ORCID Profile
0000-0002-3760-1892
Current Organisations
Curtin University of Technology
,
Curtin University
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Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0DT02855J
Abstract: Trinuclear lanthanoid clusters have been synthesised and investigated as toroidal spin systems.
Publisher: Springer Science and Business Media LLC
Date: 29-05-2018
DOI: 10.1038/S41598-018-24672-W
Abstract: Mitochondrial morphology is important for the function of this critical organelle and, accordingly, altered mitochondrial structure is exhibited in many pathologies. Imaging of mitochondria can therefore provide important information about disease presence and progression. However, mitochondrial imaging is currently limited by the availability of agents that have the capacity to image mitochondrial morphology in both live and fixed s les. This can be particularly problematic in clinical studies or large, multi-centre cohort studies, where tissue archiving by fixation is often more practical. We previously reported the synthesis of an iridium coordination complex [Ir( ppy ) 2 ( MeTzPyPhCN )] + where ppy is a cyclometalated 2-phenylpyridine and TzPyPhCN is the 5-(5-(4-cyanophen-1-yl)pyrid-2-yl)tetrazolate ligand and showed that this complex (herein referred to as IraZolve-Mito) has a high specificity for mitochondria in live cells. Here we demonstrate that IraZolve-Mito can also effectively stain mitochondria in both live and fixed tissue s les. The staining protocol proposed is versatile, providing a universal procedure for cell biologists and pathologists to visualise mitochondria.
Publisher: Impact Journals, LLC
Date: 30-10-2018
Publisher: Elsevier BV
Date: 05-2018
Publisher: Wiley
Date: 07-08-2017
Abstract: A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The complexes are distinguished by variations of the substituents or degree of π conjugation on either the phenylpyridine or tetrazolato ligands. The photophysical properties of these species have been evaluated in organic and aqueous media, revealing predominantly a solvatochromic emission originating from mixed metal-to-ligand and ligand-to-ligand charge transfer excited states of triplet multiplicity. These emissions are characterised by typically long excited-state lifetimes (∼hundreds of ns), and quantum yields around 5-10 % in aqueous media. Methylation of the complexes caused a systematic red-shift of the emission profiles. The behaviour and the effects of the different complexes were then examined in cells. The neutral species localised mostly in the endoplasmic reticulum and lipid droplets, whereas the majority of the cationic complexes localised in the mitochondria. The amount of complexes found within cells does not depend on lipophilicity, which potentially suggests erse uptake mechanisms. Methylated analogues were found to be more cytotoxic compared to the neutral species, a behaviour that might to be linked to a combination of uptake and intracellular localisation.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00397F
Abstract: The readily synthesised rhodamine–naphthalimide–benzamide trichromophoric system forms unique AIE emissive species in DMSO solutions with traces of water ( %) and high water content ( %) and responds to pH changes in both solution and solid state.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8DT04116D
Abstract: Novel bis(2,9-diaryl-1,10-phenanthroline)copper( i ) complexes were prepared to study a photoredox-catalysed reaction.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NJ01453A
Abstract: A newly reported alkylated naphthalene flanked DPP monomers without any further functionalization show high hole mobility in OFET devices.
No related grants have been discovered for Chiara Caporale.