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ORCID Profile
Orcid icon. 0009-0003-0131-3076

Current Organisations
CeMM Research Center for Molecular Medicine , Medical University of Vienna , TU Dresden , University of Vienna , Max Delbrück Center for Molecular Medicine , Institute of Molecular Biotechnology , Karolinska Institutet

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Publications

Publication

Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 03-02-2017

DOI: 10.1002/HEP.28970

Abstract: Diet‐related health issues such as nonalcoholic fatty liver disease and cardiovascular disorders are known to have a major inflammatory component. However, the exact pathways linking diet‐induced changes (e.g., hyperlipidemia) and the ensuing inflammation have remained elusive so far. We identified biological processes related to innate immunity and oxidative stress as prime response pathways in livers of low‐density lipoprotein receptor‐deficient mice on a Western‐type diet using RNA sequencing and in silico functional analyses of transcriptome data. The observed changes were independent of the presence of microbiota and thus indicative of a role for sterile triggers. We further show that malondialdehyde (MDA) epitopes, products of lipid peroxidation and markers for enhanced oxidative stress, are detectable in hepatic inflammation predominantly on dying cells and stimulate cytokine secretion as well as leukocyte recruitment in vitro and in vivo . MDA‐induced cytokine secretion in vitro was dependent on the presence of the scavenger receptors CD36 and MSR1. Moreover, in vivo neutralization of endogenously generated MDA epitopes by intravenous injection of a specific MDA antibody results in decreased hepatic inflammation in low‐density lipoprotein receptor‐deficient mice on a Western‐type diet. Conclusion : Accumulation of MDA epitopes plays a major role during diet‐induced hepatic inflammation and can be ameliorated by administration of an anti‐MDA antibody. (H epatology 2017 :1181‐1195)

Publication

Evaluation of a Rapid Dipstick (Crystal VC) for the Diagnosis of Cholera in Zanzibar and a Comparison with Previous Studies

Publisher: Public Library of Science (PLoS)

Date: 25-05-2012

Location: Sweden

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Related Funding Activities

No related grants have been discovered for Clara Jana Lui Busch.

Clara Jana Lui Busch

Researcher

Related Links

Publications

Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice

Evaluation of a Rapid Dipstick (Crystal VC) for the Diagnosis of Cholera in Zanzibar and a Comparison with Previous Studies

Related Organisations

CeMM Research Center For Molecular Medicine

Medical University Of Vienna

TU Dresden

University Of Vienna

Max Delbrück Center For Molecular Medicine

Institute Of Molecular Biotechnology

Karolinska Institutet

Related Funding Activities

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