisher: Elsevier BV
Date: 12-2022
Influence of Zr doping on the structure and ferroelectric properties of BiFeO3 thin films
Publisher: AIP Publishing
Date: 15-06-2010
DOI: 10.1063/1.3436593
Abstract: We have prepared thin films of BiFe1−xZrxO3 (x=0.0–0.15) by chemical solution deposition on Pt/Si substrates. Structural characterization of the films using x-ray diffraction and Raman spectroscopy suggests lattice distortion upon doping for x& .15. This also appears to be the limit for pure phase formation. Ferroelectric measurements reveal that Zr doping leads to reduction in the remnant polarization and an increase in the coercive field, attributed to lattice distortion. Dielectric measurements indicate that the doped compositions exhibit absence of low frequency relaxation, usually associated with defects and grain boundaries. Absence of Fe2+ in our films was verified using x-ray photoelectron spectroscopy. Role of Zr in controlling the film’s properties has been explained in terms of changes in the bond strength.
Self-Assembled Histidine Acid Phosphatase Nanocapsules in Ionic Liquid [BMIM][BF4] as Functional Templates for Hollow Metal Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 06-07-2012
DOI: 10.1021/LA3014128
Abstract: We report the biomacromolecular self-assembly of histidine acid phosphatase (HAP), an enzyme of significant biomedical and industrial importance, in the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF(4)]). The spontaneous self-assembly of HAP enzyme in [BMIM][BF(4)] results in the formation of HAP nanocapsules. The HAP enzyme molecules were found to retain their enzymatic activity after the self-assembly process, which enabled us to utilize self-assembled HAP capsules as self-catalyzing templates for the synthesis of a range of hollow metal nanoparticles (Au, Ag, Pd, and Ni) without employing any additional reducing agent. The hollow metal nanospheres with HAP encapsulated within their cavity were found to retain enzymatic activity for at least up to four cycles, as demonstrated in the case of Au-coated HAP capsules as the model system.
In-depth nano-scale analysis of complex interactions of Hg with gold nanostructures using AFM-based power spectrum density method
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B816592K
Abstract: Atomic force microscopy based power spectrum density (PSD) method along with conventional methods such as line, grain height, root mean square (rms) roughness, is used to probe complex Hg-Au interactions i.e. the amalgamation of smooth gold nanostructures (Au-ns) and partial dissolution of irregular edges of interconnecting Au-ns networks due to Hg. We have demonstrated for the first time the use of the PSD method to gain significant insights into the directional anisotropy of resultant Hg-Au-ns and the range of Au-ns responsible.
Hybrid CuTCNQ/AgTCNQ Metal‐Organic Charge Transfer Complexes via Galvanic Replacement vs Corrosion‐Recrystallization
Publisher: Wiley
Date: 06-10-2014
Lactoferrin functionalized concave cube Au nanoparticles as biocompatible antibacterial agent
Publisher: Elsevier BV
Date: 07-2023
UV-Switchable Polyoxometalate Sandwiched between TiO2 and Metal Nanoparticles for Enhanced Visible and Solar Light Photococatalysis
Publisher: American Chemical Society (ACS)
Date: 07-07-2011
DOI: 10.1021/LA201655N
Abstract: To improve the photocatalytic efficiency of TiO(2)-based nanomaterials, we demonstrate a facile, generalized, highly localized reduction approach to the decoration of TiO(2)-polyoxometalate composites with a range of metal nanoparticles including Cu, Ag, Pt, and Au. The synthesis of nanocomposite photococatalysts reported in this study has been achieved by utilizing the unique ability of the TiO(2)-bound PTA (phosphotungstic acid) molecules (a polyoxometalate, POM) to act as a highly localized UV-switchable reducing agent that specifically reduces metal ions to their nanoparticulate forms directly and only onto the TiO(2) surface. This leads to the metal contaminant-free synthesis of TiO(2)-PTA-metal nanocomposites, which is a significant advantage of the proposed approach. The study further demonstrates that polyoxometalates are regenerable photoactive molecules with outstanding electron-transfer ability and the deposition of metal nanoparticles on the TiO(2)-PTA cocatalytic surface can have a dramatic effect on increasing the overall photocatalytic performance of the composite system. Moreover, it is observed that the photococatalytic performance of the TiO(2)-PTA-metal nanoparticles can be fine tuned by choosing the composition of metal nanoparticles in the nanocomposite. Interestingly, the photococatalysts reported here are found to be active under visible and simulated solar-light conditions. The underlying reaction mechanism for enhanced solar-light photococatalysis has been proposed.
Biosynthesis of zirconia nanoparticles using the fungus Fusarium oxysporum
Publisher: Royal Society of Chemistry (RSC)
Date: 2004
DOI: 10.1039/B407904C
Flower-like Mn3O4/CeO2 microspheres as an efficient catalyst for diesel soot and CO oxidation: Synergistic effects for enhanced catalytic performance
Publisher: Elsevier BV
Date: 04-2019
A visual tutorial on the synthesis of gold nanoparticles
Publisher: Department of Biomedical Imaging, University of Malaya, Malaysia
Date: 2010
DOI: 10.2349/BIIJ.6.1.E9
Rapid, accurate, and comparative differentiation of clinically and industrially relevant microorganisms via multiple vibrational spectroscopic fingerprinting
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6AN00883F
Abstract: Comparison of the applicability and accuracy of FT-IR, Raman and SERS, as physicochemical whole organism fingerprinting approaches, for differentiation of a range of microbial s les.
Copper Tetracyanoquinodimethane (CuTCNQ): A Metal-Organic Semiconductor for Room-Temperature Visible to Long-Wave Infrared Photodetection
Publisher: American Chemical Society (ACS)
Date: 09-08-2021
Absence of morphotropic phase boundary effects in BiFeO3–PbTiO3 thin films grown via a chemical multilayer deposition method
Publisher: Springer Science and Business Media LLC
Date: 30-12-2010
Phytochemicals as Dynamic Surface Ligands to Control Nanoparticle-Protein Interactions
Publisher: American Chemical Society (ACS)
Date: 22-02-2018
Biomarker discovery and applications for foods and beverages: Proteomics to nanoproteomics
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.JPROT.2013.04.014
Abstract: Foods and beverages have been at the heart of our society for centuries, sustaining humankind - health, life, and the pleasures that go with it. The more we grow and develop as a civilization, the more we feel the need to know about the food we eat and beverages we drink. Moreover, with an ever increasing demand for food due to the growing human population food security remains a major concern. Food safety is another growing concern as the consumers prefer varied foods and beverages that are not only traded nationally but also globally. The 21st century science and technology is at a new high, especially in the field of biological sciences. The availability of genome sequences and associated high-throughput sensitive technologies means that foods are being analyzed at various levels. For ex le and in particular, high-throughput omics approaches are being applied to develop suitable biomarkers for foods and beverages and their applications in addressing quality, technology, authenticity, and safety issues. Proteomics are one of those technologies that are increasingly being utilized to profile expressed proteins in different foods and beverages. Acquired knowledge and protein information have now been translated to address safety of foods and beverages. Very recently, the power of proteomic technology has been integrated with another highly sensitive and miniaturized technology called nanotechnology, yielding a new term nanoproteomics. Nanoproteomics offer a real-time multiplexed analysis performed in a miniaturized assay, with low-s le consumption and high sensitivity. To name a few, nanomaterials - quantum dots, gold nanoparticles, carbon nanotubes, and nanowires - have demonstrated potential to overcome the challenges of sensitivity faced by proteomics for biomarker detection, discovery, and application. In this review, we will discuss the importance of biomarker discovery and applications for foods and beverages, the contribution of proteomic technology in this process, and a shift towards nanoproteomics to suitably address associated issues. This article is part of a Special Issue entitled: Translational plant proteomics.
Templated synthesis of single-component polymer capsules and their application in drug delivery
Publisher: American Chemical Society (ACS)
Date: 20-05-2008
DOI: 10.1021/NL080877C
Abstract: We report a general and facile approach for the fabrication of a new class of monodispersed, single-component and thick-walled polymer nanocapsules via the single-step assembly of macromolecules in solid core/mesoporous shell (SC/MS) silica particle templates, followed by cross-linking of the macromolecules and removal of the SC/MS templates. The general applicability of this approach is demonstrated by the preparation of nanocapsules using various polymers, including synthetic polyelectrolytes, polypeptides, and polypeptide-drug conjugates. The potential of doxorubicin (Dox)-loaded poly(L-glutamic acid) nanocapsules in tumor therapy applications is demonstrated via in vitro degradation experiments, which show a near-linear release of the Dox in the presence of a lysosomal hydrolase, nanocapsule uptake by human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death.
Study of dielectric and mechanical properties of epoxy/SiO2 nanocomposite prepared by different processing techniques
Publisher: IEEE
Date: 07-2015
Degradation of black phosphorus is contingent on UV–blue light exposure
Publisher: Springer Science and Business Media LLC
Date: 29-06-2017
DOI: 10.1038/S41699-017-0023-5
Abstract: Layered black phosphorous has recently emerged as a promising candidate for next generation nanoelectronic devices. However, the rapid ambient degradation of mechanically exfoliated black phosphorous poses challenges in its practical implementation in scalable devices. As photo-oxidation has been identified as the main cause of degradation, to-date, the strategies employed to protect black phosphorous have relied upon preventing its exposure to atmospheric oxygen. These strategies inhibit access to the material limiting its use. An understanding of the effect of in idual wavelengths of the light spectrum can lead to alternatives that do not require the complete isolation of black phosphorous from ambient environment. Here, we determine the influence of discrete wavelengths ranging from ultraviolet to infrared on the degradation of black phosphorous. It is shown that the ultraviolet component of the spectrum is primarily responsible for the deterioration of black phosphorous in ambient conditions. Based on these results, new insights into the degradation mechanism have been generated which will enable the handling and operating of black phosphorous in standard fabrication laboratory environments.
Label-Free Electrochemiluminescence Nano-aptasensor for the Ultrasensitive Detection of ApoA1 in Human Serum
Publisher: American Chemical Society (ACS)
Date: 20-10-2022
Electrochemical control of photoluminescence in two-dimensional MoS 2 nanoflakes
Publisher: American Chemical Society (ACS)
Date: 24-10-2013
DOI: 10.1021/NN4041987
Abstract: Two-dimensional (2D) transition metal dichalcogenide semiconductors offer unique electronic and optical properties, which are significantly different from their bulk counterparts. It is known that the electronic structure of 2D MoS2, which is the most popular member of the family, depends on the number of layers. Its electronic structure alters dramatically at near atomically thin morphologies, producing strong photoluminescence (PL). Developing processes for controlling the 2D MoS2 PL is essential to efficiently harness many of its optical capabilities. So far, it has been shown that this PL can be electrically or mechanically gated. Here, we introduce an electrochemical approach to actively control the PL of liquid-phase-exfoliated 2D MoS2 nanoflakes by manipulating the amount of intercalated ions including Li(+), Na(+), and K(+) into and out of the 2D crystal structure. These ions are selected as they are crucial components in many bioprocesses. We show that this controlled intercalation allows for large PL modulations. The introduced electrochemically controlled PL will find significant applications in future chemical and bio-optical sensors as well as optical modulators/switches.
