ORCID Profile
0000-0003-1411-3156
Current Organisation
Simon Fraser University
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Publisher: American Chemical Society (ACS)
Date: 11-02-2006
DOI: 10.1021/JP056131+
Abstract: Carboxylic acid-terminated monolayers on crystalline silicon surfaces can be readily modified with biological macromolecules for the fabrication of semiconductor-based biosensing devices. They were prepared by acid-catalyzed hydrolysis of alkoxycarbonyl (ester)-terminated monolayers and studied by vibrational sum frequency generation (SFG) spectroscopy. The C-H vibration region of the SFG spectra consists of strong methyl bands with significant contributions from methylene stretching modes, indicating that these monolayers are generally ordered but with considerable gauche defects in the alkyl chains in comparison with n-alkyl monolayers. After hydrolysis, the methylene stretching modes prevail, with "residues" of the methyl bands, indicating incomplete hydrolysis and disruption of the monolayer structure. This work demonstrates that SFG is capable of providing quantitative information on structure-reactivity correlations in organic monolayers.
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B600451M
Publisher: American Chemical Society (ACS)
Date: 06-2008
DOI: 10.1021/JA801023R
Abstract: Nucleic acids possess charged phosphate groups in their backbones, which require counterions to reduce the repulsive Coulombic interactions between the strands. Herein we report how different mono- and alent metal cations influence the molecular orientations of DNA molecules on silicon surfaces upon immobilization and hybridization. Our sum frequency generation (SFG) spectroscopy studies demonstrated that the degree of conformational variation of DNA self-assembled monolayers on silicon depends on the type of metal cations present. The molecular orientation change of immobilized single-stranded oligonucleotides correlates with DNA-cation affinity (Mg(2+) > Ca(2+) > K(+) approximately Na(+)): metal cations with the strongest affinity disrupt the structure of the underlying linker monolayer the most. Upon hybridization the trend is reversed, which is attributed to the greater ability of alent cations to mask the negative charges on the DNA backbone. These findings provide useful information for the construction of more sensitive DNA biosensors, particularly the optimization of on-chip hybridization performance.
Publisher: American Chemical Society (ACS)
Date: 22-07-2000
DOI: 10.1021/LA000054M
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CP52771A
Abstract: Plasmonic heating to trigger release of oligonucleotides from nanoconjugates is potentially useful for therapeutic purposes and designed assembly of DNA nanostructures. In the past, great controllability has been achieved by introducing distinctive absorption nanoparticle centers, where the anchoring bond (e.g., sulfur-gold bond) has been selectively broken. Instead of releasing the surface-bound duplex DNA via breakage of the gold-sulphur anchor bond, selective and non-destructive dehybridization of DNA under a "mild" condition on different gold nanoconjugates is demonstrated in this work. This finding will permit sequential dehybridization/release of DNA at specific regions of a complex system thus it can be extended to control gene expression and to manipulate an assembly of highly organized DNA constructs. Particularly we show herein the feasibility of selectively dehybridizing DNA-Au nanoconjugates via localized plasmonic heating, which is accomplished by controlling the laser wavelength, power, and irradiation time.
Publisher: American Chemical Society (ACS)
Date: 16-11-2009
DOI: 10.1021/JP906607S
Publisher: American Chemical Society (ACS)
Date: 17-11-2009
DOI: 10.1021/JP9062675
Location: United States of America
No related grants have been discovered for Hua-Zhong Hogan Yu (于化忠).