mercedes gonzalez-juarrero

Immunological Basis for Reactivation of Tuberculosis in Mice

Publisher: American Society for Microbiology

Date: 05-2001

DOI: 10.1128/IAI.69.5.3264-3270.2001

Abstract: In this study different inbred strains of mice appeared to control and contain a low dose aerosol infection with Mycobacterium tuberculosis in a similar manner, giving rise to a chronic state of disease. Thereafter, however, certain strains gradually began to show evidence of regrowth of the infection, whereas others consistently did not. Using C57BL/6 mice as an ex le of a resistant strain and CBA/J mice as an ex le of a strain susceptible to bacterial growth, we found that these animals revealed distinct differences in the cellular makeup of lung granulomas. The CBA/J mice exhibited a generally poor lymphocyte response within the lungs and vastly increased degenerative pathology at a time associated with regrowth of the infection. As a possible explanation for these events, it was then observed that the CBA/J mouse strain was also less able to upregulate adhesion molecules, including CD11a and CD54, on circulating lymphocytes. These results therefore suggest that a failure to control a chronic infection with M. tuberculosis may reflect an inability to localize antigen-specific lymphocytes within the lung.

Complutense University Of Madrid

Location: Spain

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Colorado State University

Location: United States of America

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Ethiopian Health And Nutrition Research Institute

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Universidad Complutense De Madrid

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International Laboratory For Research On Animal Diseases (ILRAD)

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Universidad Autonoma De Madrid

Location: Spain

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