Grandparents fostering orphans: influences of protective factors on their health and well-being.
Publisher: Informa UK Limited
Date: 10-07-2014
DOI: 10.1080/07399332.2014.916294
Abstract: In this study the authors explore the impact of protective factors on the health and well-being of grandmothers who are primary caregivers. Although researchers in Africa have studied grandparents who assume primary caregiving responsibilities, it is rare that they do so from a strength perspective, hence the need to examine the utility of personal, social, and environmental assets on caregiving. Grandmothers are the primary caregivers of orphaned children due to HIV and AIDS deaths thus it becomes pertinent to establish how they are coping without the provision of social security. The results of this study will be beneficial to all stakeholders interested in the welfare of elders with similar responsibilities. Knowledge about the health and well-being of grandmothers who are caregivers will assist public service and private sectors to formulate viable policies concerning elderly carers who foster orphans, particularly in countries with high HIV prevalence.
Fungus-mediated biosynthesis of silica and titania particles
Publisher: Royal Society of Chemistry (RSC)
Date: 2005
DOI: 10.1039/B503008K
Evaluation of the effects of gold nanoparticle shape and size on contrast enhancement in radiological imaging
Publisher: Springer Science and Business Media LLC
Date: 13-04-2011
DOI: 10.1007/S13246-011-0071-7
Abstract: There has been increasing interest in the use of a nanoparticle-based media as a contrast-enhancement agent in medical imaging, particularly with gold Nanoparticles in radiography. Particularly attractive, is the prospect of modifying the surface of these materials with monoclonal antibodies to preferentially bind the nanoparticles to tumour sites. These materials differ from conventional molecular agents in their ability to be modified with cell specificity, or tailored for size and shape for maximum uptake. We investigated the consideration that quantum confinement electronic effects in nanometre-sized metals might have an effect on the integrated photon attenuation of gold atoms in the same manner as these materials affect X-ray absorption and scattering as seen in X-ray absorption spectroscopy. This experiment has been designed to identify any effect on contrast enhancement that might result from employing gold nanoparticles with a variety of sizes. Spherical particles and nanorods were synthesised for this application. Image contrast enhancement was quantified by contrast-to-noise ratio in computed radiography. Results are consistent with existing measurements of gold nanoparticle contrast enhancement in radiography. No significant variation in attenuation depending on particle size was observed. Findings indicate that nanoparticle-based contrast agents in the size range 4-30 nm-can be synthesised for maximum stability or cell specificity (directed cellular uptake) without consideration of effect of size on contrast enhancement.
Recent developments and applications of nanomaterial-based lab-on-a-chip devices for sustainable agri-food industries
Publisher: Elsevier BV
Date: 06-2023
Measurement of jet pT correlations in Pb + Pb and pp collisions at s<
Publisher: Elsevier BV
Date: 11-2017
Probing the effect of charge transfer enhancement in off resonance mode SERS via conjugation of the probe dye between silver nanoparticles and metal substrates
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CP51646F
Abstract: The charge transfer-mediated surface enhanced Raman scattering (SERS) of crystal violet (CV) molecules that were chemically conjugated between partially polarized silver nanoparticles and optically smooth gold and silver substrates has been studied under off-resonant conditions. Tyrosine molecules were used as a reducing agent to convert silver ions into silver nanoparticles where oxidised tyrosine caps the silver nanoparticle surface with its semiquinone group. This binding through the quinone group facilitates charge transfer and results in partially oxidised silver. This establishes a chemical link between the silver nanoparticles and the CV molecules, where the positively charged central carbon of CV molecules can bind to the terminal carboxylate anion of the oxidised tyrosine molecules. After drop casting Ag nanoparticles bound with CV molecules it was found that the free terminal amine groups tend to bind with the underlying substrates. Significantly, only those CV molecules that were chemically conjugated between the partially polarised silver nanoparticles and the underlying gold or silver substrates were found to show SERS under off-resonant conditions. The importance of partial charge transfer at the nanoparticle/capping agent interface and the resultant conjugation of CV molecules to off resonant SERS effects was confirmed by using gold nanoparticles prepared in a similar manner. In this case the capping agent binds to the nanoparticle through the amine group which does not facilitate charge transfer from the gold nanoparticle and under these conditions SERS enhancement in the sandwich configuration was not observed.
Aptamer-based point-of-care diagnostic platforms
Publisher: Elsevier BV
Date: 07-2017
Premonolayer Oxidation of Nanostructured Gold: An Important Factor Influencing Electrocatalytic Activity
Publisher: American Chemical Society (ACS)
Date: 12-02-2009
DOI: 10.1021/LA8039016
Abstract: The study of the electrodeposition of polycrystalline gold in aqueous solution is important from the viewpoint that in electrocatalysis applications ill-defined micro- and nanostructured surfaces are often employed. In this work, the morphology of gold was controlled by the electrodeposition potential and the introduction of Pb(CH3COO)2 x 3H2O into the plating solution to give either smooth or nanostructured gold crystallites or large dendritic structures which have been characterized by scanning electron microscopy (SEM). The latter structures were achieved through a novel in situ galvanic replacement of lead with AuCl4-(aq) during the course of gold electrodeposition. The electrochemical behavior of electrodeposited gold in the double layer region was studied in acidic and alkaline media and related to electrocatalytic performance for the oxidation of hydrogen peroxide and methanol. It was found that electrodeposited gold is a significantly better electrocatalyst than a polished gold electrode however, performance is highly dependent on the chosen deposition parameters. The fabrication of a deposit with highly active surface states, comparable to those achieved at severely disrupted metal surfaces through thermal and electrochemical methods, does not result in the most effective electrocatalyst. This is due to significant premonolayer oxidation that occurs in the double layer region of the electrodeposited gold. In particular, in alkaline solution, where gold usually shows the most electrocatalytic activity, these active surface states may be overoxidized and inhibit the electrocatalytic reaction. However, the activity and morphology of an electrodeposited film can be tailored whereby electrodeposited gold that exhibits nanostructure within the crystallites on the surface demonstrated enhanced electrocatalytic activity compared to smaller smooth gold crystallites and larger dendritic structures in potential regions well within the double layer region.
Isothermal titration calorimetry studies on the binding of amino acids to gold nanoparticles
Publisher: American Chemical Society (ACS)
Date: 09-02-2021
DOI: 10.1021/JP048766Z
Electrocatalytic and SERS activity of Pt rich Pt-Pb nanostructures formed via the utilisation of in-situ underpotential deposition of lead
Publisher: Springer Science and Business Media LLC
Date: 05-09-2014
Synthesis of CuTCNQ/Au Microrods by Galvanic Replacement of Semiconducting Phase I CuTCNQ with KAuBr4 in Aqueous Medium
Publisher: American Chemical Society (ACS)
Date: 08-2012
DOI: 10.1021/IC300555J
Abstract: The spontaneous reaction between microrods of an organic semiconductor molecule, copper 7,7,8,8-tetracyanoquinodimethane (CuTCNQ) with [AuBr(4)](-) ions in an aqueous environment is reported. The reaction is found to be redox in nature which proceeds via a complex galvanic replacement mechanism, wherein the surface of the CuTCNQ microrods is replaced with metallic gold nanoparticles. Unlike previous reactions reported in acetonitrile, the galvanic replacement reaction in aqueous solution proceeds via an entirely different reaction mechanism, wherein a cyclical reaction mechanism involving continuous regeneration of CuTCNQ consumed during the galvanic replacement reaction occurs in parallel with the galvanic replacement reaction. This results in the driving force of the galvanic replacement reaction in aqueous medium being largely dependent on the availability of [AuBr(4)](-) ions during the reaction. Therefore, this study highlights the importance of the choice of an appropriate solvent during galvanic replacement reactions, which can significantly impact upon the reaction mechanism. The reaction progress with respect to different gold salt concentration was monitored using Fourier transform infrared (FT-IR), Raman, and X-ray photoelectron spectroscopy (XPS), as well as XRD and EDX analysis, and SEM imaging. The CuTCNQ/Au nanocomposites were also investigated for their potential photocatalytic properties, wherein the destruction of the organic dye, Congo red, in a simulated solar light environment was found to be largely dependent on the degree of gold nanoparticle surface coverage. The approach reported here opens up new possibilities of decorating metal-organic charge transfer complexes with a host of metals, leading to potentially novel applications in catalysis and sensing.
Heavy-metal remediation by a fungus as a means of production of lead and cadmium carbonate crystals
Publisher: American Chemical Society (ACS)
Date: 30-06-2005
DOI: 10.1021/LA047132G
Abstract: We show here that reaction of the fungus, Fusarium oxysporum, with the aqueous heavy-metal ions Pb2+ and Cd2+ results in the one-step formation of the corresponding metal carbonates. The metal carbonates are formed by reaction of the heavy-metal ions with CO2 produced by the fungus during metabolism and thus provide a completely biological method for production of crystals of metal carbonates. The PbCO3 and CdCO3 crystals thus produced have interesting morphologies that are shown to arise because of interaction of the growing crystals with specific proteins secreted by the fungus during reaction. An additional advantage of this approach is that the reaction leads to detoxification of the aqueous solution and could have immense potential for bioremediation of heavy metals. Under conditions of this study, the metal ions are not toxic to the fungus, which readily grows after exposure to the metal ions.
