ORCID Profile
0000-0003-3101-2090
Current Organisation
China University of Mining and Technology
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Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4RA14513E
Abstract: A scalable and facile method was developed to synthesize nitrogen-doped porous carbon foams (NPCFs) using graphitic carbon nitride (g-C 3 N 4 ) nanosheets as hard templates through the calcination of mesophase pitch.
Publisher: Springer Science and Business Media LLC
Date: 07-08-2020
Publisher: Springer Science and Business Media LLC
Date: 19-11-2020
DOI: 10.1038/S41598-020-76376-9
Abstract: Skin darkening results as a consequence of the accumulation of skin pigment melanin. To combat this, the litude of skin lightening agents are commercially available, most of which inhibit melanin synthesis. Decolorization of melanin is an alternative method of skin lightening. In this study, we show that lignin peroxidase (LiP), an extracellular enzyme purified from Phanerochaete chrysosporium NK-1 isolated from a forest soil can effectively degrade and decolorize melanin in vitro. Decolorization conditions including pH, temperature, incubation time, enzyme concentration, and mediator addition were investigated to optimize the reaction conditions. The results indicate that pH 3, 40 °C, 15 IU/ml, and 10 h incubation were the optimal conditions for the decolorization of the melanin. The use of the mediator, veratryl alcohol was also found effective to enhance the efficacy of the melanin decolonization, with up to 92% decolorization. The scanning electron microscopy results showed void spaces on the treated melanin granules as compared to the untreated s le, indicating the degradation of melanin. Changes in the fingerprint region of the melanin were observed. Between wavenumbers 1500–500 cm −1 , for ex le, the presence of new peaks in the treated melanin at 1513, 1464, and 1139 cm −1 CH 2 , CH 3 bend and C–O–C stretch represented structural changes. A new peak at 2144 cm −1 (alkynyl C≡C stretch) was also detected in the decolorized melanin. The cytotoxicity study has shown that the treated melanin and LiP have low cytotoxic effects however, the mediator of veratryl alcohol could result in high mortality which suggests that its use should be meticulously tested in formulating health and skincare products. The findings of the study suggest that LiP produced by Phanerochaete chrysosporium has the potential to be used in the medical and cosmetic industries, particularly for the development of biobased cosmetic whitening agents.
Publisher: Informa UK Limited
Date: 24-12-2022
Publisher: Elsevier BV
Date: 2022
Publisher: Hindawi Limited
Date: 23-06-2021
DOI: 10.1002/ER.6985
Publisher: Elsevier BV
Date: 10-2020
No related grants have been discovered for Fang-Jing Liu.