ORCID Profile
0000-0003-2847-2483
Current Organisations
CSIRO
,
Henkel
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Publisher: Wiley
Date: 12-2016
DOI: 10.1002/PBC.26351
Abstract: Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies.
Publisher: Springer Science and Business Media LLC
Date: 13-07-2017
DOI: 10.1038/LEU.2017.213
Publisher: Springer Science and Business Media LLC
Date: 24-03-2020
DOI: 10.1038/S41598-020-61912-4
Abstract: Following a single blind, cross-over and non-randomized design we investigated the effect of 7-day use of chlorhexidine (CHX) mouthwash on the salivary microbiome as well as several saliva and plasma biomarkers in 36 healthy in iduals. They rinsed their mouth (for 1 min) twice a day for seven days with a placebo mouthwash and then repeated this protocol with CHX mouthwash for a further seven days. Saliva and blood s les were taken at the end of each treatment to analyse the abundance and ersity of oral bacteria, and pH, lactate, glucose, nitrate and nitrite concentrations. CHX significantly increased the abundance of Firmicutes and Proteobacteria, and reduced the content of Bacteroidetes, TM7, SR1 and Fusobacteria. This shift was associated with a significant decrease in saliva pH and buffering capacity, accompanied by an increase in saliva lactate and glucose levels. Lower saliva and plasma nitrite concentrations were found after using CHX, followed by a trend of increased systolic blood pressure. Overall, this study demonstrates that mouthwash containing CHX is associated with a major shift in the salivary microbiome, leading to more acidic conditions and lower nitrite availability in healthy in iduals.
Publisher: Springer Science and Business Media LLC
Date: 22-06-2023
DOI: 10.1007/S10965-023-03641-6
Abstract: A novel fire-retardant epoxy thermoset, containing boron polyol complex, was prepared and characterised. The fire-retardant additive was a stoichiometric mixture of boric acid and glycerol. Flame retardancy of the epoxy resin was improved by the formation of stable char layer that protected the underlying epoxy from further burning. Phonon transport through the polymer matrix via hydrogen bonding was identified. The hydrogen bonding acted as a thermal bridge for intermolecular phonon transport to gain improved thermal conductivity resulting early char formation. The hydrogen bonding between the complex and the epoxy matrix was demonstrated using Fourier Transform Infrared Spectroscopy. The phonon transport and a high degree of graphitization was confirmed using Raman Spectroscopy. Thermogravimetric analysis was used for polymer decomposition to confirm a char yield of over 20%. Reaction to fire test revealed enhancement in fire retardancy and self-extinguishing properties of the blend compared to the neat epoxy. Cone calorimetry testing confirmed decreased peak heat release rate and total smoke production by the effect of boron compound in the epoxy matrix. Hydrogen bonding, formation of thick stable layer of char at the polymer surface, and a blowing out effect caused by pyrolytic gases escaping to the gaseous phase, were attributed to the improved fire retardancy. This research may find applications in thermal insulation material of electronic circuit boards, coating in aerospace materials, as well as building and construction industries.
Publisher: Elsevier BV
Date: 2014
DOI: 10.1016/J.CARBPOL.2013.10.002
Abstract: Fibre crosslinking with polycarboxylic acids can be used to improve certain properties of paper products, including wet tensile and compressive strength. In the present work it was proposed that citric acid (CA) crosslinks the cellulosic fibres of linerboard by self-catalysed esterification of cellulosic hydroxyl groups, which makes an additional catalyst unnecessary. An increase in CA dose or curing temperature increased linerboard compressive strength. In CA-treated corrugated board most of the applied CA was esterified with fibres while some CA thermolysis products were also present. A significant portion of the applied CA was unaccounted for. The deficit was attributed to thermolysis to give volatile anhydrides of unsaturated acids. Under cyclic humidity and static compressive loading, CA-treated corrugated boxes showed a greater than three-fold increase in resistance to compressive creep, showing that CA treatment can be used to extend the lifetime of corrugated boxes used for horticultural produce storage.
Publisher: Wiley
Date: 05-03-2017
DOI: 10.1111/BCP.13260
Publisher: MDPI AG
Date: 06-03-2023
Abstract: The power of computational modeling and simulation for establishing clear links between materials’ intrinsic properties and their atomic structure has more and more increased the demand for reliable and reproducible protocols. Despite this increased demand, no one approach can provide reliable and reproducible outcomes to predict the properties of novel materials, particularly rapidly cured epoxy-resins with additives. This study introduces the first computational modeling and simulation protocol for crosslinking rapidly cured epoxy resin thermosets based on solvate ionic liquid (SIL). The protocol combines several modeling approaches, including quantum mechanics (QMs) and molecular dynamics (MDs). Furthermore, it insightfully provides a wide range of thermo-mechanical, chemical, and mechano-chemical properties, which agree with experimental data.
