ORCID Profile
0000-0001-5337-4514
Current Organisations
Tong Ren hospital Shanghai jiaotong university school of medicine
,
Pacific Northwest National Laboratory Marine Sciences Laboratory
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Publications
The macro- and megabenthic fauna on the continental shelf of the eastern Amundsen Sea, Antarctica
Publisher: Elsevier BV
Date: 10-2013
DNA barcoding and molecular systematics of the benthic and demersal organisms of the CEAMARC survey
Publisher: Elsevier BV
Date: 08-2011
Comprehensive sampling reveals circumpolarity and sympatry in seven mitochondrial lineages of the Southern Ocean crinoid species Promachocrinus kerguelensis (Echinodermata)
Publisher: Wiley
Date: 31-03-2012
Insulinoma-Released Exosomes or Microparticles Are Immunostimulatory and Can Activate Autoreactive T Cells Spontaneously Developed in Nonobese Diabetic Mice
Publisher: The American Association of Immunologists
Date: 15-08-2011
Abstract: Exosomes (EXO) are secreted intracellular microparticles that can trigger inflammation and induce Ag-specific immune responses. To test possible roles of EXO in autoimmunity, we isolated small microparticles, mainly EXO, from mouse insulinoma and examined their activities to stimulate the autoimmune responses in NOD mice, a model for human type 1 diabetes. We demonstrate that the EXO contains strong innate stimuli and expresses candidate diabetes autoantigens. They can induce secretion of inflammatory cytokines through a MyD88-dependent pathway, and activate purified APC and result in T cell proliferation. To address whether EXO or the secreted microparticles are possible autoimmune targets causing islet-specific inflammation, we monitored the T cell responses spontaneously developed in prediabetic NOD mice for their reactivity to the EXO, and compared this reactivity between diabetes-susceptible and -resistant congenic mouse strains. We found that older NOD females, which have advanced islet destruction, accumulated more EXO-reactive, IFN-γ–producing lymphocytes than younger females or age-matched males, and that pancreatic lymph nodes from the prediabetic NOD, but not from the resistant mice, were also enriched with EXO-reactive Th1 cells. In vivo, immunization with the EXO accelerates insulitis development in nonobese diabetes-resistant mice. Thus, EXO or small microparticles can be recognized by the diabetes-associated autoreactive T cells, supporting that EXO might be a possible autoimmune target and/or insulitis trigger in NOD or congenic mouse strains.
Predicting habitat preferences for Anthometrina adriani (Echinodermata) on the East Antarctic continental shelf
Publisher: Inter-Research Science Center
Date: 15-11-2011
DOI: 10.3354/MEPS09330
Related Organisations
Torrey Pines Institute For Molecular Studies
Location: United States of America
Tong Ren Hospital Shanghai Jiaotong University School Of Medicine
Location: China
Pacific Northwest National Laboratory Marine Sciences Laboratory
Location: United States of America
Related Funding Activities
No related grants have been discovered for Lenaïg G. Hemery.