ORCID Profile
0000-0003-0641-9139
Current Organisations
Tunghai University
,
University of Oxford
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Future Medicine Ltd
Date: 07-2015
DOI: 10.2217/NNM.15.47
Abstract: Pathologic neovascularization of the retina is a major cause of substantial and irreversible loss of vision. Drugs are difficult to deliver to the lesions in the back of the eye and this is a major obstacle for the therapeutics. Current pharmacological approach involves an intravitreal injection of anti-VEGF agents to prevent aberrant growth of blood vessels, but it has limitations including therapeutic efficacy and side-effects associated with systemic exposure and invasive surgery. Nanotechnology provides novel opportunities to overcome the limitations of conventional delivery system to reach the back of the eye through fabrication of nanostructures capable of encapsulating and delivering small molecules. This review article introduces various forms of nanocarrier that can be adopted by ocular drug delivery systems to improve current therapy. The application of nanotechnology in medicine brings new hope for ocular drug delivery in the back of the eye to manage the major causes of blindness associated with ocular neovascularization.
Publisher: MDPI AG
Date: 11-2022
DOI: 10.3390/NANO12213855
Abstract: Infections caused by multidrug-resistant (MDR) bacteria are becoming a serious threat to public health worldwide. With an ever-reducing pipeline of last-resort drugs further complicating the current dire situation arising due to antibiotic resistance, there has never been a greater urgency to attempt to discover potential new antibiotics. The use of nanotechnology, encompassing a broad range of organic and inorganic nanomaterials, offers promising solutions. Organic nanomaterials, including lipid-, polymer-, and carbon-based nanomaterials, have inherent antibacterial activity or can act as nanocarriers in delivering antibacterial agents. Nanocarriers, owing to the protection and enhanced bioavailability of the encapsulated drugs, have the ability to enable an increased concentration of a drug to be delivered to an infected site and reduce the associated toxicity elsewhere. On the other hand, inorganic metal-based nanomaterials exhibit multivalent antibacterial mechanisms that combat MDR bacteria effectively and reduce the occurrence of bacterial resistance. These nanomaterials have great potential for the prevention and treatment of MDR bacterial infection. Recent advances in the field of nanotechnology are enabling researchers to utilize nanomaterial building blocks in intriguing ways to create multi-functional nanocomposite materials. These nanocomposite materials, formed by lipid-, polymer-, carbon-, and metal-based nanomaterial building blocks, have opened a new avenue for researchers due to the unprecedented physiochemical properties and enhanced antibacterial activities being observed when compared to their mono-constituent parts. This review covers the latest advances of nanotechnologies used in the design and development of nano- and nanocomposite materials to fight MDR bacteria with different purposes. Our aim is to discuss and summarize these recently established nanomaterials and the respective nanocomposites, their current application, and challenges for use in applications treating MDR bacteria. In addition, we discuss the prospects for antimicrobial nanomaterials and look forward to further develop these materials, emphasizing their potential for clinical translation.
Publisher: The Electrochemical Society
Date: 15-03-2013
Abstract: Significant efforts have been devoted to prepare MoS2 thin layers, including scotch tape micromechanical exfoliation, intercalation assisted exfoliation, solution exfoliation, physical vapor deposition, hydrothermal synthesis, electrochemical synthesis, sulfurization of molybdenum oxides and thermolysis of the precursor containing Mo and S atoms. However, MoS2 tends to form zero-dimensional closed structures or one-dimensional nano-rod structures. The synthetic approach to obtain high quality and large-area MoS2 atomic thin layers is still rare. Here, we shall discuss several different approaches for synthesizing MoS2 thin sheets based on chemical vapor deposition. Spectroscopic and electrical properties of these films shall also be discussed.
Publisher: IOP Publishing
Date: 13-08-2010
DOI: 10.1088/0957-4484/21/36/365604
Abstract: We demonstrate that single wall carbon nanotubes (SWCNTs) can be coated by a layer of silica through the reaction between chlorosilane and acid-treated SWCNTs. The presence of carboxylic acid groups in the SWCNTs provides the active sites where chlorosilane can be anchored to form the silica coating. Silica nanotubes with diameters ranging from 5 to 23 nm were synthesized after the calcination of silica coated SWCNTs at 900 degrees C in air. It was found that the presence of SWCNT templates and carboxylic acid groups on the SWCNTs' surface is essential to the formation of silica nanotubes. Furthermore, the dependence of the inner diameters of the silica nanotubes on the diameters of bundled or isolated SWCNTs was observed. This novel technique can be applied to the synthesis of other oxide nanotubes if a precursor such as TiCl(4) or ZrCl(4) is used.