Publisher: Springer Nature Singapore
Date: 2023
Publisher: Wiley
Date: 06-2023
Abstract: The radical‐bearing epoxy monomer could be the ideal embodiment of multifunctionality in epoxy‐based materials. This study demonstrates the potential of macroradical epoxies as surface coating materials. A diepoxide monomer derivatized with a stable nitroxide radical is polymerized with a diamine hardener under the influence of a magnetic field. The magnetically oriented and stable radicals in the polymer backbone render the coatings antimicrobial. The unconventional use of magnets during polymerization proved crucial in correlating the structure‐property relationships with antimicrobial performance inferred from oscillatory rheological technique, polarized macro‐attenuated total reflectance – infrared (macro‐ATR‐IR) spectroscopy and X‐ray photoelectron spectroscopy (XPS). The magnetic thermal curing influenced the surface morphology, resulting in a synergy of the coating's radical nature with microbiostatic performance assessed using the Kirby‐Bauer test and liquid chromatography – mass spectroscopy (LC–MS). Further, the magnetic curing of blends with a traditional epoxy monomer demonstrates that radical alignment is more critical than radical density in imparting biocidal behavior. This study shows how the systematic use of magnets during polymerization could pave for probing more significant insights into the mechanism of antimicrobial action in radical‐bearing polymers.
Publisher: Elsevier BV
Date: 09-2021
Publisher: Wiley
Date: 21-09-2016
Publisher: Elsevier BV
Date: 10-2022
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 07-12-2016
Publisher: Informa UK Limited
Date: 13-08-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SM01731D
Abstract: Improving the electrical performance of macroradical epoxy thermosets to surpass the semiconductor threshold requires a comprehensive understanding of the electrical charge transport mechanisms and characteristics.
Publisher: Elsevier BV
Date: 07-2019
DOI: 10.1016/J.FREERADBIOMED.2019.05.010
Abstract: Vegetarian diets are commonly associated with lower blood pressure levels. This has been related to greater consumption of inorganic nitrate, since vegetables are the main source of this anion. Dietary nitrate is reduced to nitrite by commensal bacteria in the mouth, which in turn leads to increased circulatory nitrite availability. Nitrite can form nitric oxide by several pathways promoting a reduction in the vascular tone and lower blood pressure. This study tested whether vegetarians have higher concentrations of nitrite in saliva and plasma, and lower blood pressure and resting metabolic rate (RMR), due to higher intakes of nitrate, compared to omnivores. Following a non-randomized, cross-over and single-blinded design we measured dietary nitrate intake, blood pressure and RMR in young and healthy vegetarians (n = 22) and omnivores (n = 19) with similar characteristics after using placebo or antibacterial mouthwash for a week to inhibit oral bacteria. Additionally, we analyzed salivary and plasma nitrate and nitrite concentrations, as well as the oral nitrate-reduction rate and oral microbiome in both groups. Dietary nitrate intake in vegetarians (97 ± 79 mg/day) was not statistically different (P > 0.05) to omnivores (78 ± 47 mg/day). Salivary and plasma nitrate and nitrite concentrations were similar after placebo mouthwash in both groups (P > 0.05). The oral nitrate-reducing capacity, abundance of oral bacterial species, blood pressure and RMR were also similar between vegetarians and omnivores (P > 0.05). Antibacterial mouthwash significantly decreased abundance of oral nitrate-reducing bacterial species in vegetarians (
Publisher: Wiley
Date: 12-2016
Publisher: Elsevier BV
Date: 12-1991
Publisher: Elsevier BV
Date: 08-2018
DOI: 10.1016/J.MOLCEL.2018.06.025
Abstract: Telomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation and its potential dissociation from control over non-homologous end joining (NHEJ)-dependent telomere fusion is of central importance to telomere-dependent cell aging and tumor suppression. Using super-resolution microscopy, we identify that ATM activation at mammalian telomeres with reduced TRF2 or at human telomeres during mitotic arrest occurs specifically with a structural change from telomere loops (t-loops) to linearized telomeres. Additionally, we find the TRFH domain of TRF2 regulates t-loop formation while suppressing ATM activity. Notably, we demonstrate that ATM activation and telomere linearity occur separately from telomere fusion via NHEJ and that linear DDR-positive telomeres can remain resistant to fusion, even during an extended G1 arrest, when NHEJ is most active. Collectively, these results suggest t-loops act as conformational switches that specifically regulate ATM activation independent of telomere mechanisms to inhibit NHEJ.
Publisher: Elsevier BV
Date: 12-2022
Publisher: MDPI AG
Date: 18-11-2022
Abstract: Several environmental and techno-economic assessments highlighted the advantage of placing polystyrene-based materials in a circular loop, from production to waste generation to product refabrication, either following the mechanical or thermochemical routes. This review provides an assortment of promising approaches to solving the dilemma of polystyrene waste. With a focus on upcycling technologies available in the last five years, the review first gives an overview of polystyrene, its chemistry, types, forms, and varied applications. This work presents all the stages that involve polystyrene's cycle of life and the properties that make this product, in mixtures with other polymers, command a demand on the market. The features and mechanical performance of the studied materials with their associated images give an idea of the influence of recycling on the structure. Notably, technological assessments of elucidated approaches are also provided. No single approach can be mentioned as effective per se hybrid technologies appear to possess the highest potential. Finally, this review correlates the amenability of these polystyrene upcycling methodologies to frontier technologies relating to 3D printing, human space habitation, flow chemistry, vertical farming, and green hydrogen, which may be less intuitive to many.
Location: Australia
Start Date: 2019
End Date: 2019
Funder: Australian Synchrotron
View Funded ActivityStart Date: 2019
End Date: 2023
Funder: Swinburne University of Technology
View Funded ActivityStart Date: 2020
End Date: 2020
Funder: Australian Synchrotron
View Funded Activity