Microstructure and dynamics of vacancy-induced nanofilamentary switching network in donor doped SrTiO3-x memristors
Publisher: IOP Publishing
Date: 18-11-2016
DOI: 10.1088/0957-4484/27/50/505210
Abstract: Donor doping of perovskite oxides has emerged as an attractive technique to create high performance and low energy non-volatile analog memories. Here, we examine the origins of improved switching performance and stable multi-state resistive switching in Nb-doped oxygen-deficient amorphous SrTiO
Cyclic RGDfK Peptide Functionalized Polymeric Nanocarriers for Targeting Gemcitabine to Ovarian Cancer Cells
Publisher: American Chemical Society (ACS)
Date: 28-03-2016
DOI: 10.1021/ACS.MOLPHARMACEUT.5B00935
Abstract: Current cancer chemotherapies commonly suffer from nonspecificity, drug resistance, poor bioavailability, and narrow therapeutic indices. To achieve the optimum drug efficacy, we designed a polymeric drug delivery system for targeted intracellular delivery of a clinically approved, water-soluble anticancer drug, gemcitabine hydrochloride (GEM). We utilized the unique ability of a cyclic pentapeptide cRGDfK to specifically target αvβ3 integrin receptors that are overexpressed on SKOV-3 human ovarian cancer cells. This significantly increased the effective intracellular drug concentration even at low doses, thereby remarkably improving the chemotherapeutic potential of GEM. cRGDfK-conjugated, GEM-loaded nanoparticles reduced the nonspecific hemolytic cytotoxicity of the drug, simultaneously influencing intracellular processes such as mitochondrial membrane potential (DΨm), reactive oxygen species (ROS) levels, and apoptosis, thereby favorably influencing drug antiproliferative efficacy.
Long‐Range Ordered Crystals of 3D Inorganic–Organic Heterojunctions via Colloidal Lithography
Publisher: Wiley
Date: 11-06-2019
Photomodulated Spatially Confined Chemical Reactivity in a Single Silver Nanoprism
Publisher: American Chemical Society (ACS)
Date: 13-08-2020
Galvanic Replacement of Semiconductor Phase I CuTCNQ Microrods with KAuBr4 to Fabricate CuTCNQ/Au Nanocomposites with Photocatalytic Properties
Publisher: American Chemical Society (ACS)
Date: 19-01-2011
DOI: 10.1021/IC1021752
Abstract: In this study, the reaction of semiconductor microrods of phase I copper 7,7,8,8-tetracyanoquinodimethane (CuTCNQ) with KAuBr(4) in acetonitrile is reported. It was found that the reaction is redox in nature and proceeds via a galvanic replacement mechanism in which the surface of CuTCNQ is replaced with metallic gold nanoparticles. Given the slight solubility of CuTCNQ in acetonitrile, two competing reactions, namely CuTCNQ dissolution and the redox reaction with KAuBr(4), were found to operate in parallel. An increase in the surface coverage of CuTCNQ microrods with gold nanoparticles occurred with an increased KAuBr(4) concentration in acetonitrile, which also inhibited CuTCNQ dissolution. The reaction progress with time was monitored using UV-visible, FT-IR, and Raman spectroscopy as well as XRD and EDX analysis, and SEM imaging. The CuTCNQ/Au nanocomposites were investigated for their photocatalytic properties, wherein the destruction of Congo red, an organic dye, by simulated solar light was found dependent on the surface coverage of gold nanoparticles on the CuTCNQ microrods. This method of decorating CuTCNQ may open the possibility of modifying this and other metal-TCNQ charge transfer complexes with a host of other metals which may have significant applications.
Synthesis and biological evaluation of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one structural derivatives as anti-cancer and apoptosis inducing agents
Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.EJMECH.2015.12.007
Abstract: A series of thirteen 5H-dibenzo [b,e][1,4]diazepin-11(10H)-one structural derivatives has been synthesized and evaluated for anti-proliferative activity against five human cancer cell lines. Compound 9a exhibited potent tumour growth inhibition in all cell lines with IC50 values in the range of 0.71-7.29 μM. Experiments on lung (A549) and breast (MDAMB-231) cancer cell lines to investigate the mechanisms of growth inhibition and apoptosis inducing effects of 9a showed that it arrested both cancer cell lines in the G2/M phase of cell cycle in a dose dependent manner. Hoechst staining analysis revealed that 9a inhibited tumour cell proliferation through apoptosis induction. Additionally, the mitochondrial membrane potential (ΔΨm) was affected and the levels of reactive oxygen species (ROS) were raised. The simple synthetic preparation and their biological properties make these dibenzodiazepinone-triazole scaffolds promising new entities for the development of cancer therapeutics.
Design, synthesis and biological evaluation of 1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents
Publisher: Elsevier BV
Date: 08-2015
DOI: 10.1016/J.EJMECH.2015.07.031
Abstract: A series of forty different pyrazole containing benzimidazole hybrids (6-45) have been designed, synthesized and evaluated for their potential anti-proliferative activity against three human tumor cell lines - lung (A549), breast (MCF-7), and cervical (HeLa). Some of the compounds, specifically 9, 17, and 28, showed potent growth inhibition against all the cell lines tested, with IC50 values in the range of 0.83-1.81 μM. Breast cancer cells were used for further detailed studies to understand the mechanism of cell growth inhibition and apoptosis inducing effect of compounds. The morphology, cell migration and long term clonogenic survival of MCF-7 breast cancer cells were severely affected by treatment with these compounds. Flow-cytometry revealed the compounds arrested MCF-7 cells in the G1 phase of the cell cycle via down regulation of cyclin D2 and CDK2. Fluorescent staining and DNA fragmentation studies showed that cell proliferation was inhibited by induction of apoptosis. Moreover, the compounds led to collapse of mitochondrial membrane potential (DΨm) and increased levels of reactive oxygen species (ROS) were noted. The ease of synthesis and the remarkable biological activities make these compounds promising new frameworks for the development of cancer therapeutics.
Synthesis and Properties of Photoswitchable Carbohydrate Fluorosurfactants
Publisher: CSIRO Publishing
Date: 2015
DOI: 10.1071/CH15434
Abstract: We describe the parallel synthesis, photocontrollable surface tension, and antibacterial performance of a new class of carbohydrate fluorosurfactant. Novel fluorosurfactants comprised a mono- or disaccharide head group linked to an azobenzene unit that was variably substituted with a trifluoromethyl group. Fluorosurfactants were rapidly assembled using the venerable CuI-catalysed azide–alkyne cycloaddition reaction and exhibited light-addressable surface activity, excellent water solubility, and selective antibacterial activity against Gram-positive Staphylococcus aureus. Notably, the physicochemical and biological activity of these novel materials was heavily dependent on the nature of the head group and the position of the trifluoromethyl substituent on the azobenzene ring. The UV-adapted cis-isomer of fluorosurfactants displayed good thermal stability at ambient temperature, with little reversion to the stable trans isomer after 16 h. These novel, light-responsive materials should find broad interest in a range of biomedical and technological fields, including drug and gene delivery, self-cleaning oleophobic surfaces, and antibacterial coatings for medical devices.
Enhanced gas permeation through graphene nanocomposites
Publisher: American Chemical Society (ACS)
Date: 09-06-2015
Detect, remove and reuse: A new paradigm in sensing and removal of Hg (II) from wastewater via SERS-active ZnO/Ag nanoarrays
Publisher: American Chemical Society (ACS)
Date: 09-12-2015
DOI: 10.1021/ES503527E
Abstract: Mercury being one of the most toxic heavy metals has long been a focus of concern due to its gravest threats to human health and environment. Although multiple methods have been developed to detect and/or remove dissolved mercury, many require complicated procedures and sophisticated equipment. Here, we describe a simple surface enhanced Raman spectroscopy (SERS) active ZnO/Ag nanoarrays that can detect Hg(2+), remove Hg(2+) and can be fully regenerated, not just from Hg(2+) contamination when heat-treated but also from the SERS marker when exposed to UV as a result of the self-cleaning ability of this schottky junction photocatalyst. The sensors are also highly selective because of the unique way mercury (among other chemicals) interacts with Ag nanoparticles, thus reducing its SERS activity.
Defining the role of humidity in the ambient degradation of few-layer black phosphorus
Publisher: IOP Publishing
Date: 30-11-2017
Unveiling the effect of 11-MUA coating on biocompatibility and catalytic activity of a gold-core cerium oxide-shell-based nanozyme
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA05547A
Abstract: Replacement of CTAB and CeO 2 nanoparticle layer by 11-MUA from the surface of Au core-CeO 2 shell nanoparticle.
Effects of plasma-treatment on the electrical and optoelectronic properties of layered black phosphorus
Publisher: Elsevier BV
Date: 09-0044
Recent Advances and a Roadmap to Wearable UV Sensor Technologies
Publisher: Wiley
Date: 12-02-2020
Hybrid Antibacterial Fabrics with Extremely High Aspect Ratio Ag/AgTCNQ Nanowires
Publisher: Wiley
Date: 10-2013
Self-Assembled Enzyme Capsules in Ionic Liquid [BMIM][BF4] as Templating Nanoreactors for Hollow Silica Nanocontainers
Publisher: American Chemical Society (ACS)
Date: 22-09-2010
DOI: 10.1021/LA101965J
Abstract: Most of the self-assembly studies have hitherto explored the aqueous media as fluid phase for self-assembly of hiphilic biomacromolecules, wherein architectural modification of biomolecules is generally a prerequisite for self-assembly of modified biomolecules. We demonstrate for the first time that ionic liquids can act as nonaqueous designer solvents to self-assemble hiphilic biomacromolecules without requiring their prior modification. To this end, we show that enzyme (phytase) molecules self-assembled in the presence of an appropriate ionic liquid, resulting in the formation of enzyme capsules. Phytase capsules synthesized using this approach were further used as templating nanoreactors for the synthesis of enzyme-containing hollow silica nanocontainers. In situ immobilized phytase enzyme in the silica nanocontainers, when subjected to enzyme-reusability application, establishes them as excellent reusable biocatalysts.
Galvanic Replacement Reaction on Metal Films: A One-Step Approach to Create Nanoporous Surfaces for Catalysis
Publisher: Wiley
Date: 18-02-2008
Ionic Liquids as Designer Solvents for the Synthesis of Metal Nanoparticles
Publisher: InTech
Date: 28-02-2011
DOI: 10.5772/14408
Quasi-Cubic Magnetite/Silica Core-Shell Nanoparticles as Enhanced MRI Contrast Agents for Cancer Imaging
Publisher: Public Library of Science (PLoS)
Date: 07-2011
Bioleaching of sand by the fungus fusarium oxysporum as a means of producing extracellular silica nanoparticles
Publisher: Wiley
Date: 04-04-2005
MOF-derived noble-metal-free Cu/CeO2 with high porosity for the efficient water–gas shift reaction at low temperatures
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CY01114E
Abstract: A metal organic framework templated Cu/CeO 2 catalyst exhibited enhanced catalytic performance for the water–gas shift reaction at low temperatures.
