ORCID Profile
0000-0002-3873-956X
Current Organisation
Northumbria University
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Publisher: Elsevier BV
Date: 04-2022
DOI: 10.1016/J.SPINEE.2021.11.007
Abstract: Prolonged bedrest induces accumulation of intramuscular lipid concentration (ILC) in the lumbar musculature however, spatial distribution of ILC has not been determined. Artificial gravity (AG) mitigates some adaptations induced by 60 day bedrest by creating a head-to-feet force while participants are in a supine position. To quantify the spatial distribution of accumulation of ILC in the lumbar musculature after 60 day bedrest, and whether this can be mitigated by AG exposure. Prospective longitudinal study. Twenty-four healthy in iduals (8 females) participated in the study: Eight received 30 min continuous AG (cAG) Eight received 6 × 5 min AG (iAG), interspersed with rests Eight were not exposed to AG (CRTL). From 3T magnetic resonance imaging (MRI), axial images were selected to assess lumbar multifidus (LM), lumbar erector spinae (LES), quadratus lumborum (QL), and psoas major (PM) muscles from L1/L2 to L5/S1 intervertebral disc levels. Chemical shift-based 2-echo lipid and/or water Dixon sequence was used to measure tissue composition. Each lumbar muscle was segmented into four equal quartiles (from medial to lateral). Participants arrived at the facility for the baseline data collection before undergoing a 60 day strict 6° head-down tilt (HDT) bedrest period. MRI of the lumbopelvic region was conducted at baseline and Day-59 of bedrest. Participants performed all activities, including hygiene, in 6° HDT and were discouraged from moving excessively or unnecessarily. At the L4/L5 and L5/S1 intervertebral disc levels, 60-day bedrest induced a greater increase in ILC in medial and lateral regions (∼+4%) of the LM than central regions (∼+2% p<.05). A smaller increase in ILC was induced in the lateral region of LES (∼+1%) at L1/L2 and L2/L3 than at the centro-medial region (∼+2% p<.05). There was no difference between CRTL and intervention groups. Inhomogeneous spatial distribution of accumulation of ILC was found in the lumbar musculature after 60 day bedrest. These findings might reflect pathophysiological mechanisms related to muscle disuse and contribute to localized lumbar spine dysfunction. Altered spatial distribution of ILC may impair lumbar spine function after prolonged body unloading, which could increase injury risk to vulnerable soft tissues, such as the lumbar intervertebral discs. These novel results may represent a new biomarker of lumbar deconditioning for astronauts, bedridden, sedentary in iduals, or those with chronic back pain. Changes are potentially modifiable but not by the AG protocols tested here.
Publisher: American Physiological Society
Date: 04-2020
DOI: 10.1152/JAPPLPHYSIOL.00756.2019
Abstract: This study presents for the first time novel insights into the adaptations to hypogravity of spinal curvatures, trunk stiffness, and paraspinal muscle activity. We showed that exposure to hypogravity reduces the displacement of the trunk by an applied perturbation, partially compensated by weaker stabilizing contributions of the paraspinal muscles and concomitant increase in abdominal muscle responses. These findings may have relevance for future recommendations for planetary surface explorations.
Publisher: American Physiological Society
Date: 07-2021
DOI: 10.1152/JAPPLPHYSIOL.00990.2020
Abstract: This study presents novel insights into the morphological adaptations occurring in the lumbar spine after 60-day head-down bed rest and the potential role of artificial gravity (AG) to mitigate them. Results demonstrated no protective effect of AG protocols used in this study. In atrophied paraspinal muscles, the ratio of lipids versus intramuscular water increased in the postural lumbar muscles, which could impair muscle function during upright standing. These findings have relevance for future space explorations.
Publisher: American Physiological Society
Date: 08-2021
DOI: 10.1152/JAPPLPHYSIOL.00180.2021
Abstract: This study presents novel insights into the effect of artificial gravity (AG) on the deterioration of standing balance and anticipatory postural adjustments (APAs) of trunk muscles induced by 60-day strict head-down bed rest. The results indicated severe balance dysfunction and delayed APAs during rapid arm movement. AG partially mitigated the deterioration in standing balance and may thus be considered as a potential countermeasure for future planetary surface explorations. Optimization of AG protocols might enhance effects.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Frontiers Media SA
Date: 11-11-2021
DOI: 10.3389/FPHYS.2021.745811
Abstract: Exposure to spaceflight and head-down tilt (HDT) bed rest leads to decreases in the mass of the gluteal muscle. Preliminary results have suggested that interventions, such as artificial gravity (AG), can partially mitigate some of the physiological adaptations induced by HDT bed rest. However, its effect on the gluteal muscles is currently unknown. This study investigated the effects of daily AG on the gluteal muscles during 60-day HDT bed rest. Twenty-four healthy in iduals participated in the study: eight received 30 min of continuous AG eight received 6 × 5 min of AG, interspersed with rest periods eight belonged to a control group. T1-weighted Dixon magnetic resonance imaging of the hip region was conducted at baseline and day 59 of HDT bed rest to establish changes in volumes and intramuscular lipid concentration (ILC). Results showed that, across groups, muscle volumes decreased by 9.2% for gluteus maximus (GMAX), 8.0% for gluteus medius (GMED), and 10.5% for gluteus minimus after 59-day HDT bed rest (all p & 0.005). The ILC increased by 1.3% for GMAX and 0.5% for GMED (both p & 0.05). Neither of the AG protocols mitigated deconditioning of the gluteal muscles. Whereas all gluteal muscles atrophied, the ratio of lipids to intramuscular water increased only in GMAX and GMED muscles. These changes could impair the function of the hip joint and increased the risk of falls. The deconditioning of the gluteal muscles in space may negatively impact the hip joint stability of astronauts when reexpose to terrestrial gravity.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Kirsty Lindsay.