ORCID Profile
0000-0002-7999-0582
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Publisher: BMJ
Date: 09-1999
Publisher: Oxford University Press (OUP)
Date: 06-1996
Abstract: A 21 year-old man developed green surface staining of the cervical margins of his teeth 10 months after starting work in a brass foundry. During this time he was exposed intermittently to brass fumes which contained approximately 75% copper and 2-5% lead. The staining of his teeth was attributed to the absence of respiratory protection in the knock-out process and was accompanied by a rising blood lead concentration. Staining of the teeth by copper was described early this century but seems to have been neglected in the recent literature and texts on occupational medicine. We suggest that in brass foundry workers it is a warning of failure to control fume or dust exposure with the attendant risk of lead toxicity.
Publisher: American Medical Association (AMA)
Date: 28-02-1994
DOI: 10.1001/ARCHINTE.154.4.457
Abstract: How are different object categories organized by the visual system? Current evidence indicates that monkeys and humans process object categories in fundamentally different ways. Functional magnetic resonance imaging (fMRI) studies suggest that humans have a ventral temporal face area, but such evidence is lacking in macaques. Instead, face-responsive neurons in macaques seem to be scattered throughout temporal cortex, with some relative concentration in the superior temporal sulcus (STS). Here, using fMRI in alert fixating macaque monkeys and humans, we found that macaques do have discrete face-selective patches, similar in relative size and number to face patches in humans. The face patches were embedded within a large swath of object-selective cortex extending from V4 to rostral TE. This large region responded better to pictures of intact objects compared to scrambled objects, with different object categories eliciting different patterns of activity, as in the human. Overall, our results suggest that humans and macaques share a similar brain architecture for visual object processing.
Publisher: BMJ
Date: 02-1998
Abstract: It has been demonstrated that APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) is involved in the regulation of several growth-related signaling pathways and thus closely associated with the development and progression of some cancers. Diallyl trisulfide (DAT), a garlic-derived bioactive compound, exerts selective cytotoxicity to various human cancer cells through interfering with pro-survival signaling pathways. However, whether and how DAT affects survival of human hepatocellular carcinoma (HCC) cells remain unclear. Herein, we tested the hypothesis of the involvement of APPL1 in DAT-induced cytotoxicity in HCC HepG2 cells. We found that Lys 63 (K63)-linked polyubiquitination of APPL1 was significantly decreased whereas phosphorylation of APPL1 at serine residues remained unchanged in DAT-treated HepG2 cells. Compared with wild-type APPL1, overexpression of APPL1 K63R mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of STAT3, Akt, and Erk1/2. In addition, DAT administration markedly reduced protein levels of intracellular TNF receptor-associated factor 6 (TRAF6). Genetic inhibition of TRAF6 decreased K63-linked polyubiquitination of APPL1. Moreover, the cytotoxicity impacts of DAT on HepG2 cells were greatly attenuated by overexpression of wild-type APPL1. Taken together, these results suggest that APPL1 polyubiquitination probably mediates the inhibitory effects of DAT on survival of HepG2 cells by modulating STAT3, Akt, and Erk1/2 pathways.
