ORCID Profile
0000-0002-2165-448X
Current Organisations
Fondazione IRCCS Istituto Nazionale dei Tumori
,
University of Melbourne
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Publisher: Elsevier BV
Date: 08-2021
Publisher: Oxford University Press (OUP)
Date: 25-09-2020
DOI: 10.1002/BJS.12050
Publisher: Inderscience Publishers
Date: 2012
Publisher: Trans Tech Publications, Ltd.
Date: 09-2013
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.393.381
Abstract: In this paper static analysis of a cantilever functionally graded sandwich beam under uniform distributed loads is carried out numerically. The beam is composed of two glass fiber reinforced plastic (GFRP) facesheets and a graded Corecell A-series foam core. The composite skins and foam core are stitched together using the same glass fiber. A finite element (FE) model is developed employing a FE commercial code to determine the stresses and deflections. To find the effect of quality of foam gradation through the thickness of the core on the deflections and stresses numerical experiments are performed. Results revealed that the quality of gradation of the foam core affected the displacements and stresses significantly so that an optimal gradation of foam can minimize the deflection, stresses and weight of the sandwich beam.
Publisher: Trans Tech Publications, Ltd.
Date: 03-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.488-489.358
Abstract: Failure analysis of one-ply thin-walled hemispherical GRP dome internally pressurized was checked via analytical approach and finite element simulations using ABAQUS and MATLAB software. Tsai-Wu failure criterion was employed during analysis. The failure factor against changes of dome’s geometrical parameters was investigated. Subsequently, laminated hemispherical GRP dome failure behavior was theoretically analyzed using MATLAB software. During the analysis some geometrical parameters were assumed to be constant. Moreover, symmetrical laminations were taken into account. The Tsai-Wu failure factor was checked based on changes of applied internal pressure, ply thickness, dome’s internal radius and ratio of dome’s internal radius over ply thickness. The behavior was determined to be linear and quadratic both.
Publisher: Trans Tech Publications, Ltd.
Date: 11-2011
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.383-390.6695
Abstract: In this study, the appropriate input parameters for achieving minimum surface roughness and high material removal rate are selected for wire electrical discharge machining of cold-work steel 2601. Mathematical modeling acquired by experimental result analysis is used to find the relation between input parameters including electrical current, gap voltage, open-circuit voltage and pulse-off time and output parameters. Subsequently, with exploitation of variance analysis, importance and effective percentages of each parameter are studied. The combination of optimum machining parameters is acquired using the analysis of ratios of signal-to-noise. Finally, according to multiple-objective optimization, outputs acquired from Non-dominated Sorting Genetic Algorithm led in achieving appropriate models. The optimization results showed suggested method has a high performance in problem solving.
Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 09-2021
Publisher: SPIE
Date: 10-2011
DOI: 10.1117/12.914614
Publisher: Elsevier BV
Date: 09-2023
Publisher: Informa UK Limited
Date: 18-06-2021
Publisher: Mathematical Sciences Publishers
Date: 12-02-2015
Publisher: Springer Science and Business Media LLC
Date: 08-2019
Publisher: Trans Tech Publications, Ltd.
Date: 09-2013
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.393.387
Abstract: The effect of low velocity impact response on the thin laminated composite cylindrical shell with different stacking sequences was investigated. Finite element simulation using ABAQUS software was the base of the study during the analysis. The framework was to study the stress and displacement in radial and circumferential directions through finite element simulation. For simplicity, an arbitrarily picked circumferential path at where the impactor impacts the shell surface was selected. The graphs plotted based on stress and displacement variables Vs radial and circumferential directions did not show the significant changes for laminations with different stacking sequences. In addition, The 90 degree along circumferential and radial directions was found to be the critical point.
Publisher: IEEE
Date: 09-2011
Publisher: SAGE Publications
Date: 26-05-2020
Abstract: The knee plays a significant role in locomotion and stability of the entire body through supporting the body weight and assisting the lower body kinematics during walking. However, the knee is at constant risk of becoming weakened due to disease, age, and accidents. One approach to treating weakened knee is wearing an assistive knee brace. To design a clinical knee brace, many factors such as weight and compliant mechanism should be considered. In this study, a novel smart assistive knee brace mechanism incorporated with wire actuators made of shape memory alloys is proposed to ameliorate the issues associated with weight and flexibility of existing brace designs. Unlike earlier studies, the proposed orthosis includes pressure sensor, shape memory actuator, and smart linkage. Furthermore, two distinct shape memory alloy actuator design concepts with improved stiffness are developed, and the best option is chosen systematically and prototyped. The novel mechanism proposed in this research overcomes the weight of the lower limb during swing phase using the combined shape memory alloy actuation and feed-forward controller design. As such, it can be used as a potential replacement to its conventional counterparts when the higher weight reduction as well as a flexible and controllable mechanism are simultaneously sought.