Inorganic materials using ‘unusual’ microorganisms
Publisher: Elsevier BV
Date: 11-2012
DOI: 10.1016/J.CIS.2012.06.013
Abstract: A promising avenue of research in materials science is to follow the strategies used by Mother Nature to fabricate ornate hierarchical structures as exemplified by organisms such as diatoms, sponges and magnetotactic bacteria. Some of the strategies used in the biological world to create functional inorganic materials may well have practical implications in the world of nanomaterials. Therefore, the strive towards exploring nature's ingenious work for designing strategies to create inorganic nanomaterials in our laboratories has led to development of biological and biomimetic synthesis routes over the past decade or so. A large proportion of these relentless efforts have explored the use of those microorganisms, which are typically not known to encounter these inorganic materials in their natural environment. Therefore, one can consider these microorganisms as 'unusual' for the purpose for which they have been utilized - it is in this context that this review has been penned down. In this extensive review, we discuss the use of these 'unusual' microorganisms for deliberate biosynthesis of various nanomaterials including biominerals, metals, sulfides and oxides nanoparticles. In addition to biosynthesis approach, we have also discussed a bioleaching approach, which can provide a noble platform for room-temperature synthesis of inorganic nanomaterials using naturally available raw materials. Moreover, the unique properties and functionalities displayed by these biogenic inorganic materials have been discussed, wherever such properties have been investigated previously. Finally, towards the end of this review, we have made efforts to summarize the common outcomes of the biosynthesis process and draw conclusions, which provide a perspective on the current status of the biosynthesis research field and highlights areas where future research in this field should be directed to realize the full potential of biological routes towards nanomaterials synthesis. Furthermore, the review clearly demonstrates that the biological route to inorganic materials synthesis is not merely an addition to the existing list of synthesis routes biological routes using 'unusual' microorganisms might in fact provide an edge over other nanomaterials synthesis routes in terms of their eco-friendliness, low energy intensiveness, and economically-viable synthesis. This review has significant importance for colloids and interface science since it underpins the synthesis of colloidal materials using 'unusual' microorganism, wherein the role of biological interfaces for controlled synthesis of technologically important nanomaterials is clearly evident.
Excess iron promotes emergence of foamy macrophages that overexpress ferritin in the lungs of silicosis patients
Publisher: Wiley
Date: 17-02-2022
DOI: 10.1111/RESP.14230
Abstract: Inhalation of high concentrations of respirable crystalline silica (RCS) can lead to silicosis. RCS contains varying levels of iron, which can cause oxidative stress and stimulate ferritin production. This study evaluated iron‐related and inflammatory markers in control and silicosis patients. A cohort of stone benchtop industry workers ( n = 18) were radiologically classified by disease severity into simple or complicated silicosis. Peripheral blood and bronchoalveolar lavage (BAL) were collected to measure iron, ferritin, C‐reactive protein, serum amyloid A and serum silicon levels. Ferritin subunit expression in BAL and transbronchial biopsies was analysed by reverse transcription quantitative PCR. Lipid accumulation in BAL macrophages was assessed by Oil Red O staining. Serum iron levels were significantly elevated in patients with silicosis, with a strong positive association with serum ferritin levels. In contrast, markers of systemic inflammation were not increased in silicosis patients. Serum silicon levels were significantly elevated in complicated disease. BAL macrophages from silicosis patients were morphologically consistent with lipid‐laden foamy macrophages. Ferritin light chain (FTL) mRNA expression in BAL macrophages was also significantly elevated in simple silicosis patients and correlated with systemic ferritin. Our findings suggest that elevated iron levels during the early phases of silicosis increase FTL expression in BAL macrophages, which drives elevated BAL and serum ferritin levels. Excess iron and ferritin were also associated with the emergence of a foamy BAL macrophage phenotype. Ferritin may represent an early disease marker for silicosis, where increased levels are independent of inflammation and may contribute to fibrotic lung remodelling.
Ultrasensitive Colorimetric Detection of Murine Norovirus Using NanoZyme Aptasensor
Publisher: American Chemical Society (ACS)
Date: 14-01-2019
DOI: 10.1021/ACS.ANALCHEM.8B03300
Abstract: Human norovirus (NoV) remains the most common cause of viral gastroenteritis and the leading cause of viral foodborne outbreaks globally. NoV is highly pathogenic with an estimated median viral infective dose (ID
Facile Approach for the Dispersion of Regenerated Cellulose in Aqueous System in the Form of Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 16-08-2012
DOI: 10.1021/BM3009022
Abstract: This study reports a facile method to disperse cellulose in deionized water, wherein a critical condition of regenerated cellulose is discovered, where it completely disperses up to a maximum of 5 g L(-1) concentration in deionized water with the help of ultrasonication. The dispersed cellulose is characterized by TEM and DLS, the latter among which shows 200 nm hydrodynamic radii of cellulose nanoparticles dispersed in deionized water. FTIR analysis of dispersed cellulose reveals that dispersed cellulose losses its crystallinity during regeneration and dispersion step employed in this study. The dispersed cellulose reported in this study is able to form free-standing, transparent films, which were characterized by SEM, XRD, TGA, EDX, and FTIR spectroscopy and show resistance against dissolution in water. Additionally, the dispersed cellulose is able to undergo at least three times faster enzymatic hydrolysis in comparison to pristine microcrystalline cellulose under similar reaction conditions. The dispersed cellulose reported here could be a better material for reinforcement, preparation of hydrogels, and drug delivery applications under physiological environment.
Reactive Oxygen Species Sequestration Induced Synthesis of β-PbO and Its Polymorphic Transformation to α-PbO at Atomically Thin Regimes
Publisher: American Chemical Society (ACS)
Date: 27-06-2022
Abstract: The emergence of attractive properties in materials at atomically thin regimes has seen an ongoing interest in two-dimensional (2D) materials. An aspect that has lacked focused attention is the effect of 2D material thickness on its crystal structure. As several layered materials naturally exist in mixed metastable phases, it raises an important question of whether a specific polymorph of these mixed-phase materials will be favored at atomically thin limits. This work attempts to address this issue by employing lead monoxide as a model 2D polymorphic system. We propose a reactive oxygen species (ROS) sequestration-mediated liquid-phase exfoliation (LPE) strategy for the facile synthesis of ultrathin PbO. This is followed by a suite of microscopic and spectroscopic analyses of the PbO nanosheets that reveals the polymorphic transformation of orthorhombic (β) PbO to its tetragonal (α) analogue with reduction in nanosheet thickness. The transformation process reveals an interesting crystal structure of ultrathin 2D PbO where [001]-oriented domains of α-PbO coexist alongside [100]-oriented regions of β-PbO. Density functional theory (DFT) calculations support our experimental data by revealing a higher thermodynamic stability of the tetragonal phase in PbO monolayers. These findings are likely to instigate interest in carefully evaluating the crystal structures of ultrathin 2D materials while promoting research in understanding the phase transformation across a range of 2D crystals.
Degradable, Surfactant-Free, Monodisperse Polymer-Encapsulated Emulsions as Anticancer Drug Carriers
Publisher: Wiley
Date: 04-05-2009
Nanostructured charge transfer complex of CuTCNQF4 for efficient photo-removal of hexavalent chromium
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA02636B
Abstract: The fabrication of a nanostructured CuTCNQF 4 organic charge transfer complex on copper foil by employing a facile redox reaction in acetonitrile and its ability to promote catalytic reduction of toxic Cr 6+ to its non-toxic Cr 3+ counterpart.
Dynamic interactions between peroxidase-mimic silver NanoZymes and chlorpyrifos-specific aptamers enable highly-specific pesticide sensing in river water
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.ACA.2019.07.066
Abstract: With growing environmental and health concerns over persistent organic compounds such as organophosphates, regulatory bodies have imposed strict regulations for their use and monitoring in water bodies. Although conventional analytical tools exist for the detection of organophosphorus pesticides, new strategies need to be developed to fulfil the ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free and deliverable to end users) criteria of the World Health Organisation. One such strategy is to employ the ability of certain nanoparticles to mimic the enzymatic activity of natural enzymes to develop optical sensors. We show that the intrinsic peroxidase-mimic NanoZyme activity of tyrosine-capped silver nanoparticles (Ag-NanoZyme) can be exploited for highly specific and rapid detection of chlorpyrifos, an organophosphorus pesticide. The underlying working principle of the proposed aptasensor is based on the dynamic non-covalent interaction of the chlorpyrifos specific aptamer (Chl) with the NanoZyme (sensor probe) vs. the pesticide target (analyte). The incorporation of the Chl aptamer ensures high specificity leading to a colorimetric response specifically in the presence of chlorpyrifos, while the sensor remains unresponsive to other pesticides from organophosphate and non-organophosphate groups. The robustness of the sensor to work directly in environmental s les was established by evaluating its ability to detect chlorpyrifos in river water s les. The excellent recovery rates demonstrate the sensor robustness, while the simplicity, and rapid sensor response (2 min) to detect the presence of chlorpyrifos highlights the capabilities of the proposed colorimetric sensing system.
Rapid colorimetric detection of mercury using biosynthesized gold nanoparticles
Publisher: Elsevier BV
Date: 11-2017
Facile, size-controlled deposition of highly dispersed gold nanoparticles on nitrogen carbon nanotubes for hydrogen sensing
Publisher: Elsevier BV
Date: 12-2011
Galvanic replacement mediated transformation of Ag nanospheres into dendritic Au–Ag nanostructures in the ionic liquid [BMIM][BF4]
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B918866E
Abstract: We demonstrate an unusual shape transformation of Ag nanospheres into {111}-oriented Au-Ag dendritic nanostructures by a galvanic replacement reaction in the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF(4)]).
