ORCID Profile
0000-0002-2095-7534
Current Organisation
University of California, San Diego
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Publisher: Springer Science and Business Media LLC
Date: 25-01-2012
DOI: 10.1038/NATURE10821
Publisher: Wiley
Date: 23-11-2018
Publisher: Springer Science and Business Media LLC
Date: 12-04-2016
Publisher: eLife Sciences Publications, Ltd
Date: 23-06-2015
DOI: 10.7554/ELIFE.07103
Abstract: Comparative genomics studies in primates are restricted due to our limited access to s les. In order to gain better insight into the genetic processes that underlie variation in complex phenotypes in primates, we must have access to faithful model systems for a wide range of cell types. To facilitate this, we generated a panel of 7 fully characterized chimpanzee induced pluripotent stem cell (iPSC) lines derived from healthy donors. To demonstrate the utility of comparative iPSC panels, we collected RNA-sequencing and DNA methylation data from the chimpanzee iPSCs and the corresponding fibroblast lines, as well as from 7 human iPSCs and their source lines, which encompass multiple populations and cell types. We observe much less within-species variation in iPSCs than in somatic cells, indicating the reprogramming process erases many inter-in idual differences. The low within-species regulatory variation in iPSCs allowed us to identify many novel inter-species regulatory differences of small magnitude.
Publisher: Springer Science and Business Media LLC
Date: 16-06-2015
Publisher: Elsevier BV
Date: 05-2012
Publisher: Springer Science and Business Media LLC
Date: 2010
DOI: 10.1038/NMETH0110-06
Publisher: Elsevier BV
Date: 2011
Publisher: Public Library of Science (PLoS)
Date: 25-02-2015
Publisher: Springer Science and Business Media LLC
Date: 22-07-2012
DOI: 10.1038/NBT.2282
Location: United States of America
Location: United States of America
No related grants have been discovered for Louise Laurent.