ORCID Profile
0000-0003-0238-7416
Current Organisations
Centre for Eye Research Australia
,
The Royal Victorian Eye & Ear Hospital
,
Central Connecticut State University
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Publisher: CSIRO Publishing
Date: 2018
DOI: 10.1071/CH18019
Abstract: Computational methods were used to investigate the stereochemical course of the extra-annular Claisen rearrangement. The stereochemical fidelity of the synthetic strategy and comparison of the optical properties support the hypothesis that the heliespirones are scalemic natural products.
Publisher: Springer Science and Business Media LLC
Date: 18-06-2018
Publisher: Springer Science and Business Media LLC
Date: 10-2018
Publisher: Elsevier BV
Date: 09-2016
Publisher: Elsevier BV
Date: 05-2023
Publisher: Oxford University Press (OUP)
Date: 21-01-2015
DOI: 10.1093/JXB/ERU513
Publisher: Wiley
Date: 04-07-2022
DOI: 10.1111/AOS.14955
Abstract: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, respectively), is uncertain. This systematic review and meta-analysis aimed to clarify the association of NLR and PLR with RVO. We searched MEDLINE (Ovid), EMBASE (Ovid) and the Cochrane Library for studies investigating the association of NLR and PLR with RVO from inception to 2 December 2020. We used random-effects inverse-variance modelling to generate pooled effect measures. We used bivariate Bayesian modelling to meta-analyse the ability of NLR and PLR to differ between in iduals with and without RVO and performed meta-regression and sensitivity analyses to explore inter-study heterogeneity. Eight studies published encompassing 1059 patients were included for analysis. Both NLR and PLR were significantly elevated in RVO, with pooled mean differences of 0.63 (95% confidence interval (CI) 0.31-0.95) and 21.49 (95% CI 10.03-32.95), respectively. The pooled sensitivity, specificity and area under the Bayesian summary receiver operating characteristic curve were, respectively, 0.629 (95% credible interval (CrI) 0.284-0.872), 0.731 (95% CrI 0.373-0.934) and 0.688 (95% CrI 0.358-0.872) for NLR and 0.645 (95% CrI 0.456-0.779), 0.616 (95% CrI 0.428-0.761) and 0.621 (95% CrI 0.452-0.741) for PLR. Mean and variability of age and diabetes mellitus prevalence partially explained between-study heterogeneity. NLR and PLR are significantly elevated in RVO. Future research is needed to investigate the potential prognostic value and independence of these findings.
Publisher: Springer New York
Date: 30-11-2018
Publisher: Elsevier BV
Date: 03-2022
DOI: 10.1016/J.AJO.2021.07.009
Abstract: To evaluate anatomic and functional intereye symmetry among in iduals with Bietti crystalline dystrophy (BCD) using clinical and multimodal imaging methods, with a focus on the number, area, and distribution of the characteristic retinal crystalline deposits. Observational case series with prospective and retrospective data. Setting: Multicenter. Thirteen Australian and New Zealand participants (26 eyes) with confirmed biallelic CYP4V2 mutations and a characteristic BCD fundus appearance. Procedures and main outcome measures: Crystals visible on color fundus photography were manually counted. Crystals were superimposed on aligned multimodal fundus images. Spearman's correlation coefficients (ρ), intraclass correlation coefficients (ICCs), and Bland-Altman plots were used to quantify symmetry between eyes. Fundus crystal area and count, and absent-autofluorescence (absent-AF) area. Median participant age was 48 years (interquartile range: 40-60 years). Intereye symmetry was high for fundus crystal area (ρ = 1.00, 95% confidence interval [CI]: 1.00-1.00 ICC = 0.97, 95% CI: 0.88-0.99), fundus crystal count (ρ = 0.98, 95% CI: 0.92-1.00 ICC = 0.97, 95% CI: 0.89-0.99), and absent-AF area (ρ = 0.88, 95% CI: 0.53-0.98 ICC = 0.98, 95% CI: 0.90-0.99). Average foveal volume, foveal crystal count and area, average and central foveal thickness, best corrected visual acuity, and average macular and central foveal sensitivity were not highly correlated between eyes. This study demonstrated strong intereye symmetry measured by fundus crystal area, fundus crystal number, and absent-AF area. This may influence the choice of outcome measures for future therapeutic trials for BCD and provides valuable clinical information for ophthalmologists involved in the care and counseling of patients with BCD.
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 10-2014
DOI: 10.1167/TVST.3.6.1
Publisher: Informa UK Limited
Date: 2007
Publisher: Springer Science and Business Media LLC
Date: 16-11-2017
DOI: 10.1038/GT.2017.85
Publisher: Wiley
Date: 07-06-2000
Publisher: Portland Press Ltd.