Genus-Wide Physicochemical Evidence of Extracellular Crystalline Silver Nanoparticles Biosynthesis by Morganella spp
Publisher: Public Library of Science (PLoS)
Date: 21-06-2011
Nanostructured WO3 films using high temperature anodization
Publisher: Elsevier BV
Date: 10-2009
Functionalized Concave Cube Gold Nanoparticles as Potent Antimicrobial Agents against Pathogenic Bacteria
Publisher: American Chemical Society (ACS)
Date: 07-02-2022
Abstract: Gold (Au) is an inert metal in a bulk state however, it can be used for the preparation of Au nanoparticles (i.e., AuNPs) for multidimensional applications in the field of nanomedicine and nanobiotechnology. Herein, monodisperse concave cube AuNPs (CCAuNPs) were synthesized and functionalized with a natural antioxidant lipoic acid (LA) and a tripeptide glutathione (GSH) because different crystal facets of AuNPs provide binding sites for distinct ligands. There was an ∼10 nm bathochromic shift of the UV-vis spectrum when CCAuNPs were functionalized with LA, and the size of the as-synthesized monodisperse CCAu nanoparticles was 76 nm. The LA-functionalized CCAu nanoparticles (i.e., CCAuLA) showed the highest antibacterial activity against
A new paradigm for signal processing of Raman spectra using a smoothing free algorithm: Coupling continuous wavelet transform with signal removal method
Publisher: Wiley
Date: 25-01-2013
DOI: 10.1002/JRS.4232
Threonine amino acid mediated photochemical synthesis of gold, silver and bimetallic Au/Ag nanoparticles and their antibacterial activity
Publisher: Unpublished
Date: 2011
Extracellular biosynthesis of magnetite using fungi
Publisher: Wiley
Date: 05-12-2006
Abstract: The development of synthetic processes for oxide nanomaterials is an issue of considerable topical interest. While a number of chemical methods are available and are extensively used, the collaborations are often energy intensive and employ toxic chemicals. On the other hand, the synthesis of inorganic materials by biological systems is characterized by processes that occur at close to ambient temperatures and pressures, and at neutral pH (ex les include magnetotactic bacteria, diatoms, and S-layer bacteria). Here we show that nanoparticulate magnetite may be produced at room temperature extracellularly by challenging the fungi, Fusarium oxysporum and Verticillium sp., with mixtures of ferric and ferrous salts. Extracellular hydrolysis of the anionic iron complexes by cationic proteins secreted by the fungi results in the room-temperature synthesis of crystalline magnetite particles that exhibit a signature of a ferrimagnetic transition with a negligible amount of spontaneous magnetization at low temperature.
Green Synthesis of Nanomaterials Using Biological Routes
Publisher: Wiley
Date: 29-08-2015
Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6SC03020C
Abstract: The photocontrollable antibacterial and biofilm modulatory activity of a panel of light responsive carbohydrate-based surfactants is reported.
Oxygen-deficient photostable Cu2 O for enhanced visible light photocatalytic activity
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7NR08388B
Abstract: Large-scale synthesis of O-deficient Cu 2 O with outstanding visible photoactivity is shown.
Role of the templating approach in influencing the suitability of polymeric nanocapsules for drug delivery: LbL vs SC/MS
Publisher: American Chemical Society (ACS)
Date: 17-09-2013
DOI: 10.1021/LA4024103
Abstract: Polymer nanocapsules play an increasingly important role for drug delivery applications. Layer-by-layer (LbL) templated synthesis has received the widest attention to fabricate polymer nanocapsules. However, for drug delivery applications, the LbL approach may not necessarily offer the optimum nanocapsules. We make the first attempt to compare the LbL approach with a more recently developed solid core/mesoporous shell (SC/MS) templated approach in context of their suitability for construction of sub-500 nm sized capsules for drug delivery applications. The nanocapsules of chitosan, poly(allylamine hydrochloride) (PAH), and poly(sodium 4-styrenesulfonate) (PSS) are fabricated using LbL and SC/MS templating approaches and loaded with curcumin, a model lipophilic anticancer drug. The influence of the templating approach on capsule aggregation, polymer loading, drug loading, cellular uptake, and therapeutic efficacy against MCF-7 breast cancer cells is compared in an effort to identify the most suitable fabrication method and polymer material for drug delivery applications. In combination, among different tested nanocapsules, chitosan nanocapsules fabricated using the SC/MS approach are found to be the most promising candidate that demonstrates the optimum cytotoxic efficiency and significant potential for drug delivery.
Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview
Publisher: American Chemical Society (ACS)
Date: 27-09-2005
DOI: 10.1021/LA0513712
Abstract: Macrophages are one of the principal immune effector cells that play essential roles as secretory, phagocytic, and antigen-presenting cells in the immune system. In this study, we address the issue of cytotoxicity and immunogenic effects of gold nanoparticles on RAW264.7 macrophage cells. The cytotoxicity of gold nanoparticles has been correlated with a detailed study of their endocytotic uptake using various microscopy tools such as atomic force microscopy (AFM), confocal-laser-scanning microscopy (CFLSM), and transmission electron microscopy (TEM). Our findings suggest that Au(0) nanoparticles are not cytotoxic, reduce the production of reactive oxygen and nitrite species, and do not elicit secretion of proinflammatory cytokines TNF-alpha and IL1-beta, making them suitable candidates for nanomedicine. AFM measurements suggest that gold nanoparticles are internalized inside the cell via a mechanism involving pinocytosis, while CFLSM and TEM studies indicate their internalization in lysosomal bodies arranged in perinuclear fashion. Our studies thus underline the noncytotoxic, nonimmunogenic, and biocompatible properties of gold nanoparticles with the potential for application in nanoimmunology, nanomedicine, and nanobiotechnology.
Gold nanospikes based microsensor as a highly accurate mercury emission monitoring system
Publisher: Springer Science and Business Media LLC
Date: 23-10-2014
DOI: 10.1038/SREP06741
Cationic Amino Acids Specific Biomimetic Silicification in Ionic Liquid: A Quest to Understand the Formation of 3-D Structures in Diatoms
Publisher: Public Library of Science (PLoS)
Date: 03-03-2011
Aqueous phase synthesis of copper nanoparticles: a link between heavy metal resistance and nanoparticle synthesis ability in bacterial systems
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2NR32887A
Abstract: We demonstrate aqueous phase biosynthesis of phase-pure metallic copper nanoparticles (CuNPs) using a silver resistant bacterium Morganella morganii. This is particularly important considering that there has been no report that demonstrates biosynthesis and stabilization of pure copper nanoparticles in the aqueous phase. Electrochemical analysis of bacterial cells exposed to Cu(2+) ions provides new insights into the mechanistic aspect of Cu(2+) ion reduction within the bacterial cell and indicates a strong link between the silver and copper resistance machinery of bacteria in the context of metal ion reduction. The outcomes of this study take us a step closer towards designing rational strategies for biosynthesis of different metal nanoparticles using microorganisms.
Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC08355J
Abstract: Enzymatic activity of cerium oxide nanoparticles modified by phosphine ligands.
Photochromic polyoxometalate–based enzyme-free reusable sensors for real-time colorimetric detection of alcohol in sweat and saliva
Publisher: Elsevier BV
Date: 08-2021
Size, shape and surface chemistry of nano-gold dictate its cellular interactions, uptake and toxicity
Publisher: Elsevier BV
Date: 10-2016
Skin color-specific and spectrally-selective naked-eye dosimetry of UVA, B and C radiations
Publisher: Springer Science and Business Media LLC
Date: 25-09-2018
DOI: 10.1038/S41467-018-06273-3
Abstract: Spectrally–selective monitoring of ultraviolet radiations (UVR) is of paramount importance across erse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spectrally selective colorimetric monitoring of UVR by developing a photoelectrochromic ink that consists of a multi-redox polyoxometalate and an e − donor. We combine this ink with simple components such as filter paper and transparency sheets to fabricate low-cost sensors that provide naked-eye monitoring of UVR, even at low doses typically encountered during solar exposure. Importantly, the erse UV tolerance of different skin colors demands personalized sensors. In this spirit, we demonstrate the customized design of robust real-time solar UV dosimeters to meet the specific need of different skin phototypes. These spectrally–selective UV sensors offer remarkable potential in managing the impact of UVR in our day-to-day life.
Influence of Physicochemical Properties of Nanomaterials on Their Antibacterial Applications
Publisher: Elsevier
Date: 2015
Fungus-mediated biotransformation of amorphous silica in rice husk to nanocrystalline silica
Publisher: American Chemical Society (ACS)
Date: 11-10-2006
DOI: 10.1021/JA062113+
Abstract: Rice husk is a cheap agro-based waste material, which harbors a substantial amount of silica in the form of amorphous hydrated silica grains. However, there have been no attempts at harnessing the enormous amount of amorphous silica present in rice husk and its room-temperature biotransformation into crystalline silica nanoparticles. In this study, we address this issue and describe how naturally deposited amorphous biosilica in rice husk can be bioleached and simultaneously biotransformed into high value crystalline silica nanoparticles. We show here that the fungus Fusarium oxysporum rapidly biotransforms the naturally occurring amorphous plant biosilica into crystalline silica and leach out silica extracellularly at room temperature in the form of 2-6 nm quasi-spherical, highly crystalline silica nanoparticles capped by stabilizing proteins that the nanoparticles are released into solution is an advantage of this process with significant application and commercial potential. Calcination of the silica nanoparticles leads to loss of occluded protein and to an apparently porous structure often of cubic morphology. The room-temperature synthesis of oxide nanomaterials using microorganisms starting from potential cheap agro-industrial waste materials is an exciting possibility and could lead to an energy-conserving and economically viable green approach toward the large-scale synthesis of oxide nanomaterials.
Decoration of TiO 2 nanotubes with metal nanoparticles using polyoxometalate as a UV-switchable reducing agent for enhanced visible and solar light photocatalysis
Publisher: American Chemical Society (ACS)
Date: 28-09-2012
DOI: 10.1021/LA3033989
Abstract: We present the employment of the Keggin ion 12-phosphotungstic acid as a UV-switchable reducing agent for the decoration of Au, Ag, Pt, and Cu nanoparticles onto the surface of TiO(2) nanotubes synthesized by electrochemical anodization. The synthesized composites were studied using SEM, GADDS XRD, and EDX, and the photocatalytic activity of the composites was examined by measuring the photodegradation of the organic dye "Congo red" under simulated solar light. Decoration with metal nanoparticles was observed to enhance the activity of the photocatalytic process by upward of 100% with respect to unmodified TiO(2) nanotubes.
Repairing and Preventing Photooxidation of Few-Layer Black Phosphorus with β-Carotene
Publisher: American Chemical Society (ACS)
Date: 24-04-2023
Comparison of nanostructures obtained from galvanic replacement in water and an ionic liquid for applications in electrocatalysis and SERS
Publisher: Elsevier BV
Date: 11-2012
Synthesis of (Z)-1-(1,3-diphenyl-1 H -pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents
Publisher: Elsevier BV
Date: 07-2016
DOI: 10.1016/J.EJMECH.2016.03.051
Abstract: A series of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives were synthesized and characterized by (1)H and (13)C NMR, ESI-MS and HRMS. All the synthesized compounds were evaluated for their anticancer activity against HT-29, PC-3, A549 and U87MG human tumor cell lines. Most of the synthesized compounds displayed potent growth inhibition selectively of A549 cancer cells and did not show significant toxicity to the non-cancerous HaCaT cells. Some of the representative compounds, particularly, 16, 22 and 28 exhibited potent growth inhibition with IC50 values in the range of 1.25-3.98 μM, which are comparable or even better than the standard chemotherapeutic drug 5-fluorouracil. Preliminary mechanistic studies revealed that these compounds could effectively inhibit the migration ability of A549 cells. Flow-cytometry analysis revealed that the compounds treatment led to G2/M cell cycle arrest. Moreover, the compounds induced apoptosis in A549 cells through depolarization of mitochondrial membrane potential (DΨm) and increased reactive oxygen species (ROS) production, suggesting their potential to act as promising lead compounds for the development of cancer chemotherapeutics.