Publisher: Wiley
Date: 24-10-2019
DOI: 10.1002/AJIM.23061
Publisher: BMJ
Date: 04-1999
DOI: 10.1136/OEM.56.4.232
Abstract: To examine the effect on hospital presentations for asthma of brief exposures to sulphur dioxide (SO2) (within the range 0-8700 micrograms/m3) emanating from two point sources in a remote rural city of 25,000 people. A time series analysis of SO2 concentrations and hospital presentations for asthma was undertaken at Mount Isa where SO2 is released into the atmosphere by a copper smelter and a lead smelter. The study examined 5 minute block mean SO2 concentrations and daily hospital presentations for asthma, wheeze, or shortness of breath. Generalised linear models and generalised additive models based on a Poisson distribution were applied. There was no evidence of any positive relation between peak SO2 concentrations and hospital presentations or admissions for asthma, wheeze, or shortness of breath. Brief exposures to high concentrations of SO2 emanating from point sources at Mount Isa do not cause sufficiently serious symptoms in asthmatic people to require presentation to hospital.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2014
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 04-2015
Publisher: BMJ
Date: 03-2000
DOI: 10.1136/OEM.57.3.165
Abstract: To examine the incidence, clinical state, personal risk factors, haematology, and biochemistry of heat exhaustion occurring at a deep underground metalliferous mine. To describe the underground thermal conditions associated with the occurrence of heat exhaustion. A 1 year prospective case series of acute heat exhaustion was undertaken. A history was obtained with a structured questionnaire. Pulse rate, blood pressure, tympanic temperature, and specific gravity of urine were measured before treatment. Venous blood was analysed for haematological and biochemical variables, during the acute presentation and after recovery. Body mass index (BMI) and maximum O2 consumption (VO2 max) were measured after recovery. Psychrometric wet bulb temperature, dry bulb temperature, and air velocity were measured at the underground sites where heat exhaustion had occurred. Air cooling power and psychrometric wet bulb globe temperature were derived from these data. 106 Cases were studied. The incidence of heat exhaustion during the year was 43.0 cases/million man-hours. In February it was 147 cases/million man-hours. The incidence rate ratio for mines operating below 1200 m compared with those operating above 1200 m was 3.17. Mean estimated fluid intake was 0.64 l/h (SD 0.29, range 0.08-1.50). The following data were increased in acute presentation compared with recovery (p value, % of acute cases above the normal clinical range): neutrophils (p < 0.001, 36%), anion gap (p < 0.001, 63%), urea (p < 0.001, 21%), creatinine (p < 0.001, 30%), glucose (p < 0.001, 15%), serum osmolality (p = 0.030, 71%), creatine kinase (p = 0.002, 45%), aspartate transaminase (p < 0.001, 14%), lactate dehydrogenase (p < 0.001, 9.5%), and ferritin (p < 0.001, 26%). The following data were depressed in acute presentation compared with recovery (p value, % of acute cases below the normal clinical range): eosinophils (p = 0.003, 38%) and bicarbonate (p = 0.011, 32%). Urea and creatinine were significantly increased in miners with heat cr s compared with miners without this symptom (p < 0.001), but there was no significant difference in sodium concentration (p = 0.384). Mean psychrometric wet bulb temperature was 29.0 degrees C (SD 2.2, range 21.0-34.0). Mean dry bulb temperature was 37.4 degrees C (SD 2.4, range 31.0-43.0). Mean air velocity was 0.54 m/s (SD 0.57, range 0.00-4.00). Mean air cooling power was 148 W/m2 (SD 49, range 33-290) Mean psychrometric wet bulb globe temperature was 31.5 degrees C (SD 2.0, range 25.2-35.3). Few cases (< 5%) occurred at psychrometric wet bulb temperature < 25.0 degrees C, dry bulb temperature 1.56 m/s, air cooling power > 248 W/m2, or psychrometric wet bulb globe temperature 250 W/m2 at all underground work sites.
Publisher: Oxford University Press (OUP)
Date: 08-2000
Abstract: This report documents a case series of miliaria rubra of the lower limbs in miners at a deep underground metalliferous mine in tropical arid Australia. During the summer months of February and March 1999, all cases of miliaria rubra of the lower limbs in underground miners seen at the mine's medical centre were clinically examined and administered a questionnaire. Twenty-five patients were seen, an incidence of 56.4 cases per million man-hours. Miliaria rubra was most often located between the ankle and knee (88% of cases). Twenty-four percent had concurrent folliculitis and 20% had concurrent tinea. Thirty-two percent had a personal history of asthma. Walking through ground-water and splashing of the legs was common. Three to 4 weeks of sedentary duties in air conditioning was generally required to achieve resolution of miliaria rubra. The incidence of miliaria rubra of the lower limbs is 38% of the incidence of heat exhaustion at the same mine. The length of disablement is greater, however. Atopics may be at increased risk of miliaria rubra. Control measures are discussed.
