ORCID Profile
0000-0003-1124-2729
Current Organisation
Region Östergötland
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Publisher: The American Association of Immunologists
Date: 06-2011
Abstract: Parasite burden predicts disease severity in malaria and risk of death in cerebral malaria patients. In murine experimental cerebral malaria (ECM), parasite burden and CD8+ T cells promote disease by mechanisms that are not fully understood. We found that the majority of brain-recruited CD8+ T cells expressed granzyme B (GzmB). Furthermore, gzmB−/− mice harbored reduced parasite numbers in the brain as a consequence of enhanced antiparasitic CD4+ T cell responses and were protected from ECM. We showed in these ECM-resistant mice that adoptively transferred, Ag-specific CD8+ T cells migrated to the brain, but did not induce ECM until a critical Ag threshold was reached. ECM induction was exquisitely dependent on Ag-specific CD8+ T cell-derived perforin and GzmB, but not IFN-γ. In wild-type mice, full activation of brain-recruited CD8+ T cells also depended on a critical number of parasites in this tissue, which in turn, was sustained by these tissue-recruited cells. Thus, an interdependent relationship between parasite burden and CD8+ T cells dictates the onset of perforin/GzmB-mediated ECM.
Publisher: American Society for Microbiology
Date: 11-01-2018
Abstract: Saccharomycopsis fermentans is an ascomycetous necrotrophic fungal pathogen that penetrates and kills fungal prey cells via targeted penetration pegs. Here, we report the draft genome sequence and scaffold assembly of this mycoparasite.
Publisher: American Society for Microbiology
Date: 16-11-2017
Abstract: Saccharomycopsis fodiens is an ascomycetous necrotrophic mycoparasite. Predator-prey interaction leads to killing of the host cell by a penetration peg and utilization of cell content by the predator. Here, we report the 14.9-Mb S. fodiens draft genome sequence assembled into 9 large scaffolds and 13 minor scaffolds ( kb).
Publisher: Springer Science and Business Media LLC
Date: 27-03-2013
DOI: 10.1038/NCOMMS2612
Publisher: Springer Science and Business Media LLC
Date: 26-04-2017
Publisher: Public Library of Science (PLoS)
Date: 09-05-2019
Publisher: Springer Science and Business Media LLC
Date: 08-10-2018
DOI: 10.1038/S41598-018-33199-Z
Abstract: Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Klara Junker.