ORCID Profile
0000-0002-0515-7192
Current Organisation
Cornell University
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Publisher: Springer Science and Business Media LLC
Date: 22-07-2022
DOI: 10.1038/S41525-022-00314-Z
Abstract: Adiponectin, encoded by ADIPOQ , is an insulin-sensitizing, anti-inflammatory, and renoprotective adipokine that activates receptors with intrinsic ceramidase activity. We identified a family harboring a 10-nucleotide deletion mutation in ADIPOQ that cosegregates with diabetes and end-stage renal disease. This mutation introduces a frameshift in exon 3, resulting in a premature termination codon that disrupts translation of adiponectin’s globular domain. Subjects with the mutation had dramatically reduced circulating adiponectin and increased long-chain ceramides levels. Functional studies suggest that the mutated protein acts as a dominant negative through its interaction with non-mutated adiponectin, decreasing circulating adiponectin levels, and correlating with metabolic disease.
Publisher: InTech
Date: 11-03-2015
DOI: 10.5772/58886
Publisher: Elsevier BV
Date: 06-2014
Publisher: Vilnius Gediminas Technical University
Date: 26-09-2013
DOI: 10.3846/20296991.2013.823704
Abstract: Seasonal snow-covered surface has a critical role in global water resource supplement especially providing fresh water for humankind and flora's consumptions as well as local underground water storages. The in situ measurements of seasonal snow-covered variability are extensively prodigal and costly particularly in existence of severe climate conditions such as high latitude regions and polar areas. It is therefore necessary to apply remote sensing techniques and observations to estimate accurately the snowpack melting and accumulation for different seasons. In this paper, we estimate snow-covered surface variability for four different seasons of year in Mount Odin, Canada using aerial photos. In order to do this, firstly Digital Elevation Model (DEM) with respect to Earth Gravitational Model 1996 (EGM96) for each flight mission of A, B, C and D from these aerial photos by applying Bundle Adjustment (BA) triangulation is being generated precisely. Moreover, the displacement of each two DEMs is computing in order to determine snow-covered surface variability between each two flight missions. The results demonstrate that flight mission C has the highest elevation topographically compare to the missions A, B and D while mission C was planned in February 2011 in existence of vast snow throughout Mount Odin area as well as mission C's DEM which has higher elevation values than the others. The proposed methodology and problem solution and the case study information with the details of each flight mission are discussed in expatiation.
Publisher: MDPI AG
Date: 09-08-2013
DOI: 10.3390/RS5084006
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2015
No related grants have been discovered for Nasser Najibi.