Publisher: BMJ
Date: 08-1994
DOI: 10.1136/OEM.51.8.553
Abstract: The aim was to compare the peak expiratory flow (PEF) of welders and non-welders over a 12 hour period from the start of work on Monday. The two study groups consisted of 20 welders and 20 non-welders, all men who had essentially never smoked, with no significant difference in age, height, ethnicity, or baseline spirometry between the groups. The PEF was measured for each welder before the start of work and 15 minutes, 30 minutes, and 1, 2, 4, 7, and 12 hours after the start of welding. The same method was applied to the non-welders, for whom a proxy time for the start of welding was used. The percentage change in baseline PEF was calculated for each subject at each of the recording times. The welder and non-welder group means for these results were significantly different at 15 minutes (p = 0.028). Also, the group mean for maximum fall in PEF (at any of the recording times during the 12 hour period) was significantly greater for the welders (p = 0.011). 50% of the welders (10/20), but only 5% of the non-welders (1/20), experienced a fall in PEF in excess of 5% (p = 0.0046). 25% of the welders (5/20) experienced drops of greater than 5% within the first 15 minutes. The results are suggestive of an immediate type reaction in welders, similar to that seen in some cases of occupational asthma, although not so severe. Studies to determine if these reactions reflect non-specific bronchial hyper-responsiveness would be useful. It is recommended that future studies also undertake breathing zone measurements to relate the response to particular constituents of the welding plume, especially the gases ozone and nitrogen dioxide.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 09-2007
Publisher: Humana Press
Date: 2013
DOI: 10.1007/978-1-62703-607-8_13
Abstract: Studies of DNA methylation in Arabidopsis have rapidly advanced from the analysis of a single reference accession to investigations of large populations. The goal of emerging population studies is to detect differentially methylated regions (DMRs) at the genome-wide scale, and to relate this variation to gene expression and phenotypic ersity.Whole-genome bisulfite sequencing (WGBS-seq) has established itself as a gold standard in DNA methylation analysis due to its high accuracy and single cytosine measurement resolution. However, scaling up the use of this technology for large population studies is currently not only cost prohibitive but also poses nontrivial bioinformatic challenges. If the end-point of the study is to detect DMRs at the level of several hundred base pairs rather than at the level of single cytosines, low-resolution array-based methods, such as MeDIP-chip, may be entirely sufficient. However, the trade-off between measurement accuracy and experimental/analytical practicality needs to be weighted carefully. To help make such experimental choices, we conducted a side-by-side comparison between the popular dual-channel MeDIP-chip Nimblegen technology and Illumina WGBS-seq in two independent Arabidopsis lines.Our analysis shows that MeDIP-chip performs reasonably well in detecting DNA methylation at probe-level resolution, yielding a genome-wide combined false-positive and false-negative rate of about 0.21. However, detection can be susceptible to strong signal distortions resulting from a combination of dye bias and the CG content of effectively unmethylated genomic regions. We show that these issues can be easily bypassed by taking appropriate data preparation steps and applying suitable analysis tools.We conclude that MeDIP-chip is a reasonable alternative to WGBS-seq in emerging Arabidopsis population epigenetic studies.
Publisher: Wiley
Date: 2004
DOI: 10.1002/AJIM.10345
Abstract: Heat illness is relatively common in the underground metalliferous mines of South Africa and Australia. Little is known about heat illness in other forms of mining and there have been no studies of heat illness in the US mining industry. Mine Safety and Health Administration (MSHA) accident, injury, illness, and employment data were used to study heat illness reported by the US mining industry from January 1, 1983 to December 31, 2001. Five hundred thirty eight cases of heat illness were reported. None of these cases were fatal. Four hundred twenty seven cases (79.4%) occurred in the summer months of June, July, and August. Incidence rates of heat illness in underground mining ranged from 0.00275/10(6) person-hours for coal, to 0.168/10(6) person-hours for metal, rate-ratio = 61.1 (P < 0.001). Incidence rates in surface mining ranged from 0.0265/10(6) person-hours for coal, to 0.0644/10(6) person-hours for stone, rate-ratio = 2.43 (P < 0.001). Incidence rates in mills reparation plants ranged from 0.0255/10(6) person-hours for coal, to 0.417/10(6) person-hours for stone, rate-ratio = 16.4 (P < 0.001). Heat illness occurs most frequently in stone mills, metal mills, and underground metal mines. Preventive measures should target the summer months of June, July, and August.
