ORCID Profile
0000-0002-5730-5249
Current Organisations
Kyushu University
,
Akademia Wychowania Fizycznego i Sportu im Jedrzeja Sniadeckiego w Gdansku
,
Uniwersytet Szczecinski
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Publisher: American Geophysical Union (AGU)
Date: 19-10-2017
DOI: 10.1002/2017JD027113
Publisher: Elsevier BV
Date: 09-2013
DOI: 10.1016/J.JSAMS.2012.10.004
Abstract: To examine the association of the COL1A1 -1997G/T and +1245G/T polymorphisms, in idually and as haplotypes, with anterior cruciate ligament ruptures in professional soccer players. Subjects were 91 male professional soccer players with surgically diagnosed primary anterior cruciate ligament ruptures. The control group consisted of 143 apparently healthy male professional soccer players, who were without any self-reported history of ligament or tendon injury. Both subjects and healthy controls are from the same soccer teams, of the same ethnicity (Polish, East-Europeans for ≥3 generations), a similar age category, and had a comparable level of exposure to anterior cruciate ligament injury. Genomic DNA was extracted from the oral epithelial cells using GenElute Mammalian Genomic DNA Miniprep Kit (Sigma, Germany). All s les were genotyped using a Rotor-Gene real-time polymerase chain reaction. Genotype distributions for both polymorphisms met the Hardy-Weinberg expectations in both subjects and controls (p>0.05). Higher frequency of the COL1A1 G-T (-1997G/T and +1245G/T polymorphisms) haplotype was significantly associated with reduced risk for anterior cruciate ligament rupture (Hap.score -1.98, p=0.048). The TT genotype was under-represented in the anterior cruciate ligament rupture group. However, this result was not statistically significant (p=0.084 Fisher's exact test, recessive mode: TT vs GT+GG). Higher frequency of the COL1A1 G-T haplotype is associated with reduced risk of anterior cruciate ligament injury in a group of professional soccer players. Consequently, carrying two copies the COL1A1 G-T haplotype may be protective against anterior cruciate ligament injury.
Publisher: American Physiological Society
Date: 03-2016
DOI: 10.1152/PHYSIOLGENOMICS.00105.2015
Abstract: Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large s le sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14–17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium.
Publisher: American Meteorological Society
Date: 08-2015
DOI: 10.1175/BAMS-D-12-00227.1
Abstract: The collective representation within global models of aerosol, cloud, precipitation, and their radiative properties remains unsatisfactory. They constitute the largest source of uncertainty in predictions of climatic change and h er the ability of numerical weather prediction models to forecast high-impact weather events. The joint European Space Agency (ESA)–Japan Aerospace Exploration Agency (JAXA) Earth Clouds, Aerosol and Radiation Explorer (EarthCARE) satellite mission, scheduled for launch in 2018, will help to resolve these weaknesses by providing global profiles of cloud, aerosol, precipitation, and associated radiative properties inferred from a combination of measurements made by its collocated active and passive sensors. EarthCARE will improve our understanding of cloud and aerosol processes by extending the invaluable dataset acquired by the A-Train satellites CloudSat, Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO), and Aqua. Specifically, EarthCARE’s cloud profiling radar, with 7 dB more sensitivity than CloudSat, will detect more thin clouds and its Doppler capability will provide novel information on convection, precipitating ice particle, and raindrop fall speeds. EarthCARE’s 355-nm high-spectral-resolution lidar will measure directly and accurately cloud and aerosol extinction and optical depth. Combining this with backscatter and polarization information should lead to an unprecedented ability to identify aerosol type. The multispectral imager will provide a context for, and the ability to construct, the cloud and aerosol distribution in 3D domains around the narrow 2D retrieved cross section. The consistency of the retrievals will be assessed to within a target of ±10 W m–2 on the (10 km)2 scale by comparing the multiview broadband radiometer observations to the top-of-atmosphere fluxes estimated by 3D radiative transfer models acting on retrieved 3D domains.
Publisher: Springer Science and Business Media LLC
Date: 03-01-2018
Publisher: Elsevier BV
Date: 2014
DOI: 10.1016/J.JSAMS.2013.02.005
Abstract: To determine the association between the α-actinin-3 (ACTN3) R577X polymorphism and elite team-sport athletic status in three cohorts of European team-sport athletes. We compared the genotype and allele frequencies of the ACTN3 R577X (rs1815739) polymorphisms between team-sport athletes (n=205), endurance athletes (n=305), sprint ower athletes (n=378), and non-athletic controls (n=568) from Poland, Russia and Spain all participants were unrelated European men. Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. Genotyping was performed using several methods, and the results were replicated following recent recommendations for genotype-phenotype association studies. Genotype distributions of all control and athletic groups met Hardy-Weinberg equilibrium (all p>0.05). Team-sport athletes were less likely to have the 577RR genotype compared to the 577XX genotype than sprint ower athletes [odds ratio: 0.58, 95% confidence interval: 0.34-0.39, p=0.045]. However, the ACTN3 R577X polymorphism was not associated with team-sports athletic status, compared to endurance athletes and non-athletic controls. Furthermore, no association was observed for any of the genotypes with respect to the level of competition (elite vs. national level). The ACTN3 R577X polymorphism was not associated with team-sport athletic status, compared to endurance athletes and non-athletic controls, and the observation that the 577RR genotype is overrepresented in power/sprint athletes compared with team-sport athletes needs to be confirmed in future studies.
