ORCID Profile
0000-0002-6920-201X
Current Organisation
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
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Publisher: Frontiers Media SA
Date: 08-10-2019
Publisher: Springer Science and Business Media LLC
Date: 18-05-2011
DOI: 10.1038/HDY.2011.35
Publisher: Wiley
Date: 04-2010
Publisher: Frontiers Media SA
Date: 09-09-2020
Publisher: Wiley
Date: 08-04-2019
DOI: 10.1111/NPH.15777
Abstract: Genome‐wide association studies (GWAS) have great promise for identifying the loci that contribute to adaptive variation, but the complex genetic architecture of many quantitative traits presents a substantial challenge. We measured 14 morphological and physiological traits and identified single nucleotide polymorphism (SNP)‐phenotype associations in a Populus trichocarpa population distributed from California, USA to British Columbia, Canada. We used whole‐genome resequencing data of 882 trees with more than 6.78 million SNPs, coupled with multitrait association to detect polymorphisms with potentially pleiotropic effects. Candidate genes were validated with functional data. Broad‐sense heritability ( H 2 ) ranged from 0.30 to 0.56 for morphological traits and 0.08 to 0.36 for physiological traits. In total, 4 and 20 gene models were detected using the single‐trait and multitrait association methods, respectively. Several of these associations were corroborated by additional lines of evidence, including co‐expression networks, metabolite analyses, and direct confirmation of gene function through RNAi. Multitrait association identified many more significant associations than single‐trait association, potentially revealing pleiotropic effects of in idual genes. This approach can be particularly useful for challenging physiological traits such as water‐use efficiency or complex traits such as leaf morphology, for which we were able to identify credible candidate genes by combining multitrait association with gene co‐expression and co‐methylation data.
Location: Spain
No related grants have been discovered for David Macaya-Sanz.