Publisher: Oxford University Press (OUP)
Date: 1998
Abstract: A 19-year-old man developed tremor in both hands and fatigue after starting work at a placer gold mine where he was exposed to mercury-gold amalgam. Examination revealed an intention tremor, dysdiadochokinesis and mild rigidity. The 24-h urinary mercury concentration reached a peak of 715 nmol/l (143 ug/l) shortly before the clinical examination, after which he was removed from working in the gold room [Mercury No. Adverse Effect Level: 250 nmol/l (50 ug/l)]. On review 7 weeks later his tremor had almost resolved and the dysdiadochokinesis and rigidity had gone. The 24-h urinary mercury concentration had fallen to 160 nmol/l (32 ug/l). The principal exposure to mercury was considered to be the smelting of retorted gold with previously unrecognized residual mercury in it. The peak air concentration of mercury vapour during gold smelting was 0.533 mg/m3 (Mercury Vapour ACGIH TLV: 0.05 mg/m3 TWA). Several engineering and procedural controls were instituted. This episode occurred at another mine site, unrelated to Mount Isa Mines Limited.
Publisher: Oxford University Press (OUP)
Date: 1994
Publisher: Wiley
Date: 10-12-2018
DOI: 10.1002/AJIM.22934
Publisher: Oxford University Press (OUP)
Date: 20-11-2009
Abstract: Health promotion initiatives are an important element of occupational medicine practice but evaluating success is complex. The publishers of a quarterly health promotion magazine asked an aluminium smelting company if it would consider providing the magazine to its employees. To evaluate the possible benefits to employees of receiving a health promotion magazine. Three issues were distributed by post over a 9 month period to employees at an aluminium smelter. Pre- and post-distribution questionnaires were mailed to employees and their partners, asking questions about health knowledge and behaviour. Statistical analysis was undertaken using chi-square and Fisher's exact test. Overall 243 of 640 employees (38%) responded to the initial questionnaire and 129 (20%) to the final questionnaire. Pre-existing knowledge about preventive health issues was high 61-100% of employees selected the correct answer to questions about diet, smoking and exercise. Following distribution of the magazines, there was an increase in employees' knowledge of sugars in 'fat-free' foods (P < 0.05), the benefits of fish oil (P < 0.01) and in how often health was considered when buying food (P < 0.05), as well as an increase in partners' knowledge of dietary fats (P < 0.001). Overall 84% of employees and 87% of their partners who returned the final questionnaire and indicated they had read the magazine showed enthusiasm for continued delivery. The results suggest that the pilot intervention was beneficial however, the findings must be interpreted with caution given the modest response rates.
Publisher: Oxford University Press (OUP)
Date: 05-2000
Abstract: The risk of heat exhaustion at a deep underground metalliferous mine was assessed in relation to the body-mass index (BMI) and predicted maximal oxygen uptake (VO2max) of miners, using case-control methodology. Sixty-five cases of acute heat exhaustion and 119 controls were studied. Heat exhaustion cases had a significantly higher BMI than controls (P = 0.006). The odds ratios increased with BMI. For a BMI of 32.00-36.99, compared to a BMI of less than 27.00 the odds ratio was 3.63 (95% confidence interval, 1.42-9.36). VO2max was not significantly lower in cases than controls. The odds ratios for heat exhaustion increased with decreasing VO2max, but not significantly. The s le size provided 80% power of detecting an odds ratio of 2.5 or greater. Deep underground miners should be advised to maintain a BMI of 24-27. Selection of miners on the basis of BMI should not be used as an alternative to satisfactory engineering controls such as ventilation and refrigeration.
