ORCID Profile
0000-0003-0221-8380
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Publisher: Cold Spring Harbor Laboratory
Date: 22-11-2022
DOI: 10.1101/2022.11.21.517331
Abstract: While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. To this end, we here employ an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics applied to a valuable cohort of resected tumour tissues from OSCC patients with (n = 19) and without (n = 12) lymph node metastasis. While all tumour tissues displayed uniform N -glycome profiles suggesting relatively stable global N -glycosylation during lymph node metastasis, glycoproteomics and advanced correlation analysis notably uncovered altered site-specific N -glycosylation and previously unknown associations with several key clinicopathological features. Importantly, focused analyses of the multi-omics data unveiled two N -glycans and three N -glycopeptides that were closely associated with patient survival. This study provides novel insight into the complex OSCC tissue N -glycoproteome forming an important resource to further explore the underpinning disease mechanisms and uncover new prognostic glyco-markers for OSCC. Deep survey of the dynamic landscape of complex sugars in oral tumours paves a way for new prognostic disease markers.
Publisher: Elsevier BV
Date: 2021
Publisher: Elsevier BV
Date: 07-2023
Publisher: Elsevier BV
Date: 08-2021
Publisher: Elsevier BV
Date: 2021
Location: Brazil
No related grants have been discovered for Fábio Malta de Sá Patroni.