Date: 14-09-2009
DOI: 10.1042/BJ20082398
Abstract: The HSPs (hereditary spastic paraplegias) are genetic conditions in which there is distal degeneration of the longest axons of the corticospinal tract, resulting in spastic paralysis of the legs. The gene encoding spartin is mutated in Troyer syndrome, an HSP in which paralysis is accompanied by additional clinical features. There has been controversy over the subcellular distribution of spartin. We show here that, at steady state, endogenous spartin exists in a cytosolic pool that can be recruited to endosomes and to lipid droplets. Cytosolic endogenous spartin is mono-ubiquitinated and we demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4 WWP2 (WW domain-containing E3 ubiquitin protein ligase 2] and AIP5 (WWP1). Surprisingly, the PPXY motif, AIP4 and AIP5 are not required for spartin's ubiquitination, and so we propose that spartin acts as an adaptor for these proteins. Our results suggest that spartin is involved in erse cellular functions, which may be of relevance to the complex phenotype seen in Troyer syndrome.
Publisher: Oxford University Press (OUP)
Date: 08-12-2005
DOI: 10.1093/HMG/DDI447
Publisher: MDPI AG
Date: 16-06-2020
DOI: 10.3390/IJMS21124273
Abstract: Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive specific neuronal cell types for therapeutic applications. Both in vitro and in vivo cellular reprogramming provide erse therapeutic pathways for modeling neurological diseases and injury repair. In particular, the retina has emerged as a promising target for clinical application of regenerative medicine. Herein, we review the potential of neuronal reprogramming to develop regenerative strategy, with a particular focus on treating retinal degenerative diseases and discuss future directions and challenges in the field.
Publisher: SLACK, Inc.
Date: 12-2017
DOI: 10.3928/23258160-20171130-06
Abstract: The aim of this study was to assess changes in retinal structure and thickness after subretinal implantation of the Retina Implant Alpha IMS (Retina Implant AG, Reutlingen, Germany). Spectral-domain optical coherence tomography (SD-OCT) imaging was performed to assess the structure and thickness of the retina anterior to the microphotodiode array preoperatively, within 6 weeks and 6 months ± 1 month after implantation. Thickness measurements were performed using the distance tool of the built-in software. Three thickness measurements were performed in each of the four quadrants of the retina on the microchip within 6 weeks and 6 months ± 1 month after implantation. The mean ± standard deviation change in retinal thickness from within 6 weeks to 6 months ± 1 month after implantation in all four quadrants combined was 24 μm ± 68 μm. None of the tested variables (location, time, or their interaction) had a statistically significant effect on the mean retinal thickness ( P = .961, P = .131, and P = .182, respectively n = 19). The authors report on qualitative and quantitative findings in retinal structure in 27 patients after subretinal implantation of the Retina Implant Alpha IMS using OCT technology. No significant changes of retinal thickness could be observed in a period of 6 months after surgery. With more patients receiving subretinal implants and with advanced OCT technology, the data set will be extended to study possible changes in retinal structure in finer detail. [ Ophthalmic Surg Lasers Imaging Retina . 2017 :993–999.]
Publisher: Wiley
Date: 12-2017
DOI: 10.1111/CEO.13080
Publisher: Elsevier BV
Date: 03-2018
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 07-11-2016
Publisher: Oxford University Press (OUP)
Date: 10-11-2004
DOI: 10.1093/HMG/DDI003
Publisher: Springer Science and Business Media LLC
Date: 07-12-2019
Publisher: American Chemical Society (ACS)
Date: 23-11-2020
Publisher: Frontiers Media SA
Date: 23-08-2017
Publisher: Wiley
Date: 09-01-2019
Abstract: The continuous amalgamation of photocatalysis into existing reversible deactivation radical polymerisation (RDRP) processes has initiated a rapidly propagating area of polymer research in recent years. We introduce bismuth oxide (Bi
Publisher: Informa UK Limited
Date: 25-02-2021
Publisher: Wiley
Date: 27-04-2011
DOI: 10.1111/J.1442-9071.2011.02556.X
Abstract: To develop, implement and evaluate a telemedicine model to reduce glaucoma blindness through the early detection of undiagnosed glaucoma in high-risk in iduals. Prospective study, private ophthalmology practice and public outpatient clinics in Tasmania. One hundred and thirty-three in iduals with primary open-angle glaucoma were invited to enrol their first-degree relatives (FDRs) to undergo an eye examination. Within the study period, 211 FDRs were available for examination. A registered nurse was trained to perform the required assessments. Clinical data were entered into a purpose-built database, converted to a portable document format and graded offsite by an ophthalmologist to determine the presence, absence or risk of developing glaucoma. Participants were notified of the grading result and recommendations for review. Incidence of undiagnosed glaucoma in a high-risk population. Previously undiagnosed glaucoma was identified in 5% of those examined. For every 19 participants screened, one new case of previously undiagnosed case of glaucoma was identified. Additionally 15% of participants showed suspicious signs of glaucoma, and 6% had ocular hypertension. A telemedicine model is an efficient method for screening, grading and notifying participants of examination results. Nurses can be adequately trained to undertake the initial screening examinations, with grading of the results performed offsite by a suitably qualified ophthalmologist. Targeted screening for glaucoma increases the yield of identifying in iduals with undiagnosed glaucoma or those at greatest risk. Cost efficiencies for this model of glaucoma screening should be further explored and implemented to prevent blindness from familial glaucoma.
