ORCID Profile
0000-0002-9494-0858
Current Organisations
National Research Council
,
Università degli Studi di Pavia
,
Università degli Studi di Milano
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 08-2006
Publisher: Wiley
Date: 26-01-2022
DOI: 10.1113/EP090171
Abstract: Exercise physiology and sport science have traditionally made use of the null hypothesis of no difference to make decisions about experimental interventions. In this article, we aim to review current statistical approaches typically used by exercise physiologists and sport scientists for the design and analysis of experimental interventions and to highlight the importance of including equivalence and non‐inferiority studies, which address different research questions from deciding whether an effect is present. Initially, we briefly describe the most common approaches, along with their rationale, to investigate the effects of different interventions. We then discuss the main steps involved in the design and analysis of equivalence and non‐inferiority studies, commonly performed in other research fields, with worked ex les from exercise physiology and sport science scenarios. Finally, we provide recommendations to exercise physiologists and sport scientists who would like to apply the different approaches in future research. We hope this work will promote the correct use of equivalence and non‐inferiority designs in exercise physiology and sport science whenever the research context, conditions, applications, researchers’ interests or reasonable beliefs justify these approaches.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 12-2009
Publisher: BMJ
Date: 12-06-2020
Publisher: American Physiological Society
Date: 07-2010
DOI: 10.1152/JAPPLPHYSIOL.00782.2009
Abstract: “Central” and “peripheral” limitations to oxidative metabolism during exercise were evaluated in 10 young males following a 35-day horizontal bed rest (BR). Incremental exercise (IE) and moderate- and heavy-intensity constant-load exercises (CLE) were carried out on a cycloergometer before and 1–2 days after BR. Pulmonary gas exchange, cardiac output (Q̇ by impedance cardiography), skeletal muscle (vastus lateralis), and brain (frontal cortex) oxygenation (by near-infrared spectroscopy) were determined. After BR, “peak” (values at exhaustion during IE) workload, peak O 2 uptake (V̇o 2peak ), peak stroke volume, Q̇ peak , and peak skeletal muscle O 2 extraction were decreased (−18, −18, −22, −19, and −33%, respectively). The gas exchange threshold was ∼60% of V̇o 2peak both before and after BR. At the highest workloads, brain oxygenation data suggest an increased O 2 extraction, which was unaffected by BR. V̇o 2 kinetics during CLE (same percentage of peak workload before and after BR) were slower (time constant of the “fundamental” component: 31.1 ± 2.0 s before vs. 40.0 ± 2.2 s after BR) the litude of the “slow component” was unaffected by BR, thus it would be greater, after BR, at the same absolute workload. A more pronounced “overshoot” of skeletal muscle O 2 extraction during CLE was observed after BR, suggesting an impaired adjustment of skeletal muscle O 2 delivery. The role of skeletal muscles in the impairment of oxidative metabolism during submaximal and maximal exercise after BR was identified. The reduced capacity of peak cardiovascular O 2 delivery did not determine a “competition” for the available O 2 between skeletal muscles and brain.
Publisher: American Physiological Society
Date: 02-2008
Publisher: Springer Science and Business Media LLC
Date: 08-2017
DOI: 10.1007/S11892-017-0903-2
Abstract: This review aimed to examine the latest evidence linking cigarette smoking and cessation to risk of incident diabetes and its complications. Abundant evidence has demonstrated that smoking is associated with increased risk of type 2 diabetes and cardiovascular disease among diabetic patients, while its relationship with microvascular complications is more limited to diabetic nephropathy and neuropathy in type 1 diabetes. In addition, diabetes risk remains high in the short term after smoking cessation, while it reduces gradually in the long term. Risk of cardiovascular complications also substantially decreases after quitting smoking, but results for microvascular complications are not consistent. Smoking is associated with increased risks of incident diabetes in the general population and cardiovascular complications among diabetic patients. Although the short-term post-cessation diabetes risk needs to be acknowledged, this review calls for urgent action to implement population-wide policies and in idual pharmaceutical and lifestyle interventions (if evidence accumulated in future) to aid smoking cessation and prevent diabetes and its complications.
Publisher: American Physiological Society
Date: 15-09-2015
No related grants have been discovered for simone porcelli.