ORCID Profile
0000-0002-4496-8051
Current Organisation
South African Equine Health and Protocols NPC
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Publisher: American Dairy Science Association
Date: 09-2023
Publisher: Springer Science and Business Media LLC
Date: 13-03-2015
Publisher: Cold Spring Harbor Laboratory
Date: 17-07-2021
DOI: 10.1101/2021.07.16.452724
Abstract: A novel Hendra virus (HeV) variant, not detected by routine testing, was identified and isolated from a Queensland horse that suffered acute, fatal disease consistent with HeV infection. Whole genome sequencing and phylogenetic analysis demonstrated the variant to have ~83% nucleotide identity to the prototype HeV strain. An updated RT-qPCR assay was designed for routine HeV surveillance. In silico and in vitro comparison of the receptor-binding protein with prototypic HeV showed that the human monoclonal antibody m102.4 used for post-exposure prophylaxis, as well as the current equine vaccine, should be effective against this variant. Genetic similarity of this virus to sequences detected from grey-headed flying-foxes suggests the variant circulates at-least in this species. Studies determining infection kinetics, pathogenicity, reservoir-species associations, viral–host co-evolution and spillover dynamics for this virus are urgently needed. Surveillance and biosecurity practices should be updated to appreciate HeV spillover risk across all regions frequented by flying foxes.
Publisher: Resilience Alliance, Inc.
Date: 2016
Publisher: Wiley
Date: 29-07-0016
Publisher: Public Library of Science (PLoS)
Date: 31-01-2014
Publisher: Centers for Disease Control and Prevention (CDC)
Date: 12-2016
Location: South Africa
No related grants have been discovered for John Grewar.