Publisher: BMJ
Date: 02-2003
Publisher: Oxford University Press (OUP)
Date: 06-2001
Abstract: Risk equations have been developed to assist in determining fitness for work of people with diseases that may cause rapid loss of control. The four equations calculate the frequency of fatal injury to the person with the disease, the frequency of fatal injury to colleagues in the workplace, and the cost of fatal injury and property damage to the employer. It is suggested that the additional risk of fatal injury to the person with the disease should not exceed the fatal injury rate in high-risk industries such as forestry, fishing and mining. It is also suggested that the additional risk of fatal injury to each colleague should be no more than one-tenth of the fatal injury rate due to motor vehicle accidents in the community. Two hypothetical case ex les are given, demonstrating the use of the equations. The equations highlight the need to examine the risks associated with in iduals, their specific jobs and their workplaces. They also highlight significant uncertainties in the determination of fitness, which perhaps have been underestimated in the past. Wherever possible, redundant defences should be utilized to prevent accidents in the event of sudden incapacity.
Publisher: Oxford University Press (OUP)
Date: 09-2005
Publisher: Oxford University Press (OUP)
Date: 08-2004
Publisher: BMJ
Date: 03-1999
Publisher: Oxford University Press (OUP)
Date: 1998
Abstract: A xanthate reagent mixer at a gold mine concentrator was exposed to carbon disulphide by extensive skin contamination with xanthate powder and solution during the reagent mixing process. Absorption of carbon disulphide was confirmed by the detection of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA). Drager colorimetric tube testing during subsequent mixing recorded a maximum concentration of at least 60 ppm carbon disulphide. An illness consisting of predominantly gastrointestinal symptoms began 20 h after the exposure. Although this may have been due to carbon disulphide toxicity this is by no means certain. The need for engineering controls, impervious protective clothing and full-face respirators with particulate and organic vapour cartridges is discussed. This episode occurred at another mine site, unrelated to Mount Isa Mines Limited.
Publisher: BMJ
Date: 08-1993
Publisher: Oxford University Press (OUP)
Date: 1994
Abstract: A 32-year-old man who took pride in his skill and speed as a welder suffered two relatively brief intense exposures (three months each) to welding fumes under relatively confined space conditions. He developed shortness of breath within 18 months of beginning work, with severe impairment of his diffusion capacity. This remains some months later despite discontinuing his welding activities.
Publisher: Oxford University Press (OUP)
Date: 07-2000
Abstract: The risk of heat exhaustion at a deep underground metalliferous mine was assessed in relation to thermal conditions prevailing on the surface. For each day of a 1-year prospective case series of heat exhaustion, surface 24-h mean wet and dry bulb temperatures were recorded. From this data, 24-h mean wet bulb globe temperatures were derived using certain assumptions. The three surface temperature variables were significantly higher on those days on which heat exhaustion occurred, compared to those days on which it did not occur (P < 0.001). The relative risk of heat exhaustion on days when the 24-h mean wet bulb globe temperature was in the range 26.0-28.0 degrees C was 4.82 (95% confidence interval 2.12-10.96). Surface temperature data could be used at this mine to warn miners about the risk of heat exhaustion.
Publisher: Oxford University Press (OUP)
Date: 03-2001
Abstract: Two hazard risk assessment matrices for the ranking of occupational health risks are described. The qualitative matrix uses qualitative measures of probability and consequence to determine risk assessment codes for hazard-disease combinations. A walk-through survey of an underground metalliferous mine and concentrator is used to demonstrate how the qualitative matrix can be applied to determine priorities for the control of occupational health hazards. The semi-quantitative matrix uses attributable risk as a quantitative measure of probability and uses qualitative measures of consequence. A practical application of this matrix is the determination of occupational health priorities using existing epidemiological studies. Calculated attributable risks from epidemiological studies of hazard-disease combinations in mining and minerals processing are used as ex les. These historic response data do not reflect the risks associated with current exposures. A method using current exposure data, known exposure-response relationships and the semi-quantitative matrix is proposed for more accurate and current risk rankings.