Electrochemical and Chemical Oxidation of [Pt2(μ-pyrophosphite)4]4− Revisited: Characterization of a Nitrosyl Derivative, [Pt2(μ-pyrophosphite)4(
Publisher: American Chemical Society (ACS)
Date: 18-02-2009
DOI: 10.1021/IC802213V
Abstract: Electrochemical studies of the salts [cat](4)[Pt(2)(mu-pop)(4)] (cat(+) = Bu(4)N(+) or PPN(+) [Ph(3)P=N=PPh(3)](+) pop = pyrophosphite, [P(2)O(5)H(2)](2-)) have been carried out in dichloromethane. In agreement with published studies of K(4)[Pt(2)(mu-pop)(4)] in water and [Ph(4)As](4)[Pt(2)(mu-pop)(4)] in acetonitrile, the [Pt(2)(mu-pop)(4)](4-) anion is found to undergo an initial one-electron oxidation under conditions of cyclic voltammetry to a short-lived trianion, [Pt(2)(mu-pop)(4)](3-). However, in the more weakly coordinating solvent dichloromethane, [Pt(2)(mu-pop)(4)](3-) appears to undergo oligomerization instead of solvent-induced disproportionation thus the overall process remains a one-electron reaction rather than an overall two-electron oxidative addition process, even under long time-scale, bulk electrolysis conditions. Chemical oxidation of [cat](4)[Pt(2)(mu-pop)(4)] with [NO][BF(4)] or AgBF(4) gives mainly a dark, insoluble, ill-defined solid that appears to contain Pt(III) according to X-ray photoelectron spectroscopy (XPS). In the case of [NO][BF(4)], a second reaction product, an orange solid, has been identified as a nitrosyl complex, [cat](3)[Pt(2)(mu-pop)(4)(NO)]. The X-ray structure of the PPN(+) salt shows the anion to consist of the usual lantern-shaped Pt(2)(mu-pop)(4) framework with an unusually large Pt-Pt separation [2.8375(6) A] one of the platinum atoms carries a bent nitrosyl group [r(N-O) = 1.111(15) A angle(Pt-N-O) = 118.1(12) degrees] occupying an axial position. The nitrosyl group migrates rapidly on the (31)P NMR time-scale between the metal atoms at room temperature but the motion is slow enough at 183 K that the expected two pairs of inequivalent phosphorus nuclei can be observed. The X-ray photoelectron (XP) spectrum of the nitrosyl-containing anion confirms the presence of two inequivalent platinum atoms whose 4f(7/2) binding energies are in the ranges expected for Pt(II) and Pt(III) an alternative interpretation is that the second platinum atom has a formal oxidation number of +4 and that its binding energy is modified by the strongly sigma-donating NO(-) ligand. Reduction of [Pt(2)(mu-pop)(4)X(2)](4-) (X = Cl, Br, I) in dichloromethane corresponds to a chemically reversible, electrochemically irreversible two-electron process involving loss of halide and formation of [Pt(2)(mu-pop)(4)](4-), as is the case in more strongly coordinating solvents.
Combining the UV-Switchability of Keggin Ions with a Galvanic Replacement Process to Fabricate TiO2–Polyoxometalate–Bimetal Nanocomposites for Improved Surface Enhanced Raman Scattering and
Publisher: American Chemical Society (ACS)
Date: 25-07-2013
DOI: 10.1021/AM401252H
Abstract: While the decoration of TiO2 surfaces with metal nanoparticles has been well-established, the modification of the composition of metal nanoparticles postdeposition onto TiO2 surfaces and applicability of such bimetallic systems for surface enhanced Raman scattering (SERS) and photocatalysis has not hitherto been investigated. In this work, we, for the first time, combine the unique UV-switchability of the Keggin ions of 12-phosphotungstic acid (PTA) to directly form metal nanoparticles (Ag and Cu) onto the colloidal TiO2 surface, with a galvanic replacement process to convert these predeposited metal nanoparticles into bimetallic systems (Ag/Au, Ag/Pt, Cu/Au, Cu/Pt, and Cu/Ag). We further demonstrate the applicability of these novel TiO2-polyoxometalate-bimetal nanocomposites toward improved SERS and solar light photocatalysis.
Electrically Activated UV-A Filters Based on Electrochromic MoO3–x
Publisher: American Chemical Society (ACS)
Date: 23-03-2020
Low-temperature fabrication of alkali metal-organic charge transfer complexes on cotton textile for optoelectronics and gas sensing
Publisher: American Chemical Society (ACS)
Date: 15-07-2015
DOI: 10.1021/LA501446B
Abstract: A generalized low-temperature approach for fabricating high aspect ratio nanorod arrays of alkali metal-TCNQ (7,7,8,8-tetracyanoquinodimethane) charge transfer complexes at 140 °C is demonstrated. This facile approach overcomes the current limitation associated with fabrication of alkali metal-TCNQ complexes that are based on physical vapor deposition processes and typically require an excess of 800 °C. The compatibility of soft substrates with the proposed low-temperature route allows direct fabrication of NaTCNQ and LiTCNQ nanoarrays on in idual cotton threads interwoven within the 3D matrix of textiles. The applicability of these textile-supported TCNQ-based organic charge transfer complexes toward optoelectronics and gas sensing applications is established.
Bacterial Kinetics-Controlled Shape-Directed Biosynthesis of Silver Nanoplates Using Morganella psychrotolerans
Publisher: American Chemical Society (ACS)
Date: 13-12-2010
DOI: 10.1021/LA1036162
Abstract: We show for the first time that by controlling the growth kinetics of Morganella psychrotolerans, a silver-resistant psychrophilic bacterium, the shape anisotropy of silver nanoparticles can be achieved. This is particularly important considering that there has been no report that demonstrates a control over shape of Ag nanoparticles by controlling the growth kinetics of bacteria during biological synthesis. Additionally, we have for the first time performed electrochemistry experiments on bacterial cells after exposing them to Ag(+) ions, which provide significant new insights about mechanistic aspects of Ag reduction by bacteria. The possibility to achieve nanoparticle shape control by using a "green" biosynthesis approach is expected to open up new exciting avenues for eco-friendly, large-scale, and economically viable shape-controlled synthesis of nanomaterials.
Room-temperature biosynthesis of ferroelectric barium titanate nanoparticles
Publisher: American Chemical Society (ACS)
Date: 19-08-2006
DOI: 10.1021/JA063011M
Abstract: The syntheses of inorganic materials by biological systems is characterized by processes that occur close to ambient temperatures, pressures, and neutral pH, as is exemplified by biosilicification and biomineralization processes in nature. Conversely, laboratory-based syntheses of oxide materials often require extremes of temperature and pressure. We have shown here the extracellular, room-temperature biosynthesis of 4-5 nm ternary oxide nanoparticles such as barium titanate (BT) using a fungus-mediated approach. The tetragonality as well as a lowered Curie transition temperature in sub-10 nm particles was established, and the ferroelectricity in these particles was shown using Kelvin probe microscopy.
Charge-switchable gold nanoparticles for enhanced enzymatic thermostability
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CP03021H
Abstract: Zwitterionic amino acids allow the synthesis of charge-switchable metal nanoparticles, which support efficient immobilization of enzymes on nanoparticles, leading to high thermal stability and enzymatic efficiency.
Synergetic Peroxidase-Mimic Catalytic Activity of Noble-Metal-Decorated Lithium Niobate Nanozymes for Potential Biological Applications
Publisher: American Chemical Society (ACS)
Date: 07-07-2023
Influence of Gold Nanoparticles on Radiation Dose Enhancement and Cellular Migration in Microbeam-Irradiated Cells
Publisher: Springer Science and Business Media LLC
Date: 23-04-2011
Measurement of lepton differential distributions and the top quark mass in $$t\bar{t}$$
Publisher: Springer Science and Business Media LLC
Date: 11-2017
Linking Flavonoids to Gold - A New Family of Gold Compounds for Potential Therapeutic Applications
Publisher: Wiley
Date: 11-08-2015
Lateral charge propagation effects during the galvanic replacement of electrodeposited MTCNQ (M=Cu, Ag) microstructures with gold and its influence on catalyzed electron transfer reactions
Publisher: Elsevier BV
Date: 12-2013
Polycyclic Aromatic Hydrocarbons (PAHs) in inland aquatic ecosystems: Perils and remedies through biosensors and bioremediation
Publisher: Elsevier BV
Date: 10-2018
DOI: 10.1016/J.ENVPOL.2018.05.016
Abstract: Polycyclic Aromatic Hydrocarbons (PAHs) are among the most ubiquitous environmental pollutants of high global concern. PAHs belong to a erse family of hydrocarbons with over one hundred compounds known, each containing at least two aromatic rings in their structure. Due to hydrophobic nature, PAHs tend to accumulate in the aquatic sediments, leading to bioaccumulation and elevated concentrations over time. In addition to their well-manifested mutagenic and carcinogenic effects in humans, they pose severe detrimental effects to aquatic life. The high eco-toxicity of PAHs has attracted a number of reviews, each dealing specifically with in idual aspects of this global pollutant. However, efficient management of PAHs warrants a holistic approach that combines a thorough understanding of their physico-chemical properties, modes of environmental distribution and bioaccumulation, efficient detection, and bioremediation strategies. Currently, there is a lack of a comprehensive study that amalgamates all these aspects together. The current review, for the first time, overcomes this constraint, through providing a high level comprehensive understanding of the complexities faced during PAH management, while also recommending future directions through potentially viable solutions. Importantly, effective management of PAHs strongly relies upon reliable detection tools, which are currently non-existent, or at the very best inefficient, and therefore have a strong prospect of future development. Notably, the currently available biosensor technologies for PAH monitoring have not so far been compiled together, and therefore a significant focus of this article is on biosensor technologies that are critical for timely detection and efficient management of PAHs. This review is focussed on inland aquatic ecosystems with an emphasis on fish bio ersity, as fish remains a major source of food and livelihood for a large proportion of the global population. This thought provoking study is likely to instigate new collaborative approaches for protecting aquatic bio ersity from PAHs-induced eco-toxicity.
Tyrosine mediated gold, silver and their alloy nanoparticles synthesis: Antibacterial activity toward gram positive and gram negative bacterial strains
Publisher: IEEE
Date: 12-2011
Impact of nanogold morphology on interactions with human serum
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CP05938A
Abstract: Following the synthesis of different shaped gold nanoparticles, their interaction with human serum albumin was studied to reveal shape affects both the affinity and strength of binding.