Publisher: MDPI AG
Date: 20-09-2022
DOI: 10.3390/MEMBRANES12100906
Abstract: Increasing antibiotic resistance has provoked the urgent need to investigate the interactions of antimicrobials with bacterial membranes. The reasons for emerging antibiotic resistance and innovations in novel therapeutic approaches are highly relevant to the mechanistic interactions between antibiotics and membranes. Due to the dynamic nature, complex compositions, and small sizes of native bacterial membranes, bacterial membrane mimetics have been developed to allow for the in vitro examination of structures, properties, dynamics, and interactions. In this review, three types of model membranes are discussed: monolayers, supported lipid bilayers, and supported asymmetric bilayers this review highlights their advantages and constraints. From monolayers to asymmetric bilayers, biomimetic bacterial membranes replicate various properties of real bacterial membranes. The typical synthetic methods for fabricating each model membrane are introduced. Depending on the properties of lipids and their biological relevance, various lipid compositions have been used to mimic bacterial membranes. For ex le, mixtures of phosphatidylethanolamines (PE), phosphatidylglycerols (PG), and cardiolipins (CL) at various molar ratios have been used, approaching actual lipid compositions of Gram-positive bacterial membranes and inner membranes of Gram-negative bacteria. Asymmetric lipid bilayers can be fabricated on solid supports to emulate Gram-negative bacterial outer membranes. To probe the properties of the model bacterial membranes and interactions with antimicrobials, three common characterization techniques, including quartz crystal microbalance with dissipation (QCM-D), surface plasmon resonance (SPR), and neutron reflectometry (NR) are detailed in this review article. Finally, we provide ex les showing that the combination of bacterial membrane models and characterization techniques is capable of providing crucial information in the design of new antimicrobials that combat bacterial resistance.
Publisher: Public Library of Science (PLoS)
Date: 06-10-2016
Publisher: American Chemical Society (ACS)
Date: 11-08-2022
Abstract: Nitric oxide (NO)-releasing nanoparticles are effective nanomedicines with erse therapeutic advantages compared with small molecule-based NO donors. Here, we report a new class of furoxan-based NO-releasing nanoparticles using a simple, creative yet facile coassembly approach. This is the first time we demonstrated that the coassembled NO-releasing nanoparticles with poly(ethylene glycol)
Publisher: American Chemical Society (ACS)
Date: 07-02-2022
Publisher: MDPI AG
Date: 18-01-2023
Abstract: A new deep eutectic solvent (DES) made from urea, magnesium chloride, lithium perchlorate and water has been developed as the electrolyte for battery-supercapacitor hybrid devices. The physicochemical characteristics of DES electrolytes and potential interactions between electrolyte components are well analyzed through electrochemical and spectroscopic techniques. It has been discovered that the properties of DES electrolytes are highly dependent on the component ratio, which allows us to engineer the electrolyte to meet the requirement of the battery application. Perylene tetracarboxylic di-imide and reduced graphene oxide ha ve been combined to produce a composite (PTCDI/rGO) that has been tested as the anode in DES electrolyte. This composite shows that the capacitive contribution is greater than 90% in a low scan rate, resulting in the high rate capability. The PTCDI/rGO electrode exhibits no sign of capacity degradation and its coulombic efficiency is close to 99% after 200 cycles, which suggests excellent reversibility and stability. On the other hand, the electrochemical performance of lithium manganese oxide as the cathode material is studied in DES electrolyte, which exhibits the maximum capacity of 76.5 mAh/g at 0.03 A/g current density. After being successfully examined in terms of electrode kinetics, capacity performance, and rate capability, the anode and cathode materials are combined to construct a two-electrode system with DES electrolyte. At a current density of 0.03 A/g, this system offers 43.5 mAh/g specific capacity and displays 55.5% retention of the maximum capacity at 1 A/g. Furthermore, an energy density of 53 Wh/kg is delivered at a power density of 35 W/kg.
