ORCID Profile
0000-0002-7947-7455
Current Organisations
Iuliu Hațieganu University of Medicine and Pharmacy
,
Queen's University
,
Universitatea Babeş-Bolyai Departamentul de Psihologie
,
Providence Care Centre
,
Providence Care Mental Health Services
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Publications
Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia: an international multicenter study
Publisher: Cambridge University Press (CUP)
Date: 09-08-2021
DOI: 10.1017/S1092852921000742
Abstract: The aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia. Twenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 ± 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects. There was a 3-year later age at onset for females ( P .001) and lower rates of negative symptoms ( P .01) and higher depression/anxiety measures ( P .05) at some stages. The age at onset manifested a distribution with a single peak for both genders with a tendency of patients with younger onset having slower advancement through illness stages ( P = .001). No significant effects were found concerning duration of illness. Our results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative s les.
Results of the COVID-19 mental health international for the health professionals (COMET-HP) study: depression, suicidal tendencies and conspiracism
Publisher: Springer Science and Business Media LLC
Date: 03-03-2023
The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.
Publisher: Elsevier BV
Date: 09-2022
COVID-19 Pandemic: The Impact of COVID-19 on Mental Health and Life Habits in the Canadian Population
Publisher: Frontiers Media SA
Date: 29-06-2022
DOI: 10.3389/FPSYT.2022.871119
Abstract: The study aims to investigate the rate of clinical depression in the adult population during the COVID-19 pandemic, as well as the changes in anxiety, distress, suicidal ideation, and their relations with several personal and interpersonal/social variables. This is an epidemiological, non-interventional study. It is part of an international multi-center study, with the main site at the Aristotle University of Thessaloniki, in Greece (COMET-G Study). We are presenting aspects of the research involving the Canadian site, based on 508 Canadian responders to the online survey (QAIRE). Of the 508 responders, 72.2% were females aged 42.57 ± 14.00 years 27.2% were males aged 42.24 ± 15.49 years and 0.6% were others aged 46.33 ± 17.79 years. Increased anxiety during the lockdown was reported by 69.3% of those surveyed. The rate of suicidal thoughts increased in 19.5% of participants during the lockdown. Depression was reported by 22% of responders, while distress was present in 18.4%. We found a greater prevalence of depression, but not distress, in in iduals with a history of any mental disorder. Based on the multiple regression analysis, we found four CORE factors equally influencing the changes in mental health during the lockdown (gender, quality of sleep, family conflicts, and changes in daily routine). In the Canadian population, two major changes acted as protective factors, significantly expressed when compared with the worldwide tendencies: fewer financial difficulties and an increase in religious beliefs. The rate of major depression, distress, and suicidal ideation was higher in Canadians than in the worldwide population (per COMET-G), but the relative risk to develop depression in the presence of a history of mental disorders was lower. Almost 90% of Canadians believed in the real story of COVID source of provenience.
Results of the COVID-19 mental health international for the general population (COMET-G) study
Publisher: Elsevier BV
Date: 2022
Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study
Publisher: Cambridge University Press (CUP)
Date: 15-04-2020
DOI: 10.1017/S1092852920001091
Abstract: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
Related Organisations
Iuliu Hațieganu University Of Medicine And Pharmacy
Location: Romania
Universitatea Babeş-Bolyai Departamentul De Psihologie
Location: Romania
Related Funding Activities
No related grants have been discovered for Felicia Iftene.