Publisher: Oxford University Press (OUP)
Date: 03-2003
Abstract: This paper presents a further analysis of biochemical data collected during a 1 year prospective study of 106 cases of heat exhaustion at a deep underground metalliferous mine. Multiple regression analysis results indicate that the haemoglobin, serum creatinine and plasma lactate concentrations are statistically significant predictors of the anion gap. Together, they explain 65% of the variance in the anion gap (R(2) = 0.650). Spearman's rho correlation results also confirm that haemoglobin, creatinine and lactate are each statistically significantly correlated with the anion gap (P < 0.001). These results indicate that dehydration and lactate are important determinants of the metabolic acidosis previously observed in occupational heat exhaustion. It is likely that dehydration in these workers has resulted in poor muscle perfusion, anaerobic conditions and elevated lactate. This constitutes Type A lactic acidosis. Creatine kinase is not a statistically significant predictor of the anion gap in multiple regression (P = 0.956). Furthermore, the Spearman's rho correlation coefficient for creatine kinase versus the anion gap is weak (r(s) = 0.175) and is not statistically significant (P = 0.073). These results suggest that there was no rhabdomyolysis contributing to the metabolic acidosis.
Publisher: Informa UK Limited
Date: 02-2014
Publisher: Oxford University Press (OUP)
Date: 05-09-2012
Abstract: Two international benchmarks assess whether the mining and processing of ores containing Naturally Occurring Radioactive Material (NORM) require management under radiological regulations set by local jurisdictions. First, the 1 Bq/g benchmark for radionuclide head of chain activity concentration determines whether materials may be excluded from radiological regulation. Second, processes may be exempted from radiological regulation where occupational above-background exposures for members of the workforce do not exceed 1 mSv/year. This is also the upper-limit of exposure prescribed for members of the public. Alcoa of Australia Limited (Alcoa) has undertaken radiological evaluations of the mining and processing of bauxite from the Darling Range of Western Australia since the 1980s. Short-term monitoring projects have demonstrated that above-background exposures for workers do not exceed 1 mSv/year. A whole-of-year evaluation of above-background, occupational radiological doses for bauxite mining, alumina refining and residue operations was conducted during 2008/2009 as part of the Alcoa NORM Quality Assurance System (NQAS). The NQAS has been guided by publications from the International Commission on Radiological Protection (ICRP), the International Atomic Energy Agency (IAEA) and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA). The NQAS has been developed specifically in response to implementation of the Australian National Directory on Radiation Protection (NDRP). Positional monitoring was undertaken to increase the accuracy of natural background levels required for correction of occupational exposures. This is important in view of the small increments in exposure that occur in bauxite mining, alumina refining and residue operations relative to natural background. Positional monitoring was also undertaken to assess the potential for exposure in operating locations. Personal monitoring was undertaken to characterise exposures in Similar Exposure Groups (SEGs). The monitoring was undertaken over 12 months, to provide annual average assessments of above-background doses, thereby reducing temporal variations, especially for radon exposures. The monitoring program concentrated on gamma and radon exposures, rather than gross alpha exposures, as past studies have shown that gross alpha exposures from inhalable dust for most of the workforce are small in comparison to combined gamma and radon exposures. The natural background determinations were consistent with data in the literature for localities near Alcoa's mining, refining and residue operations in Western Australia, and also with UNSCEAR global data. Within the mining operations, there was further consistency between the above-background dose estimates and the local geochemistry, with slight elevation of dose levels in mining pits. Conservative estimates of above-background levels for the workforce have been made using an assumption of 100% occupancy (1920 hours per year) for the SEGs considered. Total incremental composite doses for in iduals were clearly less than 1.0 mSv/year when gamma, radon progeny and gross alpha exposures were considered. This is despite the activity concentration of some materials being slightly higher than the benchmark of 1 Bq/g. The results are consistent with previous monitoring and demonstrate compliance with the 1 mSv/year exemption level within mining, refining and residue operations. These results will be of value to bauxite mines and alumina refineries elsewhere in the world.