Visible-Light-Triggered Reactive-Oxygen-Species-Mediated Antibacterial Activity of Peroxidase-Mimic CuO Nanorods
Publisher: American Chemical Society (ACS)
Date: 06-03-2018
Alkali ratio control for lead-free piezoelectric thin films utilizing elemental diffusivities in RF plasma
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CE40508G
Transparent amorphous strontium titanate resistive memories with transient photo-response
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR04372D
Abstract: Highly transparent SrTiO 3 resistive memories with transient response to optical excitations are demonstrated and the evolution of oxygen vacancies with the location of a conductive filament is optically mapped.
Robust Nanostructured Silver and Copper Fabrics with Localized Surface Plasmon Resonance Property for Effective Visible Light Induced Reductive Catalysis
Publisher: Wiley
Date: 07-01-2016
Sunscreen testing: A critical perspective and future roadmap
Publisher: Elsevier BV
Date: 12-2022
High-temperature anodized WO3 nanoplatelet films for photosensitive devices
Publisher: American Chemical Society (ACS)
Date: 24-07-2009
DOI: 10.1021/LA901944X
Abstract: Anodization at elevated temperatures in nitric acid has been used for the production of highly porous and thick tungsten trioxide nanostructured films for photosensitive device applications. The anodization process resulted in platelet crystals with thicknesses of 20-60 nm and lengths of 100-1000 nm. Maximum thicknesses of approximately 2.4 microm were obtained after 4 h of anodization at 20 V. X-ray diffraction analysis revealed that the as-prepared anodized s les contain predominantly hydrated tungstite phases depending on voltage, while films annealed at 400 degrees C for 4 h are predominantly orthorhombic WO3 phase. Photocurrent measurements revealed that the current density of the 2.4 microm nanostructured anodized film was 6 times larger than the nonanodized films. Dye-sensitized solar cells developed using these films produced 0.33 V and 0.65 mA/cm2 in open- and short-circuit conditions.
Zirconia Enrichment in Zircon Sand by Selective Fungus-Mediated Bioleaching of Silica
Publisher: American Chemical Society (ACS)
Date: 22-03-2007
DOI: 10.1021/LA062535X
Abstract: One of the important routes for the production of zirconia is by chemical treatment and removal of silica from zircon sand (ZrSixOy). We present here a completely green chemistry approach toward enrichment of zirconia in zircon sand this is based on the reaction of the fungus Fusarium oxysporum with zircon sand by a process of selective extracellular bioleaching of silica nanoparticles. Since this reaction does not result in zirconia being simultaneously leached out from the sand, there is a consequent enrichment of the zirconia component in zircon sand. We believe that fungal enzymes specifically hydrolyze the silicates present in the sand to form silicic acid, which on condensation by certain other fungal enzymes results in room-temperature synthesis of silica nanoparticles. This fungus-mediated twofold approach might have vast commercial implications in low-cost, ecofriendly, room-temperature syntheses of technologically important oxide nanomaterials from potentially cheap naturally available raw materials like zircon sand.
Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
Publisher: Oxford University Press (OUP)
Date: 2014
DOI: 10.1039/C3TX50075F
Gold nanoparticle-decorated keggin ions/TiO2 photococatalyst for improved solar light photocatalysis
Publisher: American Chemical Society (ACS)
Date: 02-05-2011
DOI: 10.1021/LA2007765
Abstract: We demonstrate a facile localized reduction approach to synthesizing a Au nanoparticle-decorated Keggin ion/TiO(2) photococatalyst for improved solar light photocatalysis application. This has been achieved by exploiting the ability of TiO(2)-bound Keggin ions to act as a UV-switchable, highly localized reducing agent. Notably, the approach proposed here does not lead to contamination of the resultant cocatalyst with free metal nanoparticles during aqueous solution-based synthesis. The study shows that for Keggin ions (phosphotungstic acid, PTA), being photoactive molecules, the presence of both Au nanoparticles and PTA on the TiO(2) surface in a cocatalytic system can have a dramatic effect on increasing the photocatalytic performance of the composite system, as opposed to a TiO(2) surface directly decorated with metal nanoparticles without a sandwiched PTA layer. The remarkable increase in the photocatalytic performance of these materials toward the degradation of a model organic Congo red dye correlates to an increase of 2.7-fold over that of anatase TiO(2) after adding Au to it and 4.3-fold after introducing PTA along with Au to it. The generalized localized reduction approach to preparing TiO(2)-PTA-Au cocatalysts reported here can be further extended to other similar systems, wherein a range of metal nanoparticles in the presence of different Keggin ions can be utilized. The composites reported here may have wide potential implications toward the degradation of organic species and solar cell applications.
Fungus-mediated Biological Approaches Towards 'Green' Synthesis of Oxide Nanomaterials
Publisher: CSIRO Publishing
Date: 2011
DOI: 10.1071/CH10343
Abstract: A promising avenue of research in materials science is to follow the strategies used by nature to fabricate ornate hierarchical materials. For many ages, organisms have been engaged in on-the-job testing to craft structural and functional materials and have evolved extensively to possibly create the best-known materials. Some of the strategies used by nature may well have practical implications in the world of nanomaterials. Therefore, the efforts to exploit nature’s ingenious work in designing strategies for nanomaterials synthesis has led to biological routes for materials synthesis. This review outlines the biological synthesis of a range of oxide nanomaterials that has hitherto been achieved using fungal biosynthesis routes. A critical overview of the current status and future scope of this field that could potentially lead to the microorganism-mediated commercial, large-scale, environmentally benign, and economically-viable ‘green’ syntheses of oxide nanomaterials is also discussed.
Time and rate dependent synaptic learning in neuro-mimicking resistive memories
Publisher: Springer Science and Business Media LLC
Date: 28-10-2019
DOI: 10.1038/S41598-019-51700-0
Abstract: Memristors have demonstrated immense potential as building blocks in future adaptive neuromorphic architectures. Recently, there has been focus on emulating specific synaptic functions of the mammalian nervous system by either tailoring the functional oxides or engineering the external programming hardware. However, high device-to-device variability in memristors induced by the electroforming process and complicated programming hardware are among the key challenges that hinder achieving biomimetic neuromorphic networks. Here, a simple hybrid complementary metal oxide semiconductor (CMOS)-memristor approach is reported to implement different synaptic learning rules by utilizing a CMOS-compatible memristor based on oxygen-deficient SrTiO 3 -x (STO x ). The potential of such hybrid CMOS-memristor approach is demonstrated by successfully imitating time-dependent (pair and triplet spike-time-dependent-plasticity) and rate-dependent (Bienenstosk-Cooper-Munro) synaptic learning rules. Experimental results are benchmarked against in-vitro measurements from hippoc al and visual cortices with good agreement. The scalability of synaptic devices and their programming through a CMOS drive circuitry elaborates the potential of such an approach in realizing adaptive neuromorphic computation and networks.
Generating strong room-temperature photoluminescence in black phosphorus using organic molecules
Publisher: IOP Publishing
Date: 30-10-2019
Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices
Publisher: Springer Science and Business Media LLC
Date: 25-07-2018
DOI: 10.1038/S41598-018-29152-9
Abstract: The design of new chiral chromophores that allow tunable assembly of higher order helical structures by using natural stimuli offers promising avenue in understanding various biological processes. In particular, access to dynamic multistimuli-responsive systems can provide real-time monitoring of chiral transformation in chemical and biological systems. We report on the synthesis of naphthalenediimide appended L-glutamate (NDI-L-Glu) that self-assembles into chiral supramolecular structures under physiological conditions. Specifically, NDI-L-Glu shows a mixture of left- and right-handed helices under physiological conditions, and any deviation from the ambient biochemical environment has a remarkable influence on the chirality of these structures. For instance, acidic environments shift the helicity to left-handedness while the alkaline conditions reversed the helical structures to right-handedness, thereby mimicking the molecular virulence mechanism of tobacco mosaic virus (TMV). The chirality of these supramolecular assemblies can also be controllably tuned by using temperature as an external stimulus, allowing reversible flip of helicity.
Aptamer-controlled reversible inhibition of gold nanozyme activity for pesticide sensing
Publisher: American Chemical Society (ACS)
Date: 28-10-2014
DOI: 10.1021/AC5028726
Abstract: This study addresses the need for rapid pesticide (acetamiprid) detection by reporting a new colorimetric biosensing assay. Our approach combines the inherent peroxidase-like nanozyme activity of gold nanoparticles (GNPs) with high affinity and specificity of an acetamiprid-specific S-18 aptamer to detect this neurotoxic pesticide in a highly rapid, specific, and sensitive manner. It is shown that the nanozyme activity of GNPs can be inhibited by its surface passivation with target-specific aptamer molecules. Similar to an enzymatic competitive inhibition process, in the presence of a cognate target, these aptamer molecules leave the GNP surface in a target concentration-dependent manner, reactivating GNP nanozyme activity. This reversible inhibition of the GNP nanozyme activity can either be directly visualized in the form of color change of the peroxidase reaction product or can be quantified using UV-visible absorbance spectroscopy. This approach allowed detection of 0.1 ppm acetamiprid within an assay time of 10 min. This reversible nanozyme activation/inhibition strategy may in principle be universally applicable for the detection of a range of environmental or biomedical molecules of interest.
Active control of silver nanoparticles spacing using dielectrophoresis for surface-enhanced Raman scattering
Publisher: American Chemical Society (ACS)
Date: 11-04-2012
DOI: 10.1021/AC203381N
Abstract: We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles. The system is benchmarked using dipicolinate (2,6-pyridinedicarboxylic acid) (DPA), which is a biomarker of Bacillus anthracis. The validity of the results is discussed using several complementing characterization scenarios.
Effect of Imidazolium-Based Ionic Liquids on the Nanoscale Morphology of CuTCNQ (TCNQ = 7,7,8,8-Tetracyanoquinodimethane) Metal–Organic Semiconductors
Publisher: American Chemical Society (ACS)
Date: 24-12-2012
DOI: 10.1021/LA303885R
Abstract: We demonstrate for the first time the ionic-liquid-mediated synthesis of nanostructured CuTCNQ by the simple immersion of copper in a solution of TCNQ where the viscosity of the medium significantly impacts the corrosion-crystallization process and the final morphology of the material.
