Scott Bartell

Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone

Publisher: Elsevier BV

Date: 08-2014

DOI: 10.1016/S1470-2045(14)70316-X

Genetic variants underlying differences in facial morphology in East Asian and European populations

Publisher: Springer Science and Business Media LLC

Date: 04-2022

DOI: 10.1038/S41588-022-01038-7

Abstract: Facial morphology-a conspicuous feature of human appearance-is highly heritable. Previous studies on the genetic basis of facial morphology were performed mainly in European-ancestry cohorts (EUR). Applying a data-driven phenotyping and multivariate genome-wide scanning protocol to a large collection of three-dimensional facial images of in iduals with East Asian ancestry (EAS), we identified 244 variants in 166 loci (62 new) associated with typical-range facial variation. A newly proposed polygenic shape analysis indicates that the effects of the variants on facial shape in EAS can be generalized to EUR. Based on this, we further identified 13 variants related to differences between facial shape in EUR and EAS populations. Evolutionary analyses suggest that the difference in nose shape between EUR and EAS populations is caused by a directional selection, due mainly to a local adaptation in Europeans. Our results illustrate the underlying genetic basis for facial differences across populations.

The Relationship between Averaged Sulfate Exposures and Concentrations: Results from Exposure Assessment Panel Studies in Four U.S. Cities

Publisher: American Chemical Society (ACS)

Date: 06-2009

DOI: 10.1021/ES900419N

Abstract: This analysis examines differences between measured ambient indoor, and personal sulfate concentrations across cities, seasons, and in iduals to elucidate how these differences may impact PM2.5 exposure measurement error. Data were analyzed from four panel studies conducted in Atlanta, Baltimore, Boston, and Steubenville (OH). Among the study locations, 1912 person-days of personal sulfate data were collected over 396 days involving 245 in idual s ling sessions. Long-term differences in ambient and personal levels averaged over time are examined. Differences between averaged ambient and personal sulfate among and within cities were observed, driven by between subject and city differences in sulfate infiltration, F(inf), from outdoors to indoors. Neglecting this source of variability in associations may introduce bias in studies examining long-term exposures and chronic health. Indoor sulfate was highly correlated with and similar in magnitude to personal sulfate, suggesting indoor PM monitoring may be another means of characterizing true exposure variability.

Limb development genes underlie variation in human fingerprint patterns

Publisher: Elsevier BV

Date: 2022

DOI: 10.1016/J.CELL.2021.12.008

Shandong University

Location: China

View Organisation

Fudan University

Location: China

View Organisation

CAS Key Laboratory Of Computational Biology, Shanghai Institute Of Nutrition And Health, University Of Chinese Academy Of Sciences, Chinese Academy Of Sciences

Location: China

View Organisation

University Of California, Irvine

Location: United States of America

View Organisation