ORCID Profile
0000-0002-2470-1077
Current Organisation
Hong Kong University of Science and Technology
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Catalysis and Mechanisms of Reactions | Organic Chemical Synthesis | Quantum Chemistry | Theoretical and Computational Chemistry
Publisher: American Chemical Society (ACS)
Date: 23-03-2022
Abstract: Microviscosity is a fundamental parameter in the biophysics of life science and governs numerous cellular processes. Thus, the development of real-time quantitative monitoring of microviscosity inside cells is important. The traditional probes for detecting microviscosity via time-resolved luminescence imaging (TRLI) are generally disturbed by autofluorescence or surrounding oxygen in cells. Herein, we developed loose packing nanoaggregates with aggregation-induced delayed fluorescence (FKP-POA and FKP-PTA) and free from the effect of oxygen and autofluorescence for viscosity mapping via TRLI. The feasibility of FKP-PTA nanoparticles (NPs) for microviscosity mapping through TRLI was demonstrated by monitoring the variation of microviscosity inside HepG2 cancer cells, which demonstrated a value change from 14.9 cP to 216.9 cP during the apoptosis. This indicates that FKP-PTA NP can be used as a probe for cellular microviscosity mapping to help people to understand the physiologically dynamic microenvironment. The present results are expected to promote the advancement of diagnostic and therapeutic methods to cope with related diseases.
Publisher: American Chemical Society (ACS)
Date: 05-09-2023
Publisher: American Chemical Society (ACS)
Date: 17-04-2023
Publisher: American Chemical Society (ACS)
Date: 10-08-2022
DOI: 10.1021/JACS.2C07443
Abstract: Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II dyes suffer from the emission quenching effect and extremely low quantum yields (QYs) in the practical usage forms. The AIE strategy has been successfully utilized to develop NIR-II dyes with donor-acceptor (D-A) structures with acceptable QYs in the aggregate state, but there is still large room for QY improvement. Here, we rationally designed a NIR-II emissive dye named TPE-BBT and its derivative (TPEO-BBT) by changing the electron-donating triphenylamine unit to tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative QYs of 31.5% and 23.9% in water, respectively. By using an integrating sphere, the absolute QY of TPE-BBT nanoparticles was measured to be 1.8% in water. Its crystals showed an absolute QY of 10.4%, which is the highest value among organic small molecules reported so far. The optimized D-A interaction and the higher rigidity of TPE-BBT in the aggregate state are believed to be the two key factors for its ultrahigh QY. Finally, we utilized TPE-BBT for NIR-II photoluminescence (PL) and chemiluminescence (CL) bioimaging through successive CL resonance energy transfer and Förster resonance energy transfer processes. The ultrahigh QY of TPE-BBT realized an excellent PL imaging quality in mouse blood vessels and an excellent CL imaging quality in the local arthrosis inflammation in mice with a high signal-to-background ratio of 130. Thus, the design strategy presented here brings new possibilities for the development of bright NIR-II dyes and NIR-II bioimaging technologies.
Publisher: American Chemical Society (ACS)
Date: 20-09-2023
Publisher: American Chemical Society (ACS)
Date: 13-09-2022
Abstract: Microalgae-based biofuels are receiving attention at the environmental, economic, and social levels because they are clean, renewable, and quickly produced. The green algae
Publisher: Springer Science and Business Media LLC
Date: 24-06-2023
DOI: 10.1038/S41467-023-39479-1
Abstract: Proximity effect, which refers to the low-lying ( n ,π*) and (π,π*) states with close energy levels, usually plays a negative role in the luminescent behaviors of heterocyclic luminogens. However, no systematic study attempts to reveal and manipulate proximity effect on luminescent properties. Here, we report a series of methylquinoxaline derivatives with different electron-donating groups, which show different photophysical properties and aggregation-induced emission behaviors. Experimental results and theoretical calculation reveal the gradually changed energy levels and different coupling effects of the closely related ( n ,π*) and (π,π*) states, which intrinsically regulate proximity effect and aggregation-induced emission behaviors of these luminogens. With the intrinsic nature of heterocycle-containing compounds, they are utilized for sensors and information encryption with dynamic responses to acid/base stimuli. This work reveals both positive and negative impacts of proximity effect in heterocyclic aggregation-induced emission systems and provides a perspective to develop functional and responsive luminogens with aggregation-induced emission properties.
