ORCID Profile
0000-0002-2524-3223
Current Organisation
Edge Hill University
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Publisher: Informa UK Limited
Date: 07-2020
Publisher: Rockefeller University Press
Date: 24-01-2018
Abstract: Lipid incorporation from endoplasmic reticulum (ER) to lipid droplet (LD) is important in controlling LD growth and intracellular lipid homeostasis. However, the molecular link mediating ER and LD cross talk remains elusive. Here, we identified Rab18 as an important Rab guanosine triphosphatase in controlling LD growth and maturation. Rab18 deficiency resulted in a drastically reduced number of mature LDs and decreased lipid storage, and was accompanied by increased ER stress. Rab3GAP1/2, the GEF of Rab18, promoted LD growth by activating and targeting Rab18 to LDs. LD-associated Rab18 bound specifically to the ER-associated NAG-RINT1-ZW10 (NRZ) tethering complex and their associated SNAREs (Syntaxin18, Use1, BNIP1), resulting in the recruitment of ER to LD and the formation of direct ER–LD contact. Cells with defects in the NRZ/SNARE complex function showed reduced LD growth and lipid storage. Overall, our data reveal that the Rab18-NRZ-SNARE complex is critical protein machinery for tethering ER–LD and establishing ER–LD contact to promote LD growth.
Publisher: SAGE Publications
Date: 08-03-2017
Abstract: This article focuses on the response by 2056 football referees across all 51 County Football Associations in England, the Isle of Man, Jersey and Guernsey to an online survey conducted from 30 September 2015 to 30 November 2015 regarding their experience of officiating since the implementation of a Respect programme in 2008 by the English Football Association. In assessing the impact of the programme, whilst 54 per cent of referees felt that it has been somewhat successful, there remains a need to implement stronger sanctions and show greater support when dealing with cases of misconduct. Some 60 per cent of referees still experience abuse every couple of games and 19 per cent have experienced some form of physical abuse. With 42 per cent of our s le officiating for less than five years, there is an urgent need for the impact and effectiveness of the programme to be re-evaluated.
Publisher: Informa UK Limited
Date: 03-07-2017
Publisher: Informa UK Limited
Date: 22-11-2205
Publisher: Informa UK Limited
Date: 22-02-2022
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Jimmy O'Gorman.