Publisher: Elsevier BV
Date: 2015
DOI: 10.1016/J.JSAMS.2013.12.008
Abstract: The A1470T polymorphism (rs1049434) in the monocarboxylate (lactate yruvate) transporter 1 gene (MCT1) has been suggested to influence athletic performance in the general population. We compared genotype distributions and allele frequencies of the MCT1 gene A1470T polymorphism between endurance athletes, sprint ower athletes and matched controls. We also examined the association between the MCT1 A1470T and the athletes' competition level ('elite' and 'national' level). The study involved endurance athletes (n=112), sprint ower athletes (n=100), and unrelated sedentary controls (n=621), all Caucasians. Genomic DNA was extracted from buccal epithelium using a standard protocol. We conducted Fisher's exact tests and multinomial logistic regression analyses to assess the association between MCT1 genotype and athletic status/competition level. Sprint ower athletes were more likely than controls to possess the minor T allele (TT genotype compared to the AA [p<0.001] TT or AT compared to the AA [p=0.007] TT compared to both AA and AT genotypes [p<0.001]). Likewise, sprint ower athletes were more likely than endurance athletes to have the TT genotype compared to the AA (p=0.029) and the TT compared to both AA and AT genotypes (p=0.027). Furthermore, elite sprint ower athletes were more likely than national-level athletes to have the TT genotype compared to the AA (p=0.044), and more likely to have the TT genotype compared to both AA and AT genotypes (recessive model) (p=0.045). The MCT1 TT genotype is associated with elite sprint ower athletic status. Future studies are encouraged to replicate these findings in other elite athlete cohorts.
Publisher: Public Library of Science (PLoS)
Date: 29-01-2016
Publisher: Public Library of Science (PLoS)
Date: 02-06-2016
Publisher: Springer Science and Business Media LLC
Date: 18-05-2014
Publisher: Index Copernicus
Date: 12-09-2014
Publisher: Wiley
Date: 14-10-2013
DOI: 10.1111/SMS.12126
Abstract: Peroxisome proliferator-activated receptor delta (PPARδ encoded by the PPARD gene) plays a role in energy metabolism and mitochondrial function. We have investigated the distribution of PPARD rs2267668, rs2016520 and rs1053049 polymorphisms, in idually and in haplotype, in a cohort of 660 elite athletes which was sub ided into four different groups based on the different metabolic demands of their respective sports and 704 healthy controls. PPARD rs2016529 and rs1053049 were in idually associated with overall elite athletic performance (P = 0.00002 and P = 0.0002) and also with athletes grouped as strength endurance (P = 0.00008 and P = 0.0003). Furthermore, PPARD A/C/C haplotype (rs2267668/rs2016520/rs1053049) was significantly underrepresented in all athletes and each subgroup of athletes when compared with controls (P < 0.000001), suggesting that harboring this specific haplotype is unfavorable for becoming an elite athlete. These results help to identify which genetic profiles may contribute to elite athletic performance, specifically the role of variants within the PPARD gene, and may be useful in talent identification or optimizing the response to training.
Publisher: American Meteorological Society
Date: 2008
Abstract: Vertical profiles of ice water content (IWC) can now be derived globally from spaceborne cloud satellite radar (CloudSat) data. Integrating these data with Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) data may further increase accuracy. Evaluations of the accuracy of IWC retrieved from radar alone and together with other measurements are now essential. A forward model employing aircraft Lagrangian spiral descents through mid- and low-latitude ice clouds is used to estimate profiles of what a lidar and conventional and Doppler radar would sense. Radar reflectivity Ze and Doppler fall speed at multiple wavelengths and extinction in visible wavelengths were derived from particle size distributions and shape data, constrained by IWC that were measured directly in most instances. These data were provided to eight teams that together cover 10 retrieval methods. Almost 3400 vertically distributed points from 19 clouds were used. Approximate cloud optical depths ranged from below 1 to more than 50. The teams returned retrieval IWC profiles that were evaluated in seven different ways to identify the amount and sources of errors. The mean (median) ratio of the retrieved-to-measured IWC was 1.15 (1.03) ± 0.66 for all teams, 1.08 (1.00) ± 0.60 for those employing a lidar–radar approach, and 1.27 (1.12) ± 0.78 for the standard CloudSat radar–visible optical depth algorithm for Ze & −28 dBZe. The ratios for the groups employing the lidar–radar approach and the radar–visible optical depth algorithm may be lower by as much as 25% because of uncertainties in the extinction in small ice particles provided to the groups. Retrievals from future spaceborne radar using reflectivity–Doppler fall speeds show considerable promise. A lidar–radar approach, as applied to measurements from CALIPSO and CloudSat, is useful only in a narrow range of ice water paths (IWP) (40 & IWP & 100 g m−2). Because of the use of the Rayleigh approximation at high reflectivities in some of the algorithms and differences in the way nonspherical particles and Mie effects are considered, IWC retrievals in regions of radar reflectivity at 94 GHz exceeding about 5 dBZe are subject to uncertainties of ±50%.
Publisher: Public Library of Science (PLoS)
Date: 16-08-2012
Publisher: Springer Science and Business Media LLC
Date: 23-01-2015
Publisher: Springer Science and Business Media LLC
Date: 13-04-2016
Publisher: Author(s)
Date: 2017
DOI: 10.1063/1.4975526
Location: Poland
No related grants have been discovered for Marek Sawczuk.