ORCID Profile
0000-0002-6213-793X
Current Organisation
Vanderbilt University Medical Center
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Publisher: Elsevier BV
Date: 08-2022
Publisher: Springer Science and Business Media LLC
Date: 09-12-2021
Publisher: Springer Science and Business Media LLC
Date: 28-10-2014
DOI: 10.1038/NCOMMS6068
Abstract: Statins effectively lower LDL cholesterol levels in large studies and the observed interin idual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1 , not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
Publisher: Public Library of Science (PLoS)
Date: 31-12-2010
Publisher: Springer Science and Business Media LLC
Date: 04-10-2013
Publisher: Springer Science and Business Media LLC
Date: 28-08-2013
DOI: 10.1038/NATURE12508
Publisher: Springer Science and Business Media LLC
Date: 26-05-2023
Location: United States of America
No related grants have been discovered for QiPing Feng.