Fine-Tuning the Antimicrobial Profile of Biocompatible Gold Nanoparticles by Sequential Surface Functionalization Using Polyoxometalates and Lysine
Publisher: Public Library of Science (PLoS)
Date: 17-10-2013
Ambient Protection of Few-Layer Black Phosphorus via Sequestration of Reactive Oxygen Species
Publisher: Wiley
Date: 12-05-2017
Abstract: Few-layer black phosphorous (BP) has emerged as a promising candidate for next-generation nanophotonic and nanoelectronic devices. However, rapid ambient degradation of mechanically exfoliated BP poses challenges in its practical deployment in scalable devices. To date, the strategies employed to protect BP have relied upon preventing its exposure to atmospheric conditions. Here, an approach that allows this sensitive material to remain stable without requiring its isolation from the ambient environment is reported. The method draws inspiration from the unique ability of biological systems to avoid photo-oxidative damage caused by reactive oxygen species. Since BP undergoes similar photo-oxidative degradation, imidazolium-based ionic liquids are employed as quenchers of these damaging species on the BP surface. This chemical sequestration strategy allows BP to remain stable for over 13 weeks, while retaining its key electronic characteristics. This study opens opportunities to practically implement BP and other environmentally sensitive 2D materials for electronic applications.
Comparative influence of pH and heat on whey protein isolate in protecting Lactobacillus plantarum A17 during spray drying
Publisher: Elsevier BV
Date: 03-2016
Nanoporous TiCN with High Specific Surface Area for Enhanced Hydrogen Evolution Reaction
Publisher: American Chemical Society (ACS)
Date: 12-04-2022
Shape dependent electrocatalytic behaviour of silver nanoparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0CE00215A
A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals
Publisher: Springer Science and Business Media LLC
Date: 22-06-2015
DOI: 10.1038/SREP11515
Abstract: Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a erse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related to human and animal related infections. In this pilot study, it is shown that the rumen of a fistulated animal provides an excellent live laboratory for assessing the properties of antimicrobial materials. We investigate microbial colonization onto model nanocomposites based on silver (Ag) nanoparticles at different concentrations into polydimethylsiloxane (PDMS). With implantable devices posing a major risk for hospital-acquired infections, the present study provides a viable solution to understand microbial colonization with the potential to reduce the incidence of infection through the introduction of Ag nanoparticles at the optimum concentrations. In vitro measurements were also conducted to show the validity of the approach. An optimal loading of 0.25 wt % Ag is found to show the greatest antimicrobial activity and observed through the in vivo tests to reduce the microbial ersity colonizing the surface.
Zinc oxide/silver nanoarrays as reusable SERS substrates with controllable 'hot-spots' for highly reproducible molecular sensing
Publisher: Elsevier BV
Date: 12-2014
DOI: 10.1016/J.JCIS.2014.09.017
Abstract: The reproducible surface enhanced Raman scattering (SERS)-based sensing of an analyte relies on high quality SERS substrates that offer uniformity over large areas. Uniform ZnO nanoarrays are expected to offer an appropriate platform for SERS sensing. Moreover, since ZnO has good photocatalytic properties, controllable decoration of silver nanoparticles on ZnO nanoarrays may offer an additional opportunity to clean up SERS substrates after each sensing event. This study employs a facile soft chemical synthesis strategy to fabricate Raman-active and recyclable ZnO/Ag nanorod arrays as reproducible SERS substrates. Arrays of ZnO nanorods were synthesized using hydrothermal method, which was followed by controllable decoration of ZnO with silver nanoparticles (AgNPs) using an electroless plating technique. The uniform density of SERS-active 'hot-spots' on ZnO nanoarrays could be controlled on a large 1×1 cm(2) substrate. These ZnO/Ag nanoarrays showed high reproducibility (0.132 RSD) towards acquiring SERS spectra of rhodamine B (RB) at 30 random locations on a single substrate. The photocatalytic nature of ZnO/Ag semiconductor/metal hybrid endowed these substrates with reusability characteristics. By controlling metal loading on a semiconductor surface, photocatalytic activity and high SERS performance can be integrated within a single package to obtain high quality, reproducible, stable and recyclable SERS substrates.
Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5OB00842E
Abstract: A series of pyrazolo–triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain (1-benzyl-1 H -1,2,3-triazol-4-yl)(1,3-diphenyl-1 H -pyrazol-4-yl)methanones.
Functional Femtoliter Droplets for Ultrafast Nanoextraction and Supersensitive Online Microanalysis
Publisher: Wiley
Date: 28-11-2019
Abstract: A universal femtoliter surface droplet-based platform for direct quantification of trace of hydrophobic compounds in aqueous solutions is presented. Formation and functionalization of femtoliter droplets, concentrating the analyte in the solution, are integrated into a simple fluidic chamber, taking advantage of the long-term stability, large surface-to-volume ratio, and tunable chemical composition of these droplets. In situ quantification of the extracted analytes is achieved by surface-enhanced Raman scattering (SERS) spectroscopy by nanoparticles on the functionalized droplets. Optimized extraction efficiency and SERS enhancement by tuning droplet composition enable quantitative determination of hydrophobic model compounds of rhodamine 6G, methylene blue, and malachite green with the detection limit of 10
3-D nanorod arrays of metal-organic KTCNQ semiconductor on textiles for flexible organic electronics
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3RA43291B
Improving efficacy, oral bioavailability, and delivery of paclitaxel using protein-grafted solid lipid nanoparticles
Publisher: American Chemical Society (ACS)
Date: 13-10-2016
DOI: 10.1021/ACS.MOLPHARMACEUT.6B00691
Abstract: Oral delivery of anticancer drugs remains challenging despite the most convenient route of drug administration. Hydrophobicity and nonspecific toxicities of anticancer agents are major impediments in the development of oral formulation. In this study, we developed wheat germ agglutinin (WGA)-conjugated, solid lipid nanoparticles to improve the oral delivery of the hydrophobic anticancer drug, paclitaxel (PTX). This study was focused to improve the PTX loading in biocompatible lipid matrix with high bioconjugation efficiency. WGA-conjugated, PTX-loaded solid lipid nanoparticles (LPSN) exhibited enhanced anticancer activity against A549 lung cancer cells after internalization through lectin receptors than free PTX. Biodistribution studies in rats revealed that LPSN significantly improved the oral bioavailability and lung targetability of PTX, which could be due to cumulative bioadhesive property of the nanocarrier system and the targeting ligand WGA.
Impact of nucleic acid encapsulated MOF crystal phase on protein corona formation
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3MA00391D
Measurement of detector-corrected observables sensitive to the anomalous production of events with jets and large missing transverse momentum in $$\varvec{pp}$$ p p collisions at $$\mathbf {\sqrt{s}=1
Publisher: Springer Science and Business Media LLC
Date: 11-2017
Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer
Publisher: Springer Science and Business Media LLC
Date: 07-04-2016
DOI: 10.1038/SREP23179
Abstract: Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type of breast cancer is more aggressive and tends to reoccur more often than HER2-negative breast cancer. In this study, we synthesized trastuzumab (TZ)-grafted dendrimers to improve delivery of docetaxel (DTX) to HER2-positive breast cancer cells. Bioconjugation of TZ on the surface of dendrimers was performed using a heterocrosslinker, MAL-PEG-NHS. For imaging of cancer cells, dendrimers were also conjugated to fluorescein isothiocyanate. Comparative in vitro studies revealed that these targeted dendrimers were more selective, and had higher antiproliferation activity, towards HER2-positive MDA-MB-453 human breast cancer cells than HER2-negative MDA-MB-231 human breast cancer cells. When compared with unconjugated dendrimers, TZ-conjugated dendrimers also displayed higher cellular internalization and induction of apoptosis against MDA-MB-453 cells. Binding of TZ to the dendrimer surface could help site-specific delivery of DTX and reduce systemic toxicity resulting from its lack of specificity. In addition, in vivo studies revealed that the pharmacokinetic profile of DTX was significantly improved by the conjugated nanosystem.
Metal–Organic Charge Transfer Complexes of Pb(TCNQ)2 and Pb(TCNQF4)2 as New Catalysts for Electron Transfer Reactions
Publisher: Wiley
Date: 09-09-2020
Abstract: The fundamental properties and applications of organic charge transfer complexes based on Pb(TCNQ) 2 (Pb = lead, TCNQ = 7,7,8,8‐tetracyanoquinodimethane) and its fluorinated derivatives are relatively unknown. Here, a facile solid–liquid approach for the synthesis of Pb(TCNQ) 2 and Pb(TCNQF 4 ) 2 is reported. These materials are thoroughly analyzed to obtain insights into their unique morphological, vibrational and optical properties, the latter extending across the UV–Vis–IR region. Subsequently, the catalytic potential of these materials is evaluated by employing a model redox reaction, which revealed two orders of magnitude higher catalytic activity of the fluorinated derivative over non‐fluorinated Pb(TCNQ) 2 crystals. Overall, the work presented here adds a new member to the growing yet limited library of metal–organic charge transfer complexes and validates the outstanding redox catalysis performance of this group of materials.
Identifying Trends in Gold Nanoparticle Toxicity and Uptake: Size, Shape, Capping Ligand, and Biological Corona
Publisher: American Chemical Society (ACS)
Date: 04-01-2019
Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
Publisher: Proceedings of the National Academy of Sciences
Date: 24-10-2022
Abstract: Organoid technology has provided unique insights into human organ development, function, and diseases. Patient-derived organoids are increasingly used for drug screening, modeling rare disorders, designing regenerative therapies, and understanding disease pathogenesis. However, the use of Matrigel to grow organoids represents a major challenge in the clinical translation of organoid technology. Matrigel is a poorly defined mixture of extracellular matrix proteins and growth factors extracted from the Engelbreth–Holm–Swarm mouse tumor. The extracellular matrix is a major driver of multiple cellular processes and differs significantly between tissues as well as in healthy and disease states of the same tissue. Therefore, we envisioned that the extracellular matrix derived from a native healthy tissue would be able to support organoid growth akin to organogenesis in vivo. Here, we have developed hydrogels from decellularized human and bovine endometrium. These hydrogels supported the growth of mouse and human endometrial organoids, which was comparable to Matrigel. Organoids grown in endometrial hydrogels were proteomically more similar to the native tissue than those cultured in Matrigel. Proteomic and Raman microspectroscopy analyses showed that the method of decellularization affects the biochemical composition of hydrogels and, subsequently, their ability to support organoid growth. The amount of laminin in hydrogels correlated with the number and shape of organoids. We also demonstrated the utility of endometrial hydrogels in developing solid scaffolds for supporting high-throughput, cell culture–based applications. In summary, endometrial hydrogels overcome a major limitation of organoid technology and greatly expand the applicability of organoids to understand endometrial biology and associated pathologies.
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