Publisher: American Chemical Society (ACS)
Date: 29-06-2016
DOI: 10.1021/ACS.LANGMUIR.6B01800
Abstract: A fundamental understanding of the effect of hiphilic protein encapsulation on the nanostructure of the bicontinuous cubic phase is crucial to progressing biomedical and biological applications of these hybrid protein-lipid materials, including as drug delivery vehicles, as biosensors, biofuel cells and for in meso crystallization. The relationship between the lipid nanomaterial and the encapsulated protein, however, remains poorly understood. In this study, we investigated the effect of incorporating the five transmembrane and lipo-proteins which make up the β-barrel assembly machinery from Gram-negative bacteria within a series of bicontinuous cubic phases. The transmembrane β-barrel BamA caused an increase in lattice parameter of the cubic phase upon encapsulation. By contrast, the mainly hydrophilic lipo-proteins BamB-E caused the cubic phase lattice parameters to decrease, despite their large size relative to the diameter of the cubic phase water channels. Analysis of the primary amino acid sequence was used to rationalize this effect, based on specific interactions between aromatic amino acids within the proteins and the polar-apolar interface. Other factors that were found to have an effect were lateral bilayer pressure and rigidity within the lipid bilayer, water channel diameter, and size and structure of the lipo-proteins. The data presented suggest that hydrophilic bioactive molecules can be selectively encapsulated within the cubic phase by using a lipid anchor or aromatic amino acids, for drug delivery or biosensing applications.
Publisher: Springer Science and Business Media LLC
Date: 14-08-2015
DOI: 10.1007/S00249-015-1068-Z
Abstract: Annexin V is of crucial importance for detection of the phosphatidylserine of apoptotic cell membranes. However, the manner in which different amounts of phosphatidylserine at the membrane surface at different stages of apoptosis contribute to binding of annexin V is unclear. We have used a quartz crystal microbalance combined with dissipative monitoring (QCM-D) and neutron reflectivity to characterize binding of human annexin V to supported bilayers of different phospholipid composition. We created model apoptotic bilayers of 1-palmitoyl-2-oleoyl-sn-glycerophosphocholine and 1-palmitoyl-2-oleoyl-sn-glycerophosphoserine (POPS) in the ratios 19:1, 9:1, 6.7:1, 4:1, 3:1, and 2:1 (w/w) in the presence of 2.5 mM CaCl2. QCM-D data revealed that annexin V bound less to supported fluid lipid bilayers with higher POPS content (>25 % POPS). Neutron reflectivity was used to further characterize the detailed composition of lipid bilayers with membrane-bound annexin V. Analysis confirmed less annexin V binding with higher POPS content, that bound annexin V formed a discrete layer above the lipid bilayer with little effect on the overall structure of the membrane, and that the thickness and volume fraction of the annexin V layer varied with POPS content. From these results we show that the POPS content of the outer surface of lipid bilayers affects the structure of membrane-bound annexin V.
Publisher: Elsevier BV
Date: 03-2017
Publisher: American Chemical Society (ACS)
Date: 29-03-2011
DOI: 10.1021/JP109360H
Abstract: We have investigated the interfacial and bulk phase structures of surfactin at different pH and in the presence of mono/ alent cations using neutron scattering techniques. Neutron reflectivity profiles were recorded at the air/water and sapphire/water interfaces as a function of pH and ionic strength. The air/water results show that surfactin has a hydrophobic ball-like structure and that changes in pH and cations lead to changes in the area per molecule and hydrophilicity of surfactin. However the adsorption of surfactin on the hydrophilic sapphire/water interface is highly pH dependent because of electrostatic interactions with the surface. The bulk phase structures were characterized by small angle neutron scattering (SANS) and are more sensitive to pH and cation than the interfacial structure. At high pH surfactin forms micellar structures with low aggregation numbers, but at low pH values the bulk phase structure becomes rod-like at pH 6.5 and lamellar at pH 5.5. The addition of cations in the subphase tends to neutralize the two acidic groups of the peptide ring and the neutralization seems to be more complete for alent cations than for monovalent cations.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA03163C
Abstract: In this study, we demonstrate the formation of azo compounds on a composite of silver nanoparticles and graphene oxides (Ag@G) through a plasmon-assisted coupling reaction between different amine compounds.
Publisher: Elsevier BV
Date: 08-2022
Publisher: IOP Publishing
Date: 07-06-2022
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.JCIS.2022.09.047
Abstract: In this work, a novel acetamide-based deep eutectic solvent (DES) with Zn
Publisher: Elsevier BV
Date: 08-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CP02805A
Abstract: A novel surface-enhanced Raman scattering (SERS) sensing system which operates by the self-assembly of Ag nanoparticles (AgNPs) onto the nanocomposite of AgNPs and graphene oxide (AgNP–GO) in the presence of two complementary DNAs has been developed.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB02465K
Abstract: ANX–PS–Phy cubosomes could be applied as a safe and robust drug delivery vehicle for targeting damaged, apoptotic cells in ocular diseases.
Publisher: The Electrochemical Society
Date: 2015
DOI: 10.1149/2.0511508JES
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Tsung-Wu Lin.