ORCID Profile
0000-0003-3220-4975
Current Organisations
University of New South Wales
,
Noakhali Science and Technology University
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Publisher: Sciencedomain International
Date: 10-01-2014
Publisher: OMICS Publishing Group
Date: 2016
Publisher: Springer Science and Business Media LLC
Date: 14-06-2017
Publisher: Elsevier BV
Date: 12-2021
Publisher: MDPI AG
Date: 27-08-2022
DOI: 10.3390/BIOM12091189
Abstract: The cerebellum, or “little brain”, is often overlooked in studies of brain metabolism in favour of the cortex. Despite this, anomalies in cerebellar amino acid homeostasis in a range of disorders have been reported. Amino acid homeostasis is central to metabolism, providing recycling of carbon backbones and ammonia between cell types. Here, we examined the role of cerebellar amino acid transporters in the cycling of glutamine and alanine in guinea pig cerebellar slices by inhibiting amino acid transporters and examining the resultant metabolism of [1-13C]d-glucose and [1,2-13C]acetate by NMR spectroscopy and LCMS. While the lack of specific inhibitors of each transporter makes interpretation difficult, by viewing results from experiments with multiple inhibitors we can draw inferences about the major cell types and transporters involved. In cerebellum, glutamine and alanine transfer is dominated by system A, blockade of which has maximum effect on metabolism, with contributions from System N. Inhibition of neural system A isoform SNAT1 by MeAIB resulted in greatly decreased metabolite pools and reduced net fluxes but showed little effect on fluxes from [1,2-13C]acetate unlike inhibition of SNAT3 and other glutamine transporters by histidine where net fluxes from [1,2-13C]acetate are reduced by ~50%. We interpret the data as further evidence of not one but several glutamate/glutamine exchange pools. The impact of amino acid transport inhibition demonstrates that the cerebellum has tightly coupled cells and that glutamate/glutamine, as well as alanine cycling, play a major role in that part of the brain.
Publisher: Academic Journals
Date: 03-02-2015
Publisher: Springer Science and Business Media LLC
Date: 29-10-2014
Publisher: Springer Science and Business Media LLC
Date: 25-03-2015
Publisher: Springer Science and Business Media LLC
Date: 18-05-2020
Publisher: Springer Science and Business Media LLC
Date: 07-07-2020
Publisher: Tabriz University of Medical Sciences
Date: 2014
DOI: 10.5681/APB.2014.003
Publisher: Pan Health Care Research Society
Date: 28-04-2013
Publisher: OMICS Publishing Group
Date: 2016
Publisher: Wiley
Date: 02-2023
DOI: 10.1002/HSR2.1097
Publisher: Sciencedomain International
Date: 10-01-2016
Publisher: Bangladesh Journals Online (JOL)
Date: 12-01-2014
DOI: 10.3329/DUJPS.V12I2.17612
Abstract: The present study was carried out to investigate the methanolic extract of leaf of Erioglossum rubiginosum and its fractionates (petroleum ether, carbontetrachloride and chloroform fractions) for their in vitro antioxidant, thrombolytic and cytotoxic activities. Among the different fractions, the carbontetrachloride soluble fraction (CTF) showed significant antioxidant activity (IC50=30.32±0.08 ?g/ml) as compared to standard ascorbic acid (IC50=5.87±0.21 ?g/ml) and BHT (IC50=27.50±0.64 ?g/ml). The extract also inhibited 58.44±0.97% lipid from peroxidation and reveled excellent phenolic profile of about 128.56±1.02 mg of GAE /g of extract. In the thrombolytic assay the highest % of clot lysis was exhibited by the chloroform soluble fraction (CF) (28.57±0.83%), while for streptokinase it was about 66.77±0.92%. The LC50 values were found within the range of 12.92 to 80.06 ?g/ml, while different solvent fractions were tested for cytotoxicity against brine shrimp nauplii. This is the first report of antioxidant, thrombolytic and cytotoxic activities of E. rubiginosum. Dhaka Univ. J. Pharm. Sci. 12(2): 153-158, 2013 (December) DOI: 0.3329/dujps.v12i2.17612
Publisher: Springer Science and Business Media LLC
Date: 22-08-2018
