ORCID Profile
0000-0002-6281-489X
Current Organisation
Washington University in Saint Louis School of Medicine
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Publisher: Oxford University Press (OUP)
Date: 05-02-2013
DOI: 10.1093/JNCI/DJS635
Publisher: Oxford University Press (OUP)
Date: 04-2015
DOI: 10.1093/IJE/DYV059
Publisher: Elsevier BV
Date: 03-2014
Publisher: Public Library of Science (PLoS)
Date: 08-07-2014
Publisher: Springer Science and Business Media LLC
Date: 23-11-2022
DOI: 10.1007/S10549-022-06792-0
Abstract: Circadian rhythm disruptors (e.g., night-shift work) are risk factors for breast cancer, however studies on their association with prognosis is limited. A small but growing body of research suggests that altered sleep patterns and eating behaviours are potential mechanistic links between circadian rhythm disruptors and breast cancer. We therefore systematically summarised literature examining the influence of circadian rhythm disrupting behaviours on cancer outcomes in women with breast cancer. A systematic search of five databases from inception to January 2021 was conducted. Original research published in English, assessing the relationship between post-diagnosis sleep patters and eating behaviours, and breast cancer outcomes were considered. Risk of bias was assessed using the Newcastle–Ottawa Assessment Scale for Cohort Studies. Eight studies published original evidence addressing sleep duration and/or quality ( k = 7) and, eating time and frequency ( k = 1). Longer sleep duration (≥ 9 h versus [referent range] 6-8 h) was consistently associated with increased risk of all outcomes of interest (HR range: 1.37–2.33). There was limited evidence to suggest that measures of better sleep quality are associated with lower risk of all-cause mortality (HR range: 0.29-0.97). Shorter nightly fasting duration ( 13 h versus ≥ 13 h) was associated with higher risk of all breast cancer outcomes (HR range: 1.21–1.36). Our review suggests that circadian rhythm disrupting behaviours may influence cancer outcomes in women with breast cancer. While causality remains unclear, to further understand these associations future research directions have been identified. Additional well-designed studies, examining other exposures (e.g., light exposure, temporal eating patterns), biomarkers, and patient-reported outcomes, in erse populations (e.g., breast cancer subtype-specific, socio-demographic ersity) are warranted.
Publisher: Springer Science and Business Media LLC
Date: 02-08-2020
Publisher: American Association for Cancer Research (AACR)
Date: 12-04-2018
DOI: 10.1158/0008-5472.CAN-17-3043
Abstract: In contrast to the convincing evidence that obesity (measured by body mass index, BMI) increases the risk of many different types of cancer, there is an ambiguity in the role of obesity in survival among cancer patients. Some studies suggested that higher BMI decreased mortality risk in cancer patients, a phenomenon called the obesity paradox. The spurious positive association between BMI and cancer survival is likely to be explained by several methodologic limitations including confounding, reverse causation, and collider stratification bias. Also, the inadequacy of BMI as a measure of body fatness in cancer patients commonly experiencing changes in body weight and body composition may have resulted in the paradox. Other factors contributing to the ergent results in literature are significant heterogeneity in study design and method (e.g., study population, follow-up length) time of BMI assessment (pre-, peri-, or post-diagnosis) and lack of consideration for variability in the strength and directions of associations by age, sex, race/ethnicity, and cancer subtype. Robust but practical methods to accurately assess body fatness and body compositions and weight trajectories in cancer survivors are needed to advance this emerging field and to develop weight guidelines to improve both the length and the quality of cancer survival. Cancer Res 78(8) 1898–903. ©2018 AACR.
