ORCID Profile
0000-0002-7928-9673
Current Organisation
University of Southampton
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Publisher: SAGE Publications
Date: 07-2022
DOI: 10.1177/20438087221112330
Abstract: Intolerance of uncertainty (IU) is a transdiagnostic risk factor for psychiatric disorders, and plays an important role in fear and threat learning under uncertainty. The ‘reinstatement of fear/threat’ is an understudied phenomenon thought to represent clinical symptom relapse. Reinstatement of conditioned responding can be captured in the laboratory by presenting unsignaled presentations of an aversive unconditional stimulus. The present study investigated IU as a predictor of reinstatement effects, such that in iduals higher in IU, relative to lower IU, would show larger reinstatement. Sixty-two participants completed the Intolerance of Uncertainty Scale and provided threat expectancy ratings (i.e. certainty of receiving a shock) during a differential threat conditioning and extinction paradigm with reinstatement. Findings suggested a differential increase in threat expectancy ratings to both the threat and safety cue following reinstatement, although this effect was small and did not survive follow-up tests. Nevertheless, IU was a significant predictor of reinstatement to the threat cue but not the safety cue, although this effect was not in the expected direction. Specifically, higher IU was associated with reduced threat expectancy ratings post-reinstatement. These findings provide support for the limited literature demonstrating an important role for IU in reinstatement effects and should be investigated further.
Publisher: Center for Open Science
Date: 26-06-2019
Abstract: In iduals who score high in self-reported Intolerance of Uncertainty (IU) display difficulties updating threat associations to safe associations. Here we sought to determine whether in iduals who score high in IU can learn and retain new safety associations if given more exposure. We recorded skin conductance response, pupil dilation and expectancy ratings during an associative threat learning task with acquisition, same-day extinction and next-day extinction phases. Participants (n = 144) were assigned to either a regular exposure (32 trials of same-day and next-day extinction) or extended exposure condition (48 trials of same-day and next-day extinction). We failed to replicate previous work showing that IU is associated with poorer safety-learning indexed via SCR, although the results were at trend and in the expected direction. We found preliminary evidence for promoted safety-retention in in iduals with higher Inhibitory IU in the extended exposure condition, relative to in iduals with higher Inhibitory IU in the regular exposure condition, indexed via SCR. These findings further our current understanding of the role of IU in safety-learning and -retention, informing models of IU and exposure-based treatments.
Publisher: Center for Open Science
Date: 12-01-2020
Abstract: Difficulty updating threat associations to safe associations has been observed in in iduals who score high in self-reported Intolerance of Uncertainty (IU). Here we sought to determine whether an instruction based on fundamental principles of Cognitive Behavioural Therapy (CBT) could promote safety learning in in iduals with higher levels of IU, whilst controlling for self-reported trait anxiety (STICSA). We measured skin conductance response (SCR), pupil dilation and expectancy ratings during an associative threat learning task in which participants either received a cognitive behavioural instruction (CB) or no instruction prior to threat extinction (n = 92). Analyses revealed that both self-reported IU and STICSA similarly predicted differences in SCR. Only in iduals with lower IU/STICSA in the CB instruction condition displayed successful safety learning via SCR. These initial results provide some insight into how simple CB instructions combined with exposure are applied differently in in iduals with varying levels of self-reported anxiety. Conclusions. The results further our understanding of the role of basic CBT principles and self-reported anxiety in safety learning.
Publisher: Informa UK Limited
Date: 21-06-2019
DOI: 10.1080/17470919.2018.1486735
Abstract: The neural circuitry associated with threat regulation in the absence of other people is well established. An examination of threat regulatory processes with people from different domains of an in idual's social world is key to understanding social emotion regulation and personality functioning conceptualised as social domain organisation. In this study, 42 healthy female participants completed functional magnetic imaging sessions in which they underwent a scan in the presence of a romantic partner or friend, whilst completing a threat of shock task. In the presence of a romantic partner vs. friend, we found a reduction in amygdala activation to threat vs. safe trials over time. Furthermore, in the presence of a romantic partner vs. friend we observed greater subgenual anterior cingulate cortex and ventromedial prefrontal cortex activation to threat vs. safe trials overall. The results support the hypothesis that recruitment of threat regulation circuitry is modulated by romantic partner relative to another person well-known to the in idual. Future work needs to examine neural responses to a wider range of stimuli across more social domains, and implications of failures of this neural organisation for psychopathology.
