ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0003-4415-0150

Current Organisation
Bio-Rad (France)

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Publications

Publication

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

Publisher: Springer Science and Business Media LLC

Date: 25-02-2015

DOI: 10.1038/SREP08543

Abstract: Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected in iduals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that the pre-treatment genotypic “tropism tests” to determine virus susceptibility to maraviroc have been developed primarily for HIV-1 subtype B strains, which account for only 10% of infections worldwide. We therefore developed PhenoSeq, a suite of HIV-1 genotypic tropism assays that are highly sensitive and specific for establishing the tropism of HIV-1 subtypes A, B, C, D and circulating recombinant forms of subtypes AE and AG, which together account for 95% of HIV-1 infections worldwide. The PhenoSeq platform will inform the appropriate use of maraviroc and future CCR5 blocking drugs in regions of the world where non-B HIV-1 predominates, which are burdened the most by the HIV-1 pandemic.

Publication

Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern

Publisher: MDPI AG

Date: 06-10-2023

Location: France

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Related Funding Activities

No related grants have been discovered for Danielle Perez Bercoff.

Danielle Perez Bercoff

Researcher

Related Links

Publications

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern

Related Organisations

McGill University

Institut Pasteur

Luxembourg Institute Of Health

INSERM

Institut Cochin De Génétique Moléculaire

Bio-Rad (France)

Université De Strasbourg

Université Paris Diderot

Related Funding Activities

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