ORCID Profile
0000-0001-5018-7537
Current Organisations
The University of Edinburgh
,
Southwest Research Institute
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Publisher: Springer Science and Business Media LLC
Date: 16-02-2021
DOI: 10.1038/S41467-021-21491-Y
Abstract: A Correction to this paper has been published: 0.1038/s41467-021-21491-y
Publisher: American Astronomical Society
Date: 04-2021
DOI: 10.3847/PSJ/ABE6AA
Abstract: Persephone is a NASA concept mission study that addresses key questions raised by New Horizons’ encounters with Kuiper Belt objects (KBOs), with arguably the most important being, “Does Pluto have a subsurface ocean?” More broadly, Persephone would answer four significant science questions: (1) What are the internal structures of Pluto and Charon? (2) How have the surfaces and atmospheres in the Pluto system evolved? (3) How has the KBO population evolved? (4) What are the particles and magnetic field environments of the Kuiper Belt? To answer these questions, Persephone has a comprehensive payload, and it would both orbit within the Pluto system and encounter other KBOs. The nominal mission is 30.7 yr long, with launch in 2031 on a Space Launch System Block 2 rocket with a Centaur kick stage, followed by a 27.6 yr cruise powered by existing radioisotope electric propulsion and a Jupiter gravity assist to reach Pluto in 2058. En route to Pluto, Persephone would have one 50–100 km class KBO encounter before starting a 3.1-Earth-year orbital c aign of the Pluto system. The mission also includes the potential for an 8 yr extended mission, which would enable the exploration of another KBO in the 100–150 km size class. The mission payload includes 11 instruments: Panchromatic and Color High-Resolution Imager, Low-Light Camera, Ultra-Violet Spectrometer, Near-Infrared (IR) Spectrometer, Thermal IR Camera, Radio Frequency Spectrometer, Mass Spectrometer, Altimeter, Sounding Radar, Magnetometer, and Plasma Spectrometer. The nominal cost of this mission is $3.0 billion, making it a large strategic science mission.
Publisher: Elsevier BV
Date: 11-2007
DOI: 10.1016/J.VIROL.2007.06.018
Abstract: It is now well established that the clade of simian immunodeficiency viruses (SIVs) infecting west central African chimpanzees (Pan troglodytes troglodytes) and western gorillas (Gorilla gorilla gorilla) comprises the progenitors of human immunodeficiency virus type 1 (HIV-1). In this study, we have greatly expanded our previous molecular epidemiological survey of SIVcpz in wild chimpanzees in Cameroon. The new results confirm a wide but uneven distribution of SIVcpzPtt in P. t. troglodytes throughout southern Cameroon and indicate the absence of SIVcpz infection in Pan troglodytes vellerosus. Analyzing 725 fecal s les from 15 field sites, we obtained partial nucleotide sequences from 16 new SIVcpzPtt strains and determined full-length sequences for two of these. Phylogenetic analyses of these new viruses confirmed the previously reported phylogeographic clustering of SIVcpzPtt lineages, with viruses related to the ancestors of HIV-1 groups M and N circulating exclusively in southeastern and south central P. t. troglodytes communities, respectively. Importantly, the SIVcpzPtt strains from the southeastern corner of Cameroon represent a relatively isolated clade indicating a defined geographic origin of the chimpanzee precursor of HIV-1 group M. Since contacts between humans and apes continue, the possibility of ongoing transmissions of SIV from chimpanzees (or gorillas) to humans has to be considered. In this context, our finding of distinct SIVcpzPtt envelope V3 sequence clades suggests that these peptides may be useful for the serological differentiation of SIVcpzPtt and HIV-1 infections, and thus the diagnosis of new cross-species transmissions if they occurred.
Publisher: Wiley
Date: 08-2011
Publisher: Cambridge University Press (CUP)
Date: 12-2005
DOI: 10.1017/S1743921306004522
Abstract: The Working Group was formed at the request of the Board of DivisionIII and approved by the IAU Executive committee in March 2004. This was in recognition of the fact that discoveries in the Trans Neptunian region were repeatedly raising the question of “what is a planet”. The task of the WG was to investigate the options available and give indications of the level of support and opposition for each if more than one option was emerging.
Publisher: Proceedings of the National Academy of Sciences
Date: 20-08-2018
Abstract: Chimpanzees, bonobos, and gorillas harbor close relatives of human Plasmodium vivax , but current knowledge of these parasites is limited to a small number of gene fragments derived almost exclusively from mitochondrial DNA. We compared nearly full-length genomes of ape parasites with a global s le of human P. vivax and tested the function of human and ape P. vivax proteins believed to be important for erythrocyte binding. The results showed that ape parasites are 10-fold more erse than human P. vivax and exhibit no evidence of species specificity, whereas human P. vivax represents a bottlenecked lineage that emerged from within this parasite group. Thus, African apes represent a large P. vivax reservoir whose impact on human malaria eradication requires careful monitoring.
Publisher: Springer Science and Business Media LLC
Date: 04-10-2019
DOI: 10.1038/S41467-019-12294-3
Abstract: Plasmodium species are frequently host-specific, but little is currently known about the molecular factors restricting host switching. This is particularly relevant for P. falciparum , the only known human-infective species of the Laverania sub-genus, all other members of which infect African apes. Here we show that all tested P. falciparum isolates contain an inactivating mutation in an erythrocyte invasion associated gene, PfEBA165 , the homologues of which are intact in all ape-infective Laverania species. Recombinant EBA165 proteins only bind ape, not human, erythrocytes, and this specificity is due to differences in erythrocyte surface sialic acids. Correction of PfEBA165 inactivating mutations by genome editing yields viable parasites, but is associated with down regulation of both PfEBA165 and an adjacent invasion ligand, which suggests that PfEBA165 expression is incompatible with parasite growth in human erythrocytes. Pseudogenization of PfEBA165 may represent a key step in the emergence and evolution of P. falciparum .
Publisher: American Astronomical Society
Date: 04-09-2019
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for S.A. Stern.