ORCID Profile
0000-0002-9384-5648
Current Organisations
The Hong Kong Polytechnic University
,
Vanderbilt University Medical Center
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Publisher: Elsevier BV
Date: 09-2008
Publisher: Springer Science and Business Media LLC
Date: 02-10-2023
Publisher: Oxford University Press (OUP)
Date: 03-10-2020
DOI: 10.1093/JNCI/DJAA154
Abstract: In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome of aggressive prostate cancer, but studies have defined this outcome differently. We aimed to develop an evidence-based consensus definition of aggressive prostate cancer using clinical features at diagnosis for etiologic epidemiologic research. Among prostate cancer cases diagnosed in 2007 in the National Cancer Institute’s Surveillance, Epidemiology, and End Results-18 database with follow-up through 2017, we compared the performance of categorizations of aggressive prostate cancer in discriminating fatal prostate cancer within 10 years of diagnosis, placing the most emphasis on sensitivity and positive predictive value (PPV). In our case population (n = 55 900), 3073 men died of prostate cancer within 10 years. Among 12 definitions that included TNM staging and Gleason score, sensitivities ranged from 0.64 to 0.89 and PPVs ranged from 0.09 to 0.23. We propose defining aggressive prostate cancer as diagnosis of category T4 or N1 or M1 or Gleason score of 8 or greater prostate cancer, because this definition had one of the higher PPVs (0.23, 95% confidence interval = 0.22 to 0.24) and reasonable sensitivity (0.66, 95% confidence interval = 0.64 to 0.67) for prostate cancer death within 10 years. Results were similar across sensitivity analyses. We recommend that etiologic epidemiologic studies of prostate cancer report results for this definition of aggressive prostate cancer. We also recommend that studies separately report results for advanced category (T4 or N1 or M1), high-grade (Gleason score ≥8), and fatal prostate cancer. Use of this comprehensive set of endpoints will facilitate comparison of results from different studies and help elucidate prostate cancer etiology.
Publisher: American Association for Cancer Research (AACR)
Date: 03-03-2022
DOI: 10.1158/1055-9965.EPI-21-1085
Abstract: Evidence on associations between dietary intake and risk of breast cancer subtypes is limited and inconsistent. We evaluated associations of fruit, vegetable, meat, and fish consumption with risk of breast cancer overall and by molecular subtype in the Vietnamese Breast Cancer Study (VBCS). VBCS includes 476 incident breast cancer cases and 454 age-matched controls. Dietary habits over the past 5 years were assessed by in-person interviews using a validated food frequency questionnaire. Associations of food groups with breast cancer were evaluated via logistic regression for overall and molecular subtype with adjustment for age, education, income, family history of cancer, menopausal status, body mass index, exercise, total energy intake, and other potential dietary confounders. Odds ratio (OR) was used to approximate relative risk. High fruit intake was inversely associated with breast cancer risk, with adjusted ORs [95% confidence intervals (CI)] of 0.67 (95% CI, 0.47–0.95) and 0.41 (95% CI, 0.27–0.61) for second and third tertiles versus first tertile, respectively (Ptrend & 0.001). This association was stronger for triple-negative than other subtypes (Pheterogeneity & 0.001). High intake of freshwater fish was inversely associated with overall breast cancer (ORT3vsT1 = 0.63 95% CI, 0.42–0.95 Ptrend = 0.03). An inverse association was observed between HER2-enriched subtype and red and organ meat intake (ORT3vsT1 = 0.40 95% CI, 0.17–0.93 Ptrend = 0.04 Pheterogeneity = 0.50). High intakes of fruit and freshwater fish were associated with reduced breast cancer risk association for the former was stronger for triple-negative subtype. Our findings suggest high intakes of fruit and freshwater fish may reduce breast cancer risk among Vietnamese women.
Publisher: Elsevier BV
Date: 10-2002
Location: China
Location: United States of America
No related grants have been discovered for Qiuyin Cai.