Publisher: Springer Science and Business Media LLC
Date: 18-04-2020
Publisher: MDPI AG
Date: 15-01-2018
Publisher: SAGE Publications
Date: 22-05-2018
Abstract: Background. Epilepsy is one of the chronic and heterogeneous epidemic neurological disorders leading to substantial mortality. The aim of the present study was to investigate the serum levels of malondialdehyde (MDA), vitamin C, and trace elements namely zinc (Zn), copper (Cu), and manganese (Mn) in epileptic patients of Bangladesh and to establish if there are any pathophysiological correlations. Methods. This was a case-control study with 40 generalized epileptic patients and 40 healthy subjects as controls. Epilepsy was determined by the presence of seizure events with an abnormal electroencephalography and magnetic resonance imaging report of brain. Results. Anthropometric parameters highlighted that age is a major risk factor of epilepsy and men are more prone to epilepsy than women. Blood serum analysis demonstrated significantly ( P .001) higher values of MDA and lower level of vitamin C in the patient group (4.41 ± 0.76 μmol/mL and 18.31 ± 0.84 μmol/L, respectively) compared with control (1.81 ± 0.70 μmol/mL and 29.72 ± 1.06 μmol/L, respectively). Pearson’s correlation analysis revealed a negative correlation between the serum level of MDA and vitamin C for both patient ( r = −0.023, P = .887) and control group ( r = −0.142, P = .383). This study also revealed that the trace elements (Zn, Cu) were significantly ( P .05) lower in epileptics (68.32 ± 4.59 and 50.81 ± 2.54 μg/dL, respectively) where the level of Mn in patients (187.71 ± 9.04 μg/dL) was almost similar to that of the control group ( P .05). The univariate analysis demonstrated that zinc μg/dL (odds ratio = 3.56, P .05) and copper μg/dL were associated (odds ratio = 14.73, P .001) with an increased risk of epilepsy. Establishment of interelement relationship strongly supported that there was a disturbance in the element homeostasis of epileptic patients. Conclusions. The study results strengthen the role of lipid peroxidation, antioxidants and trace elements in the pathogenesis and warrant larger studies to investigate the association of these biochemical parameters with epilepsy.
Publisher: Elsevier BV
Date: 12-2017
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.DSX.2019.01.041
Abstract: Obesity is associated with metabolic dysfunction and over nutrition. Increased body mass index and obesity are strongly amalgamated with changes in the physiological function of adipose tissue, leading to altered secretion of adipocytokines, inflammatory mediators release as well as chronic inflammation and insulin resistance. The purposes of this study were to review the evidence of how obesity and inflammation may lead to insulin resistance and cancer. Recent findings suggested that increased level of inflammatory mediators in obesity, plays an introductory and cabalistic role in the development of different types of inflammatory disorders including type 2 diabetes mellitus. Link between elevated body mass index and type 2 diabetes mellitus (T2DM). Several of the factors-such as increased levels of leptin, plasminogen activator inhibitor-1, decreased levels of adiponectin, insulin resistance, chronic inflammation etc. consequently result in carcinogenesis and carcinogenic progression too. This review summarizes how cytokine production in adipose tissue of obese subject creates a chronic inflammatory environment that favors tumor cell motility and invasion to enhance the metastatic potential of tumor cells. High levels of cytokine in the circulation of affected in iduals have been associated with a significantly worse outcome. This article also reconnoiters the mechanisms that link obesity to numerous disorders such as inflammation, diabetes, cancers and most specifically combine these processes in a single image. Understanding these mechanisms may assist to understand the consequences of obesity.
Publisher: EManuscript Technologies
Date: 05-2013
No related grants have been discovered for Abhijit Das.