ORCID Profile
0000-0002-8013-2745
Current Organisations
Karolinska University Hospital
,
Università degli Studi di Milano-Bicocca Dipartimento di Medicina Clinica e Prevenzione
,
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
,
Karolinska Institutet
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Publications
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Publisher: Wiley
Date: 23-11-2018
Urinary Leukotriene E4and Prostaglandin D2Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study
Publisher: American Thoracic Society
Date: 2021
Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration
Publisher: European Respiratory Society (ERS)
Date: 03-2019
Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.EJVS.2013.07.020
Abstract: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty as to which is most appropriate. Trial surgeons and interventionalists are expected to use their usual techniques and CE-approved devices. We report baseline characteristics and blinded combined interim results for 30-day mortality and major morbidity for 986 patients in the ongoing trial up to September 2012. A total of 986 patients (687 men, 299 women), mean age 68.7 years (SD ± 8.1) were randomized equally to CEA or CAS. Most (96%) had ipsilateral stenosis of 70-99% (median 80%) with contralateral stenoses of 50-99% in 30% and contralateral occlusion in 8%. Patients were on appropriate medical treatment. For 691 patients undergoing intervention with at least 1-month follow-up and Rankin scoring at 6 months for any stroke, the overall serious cardiovascular event rate of periprocedural (within 30 days) disabling stroke, fatal myocardial infarction, and death at 30 days was 1.0%. Early ACST-2 results suggest contemporary carotid intervention for asymptomatic stenosis has a low risk of serious morbidity and mortality, on par with other recent trials. The trial continues to recruit, to monitor periprocedural events and all types of stroke, aiming to randomize up to 5,000 patients to determine any differential outcomes between interventions. ISRCTN21144362.
Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.
Publisher: European Respiratory Society (ERS)
Date: 06-2017
DOI: 10.1183/13993003.02322-2016
Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD. Serum from healthy never-smokers (healthy), smokers with normal lung function (smokers), and smokers with COPD (COPD Global Initiative for Chronic Obstructive Lung Disease stages I–II/A–B) from the Karolinska COSMIC cohort (n=116) was analysed using our nontargeted liquid chromatography–high resolution mass spectrometry metabolomics platform. Pathway analyses revealed that several altered metabolites are involved in oxidative stress. Supervised multivariate modelling showed significant classification of smokers from COPD (p=2.8×10 −7 ). Sex stratification indicated that the separation was driven by females (p=2.4×10 −7 ) relative to males (p=4.0×10 −4 ). Significantly altered metabolites were confirmed quantitatively using targeted metabolomics. Multivariate modelling of targeted metabolomics data confirmed enhanced metabolic dysregulation in females with COPD (p=3.0×10 −3 ) relative to males (p=0.10). The autotaxin products lysoPA (16:0) and lysoPA (18:2) correlated with lung function (forced expiratory volume in 1 s) in males with COPD (r=0.86 p .0001), but not females (r=0.44 p=0.15), potentially related to observed dysregulation of the miR-29 family in the lung. These findings highlight the role of oxidative stress in COPD, and suggest that sex-enhanced dysregulation in oxidative stress, and potentially the autotaxin–lysoPA axis, are associated with disease mechanisms and/or prevalence.
Related Organisations
Università Degli Studi Di Milano-Bicocca Dipartimento Di Medicina Clinica E Prevenzione
Location: Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Location: Italy
Istituto Auxologico Italiano Istituto Di Ricovero E Cura A Carattere Scientifico
Location: Italy
Related Funding Activities
No related grants have been discovered for Asa Wheelock.