ORCID Profile
0000-0001-8501-6199
Current Organisations
Diponegoro University
,
Brown University
,
University of Washington
,
Rockefeller University
,
Indiana University Bloomington
,
Yale University School of Medicine
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Publications
Hardwiring the bain: Endocannabinoids shape neuronal connectivity
Publisher: American Association for the Advancement of Science (AAAS)
Date: 25-05-2007
Abstract: The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB 1 cannabinoid receptors (CB 1 Rs) are enriched in the axonal growth cones of γ-aminobutyric acid–containing (GABAergic) interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CB 1 R internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CB 1 Rs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.
GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage
Publisher: American Association for the Advancement of Science (AAAS)
Date: 08-12-2017
DOI: 10.1126/SCIIMMUNOL.AAO1135
Abstract: GPR55 regulates intraepithelial lymphocyte interaction with the epithelium and restrains cell homing to the small intestine.
Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats
Publisher: Elsevier BV
Date: 03-2008
Micronutrients and Nutrition Status of School-Aged Children in Indonesia
Publisher: Hindawi Limited
Date: 05-09-2023
DOI: 10.1155/2023/4610038
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
Publisher: Proceedings of the National Academy of Sciences
Date: 22-09-2009
Abstract: GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors CB 1 and CB 2 affect bone metabolism, we examined the role of GPR55 in bone biology. GPR55 was expressed in human and mouse osteoclasts and osteoblasts expression was higher in human osteoclasts than in macrophage progenitors. Although the GPR55 agonists O-1602 and LPI inhibited mouse osteoclast formation in vitro, these ligands stimulated mouse and human osteoclast polarization and resorption in vitro and caused activation of Rho and ERK1/2. These stimulatory effects on osteoclast function were attenuated in osteoclasts generated from GPR55 −/− macrophages and by the GPR55 antagonist cannabidiol (CBD). Furthermore, treatment of mice with this non-psychoactive constituent of cannabis significantly reduced bone resorption in vivo. Consistent with the ability of GPR55 to suppress osteoclast formation but stimulate osteoclast function, histomorphometric and microcomputed tomographic analysis of the long bones from male GPR55 −/− mice revealed increased numbers of morphologically inactive osteoclasts but a significant increase in the volume and thickness of trabecular bone and the presence of unresorbed cartilage. These data reveal a role of GPR55 in bone physiology by regulating osteoclast number and function. In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo.
Related Organisations
Yale University School Of Medicine
Location: United States of America
Related Funding Activities
No related grants have been discovered for Ken Mackie.