Publisher: Elsevier BV
Date: 10-2021
DOI: 10.1093/JN/NXAB241
Abstract: Although fruit and vegetable intake during adolescence, a potentially sensitive time period for prostate cancer (PCa) development, has been proposed to protect against PCa risk, few studies have investigated the role of adolescent plant product intake in PCa development. Intake of various vegetables, fruit, and grains by males at ages 12-13 y was examined in relation to later PCa risk and mortality in the NIH-AARP Diet and Health Study. Cox proportional hazards regression was used to calculate HRs and 95% CIs of nonadvanced (n = 14,238) and advanced (n = 2,170) PCa incidence and PCa mortality (n = 760) during 1,729,896 person-years of follow-up. None of the plant products examined were associated consistently with all PCa outcomes. However, greater adolescent intakes of tomatoes (P-trend = 0.004) and nonstarch vegetables (P-trend = 0.025) were associated with reduced risk of nonadvanced PCa, and greater intakes of broccoli (P-trend = 0.050) and fruit juice (P-trend = 0.019-0.025) were associated with reduced risk of advanced PCa and/or PCa mortality. Positive trends were also observed for greater intakes of fruit juice (P-trend = 0.002), total fruit (P-trend = 0.014), and dark bread (P-trend = 0.035) with nonadvanced PCa risk and for greater intakes of legumes (P-trend < 0.001), fiber (P-trend = 0.001), and vegetable protein (P-trend = 0.013-0.040) with advanced PCa risk or PCa mortality. Our findings do not provide strong evidence to suggest that adolescent plant product intake is associated with reduced PCa risk.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 08-2019
Publisher: Springer Science and Business Media LLC
Date: 16-10-2019
DOI: 10.1186/S13058-019-1190-4
Abstract: The benefits of chemotherapy in node-negative, hormone receptor-positive, and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients with the 21-gene recurrence score (RS) of 18–30, particularly those with RS 26–30, are not known. Using the Surveillance, Epidemiology, and End Results (SEER) data, we retrospectively identified 29,137 breast cancer patients with the 21-gene RS of 18–30 diagnosed between 2004 and 2015. Mortality risks according to the RS and chemotherapy use were compared by the Kaplan-Meier method and Cox’s proportional hazards model. Among the breast cancer patients with the RS 18–30, 21% of them had RS 26–30. Compared to breast cancer patients with RS 18–25, patients with RS 26–30 had more aggressive tumor characteristics and chemotherapy use and increased risk of breast cancer-specific mortality and overall mortality. In breast cancer patients who were aged ≤ 70 years and had RS of 26–30, chemotherapy administration was associated with a 32% lower risk of breast cancer-specific mortality (hazard ratio [HR], 0.68 95% confidence interval [CI], 0.47–0.99) and a 42% lower risk of overall mortality (HR, 0.58 95% CI, 0.44–0.76). Survival benefits were most pronounced in breast cancer patients who were younger or had grade III tumor. The 21-gene RS of 18–30 showed heterogeneous outcomes, and the RS 26–30 was a significant prognostic factor for an increased risk of mortality. Adjuvant chemotherapy could improve the survival of node-negative, hormone receptor-positive, and HER2-negative breast cancer patients with the 21-gene RS 26–30 and should be considered for patients, especially younger patients or patients with high-grade tumors.
Publisher: Springer Science and Business Media LLC
Date: 14-08-2018
Publisher: American Association for Cancer Research (AACR)
Date: 12-04-2018
Publisher: Wiley
Date: 25-02-2020
DOI: 10.1002/CNCR.32798
Abstract: Advanced glycation end products (AGEs) are reactive metabolites produced as a by‐product of sugar metabolism and are consumed through the diet in high‐fat and highly processed foods. They are associated with chronic inflammatory diseases, and evidence suggests that they play a role in carcinogenesis. The authors evaluated the association of dietary AGE intake and the risk of postmenopausal invasive breast cancer. This was a prospective cohort study of 183,548 postmenopausal women in the National Institutes of Health‐AARP Diet and Health Study. The main outcome was incident invasive breast cancer. AGE intake was estimated from food‐frequency questionnaires. Incident breast cancer cases were identified through state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals for developing breast cancer according to AGE intake quintiles. Multivariable regression models were adjusted for breast cancer risk factors. The mean follow‐up was 12.8 years, and 9851 breast cancers (1978 advanced stage) were identified. The median AGE daily intake was 5932 kilo units per 100 kilocalories (KU/1000 kcal). Women with higher intake tended to have lower education levels, higher body mass index, less physical activity, were current smokers, and had higher fat and meat intake. The highest quintile of AGE intake (compared with the lowest) was associated with an increased risk of breast cancer (HR, 1.09 95% CI, 1.02‐1.16 P = .03) after adjusting for breast cancer risk factors and particularly was associated with 37% of advanced‐stage tumors (HR, 1.37 95% CI, 1.09‐1.74 P .02) after adjusting for risk factors and fat and meat intake. Dietary AGEs may play a role in the development of postmenopausal breast cancer.
