ORCID Profile
0000-0001-7106-3461
Current Organisation
Austin Health
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Elsevier BV
Date: 2018
Publisher: Wiley
Date: 05-11-2022
DOI: 10.1111/ANS.17362
Publisher: Springer Science and Business Media LLC
Date: 09-05-2017
DOI: 10.1038/TP.2017.69
Abstract: Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The s le comprised a total of 249 participants (schizophrenia spectrum disorder n =98 bipolar affective disorder n =35 major depression n =31 other psychiatric conditions n =31 and healthy controls n =54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.
Publisher: Oxford University Press (OUP)
Date: 06-2017
DOI: 10.1093/JSCR/RJX120
Publisher: Edorium Journals Pvt. Ltd.
Date: 2017
Publisher: Annex Publishers, LLC
Date: 08-2018
Publisher: Springer Science and Business Media LLC
Date: 12-09-2023
No related grants have been discovered for Zexi Allan.