Publisher: Informa UK Limited
Date: 10-2021
Publisher: Elsevier BV
Date: 02-2020
Publisher: MDPI AG
Date: 18-05-2021
DOI: 10.3390/MA14102650
Abstract: This paper introduces a new spark plasma sintering technique that is able to order crystalline anisotropy by in-series/in situ DC electric coupled magnetic field. The process control parameters have been investigated on the production of anisotropic BaFe12O19 magnets based on resulted remanence (Mr). Sintering holding time (H.T.), cooling rate (C.R.), pressure (P), and sintering temperature (S.T.) are optimized by Taguchi with L9 orthogonal array (OA). The remanent magnetization of nanocrystalline BaFe12O19 in parallel (Mrǁ) and perpendicular (MrꞱ) to the applied magnetic field was regarded as a measure of performance. The Taguchi study calculated optimum process parameters, which significantly improved the sintering process based on the confirmation tests of BaFe12O19 anisotropy. The magnetic properties in terms of Mrǁ and MrꞱ were greatly affected by sintering temperature and pressure according to ANOVA results. In addition, regression models were developed for predicting the Mrǁ as well as MrꞱ respectively.
Publisher: Elsevier BV
Date: 08-2015
Publisher: Elsevier BV
Date: 11-2021
Publisher: Elsevier BV
Date: 10-2019
Publisher: The American Association of Immunologists
Date: 15-09-2009
Abstract: TLR4 is the primary sensor of LPS. In this study, we describe for the first time TLR4 interactor with leucine-rich repeats (TRIL), which is a novel component of the TLR4 complex. TRIL is expressed in a number of tissues, most prominently in the brain but also in the spinal cord, lung, kidney, and ovary. TRIL is composed of a signal sequence, 13 leucine-rich repeats, a fibronectin domain, and a single transmembrane spanning region. TRIL is induced by LPS in the human astrocytoma cell line U373, in murine brain following i.p. injection, and in human PBMC. Endogenous TRIL interacts with TLR4 and this interaction is greatly enhanced following LPS stimulation. TRIL also interacts with the TLR4 ligand LPS. Furthermore, U373 cells stably overexpressing TRIL display enhanced cytokine production in response to LPS. Finally, knockdown of TRIL using small interfering RNA attenuates LPS signaling and cytokine production in cell lines, human PBMC, and primary murine mixed glial cells. These results demonstrate that TRIL is a novel component of the TLR4 complex which may have particular relevance for the functional role of TLR4 in the brain.
Publisher: Springer Science and Business Media LLC
Date: 12-09-2010
DOI: 10.1038/NI.1935
Publisher: Elsevier BV
Date: 08-2020
Publisher: Elsevier BV
Date: 07-2022
Publisher: Elsevier BV
Date: 2023
Publisher: IOP Publishing
Date: 31-07-2018
Publisher: Elsevier BV
Date: 12-2016
DOI: 10.1016/J.TRSL.2016.07.011
Abstract: The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity and counter indications such as infection and cancer. Furthermore, immunosuppressants do little to prevent ischemia-reperfusion injury during the transplantation procedure itself hence there is a growing need to develop novel immunosuppressive drugs specifically aimed at prolonging graft survival. Linear tetrapyrroles derived from the breakdown of mammalian heme have been shown in numerous studies to play a protective role in allograft transplantation and ischemia-reperfusion injury however, commercial sources of these products have not been approved for use in humans. Plants and algae produce equivalent linear tetrapyrroles called bilins that serve as chromophores in light-sensing. One such marine-derived tetrapyrrole, phycocyanobilin (PCB), shows significant structural similarity to mammalian biliverdin (BV) and may prove to be a safer alternative for use in the clinic if it can exert direct effects on human immune cells. Using a mixed lymphocyte reaction, we quantified the allogeneic responses of recipient cells to donor cells and found that PCB, like BV, effectively suppressed proliferation and proinflammatory cytokine production. In addition, we found that BV and PCB can directly downregulate the proinflammatory responses of both innate dendritic cells and adaptive T cells. We therefore propose that PCB may be an effective therapeutic drug in the clinical setting of transplantation and may also have wider applications in regulating inappropriate inflammation.
Publisher: Springer Science and Business Media LLC
Date: 12-2013
Publisher: Elsevier BV
Date: 09-2020
Publisher: Trans Tech Publications, Ltd.