Publisher: Oxford University Press (OUP)
Date: 08-2001
Abstract: Penalizing line management for the occurrence of lost time injuries has in some cases had unintended negative consequences. These are discussed. An alternative system is suggested that penalizes line management for accidents where the combination of the probability of recurrence and the maximum reasonable consequences such a recurrence may have exceeds an agreed limit. A reward is given for prompt effective control of the risk to below the agreed risk limit. The reward is smaller than the penalty. High-risk accidents require independent investigation by a safety officer using analytical techniques. Two case ex les are given to illustrate the system. Continuous safety improvement is driven by a planned reduction in the agreed risk limit over time and reward for proactive risk assessment and control.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7FD90076G
Publisher: Oxford University Press (OUP)
Date: 15-10-2015
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-2014
Publisher: Oxford University Press (OUP)
Date: 05-2002
Abstract: This paper presents an analysis of personal respirable coal dust measurements recorded by the Joint Coal Board in the underground longwall mines of New South Wales from 1985 to 1999. A description of the longwall mining process is given. In the study, 11 829 measurements from 33 mines were analysed and the results given for each occupation, for seven occupational groups, for in idual de-identified mines and for each year of study. The mean respirable coal dust concentration for all jobs was 1.51 mg/m(3) (SD 1.08 mg/m(3)). Only 6.9% of the measurements exceeded the Australian exposure standard of 3 mg/m(3). Published exposure-response relationships were used to predict the prevalence of progressive massive fibrosis and the mean loss of FEV(1), after a working lifetime (40 years) of exposure to the mean observed concentration of 1.5 mg/m(3). Prevalences of 1.3 and 2.9% were predicted, based on data from the UK and the USA, respectively. The mean loss of FEV(1) was estimated to be 73.7 ml.
Publisher: Springer Science and Business Media LLC
Date: 09-07-2022
DOI: 10.1038/S43856-022-00147-Y
Abstract: Rapid antigen (RA) tests are being increasingly employed to detect SARS-CoV-2 infections in quarantine and surveillance. Prior research has focused on RT-PCR testing, a single RA test, or generic diagnostic characteristics of RA tests in assessing testing strategies. We have conducted a comparative analysis of the post-quarantine transmission, the effective reproduction number during serial testing, and the false-positive rates for 18 RA tests with emergency use authorization from The United States Food and Drug Administration and an RT-PCR test. To quantify the extent of transmission, we developed an analytical mathematical framework informed by COVID-19 infectiousness, test specificity, and temporal diagnostic sensitivity data. We demonstrate that the relative effectiveness of RA tests and RT-PCR testing in reducing post-quarantine transmission depends on the quarantine duration and the turnaround time of testing results. For quarantines of two days or shorter, conducting a RA test on exit from quarantine reduces onward transmission more than a single RT-PCR test (with a 24-h delay) conducted upon exit. Applied to a complementary approach of performing serial testing at a specified frequency paired with isolation of positives, we have shown that RA tests outperform RT-PCR with a 24-h delay. The results from our modeling framework are consistent with quarantine and serial testing data collected from a remote industry setting. These RA test-specific results are an important component of the tool set for policy decision-making, and demonstrate that judicious selection of an appropriate RA test can supply a viable alternative to RT-PCR in efforts to control the spread of disease.
Publisher: Oxford University Press (OUP)
Date: 06-2021
Publisher: Oxford University Press (OUP)
Date: 07-2022
DOI: 10.1093/PNASNEXUS/PGAC100
Abstract: Quarantine and serial testing strategies for a disease depend principally on its incubation period and infectiousness profile. In the context of COVID-19, these primary public health tools must be modulated with successive SARS CoV-2 variants of concern that dominate transmission. Our analysis shows that (1) vaccination status of an in idual makes little difference to the determination of the appropriate quarantine duration of an infected case, whereas vaccination coverage of the population can have a substantial effect on this duration, (2) successive variants can challenge disease control efforts by their earlier and increased transmission in the disease time course relative to prior variants, and (3) sufficient vaccine boosting of a population substantially aids the suppression of local transmission through frequent serial testing. For instance, with Omicron, increasing immunity through vaccination and boosters—for instance with 100% of the population is fully immunized and at least 24% having received a third dose—can reduce quarantine durations by up to 2 d, as well as substantially aid in the repression of outbreaks through serial testing. Our analysis highlights the paramount importance of maintaining high population immunity, preferably by booster uptake, and the role of quarantine and testing to control the spread of SARS CoV-2.