Publisher: Springer Science and Business Media LLC
Date: 26-07-2022
DOI: 10.3758/S13415-021-00932-7
Abstract: Heightened responding to uncertain threat is considered a hallmark of anxiety disorder pathology. We sought to determine whether in idual differences in self-reported intolerance of uncertainty (IU), a key transdiagnostic dimension in anxiety-related pathology, underlies differential recruitment of neural circuitry during cue-signalled uncertainty of threat ( n = 42). In an instructed threat of shock task, cues signalled uncertain threat of shock (50%) or certain safety from shock. Ratings of arousal and valence, skin conductance response (SCR), and functional magnetic resonance imaging were acquired. Overall, participants displayed greater ratings of arousal and negative valence, SCR, and amygdala activation to uncertain threat versus safe cues. IU was not associated with greater arousal ratings, SCR, or amygdala activation to uncertain threat versus safe cues. However, we found that high IU was associated with greater ratings of negative valence and greater activity in the medial prefrontal cortex and dorsomedial rostral prefrontal cortex to uncertain threat versus safe cues. These findings suggest that during cue-signalled uncertainty of threat, in iduals high in IU rate uncertain threat as aversive and engage prefrontal cortical regions known to be involved in safety-signalling and conscious threat appraisal. Taken together, these findings highlight the potential of IU in modulating safety-signalling and conscious appraisal mechanisms in situations with cue-signalled uncertainty of threat, which may be relevant to models of anxiety-related pathology.
Publisher: Center for Open Science
Date: 19-11-2019
Abstract: In iduals who score high in Intolerance of Uncertainty (IU) have a tendency to find uncertainty and the unknown aversive. However, there is a dearth of literature on the extent to which the known vs. the unknown during threatening contexts induce fear and anxiety in in iduals with high IU. In the following registered report we attempted to address this question by manipulating the known and unknown in the threat of predictable and unpredictable aversive events task. Throughout the task, we measured a variety of self-report (ratings of valence and arousal) and physiological indices (skin conductance, pupil dilation, orbicularis oculi, corrugator supercilli). We collected data from 93 participants. Higher IU, relative to lower IU was associated with: (1) less discriminatory orbicularis oculi activity between cue and interstimulus interval periods across conditions, and (2) larger corrugator supercilii activity to the known predictable shock condition and smaller corrugator supercilii activity to the known unpredictable shock condition, compared to the other conditions. These findings provide evidence that IU-related biases manifest differently depending on the physiological marker of fear and anxiety and the type of known-unknown threat i.e. orbicularis oculi activity was related to generalisation across conditions, whilst corrugator supercilli activity reflected distress/relief during conditions with known threat. Ultimately, this research will inform future models of IU in relation to anxiety and stress disorders.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Center for Open Science
Date: 12-10-2022
Abstract: In iduals high in self-reported Intolerance of Uncertainty (IU) tend to view uncertainty as unbearable and stressful. Notably, IU is transdiagnostic, and high levels of IU are observed across many different emotional disorders (e.g. anxiety, depression). Research has primarily focused on how IU evokes and modulates emotional states such as fear and anxiety. However, recent research suggests that IU may have relevance for a broader range of emotional states. Here, an online survey was conducted (n = 231) to examine whether IU evokes and modulates a range of negative (e.g. fear/anxiety, sadness/upset, anger/frustration, disgust) and positive (e.g. happiness/joy, excitement/enthusiasm, surprise/interest) emotional states. Findings from the study revealed that in iduals with higher levels of IU report: (1) that uncertainty in general and uncertainty under ambiguity are more likely to evoke negative emotional states and less likely to evoke positive emotional states, (2) that uncertainty under risk is less likely to evoke positive emotional states, and (3) that uncertainty heightens existing negative emotional states and d ens existing positive emotional states. Importantly, these IU-related findings remained when controlling for current experiences of general distress, anxious arousal, and anhedonic depression. Taken together, these findings suggest that IU is involved in evoking and modulating a wide array of emotional phenomena, which likely has relevance for transdiagnostic models and treatment plans for emotional disorders.
Publisher: Center for Open Science
Date: 26-08-2022
Abstract: Previous research has demonstrated that in iduals with high levels of Intolerance of Uncertainty (IU) have difficulty updating threat associations to safety associations. Notably, prior research has focused on measuring IU-related differences in threat and safety learning using arousal-based measures such as skin conductance response. Here we assessed whether IU-related differences in threat and safety learning could be captured using eye-tracking metrics linked with gaze behaviours such as dwelling and scanning. Participants (N = 144) completed self-report questionnaires assessing levels of IU and trait anxiety. Eye movements were then recorded during each conditioning phase: acquisition, extinction learning, and extinction retention. Fixation count and fixation duration served as indices of conditioned responding. Patterns of threat and safety learning typically reported for physiology and self-report were observed for the fixation count and fixation duration metrics during acquisition and to some extent in extinction learning, but not for extinction retention. There was little evidence for specific associations between IU and disrupted safety learning (e.g., greater differential responses to the threat vs. safe cues during extinction learning and retention). While there was tentative evidence that IU was associated with shorter fixation durations (e.g., scanning) to threat vs. safe cues during extinction retention, this effect did not remain after controlling for trait anxiety. IU and trait anxiety similarly predicted greater fixation count and shorter fixation durations overall during extinction learning, and greater fixation count overall during extinction retention. IU further predicted shorter fixation durations overall during extinction retention. However, the only IU-based effect that remained significant after controlling for trait anxiety was that of fixation duration overall during threat extinction learning. Our results inform models of anxiety, particularly in relation to how in idual differences modulate gaze behaviour during threat conditioning.