Date: 03-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.488-489.530
Abstract: Externally pressurized thin-walled GFRP composite cylindrical shell strength was studied against failure. Fiber breakage, matrix breakage, interlaminate shear deformation, delamination shear deformation and micro buckling failure were investigated employing maximum failure criteria as volumetric fiber fraction factor varied. One-ply cylindrical shell with fiber angle orientation of 0 degree was modeled in ABAQUS finite element simulation and the result was varied using analytical approaches. Moreover, the pressure fluctuations for various volumetric fiber fraction factors were quadratic according to plotted graphs obtained. Meanwhile, MATLAB software was used for theoretical analysis. The comparison of two approaches was proved to be accurate. Subsequently, failure strength of various laminated GFRP cylindrical shell with different fiber angle orientations at each ply was studied for erse volumetric fiber fraction factors. Stacking sequence, fiber angle orientations were mainly effective on failure strength.
Publisher: Elsevier BV
Date: 06-2016
Publisher: MDPI AG
Date: 08-10-2021
DOI: 10.3390/MA14195893
Abstract: Commercial poly methyl methacrylate (PMMA)-based cement is currently used in the field of orthopedics. However, it suffers from lack of bioactivity, mechanical weakness, and monomer toxicity. In this study, a PMMA-based cement nanocomposite reinforced with hydroxyapatite (HA) nanofibers and two-dimensional (2D) magnesium phosphate MgP nanosheets was synthesized and optimized in terms of mechanical property and cytocompatibility. The HA nanofibers and the MgP nanosheets were synthesized using a hydrothermal homogeneous precipitation method and tuning the crystallization of the sodium-magnesium-phosphate ternary system, respectively. Compressive strength and MTT assay tests were conducted to evaluate the mechanical property and the cytocompatibility of the PMMA-HA-MgP nanocomposites prepared at different ratios of HA and MgP. To optimize the developed nanocomposites, the standard response surface methodology (RSM) design known as the central composite design (CCD) was employed. Two regression models generated by CCD were analyzed and compared with the experimental results, and good agreement was observed. Statistical analysis revealed the significance of both factors, namely, the HA nanofibers and the MgP nanosheets, in improving the compressive strength and cell viability of the PMMA-MgP-HA nanocomposite. Finally, it was demonstrated that the HA nanofibers of 7.5% wt and the MgP nanosheets of 6.12% wt result in the PMMA-HA-MgP nanocomposite with the optimum compressive strength and cell viability.
Publisher: Elsevier BV
Date: 12-2023
Publisher: Trans Tech Publications, Ltd.
Date: 02-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.463-464.399
Abstract: In this study a single step of the chemical pre-treatment is implemented to tungsten carbide (WC 6 [%]) at the surface of the substrate in order to solve poor adhesion problem. During the pre-treatment process, numerous parameters such as etching time, acid temperature and concentration affect on the surface roughness and Cobalt content of WC-Co substrate are investigated. Optimal selection of these parameters is one of the significant issues to achieve high-quality work-piece in etching process. Thus, the statistical model based on nonlinear polynomial equations is developed for the different responses. Non-dominated Sorting Genetic Algorithm (NSGA-II) with the use of MATLAB Software codes is used to solve multi-objective optimization problem in order to provide a preferred solution for a process engineer in a short period of time.
Publisher: Trans Tech Publications, Ltd.
Date: 02-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.463-464.477
Abstract: One-ply thick externally pressurized GFRP cylinders were analyzed using computational numerical simulation and analytical method. The main part of the work was to study the critical external pressure to avoid failure in the laminated shells by employing various phenomenological failure criteria. Comparison between ABAQUS FEM simulation results and analytical solutions using MATLAB programming codes proved high accuracy of the analytical approach. Various fiber angles stacking sequences were chosen for optimization analysis. The results did not show any increase in stability as the layer number increased. The results also showed high correlation with corresponding failure criteria. The analytical solutions gave higher accuracy as the number of plies and the total laminate thicknesses were reduced.
Publisher: Springer Science and Business Media LLC
Date: 18-02-2021
Publisher: American Society of Clinical Oncology (ASCO)
Date: 2021
DOI: 10.1200/JCO.20.01933
Abstract: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9% adjusted odds ratio [aOR], 0.62 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6% aOR, 0.53 95% CI, 0.36 to 0.76). Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
Publisher: Elsevier BV
Date: 09-2021
Publisher: BMJ
Date: 19-07-2021
DOI: 10.1136/MEDETHICS-2020-107017
Abstract: Disproportional morbidity and mortality experienced by ethnic minorities in the UK have been highlighted by the COVID-19 pandemic. The ‘Black Lives Matter’ movement has exposed structural racism’s contribution to these health inequities. ‘Cultural Safety’, an antiracist, decolonising and educational innovation originating in New Zealand, has been adopted in Australia. Cultural Safety aims to dismantle barriers faced by colonised Indigenous peoples in mainstream healthcare by addressing systemic racism. This paper explores what it means to be ‘culturally safe’. The ways in which New Zealand and Australia are incorporating Cultural Safety into educating healthcare professionals and in day-to-day practice in medicine are highlighted. We consider the ‘nuts and bolts’ of translating Cultural Safety into the UK to reduce racism within healthcare. Listening to the voices of black, Asian and minority ethnic National Health Service (NHS) consumers, education in reflexivity, both personal and organisational within the NHS are key. By listening to Indigenous colonised peoples, the ex-Empire may find solutions to health inequity. A decolonising feedback loop is required however, we should take care not to culturally appropriate this valuable reverse innovation.