Publisher: Oxford University Press (OUP)
Date: 12-2008
Publisher: Wiley
Date: 22-12-2010
DOI: 10.1002/AJIM.20925
Abstract: To examine the incidence of occupational asthma in the seven aluminum smelters of Australia and New Zealand from 1991 to 2006. Incidence and exposure data were collected by survey from the smelters prospectively during the study period. The incidence of occupational asthma across all smelters combined was highest in 1992 at 9.46/1,000/year, declining to 0.36/1,000/year in 2006 a 96.2% reduction. The incidence of occupational asthma was correlated with geometric mean total fluoride concentration, measured as personal s les from employees undertaking anode changing (r(s) = 0.497, P < 0.001). The control of exposures, respiratory protection and pre-placement medical assessments undertaken during the study period seem to have contributed to the substantial decline in occupational asthma incidence.
Publisher: Wiley
Date: 19-07-2010
DOI: 10.1111/J.1365-4632.2009.04397.X
Abstract: Diphoterine is a commercially available hoteric, hypertonic, chelating solution used to decontaminate and irrigate chemical splashes. The aim of this study was to evaluate the implementation of Diphoterine at three alumina refineries. This is the largest case series reported to date. One hundred eighty cases of alkali splashes to the skin were evaluated clinically. Two groups were compared those who had applied Diphoterine first and those who had applied water first. There were no signs of chemical burn in 52.9% of the group who applied Diphoterine first compared with 21.4% of the group who applied water first. Only 7.9% of the group who applied Diphoterine first had blisters or more severe signs compared with 23.8% of the group who applied water first. The differences were statistically significant (P < 0.001). After implementation of Diphoterine the "first aid" injury rate for chemical burns fell 24.7% (95% CI 0.5–43.0%). Applying Diphoterine first was associated with significantly better outcomes following alkali skin splashes than applying water first.
Publisher: Cold Spring Harbor Laboratory
Date: 26-08-2021
DOI: 10.1101/2021.08.23.21262499
Abstract: Rapid antigen (RA) tests are being increasingly employed to detect SARS-CoV-2 infections in quarantine and surveillance. Prior research has focused on RT-PCR testing, a single RA test, or generic diagnostic characteristics of RA tests in assessing testing strategies. For 18 RA tests with emergency use authorization from the United States of America FDA and an RT-PCR test, we conducted a comparative analysis of the post-quarantine transmission, the effective reproduction number during serial testing, and the false-positive rates. To quantify the extent of transmission, we developed an analytical mathematical framework informed by COVID-19 infectiousness, test specificity, and temporal diagnostic sensitivity data. We demonstrate that the relative effectiveness of RA and RT-PCR tests in reducing post-quarantine transmission depends on the quarantine duration and the turnaround time of testing results. For quarantines of two days or shorter, conducting a RA test on exit from quarantine reduces onward transmission more than a single RT-PCR test (with a 24-h delay) conducted upon exit. Applied to a complementary approach of performing serial testing at a specified frequency paired with isolation of positives, we have shown that RA tests outperform RT-PCR with a 24-h delay. The results from our modeling framework are consistent with quarantine and serial testing data collected from a remote industry setting. These RA test-specific results are an important component of the tool set for policy decision-making, and demonstrate that judicious selection of an appropriate RA test can supply a viable alternative to RT-PCR in efforts to control the spread of disease. Previous research has determined optimal timing for testing in quarantine and the utility of different frequencies of testing for disease surveillance using RT-PCR and generalized rapid antigen tests. However, these strategies can depend on the specific rapid antigen test used. By examining 18 rapid antigen tests, we demonstrate that a single rapid antigen test performs better than RT-PCR when quarantines are two days or less in duration. In the context of disease surveillance, the ability of a rapid antigen test to provide results quickly counteracts its lower sensitivity with potentially more false positives. These analytical results based on highly controlled test validation were consistent with real-world data obtained from quarantine and serial testing in an industrial setting.
Publisher: BMJ
Date: 11-07-2014
Location: United Kingdom of Great Britain and Northern Ireland
Location: Australia
No related grants have been discovered for A. Michael Donoghue.