ORCID Profile
0000-0002-5595-7243
Current Organisation
SIB Swiss Institute of Bioinformatics
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Publisher: F1000 Research Ltd
Date: 07-11-2022
DOI: 10.12688/F1000RESEARCH.126734.1
Abstract: In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community believes that the infrastructure aspects of systems biology - databases, (modelling) tools and standards development, as well as training and access to cloud infrastructure - are not only appropriate components of the ELIXIR infrastructure, but will prove key components of ELIXIR’s future support of advanced biological applications and personalised medicine. By way of a series of meetings, the Community identified seven key areas for its future activities, reflecting both future needs and previous and current activities within ELIXIR Platforms and Communities. These are: overcoming barriers to the wider uptake of systems biology linking new and existing data to systems biology models interoperability of systems biology resources further development and embedding of systems medicine provisioning of modelling as a service building and coordinating capacity building and training resources and supporting industrial embedding of systems biology. A set of objectives for the Community has been identified under four main headline areas: Standardisation and Interoperability, Technology, Capacity Building and Training, and Industrial Embedding. These are grouped into short-term (3-year), mid-term (6-year) and long-term (10-year) objectives.
Publisher: American Geophysical Union (AGU)
Date: 18-01-2019
DOI: 10.1029/2018GL080410
Publisher: American Geophysical Union (AGU)
Date: 07-2021
DOI: 10.1029/2020EF001833
Abstract: The NARCliM project contributes to the CORDEX initiative for Australasia. The first generation of NARCliM (N1.0) used CMIP3 global climate models (GCMs) and provided near and far future estimates of climate change across Australasia at 50‐km and southeast Australia at 10‐km resolution under a business‐as‐usual climate scenario. However, multiple sets of 20‐year periods in N1.0 did not permit analysis of long‐term, inter‐annual to decadal trends across the 21st century. Feedback on user needs for regional climate information revealed the desire for multiple emission scenarios and use of newer CMIP5 GCMs for dynamical downscaling. These limitations led to development of the second iteration of NARCliM, namely NARCliM1.5 (N1.5). The N1.5 downscaling exercise uses CMIP5 GCMs and is temporally expanded to cover 150 years (1950–2100) for two future Representative Concentration Pathways (RCP4.5 and RCP8.5). N1.5 simulations remain at the 50‐km and 10 km resolutions over the same domains as N1.0, thus producing an expanded and complementary data set for regional climate change. N1.5 simulations substantially improve over N1.0 in capturing the seasonal patterns and magnitudes of precipitation, including improvements in overall bias. Conversely, N1.5 shows similar results to N1.0 for maximum and minimum temperature, with no substantial improvement in overall bias. N1.5 projections project a hotter and drier future relative to N1.0. The combined N1.0 and N1.5 ensemble provides a wider spread of future climates more representative of that found in the full CMIP5 ensemble. Together, N1.0 and N1.5 ensembles provide an improved, more comprehensive data set for studying climate change.
Publisher: Elsevier BV
Date: 03-2018
No related grants have been discovered for Stephanie Downes.