Publisher: Elsevier BV
Date: 05-2014
DOI: 10.1038/MI.2014.93
Publisher: SAGE Publications
Date: 06-2020
Abstract: Shape memory alloys are increasingly used in numerous smart engineering structures. This study experimentally investigates static flexural and free vibration characteristics of composite beams reinforced with shape memory alloy wires. The key to this study is using shape memory alloy fibers as a means for influencing and tuning the static and dynamic responses of structures. A series of static three-point bending and modal experiments is performed to capture the capability of shape memory alloy wires in controlling the static and dynamic responses of a reinforced beam. Static and dynamic behaviors of the fiber-reinforced beam with different volumetric fiber fractions are examined. Before heat excitation, increasing the number of shape memory alloy wires leads to higher beam stiffness and lower beam deflection. However, with both heat activation and the higher number of shape memory alloy wires, beam deflection is significantly reduced. The modal vibration tests demonstrated that when shape memory alloy wires are not activated, the magnitude of natural frequencies slightly decreases by increasing the number of shape memory alloy wires. However, with heat excitation, the higher number of shape memory alloy wires, in contrast, increases the magnitude of natural frequencies. Furthermore, the higher number of activated shape memory alloy wires shows to predominantly increase the magnitude of higher modes of vibration rather than lower modes.
Publisher: Elsevier BV
Date: 2021
Publisher: Frontiers Media SA
Date: 11-09-2019
Publisher: SAGE Publications
Date: 29-06-2022
DOI: 10.1177/00219983221107257
Abstract: A Levi-type analytical solution procedure is developed to characterize static and dynamic deformation response of smart laminated simply-supported composite rectangular plates induced by inclined piezoelectric actuators under (1) constant electrical voltage and (2) time-dependent electrical voltage with excitation frequency. The key to development of this analytical solution is to employ higher order finite integral transform and discretized higher order partial differential unit step function equations. Unlike earlier studies, this research aims to investigate the effect of inclination angle of piezoelectric actuators on static and dynamic deformation response of laminated composite plates under both static and dynamic conditions. The developed analytical solution procedure is implemented computationally through Matlab-based computer code. Its accuracy is initially investigated through convergence study and results comparison with the published literature for a particular case when inclination angle is θ = 0°, which is only limited to bending deformation response. Since there is no published benchmark data for twisting deformation response analysis caused by inclination angle of piezoelectric actuators (θ ≠ 0°), a set of robust and realistic numerical analysis using Abaqus finite element analysis (FEA) is conducted. Good agreement between the analytical and numerical results is observed. Unlike applied electrical voltage, inclination angle of a piezoelectric actuator does not have a significant impact on twisting deformation response during static mode whereas, both the excitation frequency and inclination angle can significantly influence maximum litude of vibration.
Publisher: Elsevier BV
Date: 02-2017
Publisher: Springer Science and Business Media LLC
Date: 06-07-2018
DOI: 10.1038/S41598-018-28488-6
Abstract: Psoriasis is a chronic autoimmune disease mediated by dysregulated immune responses in dendritic cells (DC) and T cells. The stress-response enzyme heme oxygenase-1 (HO-1) has been described as protective in animal models of psoriasis, however, implementation of HO-1-based therapies is hindered by the lack of clinically-suitable HO-1 inducers. The plant-derived polyphenols, carnosol and curcumin, have been identified as candidate HO-1 inducers however there has been little investigation into their effects on human immune cells. We demonstrate that treatment of human DC with these polyphenols limits DC maturation, reduces pro-inflammatory cytokine production, and prevents induction of allospecific T cell responses, in a manner partially dependent on carbon monoxide (CO). We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNγ, IL-17, GM-CSF and IL-22. This study therefore supports reports highlighting the therapeutic potential of curcumin in psoriasis by providing insight into its immunological effects on healthy human DC and psoriasis PBMC. We also demonstrate, for the first time, the anti-inflammatory effects of carnosol in human immune cells.
Publisher: Elsevier BV
Date: 06-2016
Publisher: Elsevier BV
Date: 09-2012
Publisher: Springer Science and Business Media LLC
Date: 09-2018
Publisher: Informa UK Limited
Date: 15-01-2022
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Soheil Gohari.