ORCID Profile
0000-0001-8518-5136
Current Organisations
University of Warwick
,
University of Oxford
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Publisher: Elsevier BV
Date: 09-2020
Publisher: MDPI AG
Date: 12-04-2023
DOI: 10.3390/BIOENGINEERING10040466
Abstract: Chemical reaction networks can be utilised as basic components for nucleic acid feedback control systems’ design for Synthetic Biology application. DNA hybridisation and programmed strand-displacement reactions are effective primitives for implementation. However, the experimental validation and scale-up of nucleic acid control systems are still considerably falling behind their theoretical designs. To aid with the progress heading into experimental implementations, we provide here chemical reaction networks that represent two fundamental classes of linear controllers: integral and static negative state feedback. We reduced the complexity of the networks by finding designs with fewer reactions and chemical species, to take account of the limits of current experimental capabilities and mitigate issues pertaining to crosstalk and leakage, along with toehold sequence design. The supplied control circuits are quintessential candidates for the first experimental validations of nucleic acid controllers, since they have a number of parameters, species, and reactions small enough for viable experimentation with current technical capabilities, but still represent challenging feedback control systems. They are also well suited to further theoretical analysis to verify results on the stability, performance, and robustness of this important new class of control systems.
Publisher: IEEE
Date: 12-2018
Publisher: Elsevier BV
Date: 06-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2019
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Nuno Paulino.