Publisher: American Chemical Society (ACS)
Date: 09-10-2023
DOI: 10.1021/JACS.3C08627
Publisher: American Chemical Society (ACS)
Date: 08-08-2023
DOI: 10.1021/JACS.3C04027
Publisher: American Chemical Society (ACS)
Date: 03-11-2022
DOI: 10.1021/JACS.2C07657
Abstract: Liver sequestration, mainly resulting from the phagocytosis of mononuclear phagocyte system (MPS) cells, is a long-standing barrier in nanoparticle delivery, which severely decreases the disease-targeting ability, leads to nanotoxicity, and inhibits clinical translation. To avoid long-term liver sequestration, we elaborately designed luminescent gold-silver bimetallic nanoparticles that could be rapidly transformed by the hepatic sinusoidal microenvironment rich in glutathione and oxygen, significantly different from monometallic gold nanoparticles that were rapidly sequestrated by Kupffer cells due to the much slower biotransformation. We found that the rapid sinusoidal biotransformation induced by the synergistic reactions of glutathione and oxygen with the reactive silver atoms could help bimetallic nanoparticles to avoid MPS phagocytosis, promote fast release from the liver, prolong blood circulation, enhance renal clearance, and increase disease targeting. With the fast biotransformation in sinusoids, liver sequestration could be turned into a beneficial storage mechanism for nanomedicines to maximize targeting.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8AN00940F
Abstract: Two novel highly selective quinoline-based fluorescent probes with an aggregation induced emission (AIE) feature are used for rapid analysis of Cu 2+ in aqueous media and on paper strips with a fluorescence quenching mechanism.
Publisher: Springer Science and Business Media LLC
Date: 02-09-2023
Publisher: Wiley
Date: 05-03-2018
Publisher: American Chemical Society (ACS)
Date: 13-01-2022
DOI: 10.1021/ACS.INORGCHEM.1C02964
Abstract: This report details the synthesis and characterization of a small family of previously unreported, structurally related chromium, molybdenum, tungsten, manganese, and iron complexes bearing N-heterocyclic carbene and carbonyl supporting ligands. These complexes have the general form [ML(CO)
Publisher: American Chemical Society (ACS)
Date: 10-08-2023
Publisher: American Chemical Society (ACS)
Date: 24-02-2022
Publisher: Research Square Platform LLC
Date: 31-03-2023
DOI: 10.21203/RS.3.RS-2690391/V1
Abstract: We report the construction of covalent organic framework (COF-919) from planar and twisted AIEgens-based motifs as a pyroptosis and ferroptosis dual-inducer that can elicit strong inflammatory response for efficient antitumor immunity. Mechanistic studies revealed that, in contrast to traditional COFs constructed with solely planar or twisted motifs, COF-919 displays stronger near-infrared light absorption, lower band energy and longer lifetime to favor the reactive oxygen species (ROS) generation and photothermal conversion for trigger pyroptosis. Because of its outstanding ROS production capability, intracellular lipid peroxidation was also upregulated to lead to glutathione depletion, glutathione peroxidase 4 low expression, and the induction of ferroptosis. Moreover, COF-919 induced pyroptosis and ferroptosis can effectively reshape the tumor immune microenvironment (TME) via promote T cells infiltration and relieve immunosuppressed TME to boost a T-cell-mediated immune response, which is favorable for inhibiting tumor metastasis and recurrence, with 99% tumor growth inhibition and 80% cure rates.
Publisher: Wiley
Date: 05-05-2023
Abstract: Recent advancements in aggregation‐induced emission (AIE) macromolecular materials have brought their attention as potential antibacterial solutions, these materials offer new approaches to cure multidrug‐resistant infections and biofilms in bacterial infections as well as real‐time monitoring and specific targeting of bacteria. This review provides an overview of the three main categories of AIE macromolecular materials with antibacterial properties namely AIE‐active polymers, AIEgen@polymer complexes, and clusterization‐triggered emission (CTE) based polymers. The mechanisms and applications of these materials in antibacterial treatment, wound care, and protective equipment are also discussed. The potential for future developments and application directions of AIE‐based antimicrobial materials are finally highlighted.
Publisher: Wiley
Date: 05-03-2018
Abstract: Counterion-induced stereocontrol is a powerful tool in organic synthesis. However, such enantiocontrol on tetrahedral ammonium cations remains challenging. Described here is the first ex le of using chiral anion phase-transfer catalysis to achieve intermolecular ring-opening of azetidiniums with excellent enantioselectivity (up to 97 % ee). Precise control over the formation and reaction of the chiral ion pair as well as inhibition of the background reaction by the biphasic system is key to the success of the reaction.
Publisher: American Chemical Society (ACS)
Date: 30-10-2023
Start Date: 03-2021
End Date: 03-2025
Amount: $560,000.00
Funder: Australian Research Council
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