ORCID Profile
0000-0003-1245-3747
Current Organisations
Technical University of Denmark
,
University of Aberdeen
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Publisher: Wiley
Date: 04-12-2014
Publisher: Informa UK Limited
Date: 09-2008
Publisher: The Company of Biologists
Date: 02-2013
DOI: 10.1242/JEB.074518
Abstract: Seasonal trends in energy storage of the minke whale (Balaenoptera acutorostrata), a capital breeder, were investigated in Iceland, a North Atlantic feeding ground. The aim was to better understand the energy acquisition strategies of minke whales and the energetic costs that different reproductive classes face during the breeding season. We modelled total blubber volume, using blubber thickness and morphometric measurements of in idual whales. Blubber volume was influenced by body length, and was higher for pregnant females than mature whales. Blubber volume increased linearly through the feeding season at the same rate for mature (mean ± s.e.m.=0.0028±0.00103 m3 day−1 N=61 male, 5 female) and pregnant whales (0.0024±0.00100 m3 day−1 N=49), suggesting that minke whales aim to maximise energy storage while on the feeding grounds. The total amount of blubber accumulated over the feeding season (0.51±0.119 m3 for mature and 0.43±0.112 m3 for pregnant whales), together with energy stored as muscle and intra-abdominal fats, constitutes the total amount of energy available for reproduction (fetus development and lactation) on the breeding grounds, as well as migration, daily field metabolic rates, growth and body maintenance. No seasonal variation was observed for immature whales (N=4 male, 12 female), suggesting that they are investing most of their excess energy into growth rather than reproduction, in order to reach the length of sexual maturity faster and start reproducing earlier. Our novel modelling approach provides insight into large whale bioenergetics and life history strategies, as well as the relationship between single-site measurement of blubber thickness and total blubber volume.
Publisher: Oxford University Press (OUP)
Date: 2013
Publisher: Informa UK Limited
Date: 2008
Publisher: Cambridge University Press (CUP)
Date: 12-2008
Publisher: Wiley
Date: 27-03-2015
DOI: 10.1111/CONL.12166
Publisher: The Royal Society
Date: 12-2016
DOI: 10.1098/RSOS.160560
Abstract: Food provisioning of wildlife is a major concern for management and conservation agencies worldwide because it encourages unnatural behaviours in wild animals and increases each in idual's risk for injury and death. Here we investigate the contributing factors and potential fitness consequences of a recent increase in the frequency of human interactions with common bottlenose dolphins ( Tursiops truncatus ) in Sarasota Bay, Florida. A rising proportion of the local long-term resident dolphin community is becoming conditioned to human interactions through direct and indirect food provisioning. We investigate variables that are affecting conditioning and if the presence of human-induced injuries is higher for conditioned versus unconditioned dolphins. Using the most comprehensive long-term dataset available for a free-ranging bottlenose dolphin population (more than 45 years more than 32 000 dolphin group sightings more than 1100 in iduals), we found that the association with already conditioned animals strongly affected the probability of dolphins becoming conditioned to human interactions, confirming earlier findings that conditioning is partly a learned behaviour. More importantly, we found that conditioned dolphins were more likely to be injured by human interactions when compared with unconditioned animals. This is alarming, as conditioning could lead to a decrease in survival, which could have population-level consequences. We did not find a significant relationship between human exposure or natural prey availability and the probability of dolphins becoming conditioned. This could be due to low s le size or insufficient spatio-temporal resolution in the available data. Our findings show that wildlife provisioning may lead to a decrease in survival, which could ultimately affect population dynamics.
Publisher: Public Library of Science (PLoS)
Date: 15-05-2007
Publisher: Spandidos Publications
Date: 13-11-2015
Abstract: While various tyrosine kinases have been associated with the pathogenesis of hepatocellular carcinoma (HCC), the identification of a dominant therapeutic target among them remains a challenge. Here, we investigated the role of Tyro3, a relatively uncharacterized member of the TAM (Tyro3, Axl and Mer) receptor family. The present study aimed to profile and identify potential association between Tyro3 expression in HCC and cancer phenotypes. RNAs obtained from 55 HCC patients were quantified for Tyro3 expression in both cancerous tissue and the adjacent normal tissue. Expression profile was correlated with clinical data. These observations were further substantiated with in vitro HCC cell culture investigations.Tyro3 was strongly upregulated (>2-fold elevation) in the tumor tissue of ~42% of the patients. It was shown that higher expression level of Tyro3 was associated with the key tumor marker AFP, and the tumor diameter and liver injury marker ALT. Subsequent cell culture models indicated high expression in various HCC cell lines, in particular Hep3B. Gene silencing of Tyro3 in Hep3B effectively reduced cell proliferation, ERK phosphorylation and cyclin D1 expression, indicating a key in maintaining the proliferative state of these cells. Notably, silencing also suppressed the transcriptional and translational expression of HCC tumor marker AFP. Overall, these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction. Inhibition of Tyro3 and its aberrant signaling in tumors with high expression could present new opportunities for HCC treatment.
Publisher: Frontiers Media SA
Date: 26-05-2020
Publisher: Cambridge University Press
Date: 27-03-2012
Publisher: Elsevier BV
Date: 09-2012
DOI: 10.1016/J.BEPROC.2012.04.011
Abstract: Synchronized swimming in cetaceans has been hypothesized to play a role in affiliative processes as well as anti-predatory responses. We compared observed variation in synchronized swimming at two research sites in relation to disturbance exposure to test these two hypotheses. This study describes and quantifies pair synchronization in long-finned pilot whales at the Strait of Gibraltar, Spain and Cape Breton, Canada. Synchronization differed depending on the behavioral state and the response is different in the two sites leading to the conclusion that environment can shape the occurrence and magnitude of certain behaviors. We also analyzed intra-population variations in synchronization among 4 social units of Pilot whales in the Strait of Gibraltar and the results of this study confirmed the affiliative role of synchronization and highlighted an influence of disturbance on synchronization. We can conclude that synchronization is a common behavior in long-finned pilot whales that allow for close proximity and rapid coordinated response of in iduals, with the multiple functions of showing affiliation and reacting to disturbance.
Publisher: Public Library of Science (PLoS)
Date: 13-05-2015
Publisher: Elsevier BV
Date: 10-2014
Publisher: Wiley
Date: 25-09-2012
Publisher: Wiley
Date: 24-10-2008
Publisher: Elsevier BV
Date: 12-2014
Publisher: Inter-Research Science Center
Date: 17-03-2010
DOI: 10.3354/ESR00265
Publisher: Wiley
Date: 26-04-2012
Publisher: Elsevier BV
Date: 11-2010
Publisher: Inter-Research Science Center
Date: 19-01-2016
DOI: 10.3354/MEPS11497
Publisher: Frontiers Media SA
Date: 28-05-2020
Publisher: Wiley
Date: 02-2015
DOI: 10.1002/JWMG.836
Publisher: Inter-Research Science Center
Date: 25-03-2013
DOI: 10.3354/MEPS10163
Publisher: Wiley
Date: 30-03-2011
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for David Lusseau.