Publisher: Center for Open Science
Date: 30-03-2020
Abstract: In iduals who score high in Intolerance of Uncertainty (IU) display reduced threat extinction. Recently, it was shown that replacing threat associations with novel associations during extinction learning (i.e. presenting a novel tone 100% of the time) can promote threat extinction retention in in iduals with high IU. This novelty facilitated extinction (NFE) effect could be driven by the tone’s novelty or reliability. Here we sought to address this question by adjusting the reliability of the novel tone (i.e., the reinforcement rate) during NFE. We measured skin conductance response during an associative learning task in which participants (n = 92) were assigned to one of three experimental groups: standard extinction, NFE 100% reinforcement or NFE 50% reinforcement. For standard extinction, compared to NFE 100% and 50% reinforcement groups, we observed a trend for greater recovery of the conditioned response during extinction retention. In iduals with high IU relative to low IU in the standard extinction group demonstrated a larger recovery of the conditioned response during extinction retention. These findings tentatively suggest that NFE effects are driven by the novelty rather than the reliability of the new stimulus. The implications of these findings for translational and clinical research in anxiety disorder pathology are discussed.
Publisher: University of California Press
Date: 2023
Abstract: Previous research has demonstrated that in iduals with high levels of Intolerance of Uncertainty (IU) have difficulty updating threat associations to safety associations. Notably, prior research has focused on measuring IU-related differences in threat and safety learning using arousal-based measures such as skin conductance response. Here we assessed whether IU-related differences in threat and safety learning could be captured using eye-tracking metrics linked with gaze behaviours such as dwelling and scanning. Participants (N = 144) completed self-report questionnaires assessing levels of IU and trait anxiety. Eye movements were then recorded during each conditioning phase: acquisition, extinction learning, and extinction retention. Fixation count and fixation duration served as indices of conditioned responding. Patterns of threat and safety learning typically reported for physiology and self-report were observed for the fixation count and fixation duration metrics during acquisition and to some extent in extinction learning, but not for extinction retention. There was little evidence for specific associations between IU and disrupted safety learning (e.g., greater differential responses to the threat vs. safe cues during extinction learning and retention). While there was tentative evidence that IU was associated with shorter fixation durations (e.g., scanning) to threat vs. safe cues during extinction retention, this effect did not remain after controlling for trait anxiety. IU and trait anxiety similarly predicted greater fixation count and shorter fixation durations overall during extinction learning, and greater fixation count overall during extinction retention. IU further predicted shorter fixation durations overall during extinction retention. However, the only IU-based effect that remained significant after controlling for trait anxiety was that of fixation duration overall during threat extinction learning. Our results inform models of anxiety, particularly in relation to how in idual differences modulate gaze behaviour during threat conditioning.
Publisher: Elsevier BV
Date: 07-2020
Publisher: Center for Open Science
Date: 14-09-2021
Abstract: Uncertainty and emotion are an inevitable part of everyday life and play a vital role in mental health. Yet, our understanding of how uncertainty and emotion interact is limited. Here, an online survey was conducted (n = 231) to examine whether uncertainty evokes and modulates a range of negative and positive emotions. The data show that uncertainty is predominantly associated with negative emotional states such as fear/anxiety. However, uncertainty was also found to modulate a variety of other negative (i.e. sadness/upset, anger/frustration, confusion) and positive (i.e. surprise/interest and excited/enthusiastic) emotional states, depending on the valence of an anticipated outcome (i.e. negative, positive) and the sub parameter of uncertainty (i.e. risk and ambiguity). Uncertainty increased the intensity of negative emotional states and decreased the intensity of positive emotional states. These findings support prior research suggesting that uncertainty is aversive and associated with negative emotional states such as fear and anxiety. However, the findings also revealed that uncertainty is involved in eliciting and modulating a wide array of emotional phenomena beyond fear and anxiety. This study highlights an opportunity for further study of how uncertainty and emotion interactions are conceptualised generally and in relation to mental health.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Jayne Morriss.