Publisher: Elsevier BV
Date: 2019
Publisher: Jaypee Brothers Medical Publishers (P) Ltd.
Date: 2014
Publisher: Wiley
Date: 12-06-2022
DOI: 10.1111/CEO.14110
Abstract: Emerging treatments are being developed for inherited retinal diseases, requiring a clear understanding of natural progression and a database of potential participants for clinical trials. This article describes the rationale, study design and methodology of the Victorian Evolution of inherited retinal diseases NaTUral history REgistry (VENTURE), including data from the first 150 participants enrolled. VENTURE collects retrospective and prospective data from people with inherited retinal diseases. Following registration, participants are asked to attend a baseline examination using a standardised protocol to confirm their inherited retinal disease diagnosis. Examination procedures include (i) retinal function, using visual acuity and perimetry (ii) retinal structure, using multimodal imaging and (iii) patient‐reported outcomes. Participants' molecular diagnoses are obtained from their clinical records or through targeted‐panel genetic testing by an independent laboratory. Phenotype and genotype data are used to enrol participants into disease‐specific longitudinal cohort sub‐studies. From 7 July 2020 to 30 December 2021, VENTURE enrolled 150 registrants (138 families) and most (63%) have a rod‐cone dystrophy phenotype. From 93 participants who have received a probable molecular diagnosis, the most common affected genes are RPGR (13% of all registrants), USH2A (10%), CYP4V2 (7%), ABCA4 (5%), and CHM (5%). Most participants have early to moderate vision impairment, with over half (55%) having visual acuities of better than 6/60 (20/200) at registration. The VENTURE study will complement existing patient registries and help drive inherited retinal disease research in Australia, facilitating access to research opportunities for in iduals with inherited retinal diseases.
Publisher: Wiley
Date: 19-04-2017
DOI: 10.1111/CGE.13021
Publisher: Massachusetts Medical Society
Date: 19-05-2016
DOI: 10.1056/NEJMC1509501
Publisher: Elsevier BV
Date: 06-2015
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 30-10-2017
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 12-07-2016
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 29-08-2016
Publisher: Jaypee Brothers Medical Publishers (P) Ltd.
Date: 2014
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5OB00852B
Abstract: The total synthesis of a number of carbazolo-1,4-quinone natural products using on-water chemistry is described.
Publisher: Informa UK Limited
Date: 02-2018
DOI: 10.2147/RSRR.S122301
Publisher: Elsevier BV
Date: 08-2014
Publisher: Oxford University Press (OUP)
Date: 20-07-2009
DOI: 10.1093/HMG/DDP324
Publisher: Informa UK Limited
Date: 02-03-2021
Publisher: Springer Science and Business Media LLC
Date: 16-01-2015
DOI: 10.1038/EYE.2014.326
Publisher: Wiley
Date: 19-06-2012
DOI: 10.1111/J.1442-9071.2012.02804.X
Abstract: To characterize the clinical and genetic abnormalities within two Australian pedigrees with high incidences of retinal detachment and visual disability. Prospective review of two extended Australian pedigrees with high rates of retinal detachment. Twenty-two family members from two extended Australian pedigrees with high rates of retinal detachment were examined. A full ophthalmic history and examination were performed, and DNA was analysed by linkage analysis and mutation screening. Characterization of a causative hereditary gene mutation in each family. All affected family members of one pedigree carried a C192A COL2A1 exon 2 mutation. None of the affected family members had early-onset arthritis, hearing abnormalities, abnormal clefting or facial features characteristic of classical Stickler syndrome. All affected members of the familial exudative vitreoretinopathy pedigree carried a 957delG FZD4 mutation. Patients with retinal detachment and a positive family history should be investigated for heritable conditions associated with retinal detachment such as Stickler syndrome and familial exudative vitreoretinopathy. The absence of non-ocular features of Stickler syndrome should raise the possibility of mutations in exon 2 of COL2A1. Similarly, late-onset familial exudative vitreoretinopathy may appear more like a rhegmatogenous detachment and not be correctly diagnosed. When a causative gene mutation is identified, cascade genetic screening of the family will facilitate genetic counselling and screening of high-risk relatives, allowing targeted management of the pre-detachment changes in affected patients.
Publisher: Elsevier BV
Date: 05-2022
Location: United States of America
Location: United States of America
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Thomas Edwards.