Publisher: American Medical Association (AMA)
Date: 23-04-2019
Publisher: Wiley
Date: 23-05-2014
DOI: 10.1111/BJH.12935
Publisher: BMJ
Date: 28-02-2017
DOI: 10.1136/BMJ.J908
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 03-2012
Publisher: Springer Science and Business Media LLC
Date: 31-10-2022
DOI: 10.1038/S41416-022-02035-7
Abstract: Although adolescent diet has been proposed to contribute to prostate cancer (PCa) development, no studies have investigated the relation between adolescent dietary patterns and PCa risk or mortality. Using data from 164,079 men in the NIH-AARP Diet and Health Study, we performed factor analysis to identify dietary patterns at ages 12-13 years and then used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of total (n = 17,861), non-advanced (n = 15,499), advanced (n = 2362), and fatal PCa (n = 832). Although not entirely consistent across analyses, a higher adolescent plant-based pattern (characterised by vegetables, fruits, and dark bread) score was associated with slightly reduced risks of total (fully adjusted HR We found evidence to support a modest, protective role for a plant-based dietary pattern during adolescence on PCa risk. If confirmed in future studies, our findings may help to inform the development of new, primary prevention strategies for PCa.
Publisher: Massachusetts Medical Society
Date: 02-12-2010
Publisher: American Association for Cancer Research (AACR)
Date: 03-2013
DOI: 10.1158/1055-9965.EPI-12-1183-T
Abstract: Background: Approximately half of epithelial ovarian cancers are fatal within 3 years however, roughly 35% of women survive for at least 10 years. In the Nurses' Health Study, New England Case-Control Study, Australian Ovarian Cancer Study, and NIH-AARP Diet and Health Study, we investigated potential differences in the associations with ovarian cancer risk factors by tumor aggressiveness, defined on the basis of time from diagnosis until death. Methods: We calculated relative risks (RR) and 95% confidence intervals (CI) for associations of known or suspected ovarian cancer risk factors with rapidly fatal (death within 3 years of diagnosis) and less aggressive tumors (all others) using Cox proportional hazards competing risks analysis (NHS and AARP) or polytomous logistic regression (NECC, AOCS). Results were combined using random effects meta-analysis. Results: Increasing age was associated with greater risk of rapidly fatal versus less aggressive disease (RR, 5-year increase: 1.39 95% CI, 1.29–1.49 vs. RR, 1.09 95% CI, 1.03–1.16, respectively Pdiff & 0.0001). Oral contraceptive use was associated with a greater decreased risk of rapidly fatal (RR, 5-year increase: 0.69 95% CI, 0.58–0.82) versus less aggressive disease (RR, 0.81 95% CI, 0.74–0.89 Pdiff, 0.002). Conversely, increasing parity was associated only with less aggressive disease (RR per child, 0.87 95% CI, 0.81–0.93). Conclusion: In this analysis of 4,342 cases, there were clear differences in risk factors for rapidly fatal versus less aggressive ovarian tumors. Impact: Differences in risk factor associations by tumor aggressiveness suggests the developmental pathways through which the tumors develop and may be important for developing primary preventive strategies for the most aggressive cancers. Cancer Epidemiol Biomarkers Prev 22(3) 429–36. ©2013 AACR.
Publisher: Oxford University Press (OUP)
Date: 05-04-2021
DOI: 10.1093/JNCI/DJAB054
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2017
Location: United States of America
No related grants have been discovered for Yikyung Park.