ORCID Profile
0000-0002-8542-3760
Current Organisation
SRM Institute of Science and Technology
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Publisher: Japan Atherosclerosis Society
Date: 2016
DOI: 10.5551/JAT.35949
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 09-2022
Publisher: Bentham Science Publishers Ltd.
Date: 31-12-2021
DOI: 10.2174/1871530321666210421125231
Abstract: Cancer, a set of diseases characterized by abnormal cell growth resulting from alteration in the expression pattern of erse genes, is one of the prominent causes of mortality and morbidity worldwide. This modification of various genes leads to altered signalling cascades and changes in the molecular network. These changes eventually give rise to cellular dysfunction and then to systemic failure causing death. Of the several pathways that are aberrantly activated in cancer, Notch signalling pathway is a prominent one. Notch signalling pathway is a juxtracrine signalling pathway which activates the genes associated with cell proliferation, survival and angiogenesis. Notch signalling pathway components are seen to be upregulated in several types of cancer. Oral squamous cell carcinoma (OSCC) is a predominant category of oral cancer where aberrant activation of Notch signalling causes tumour progression and metastasis. In this review, we discuss the Notch signalling pathway, its components, forms and its role in the progression and metastasis of oral squamous cell carcinoma.
Publisher: Springer Science and Business Media LLC
Date: 02-10-2018
Publisher: Springer International Publishing
Date: 2021
Abstract: Stem cells have emerged as a promising source of cell-based therapy in regenerative medicine with several stem cell-based products currently in clinical trials. Despite the immense therapeutic potential, their isolation from some of the emerging sources and their characterization has been naïve owing to the lack of standard markers for the same. Some biomarkers have now been well established for the isolation and characterization of stem cells. However, there are emerging markers that can be used in addition to these conventional markers or independent of them to establish the identity of the stem cells. In this review, an attempt has been made to describe a few conventionally used markers and emerging markers for the identification, isolation and characterization of stem cells from various niches across the three germ layer origins.
Publisher: Public Library of Science (PLoS)
Date: 08-02-2019
Publisher: Wiley
Date: 15-05-2023
DOI: 10.1111/JCMM.17755
Abstract: This short communication will enlighten the readers about the exosome and the epithelial‐mesenchymal transition (EMT) related to several complicated events. It also highlighted the therapeutic potential of exosomes against EMT. Exosome toxicology, exosome heterogeneity, and a single exosome profiling approach are also covered in this article. In the future, exosomes could help us get closer to cancer vaccine and precision oncology.
Publisher: Springer Science and Business Media LLC
Date: 11-03-2021
DOI: 10.1007/S13402-021-00591-3
Abstract: Oral squamous cell carcinoma (OSCC) is a malignant oral cavity neoplasm that affects many people, especially in developing countries. Despite several advances that have been made in diagnosis and treatment, the morbidity and mortality rates due to OSCC remain high. Accumulating evidence indicates that aberrant activation of cellular signaling pathways, such as the Notch, Wnt and Hedgehog pathways, occurs during the development and metastasis of OSCC. In this review, we have articulated the roles of the Notch, Wnt and Hedgehog signaling pathways in OSCC and their crosstalk during tumor development and progression. We have also examined possible interactions and associations between these pathways and treatment regimens that could be employed to effectively tackle OSCC and/or prevent its recurrence. Activation of the Notch signaling pathway upregulates the expression of several genes, including c-Myc, β-catenin, NF-κB and Shh. Associations between the Notch signaling pathway and other pathways have been shown to enhance OSCC tumor aggressiveness. Crosstalk between these pathways supports the maintenance of cancer stem cells (CSCs) and regulates OSCC cell motility. Thus, application of compounds that block these pathways may be a valid strategy to treat OSCC. Such compounds have already been employed in other types of cancer and could be repurposed for OSCC.
Publisher: Informa UK Limited
Date: 29-06-2023
Publisher: Wiley
Date: 29-06-2023
DOI: 10.1002/CTD2.218
Abstract: Exosome is nanosized tiny membrane‐bound vesicles and is a subpopulation of extracellular vesicles (EVs). In general, it participates in intercellular communication and acts as a messenger of several pathological complications. Exosome and cancer interlink is the most exciting domain of current cancer research. The internal molecular cargos (proteins, lipids, metabolites, miRNA, and DNA) of tumor derived exosomes (TEXs) are capable of transforming normal cells into tumor phenotypes. Exosome DNA is the less explored area of EVs research. It is involved in several events in cancer progression such as uncontrol cell growth, reprogramming of immune cells, metastasis, and therapeutic resistance. Exo‐DNA is also involved in epigenetic alteration, which promotes cancer. It has a great impact on cancer theranostics (biomarker and therapeutics) research. Exo‐DNA‐based cancer examination supports more detailed cancer research.
Publisher: Springer Science and Business Media LLC
Date: 18-06-2018
Publisher: Wiley
Date: 26-05-2023
DOI: 10.1002/CTD2.208
Abstract: Extracellular vesicles (EVs) are an innovative orientation of next‐generation cancer medicine. In EVs, the exosome is the most exciting domain associated with cancer research current decade.Exosomes have both cancer progression related and cancer healing capabilities depending on the source. It develops a new platform for cancer personalized and precision medicine visionary project to come to reality.
Publisher: Elsevier BV
Date: 11-2018
Publisher: Wiley
Date: 06-2023
DOI: 10.1002/CTM2.1288
Publisher: ResearchersLinks Ltd
Date: 05-2017
No related grants have been discovered for DEVI ARIKKETH.